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Items: 1 to 50 of 53

1.

Redox signals at the ER-mitochondria interface control melanoma progression.

Zhang X, Gibhardt CS, Will T, Stanisz H, Körbel C, Mitkovski M, Stejerean I, Cappello S, Pacheu-Grau D, Dudek J, Tahbaz N, Mina L, Simmen T, Laschke MW, Menger MD, Schön MP, Helms V, Niemeyer BA, Rehling P, Vultur A, Bogeski I.

EMBO J. 2019 Aug 1;38(15):e100871. doi: 10.15252/embj.2018100871. Epub 2019 Jul 15.

2.

Coming together to define membrane contact sites.

Scorrano L, De Matteis MA, Emr S, Giordano F, Hajnóczky G, Kornmann B, Lackner LL, Levine TP, Pellegrini L, Reinisch K, Rizzuto R, Simmen T, Stenmark H, Ungermann C, Schuldiner M.

Nat Commun. 2019 Mar 20;10(1):1287. doi: 10.1038/s41467-019-09253-3. Review.

3.

Author Correction: Caveolin-1 impairs PKA-DRP1-mediated remodelling of ER-mitochondria communication during the early phase of ER stress.

Bravo-Sagua R, Parra V, Ortiz-Sandoval C, Navarro-Marquez M, Rodríguez AE, Diaz-Valdivia N, Sanhueza C, Lopez-Crisosto C, Tahbaz N, Rothermel BA, Hill JA, Cifuentes M, Simmen T, Quest AFG, Lavandero S.

Cell Death Differ. 2019 Feb 11. doi: 10.1038/s41418-019-0279-8. [Epub ahead of print]

PMID:
30742089
4.

Real-Time Imaging of Mitochondrial ATP Dynamics Reveals the Metabolic Setting of Single Cells.

Depaoli MR, Karsten F, Madreiter-Sokolowski CT, Klec C, Gottschalk B, Bischof H, Eroglu E, Waldeck-Weiermair M, Simmen T, Graier WF, Malli R.

Cell Rep. 2018 Oct 9;25(2):501-512.e3. doi: 10.1016/j.celrep.2018.09.027.

5.

Caveolin-1 impairs PKA-DRP1-mediated remodelling of ER-mitochondria communication during the early phase of ER stress.

Bravo-Sagua R, Parra V, Ortiz-Sandoval C, Navarro-Marquez M, Rodríguez AE, Diaz-Valdivia N, Sanhueza C, Lopez-Crisosto C, Tahbaz N, Rothermel BA, Hill JA, Cifuentes M, Simmen T, Quest AFG, Lavandero S.

Cell Death Differ. 2019 Jul;26(7):1195-1212. doi: 10.1038/s41418-018-0197-1. Epub 2018 Sep 12. Erratum in: Cell Death Differ. 2019 Feb 11;:.

PMID:
30209302
6.

Plastic mitochondria-endoplasmic reticulum (ER) contacts use chaperones and tethers to mould their structure and signaling.

Simmen T, Herrera-Cruz MS.

Curr Opin Cell Biol. 2018 Aug;53:61-69. doi: 10.1016/j.ceb.2018.04.014. Epub 2018 Jun 2. Review.

PMID:
29870872
7.

Redox crosstalk at endoplasmic reticulum (ER) membrane contact sites (MCS) uses toxic waste to deliver messages.

Yoboue ED, Sitia R, Simmen T.

Cell Death Dis. 2018 Feb 28;9(3):331. doi: 10.1038/s41419-017-0033-4. Review.

8.

Expression of a T39N mutant Rab32 protein arrests mitochondria movement within neurites of differentiated SH-SY5Y cells.

Rybnicek J, Samtleben S, Herrera-Cruz MS, Simmen T.

Small GTPases. 2018 Jan 7:1-4. doi: 10.1080/21541248.2017.1411312. [Epub ahead of print]

PMID:
29261068
9.

Over Six Decades of Discovery and Characterization of the Architecture at Mitochondria-Associated Membranes (MAMs).

Herrera-Cruz MS, Simmen T.

Adv Exp Med Biol. 2017;997:13-31. doi: 10.1007/978-981-10-4567-7_2. Review.

PMID:
28815519
10.

Organelle Communication at Membrane Contact Sites (MCS): From Curiosity to Center Stage in Cell Biology and Biomedical Research.

Simmen T, Tagaya M.

Adv Exp Med Biol. 2017;997:1-12. doi: 10.1007/978-981-10-4567-7_1. Review.

PMID:
28815518
11.

Endoplasmic reticulum chaperones tweak the mitochondrial calcium rheostat to control metabolism and cell death.

Gutiérrez T, Simmen T.

Cell Calcium. 2018 Mar;70:64-75. doi: 10.1016/j.ceca.2017.05.015. Epub 2017 May 31. Review.

PMID:
28619231
12.

Cancer: Untethering Mitochondria from the Endoplasmic Reticulum?

Herrera-Cruz MS, Simmen T.

Front Oncol. 2017 May 26;7:105. doi: 10.3389/fonc.2017.00105. eCollection 2017. Review.

13.

Caught in the act - protein adaptation and the expanding roles of the PACS proteins in tissue homeostasis and disease.

Thomas G, Aslan JE, Thomas L, Shinde P, Shinde U, Simmen T.

J Cell Sci. 2017 Jun 1;130(11):1865-1876. doi: 10.1242/jcs.199463. Epub 2017 May 5. Review.

14.

Of yeast, mice and men: MAMs come in two flavors.

Herrera-Cruz MS, Simmen T.

Biol Direct. 2017 Jan 25;12(1):3. doi: 10.1186/s13062-017-0174-5. Review.

15.

Rab32 connects ER stress to mitochondrial defects in multiple sclerosis.

Haile Y, Deng X, Ortiz-Sandoval C, Tahbaz N, Janowicz A, Lu JQ, Kerr BJ, Gutowski NJ, Holley JE, Eggleton P, Giuliani F, Simmen T.

J Neuroinflammation. 2017 Jan 23;14(1):19. doi: 10.1186/s12974-016-0788-z.

16.

TMX1 determines cancer cell metabolism as a thiol-based modulator of ER-mitochondria Ca2+ flux.

Raturi A, Gutiérrez T, Ortiz-Sandoval C, Ruangkittisakul A, Herrera-Cruz MS, Rockley JP, Gesson K, Ourdev D, Lou PH, Lucchinetti E, Tahbaz N, Zaugg M, Baksh S, Ballanyi K, Simmen T.

J Cell Biol. 2016 Aug 15;214(4):433-44. doi: 10.1083/jcb.201512077. Epub 2016 Aug 8.

17.

ER-luminal thiol/selenol-mediated regulation of Ca2+ signalling.

Appenzeller-Herzog C, Simmen T.

Biochem Soc Trans. 2016 Apr 15;44(2):452-9. doi: 10.1042/BST20150233. Review.

PMID:
27068954
18.

Transit of H2O2 across the endoplasmic reticulum membrane is not sluggish.

Appenzeller-Herzog C, Bánhegyi G, Bogeski I, Davies KJ, Delaunay-Moisan A, Forman HJ, Görlach A, Kietzmann T, Laurindo F, Margittai E, Meyer AJ, Riemer J, Rützler M, Simmen T, Sitia R, Toledano MB, Touw IP.

Free Radic Biol Med. 2016 May;94:157-60. doi: 10.1016/j.freeradbiomed.2016.02.030. Epub 2016 Feb 27.

PMID:
26928585
19.

Interaction with the effector dynamin-related protein 1 (Drp1) is an ancient function of Rab32 subfamily proteins.

Ortiz-Sandoval CG, Hughes SC, Dacks JB, Simmen T.

Cell Logist. 2014 Oct 2;4(4):e986399. eCollection 2014 Oct-Dec.

20.

A role for the ancient SNARE syntaxin 17 in regulating mitochondrial division.

Arasaki K, Shimizu H, Mogari H, Nishida N, Hirota N, Furuno A, Kudo Y, Baba M, Baba N, Cheng J, Fujimoto T, Ishihara N, Ortiz-Sandoval C, Barlow LD, Raturi A, Dohmae N, Wakana Y, Inoue H, Tani K, Dacks JB, Simmen T, Tagaya M.

Dev Cell. 2015 Feb 9;32(3):304-17. doi: 10.1016/j.devcel.2014.12.011. Epub 2015 Jan 22.

21.

Endoplasmic reticulum chaperones and oxidoreductases: critical regulators of tumor cell survival and immunorecognition.

Gutiérrez T, Simmen T.

Front Oncol. 2014 Oct 27;4:291. doi: 10.3389/fonc.2014.00291. eCollection 2014. Review.

22.

Organelle communication: signaling crossroads between homeostasis and disease.

Bravo-Sagua R, Torrealba N, Paredes F, Morales PE, Pennanen C, López-Crisosto C, Troncoso R, Criollo A, Chiong M, Hill JA, Simmen T, Quest AF, Lavandero S.

Int J Biochem Cell Biol. 2014 May;50:55-9. doi: 10.1016/j.biocel.2014.01.019. Epub 2014 Feb 15. Review.

PMID:
24534274
23.

Redox dependence of endoplasmic reticulum (ER) Ca²⁺ signaling.

Raturi A, Ortiz-Sandoval C, Simmen T.

Histol Histopathol. 2014 May;29(5):543-52. doi: 10.14670/HH-29.10.543. Epub 2013 Nov 7. Review.

PMID:
24197491
24.

Palmitoylation is the switch that assigns calnexin to quality control or ER Ca2+ signaling.

Lynes EM, Raturi A, Shenkman M, Ortiz Sandoval C, Yap MC, Wu J, Janowicz A, Myhill N, Benson MD, Campbell RE, Berthiaume LG, Lederkremer GZ, Simmen T.

J Cell Sci. 2013 Sep 1;126(Pt 17):3893-903. doi: 10.1242/jcs.125856. Epub 2013 Jul 10.

25.

Dimerization-dependent green and yellow fluorescent proteins.

Alford SC, Ding Y, Simmen T, Campbell RE.

ACS Synth Biol. 2012 Dec 21;1(12):569-75. doi: 10.1021/sb300050j. Epub 2012 Aug 14.

26.

Rab proteins of the endoplasmic reticulum: functions and interactors.

Ortiz Sandoval C, Simmen T.

Biochem Soc Trans. 2012 Dec 1;40(6):1426-32. doi: 10.1042/BST20120158. Review.

PMID:
23176493
27.

Where the endoplasmic reticulum and the mitochondrion tie the knot: the mitochondria-associated membrane (MAM).

Raturi A, Simmen T.

Biochim Biophys Acta. 2013 Jan;1833(1):213-24. doi: 10.1016/j.bbamcr.2012.04.013. Epub 2012 May 2. Review.

28.

The chemotherapeutic agent paclitaxel inhibits autophagy through two distinct mechanisms that regulate apoptosis.

Veldhoen RA, Banman SL, Hemmerling DR, Odsen R, Simmen T, Simmonds AJ, Underhill DA, Goping IS.

Oncogene. 2013 Feb 7;32(6):736-46. doi: 10.1038/onc.2012.92. Epub 2012 Mar 19.

PMID:
22430212
29.

Mechanisms of cytosolic targeting of matrix metalloproteinase-2.

Ali MA, Chow AK, Kandasamy AD, Fan X, West LJ, Crawford BD, Simmen T, Schulz R.

J Cell Physiol. 2012 Oct;227(10):3397-404. doi: 10.1002/jcp.24040.

PMID:
22212960
30.

Palmitoylated TMX and calnexin target to the mitochondria-associated membrane.

Lynes EM, Bui M, Yap MC, Benson MD, Schneider B, Ellgaard L, Berthiaume LG, Simmen T.

EMBO J. 2012 Jan 18;31(2):457-70. doi: 10.1038/emboj.2011.384. Epub 2011 Nov 1.

31.

Granule-derived granzyme B mediates the vulnerability of human neurons to T cell-induced neurotoxicity.

Haile Y, Simmen KC, Pasichnyk D, Touret N, Simmen T, Lu JQ, Bleackley RC, Giuliani F.

J Immunol. 2011 Nov 1;187(9):4861-72. doi: 10.4049/jimmunol.1100943. Epub 2011 Sep 30.

32.

Urban planning of the endoplasmic reticulum (ER): how diverse mechanisms segregate the many functions of the ER.

Lynes EM, Simmen T.

Biochim Biophys Acta. 2011 Oct;1813(10):1893-905. doi: 10.1016/j.bbamcr.2011.06.011. Epub 2011 Jul 2. Review.

33.

Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress.

Bravo R, Vicencio JM, Parra V, Troncoso R, Munoz JP, Bui M, Quiroga C, Rodriguez AE, Verdejo HE, Ferreira J, Iglewski M, Chiong M, Simmen T, Zorzano A, Hill JA, Rothermel BA, Szabadkai G, Lavandero S.

J Cell Sci. 2011 Jul 1;124(Pt 13):2143-52. doi: 10.1242/jcs.080762. Epub 2011 May 31.

34.

Hax-1: a regulator of calcium signaling and apoptosis progression with multiple roles in human disease.

Simmen T.

Expert Opin Ther Targets. 2011 Jun;15(6):741-51. doi: 10.1517/14728222.2011.561787. Epub 2011 Mar 11. Review.

PMID:
21391832
35.

Rab32 modulates apoptosis onset and mitochondria-associated membrane (MAM) properties.

Bui M, Gilady SY, Fitzsimmons RE, Benson MD, Lynes EM, Gesson K, Alto NM, Strack S, Scott JD, Simmen T.

J Biol Chem. 2010 Oct 8;285(41):31590-602. doi: 10.1074/jbc.M110.101584. Epub 2010 Jul 29.

36.

Oxidative protein folding in the endoplasmic reticulum: tight links to the mitochondria-associated membrane (MAM).

Simmen T, Lynes EM, Gesson K, Thomas G.

Biochim Biophys Acta. 2010 Aug;1798(8):1465-73. doi: 10.1016/j.bbamem.2010.04.009. Epub 2010 Apr 27. Review.

37.

Ero1alpha requires oxidizing and normoxic conditions to localize to the mitochondria-associated membrane (MAM).

Gilady SY, Bui M, Lynes EM, Benson MD, Watts R, Vance JE, Simmen T.

Cell Stress Chaperones. 2010 Sep;15(5):619-29. doi: 10.1007/s12192-010-0174-1. Epub 2010 Feb 26.

38.

Accelerated senescence in kidneys of low-birth-weight rats after catch-up growth.

Luyckx VA, Compston CA, Simmen T, Mueller TF.

Am J Physiol Renal Physiol. 2009 Dec;297(6):F1697-705. doi: 10.1152/ajprenal.00462.2009. Epub 2009 Oct 14.

39.

A di-arginine motif contributes to the ER localization of the type I transmembrane ER oxidoreductase TMX4.

Roth D, Lynes E, Riemer J, Hansen HG, Althaus N, Simmen T, Ellgaard L.

Biochem J. 2009 Dec 14;425(1):195-205. doi: 10.1042/BJ20091064.

PMID:
19811453
40.

The subcellular distribution of calnexin is mediated by PACS-2.

Myhill N, Lynes EM, Nanji JA, Blagoveshchenskaya AD, Fei H, Carmine Simmen K, Cooper TJ, Thomas G, Simmen T.

Mol Biol Cell. 2008 Jul;19(7):2777-88. doi: 10.1091/mbc.E07-10-0995. Epub 2008 Apr 16.

41.

PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis.

Simmen T, Aslan JE, Blagoveshchenskaya AD, Thomas L, Wan L, Xiang Y, Feliciangeli SF, Hung CH, Crump CM, Thomas G.

EMBO J. 2005 Feb 23;24(4):717-29. Epub 2005 Feb 3. Erratum in: EMBO J. 2005 Mar 23;24(6):1301.

42.

Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation.

Köttgen M, Benzing T, Simmen T, Tauber R, Buchholz B, Feliciangeli S, Huber TB, Schermer B, Kramer-Zucker A, Höpker K, Simmen KC, Tschucke CC, Sandford R, Kim E, Thomas G, Walz G.

EMBO J. 2005 Feb 23;24(4):705-16. Epub 2005 Feb 3.

43.

Two conserved cysteine triads in human Ero1alpha cooperate for efficient disulfide bond formation in the endoplasmic reticulum.

Bertoli G, Simmen T, Anelli T, Molteni SN, Fesce R, Sitia R.

J Biol Chem. 2004 Jul 16;279(29):30047-52. Epub 2004 May 10.

44.

Thiol-mediated protein retention in the endoplasmic reticulum: the role of ERp44.

Anelli T, Alessio M, Bachi A, Bergamelli L, Bertoli G, Camerini S, Mezghrani A, Ruffato E, Simmen T, Sitia R.

EMBO J. 2003 Oct 1;22(19):5015-22.

45.

ERdj5, an endoplasmic reticulum (ER)-resident protein containing DnaJ and thioredoxin domains, is expressed in secretory cells or following ER stress.

Cunnea PM, Miranda-Vizuete A, Bertoli G, Simmen T, Damdimopoulos AE, Hermann S, Leinonen S, Huikko MP, Gustafsson JA, Sitia R, Spyrou G.

J Biol Chem. 2003 Jan 10;278(2):1059-66. Epub 2002 Oct 30.

46.

ERp44, a novel endoplasmic reticulum folding assistant of the thioredoxin family.

Anelli T, Alessio M, Mezghrani A, Simmen T, Talamo F, Bachi A, Sitia R.

EMBO J. 2002 Feb 15;21(4):835-44.

47.

AP-4 binds basolateral signals and participates in basolateral sorting in epithelial MDCK cells.

Simmen T, Höning S, Icking A, Tikkanen R, Hunziker W.

Nat Cell Biol. 2002 Feb;4(2):154-9.

PMID:
11802162
48.

Manipulation of oxidative protein folding and PDI redox state in mammalian cells.

Mezghrani A, Fassio A, Benham A, Simmen T, Braakman I, Sitia R.

EMBO J. 2001 Nov 15;20(22):6288-96.

49.
50.

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