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Items: 14

1.

TMC647055, a potent nonnucleoside hepatitis C virus NS5B polymerase inhibitor with cross-genotypic coverage.

Devogelaere B, Berke JM, Vijgen L, Dehertogh P, Fransen E, Cleiren E, van der Helm L, Nyanguile O, Tahri A, Amssoms K, Lenz O, Cummings MD, Clayton RF, Vendeville S, Raboisson P, Simmen KA, Fanning GC, Lin TI.

Antimicrob Agents Chemother. 2012 Sep;56(9):4676-84. doi: 10.1128/AAC.00245-12. Epub 2012 Jun 18.

2.

In vitro resistance profile of the hepatitis C virus NS3/4A protease inhibitor TMC435.

Lenz O, Verbinnen T, Lin TI, Vijgen L, Cummings MD, Lindberg J, Berke JM, Dehertogh P, Fransen E, Scholliers A, Vermeiren K, Ivens T, Raboisson P, Edlund M, Storm S, Vrang L, de Kock H, Fanning GC, Simmen KA.

Antimicrob Agents Chemother. 2010 May;54(5):1878-87. doi: 10.1128/AAC.01452-09. Epub 2010 Feb 22.

3.

1a/1b subtype profiling of nonnucleoside polymerase inhibitors of hepatitis C virus.

Nyanguile O, Devogelaere B, Vijgen L, Van den Broeck W, Pauwels F, Cummings MD, De Bondt HL, Vos AM, Berke JM, Lenz O, Vandercruyssen G, Vermeiren K, Mostmans W, Dehertogh P, Delouvroy F, Vendeville S, VanDyck K, Dockx K, Cleiren E, Raboisson P, Simmen KA, Fanning GC.

J Virol. 2010 Mar;84(6):2923-34. doi: 10.1128/JVI.01980-09. Epub 2010 Jan 13.

4.

1,5-benzodiazepines, a novel class of hepatitis C virus polymerase nonnucleoside inhibitors.

Nyanguile O, Pauwels F, Van den Broeck W, Boutton CW, Quirynen L, Ivens T, van der Helm L, Vandercruyssen G, Mostmans W, Delouvroy F, Dehertogh P, Cummings MD, Bonfanti JF, Simmen KA, Raboisson P.

Antimicrob Agents Chemother. 2008 Dec;52(12):4420-31. doi: 10.1128/AAC.00669-08. Epub 2008 Oct 13.

5.

Binding-site identification and genotypic profiling of hepatitis C virus polymerase inhibitors.

Pauwels F, Mostmans W, Quirynen LM, van der Helm L, Boutton CW, Rueff AS, Cleiren E, Raboisson P, Surleraux D, Nyanguile O, Simmen KA.

J Virol. 2007 Jul;81(13):6909-19. Epub 2007 Apr 25.

6.

Application of the trak-C HCV core assay for monitoring antiviral activity in HCV replication systems.

Cagnon L, Wagaman P, Bartenschlager R, Pietschmann T, Gao T, Kneteman NM, Tyrrell DL, Bahl C, Niven P, Lee S, Simmen KA.

J Virol Methods. 2004 Jun 1;118(1):23-31.

PMID:
15158065
7.

Development of a novel influenza A antiviral assay.

Wagaman PC, Leong MA, Simmen KA.

J Virol Methods. 2002 Aug;105(1):105-14.

PMID:
12176147
8.

Global modulation of cellular transcription by human cytomegalovirus is initiated by viral glycoprotein B.

Simmen KA, Singh J, Luukkonen BG, Lopper M, Bittner A, Miller NE, Jackson MR, Compton T, Früh K.

Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7140-5. Epub 2001 Jun 5.

9.

Protein interactions in the herpes simplex virus type 1 VP16-induced complex: VP16 peptide inhibition and mutational analysis of host cell factor requirements.

Simmen KA, Newell A, Robinson M, Mills JS, Canning G, Handa R, Parkes K, Borkakoti N, Jupp R.

J Virol. 1997 May;71(5):3886-94.

10.

Common and unique transcription factor requirements of human U1 and U6 snRNA genes.

Bernués J, Simmen KA, Lewis JD, Gunderson SI, Polycarpou-Schwarz M, Moncollin V, Egly JM, Mattaj IW.

EMBO J. 1993 Sep;12(9):3573-85.

11.

Cofractionation of the TATA-binding protein with the RNA polymerase III transcription factor TFIIIB.

Simmen KA, Bernués J, Lewis JD, Mattaj IW.

Nucleic Acids Res. 1992 Nov 25;20(22):5889-98.

12.

Proximal sequence element factor binding and species specificity in vertebrate U6 snRNA promoters.

Simmen KA, Waldschmidt R, Bernués J, Parry HD, Seifart KH, Mattaj IW.

J Mol Biol. 1992 Feb 20;223(4):873-84.

PMID:
1538402
13.

TFIID is required for in vitro transcription of the human U6 gene by RNA polymerase III.

Simmen KA, Bernués J, Parry HD, Stunnenberg HG, Berkenstam A, Cavallini B, Egly JM, Mattaj IW.

EMBO J. 1991 Jul;10(7):1853-62.

14.

Complex requirements for RNA polymerase III transcription of the Xenopus U6 promoter.

Simmen KA, Mattaj IW.

Nucleic Acids Res. 1990 Oct 11;18(19):5649-57.

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