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Beyond TCR Signaling: Emerging Functions of Lck in Cancer and Immunotherapy.

Bommhardt U, Schraven B, Simeoni L.

Int J Mol Sci. 2019 Jul 16;20(14). pii: E3500. doi: 10.3390/ijms20143500. Review.


[The health determinants in young children: testing a new surveillance system in Italy].

Pizzi E, Spinelli A, Battilomo S, Azzarito C, Balducci MT, Bettinelli ME, Campostrini S, Germinario C, Mazzarella G, Mignuoli AD, Morbidoni M, Porchia S, Simeoni L, Speri L; Gruppo sorveglianza bambini 0-2 anni.

Epidemiol Prev. 2019 Jan-Feb;43(1):66-70. doi: 10.19191/EP19.1.P66.022. Italian.


Lactate modulates CD4+ T-cell polarization and induces an immunosuppressive environment, which sustains prostate carcinoma progression via TLR8/miR21 axis.

Comito G, Iscaro A, Bacci M, Morandi A, Ippolito L, Parri M, Montagnani I, Raspollini MR, Serni S, Simeoni L, Giannoni E, Chiarugi P.

Oncogene. 2019 May;38(19):3681-3695. doi: 10.1038/s41388-019-0688-7. Epub 2019 Jan 21.


NF-κB inducing kinase (NIK) is an essential post-transcriptional regulator of T-cell activation affecting F-actin dynamics and TCR signaling.

Lacher SM, Thurm C, Distler U, Mohebiany AN, Israel N, Kitic M, Ebering A, Tang Y, Klein M, Wabnitz GH, Wanke F, Samstag Y, Bopp T, Kurschus FC, Simeoni L, Tenzer S, Waisman A.

J Autoimmun. 2018 Nov;94:110-121. doi: 10.1016/j.jaut.2018.07.017. Epub 2018 Jul 29.


Lck activation: puzzling the pieces together.

Simeoni L.

Oncotarget. 2017 Nov 7;8(61):102761-102762. doi: 10.18632/oncotarget.22309. eCollection 2017 Nov 28. No abstract available.


Biological activity of dihydropyrimidinone (DHPM) derivatives: A systematic review.

Matos LHS, Masson FT, Simeoni LA, Homem-de-Mello M.

Eur J Med Chem. 2018 Jan 1;143:1779-1789. doi: 10.1016/j.ejmech.2017.10.073. Epub 2017 Oct 31. Review.


Effects of metformin on endometrial cancer: Systematic review and meta-analysis.

Meireles CG, Pereira SA, Valadares LP, Rêgo DF, Simeoni LA, Guerra ENS, Lofrano-Porto A.

Gynecol Oncol. 2017 Oct;147(1):167-180. doi: 10.1016/j.ygyno.2017.07.120. Epub 2017 Jul 29. Review.


A highly conserved redox-active Mx(2)CWx(6)R motif regulates Zap70 stability and activity.

Thurm C, Poltorak MP, Reimer E, Brinkmann MM, Leichert L, Schraven B, Simeoni L.

Oncotarget. 2017 May 9;8(19):30805-30816. doi: 10.18632/oncotarget.16486.


Pouteria torta epicarp as a useful source of α-amylase inhibitor in the control of type 2 diabetes.

de Sales PM, de Souza PM, Dartora M, Resck IS, Simeoni LA, Fonseca-Bazzo YM, de Oliveira Magalhães P, Silveira D.

Food Chem Toxicol. 2017 Nov;109(Pt 2):962-969. doi: 10.1016/j.fct.2017.03.015. Epub 2017 Mar 10.


De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling.

Philipsen L, Reddycherla AV, Hartig R, Gumz J, Kästle M, Kritikos A, Poltorak MP, Prokazov Y, Turbin E, Weber A, Zuschratter W, Schraven B, Simeoni L, Müller AJ.

Sci Signal. 2017 Jan 17;10(462). pii: eaaf4736. doi: 10.1126/scisignal.aaf4736.


Extracts of Morus nigra L. Leaves Standardized in Chlorogenic Acid, Rutin and Isoquercitrin: Tyrosinase Inhibition and Cytotoxicity.

de Freitas MM, Fontes PR, Souza PM, William Fagg C, Neves Silva Guerra E, de Medeiros Nóbrega YK, Silveira D, Fonseca-Bazzo Y, Simeoni LA, Homem-de-Mello M, Oliveira Magalhães P.

PLoS One. 2016 Sep 21;11(9):e0163130. doi: 10.1371/journal.pone.0163130. eCollection 2016.


Early changes in the metabolic profile of activated CD8(+) T cells.

Cammann C, Rath A, Reichl U, Lingel H, Brunner-Weinzierl M, Simeoni L, Schraven B, Lindquist JA.

BMC Cell Biol. 2016 Jul 7;17(1):28. doi: 10.1186/s12860-016-0104-x.


Cytotoxic effect of Erythroxylum daphnites extract is associated with G1 cell cycle arrest and apoptosis in oral squamous cell carcinoma.

Elias ST, Macedo CC, Simeoni LA, Silveira D, Magalhães PO, Lofrano-Porto A, Coletta RD, Neves FA, Guerra EN.

Cell Cycle. 2016;15(7):948-56. doi: 10.1080/15384101.2016.1151583.


Redox homeostasis, T cells and kidney diseases: three faces in the dark.

Simeoni L, Thurm C, Kritikos A, Linkermann A.

Clin Kidney J. 2016 Feb;9(1):1-10. doi: 10.1093/ckj/sfv135. Epub 2015 Dec 13.


Combined paclitaxel, cisplatin and fluorouracil therapy enhances ionizing radiation effects, inhibits migration and induces G0/G1 cell cycle arrest and apoptosis in oral carcinoma cell lines.

Elias ST, Borges GA, Rêgo DF, E Silva LF, Avelino S, DE Matos Neto JN, Simeoni LA, Guerra EN.

Oncol Lett. 2015 Sep;10(3):1721-1727. Epub 2015 Jul 6.


T cells and reactive oxygen species.

Belikov AV, Schraven B, Simeoni L.

J Biomed Sci. 2015 Oct 15;22:85. doi: 10.1186/s12929-015-0194-3. Review.


Insulin and insulin-like growth factor-1 can modulate the phosphoinositide-3-kinase/Akt/FoxO1 pathway in SZ95 sebocytes in vitro.

Mirdamadi Y, Thielitz A, Wiede A, Goihl A, Papakonstantinou E, Hartig R, Zouboulis CC, Reinhold D, Simeoni L, Bommhardt U, Quist S, Gollnick H.

Mol Cell Endocrinol. 2015 Nov 5;415:32-44. doi: 10.1016/j.mce.2015.08.001. Epub 2015 Aug 6.


miR-20a inhibits TCR-mediated signaling and cytokine production in human naïve CD4+ T cells.

Reddycherla AV, Meinert I, Reinhold A, Reinhold D, Schraven B, Simeoni L.

PLoS One. 2015 Apr 17;10(4):e0125311. doi: 10.1371/journal.pone.0125311. eCollection 2015.


Redox regulation of T-cell receptor signaling.

Simeoni L, Bogeski I.

Biol Chem. 2015 May;396(5):555-68. doi: 10.1515/hsz-2014-0312. Review.


Selective targeting of transforming growth factor-beta1 into TCR/CD28 signalling plasma membrane domains silences T cell activation.

Harder T, Guttek K, Philipsen L, Simeoni L, Schraven B, Reinhold D.

Cell Commun Signal. 2014 Dec 8;12:74. doi: 10.1186/s12964-014-0074-6.


Advice on Degradation Products in Pharmaceuticals: A Toxicological Evaluation.

Melo SR, Homem-de-Mello M, Silveira D, Simeoni LA.

PDA J Pharm Sci Technol. 2014 5/6;68(3):221-238. Review.


Radiation induced a supra-additive cytotoxic effect in head and neck carcinoma cell lines when combined with plant extracts from Brazilian Cerrado biome.

Elias ST, Borges GA, Amorim DA, Rêgo DF, Simeoni LA, Silveira D, Fonseca-Bazzo YM, Paula JE, Fagg CW, Barros IM, Abreu WC, Pinto-Júnior DS, Magalhães PO, Neves FA, Lofrano-Porto A, Guerra EN.

Clin Oral Investig. 2015 Apr;19(3):637-46. doi: 10.1007/s00784-014-1289-z. Epub 2014 Aug 7.


TCR-triggered extracellular superoxide production is not required for T-cell activation.

Belikov AV, Schraven B, Simeoni L.

Cell Commun Signal. 2014 Aug 1;12:50. doi: 10.1186/s12964-014-0050-1.


Cytotoxic effect of Pouteria torta leaf extracts on human oral and breast carcinomas cell lines.

Elias ST, Salles PM, de Paula JE, Simeoni LA, Silveira D, Guerra EN, Motoyama AB.

J Cancer Res Ther. 2013 Oct-Dec;9(4):601-6. doi: 10.4103/0973-1482.126454.


Sos1 regulates sustained TCR-mediated Erk activation.

Poltorak M, Meinert I, Stone JC, Schraven B, Simeoni L.

Eur J Immunol. 2014 May;44(5):1535-40. doi: 10.1002/eji.201344046. Epub 2014 Feb 20.


Use of sanitizing products: safety practices and risk situations.

Silva AA, Passos RS, Simeoni LA, Neves Fde A, Carvalho Ed.

J Pediatr (Rio J). 2014 Mar-Apr;90(2):149-54. doi: 10.1016/j.jped.2013.08.011. Epub 2013 Dec 25.


PAG/Cbp suppression reveals a contribution of CTLA-4 to setting the activation threshold in T cells.

Smida M, Cammann C, Gurbiel S, Kerstin N, Lingel H, Lindquist S, Simeoni L, Brunner-Weinzierl MC, Suchanek M, Schraven B, Lindquist JA.

Cell Commun Signal. 2013 Apr 19;11(1):28. doi: 10.1186/1478-811X-11-28.


T cell activation results in conformational changes in the Src family kinase Lck to induce its activation.

Stirnweiss A, Hartig R, Gieseler S, Lindquist JA, Reichardt P, Philipsen L, Simeoni L, Poltorak M, Merten C, Zuschratter W, Prokazov Y, Paster W, Stockinger H, Harder T, Gunzer M, Schraven B.

Sci Signal. 2013 Feb 19;6(263):ra13. doi: 10.1126/scisignal.2003607.


TCR activation kinetics and feedback regulation in primary human T cells.

Poltorak M, Arndt B, Kowtharapu BS, Reddycherla AV, Witte V, Lindquist JA, Schraven B, Simeoni L.

Cell Commun Signal. 2013 Jan 14;11:4. doi: 10.1186/1478-811X-11-4.


Cooperative immunoregulatory function of the transmembrane adaptor proteins SIT and LAX.

Arndt B, Kalinski T, Reinhold D, Thielitz A, Roessner A, Schraven B, Simeoni L.

J Leukoc Biol. 2013 Mar;93(3):353-62. doi: 10.1189/jlb.0312152. Epub 2013 Jan 10.


Analysis of TCR activation kinetics in primary human T cells upon focal or soluble stimulation.

Arndt B, Poltorak M, Kowtharapu BS, Reichardt P, Philipsen L, Lindquist JA, Schraven B, Simeoni L.

J Immunol Methods. 2013 Jan 31;387(1-2):276-83. doi: 10.1016/j.jim.2012.11.006. Epub 2012 Nov 22.


Plants from Brazilian Cerrado with potent tyrosinase inhibitory activity.

Souza PM, Elias ST, Simeoni LA, de Paula JE, Gomes SM, Guerra EN, Fonseca YM, Silva EC, Silveira D, Magalhães PO.

PLoS One. 2012;7(11):e48589. doi: 10.1371/journal.pone.0048589. Epub 2012 Nov 16.


[Increasing immunization coverage by intervening on determinants of refusal].

Brunelli M, Valsecchi M, Speri L, Simeoni L, Campara P, Porchia S, Bolzonello E, Russo F, Bonavina MG, Bovo C.

Ann Ig. 2012 Jan-Feb;24(1 Suppl 1):15-20. Italian.


GQ-16, a novel peroxisome proliferator-activated receptor γ (PPARγ) ligand, promotes insulin sensitization without weight gain.

Amato AA, Rajagopalan S, Lin JZ, Carvalho BM, Figueira AC, Lu J, Ayers SD, Mottin M, Silveira RL, Souza PC, Mourão RH, Saad MJ, Togashi M, Simeoni LA, Abdalla DS, Skaf MS, Polikparpov I, Lima MC, Galdino SL, Brennan RG, Baxter JD, Pitta IR, Webb P, Phillips KJ, Neves FA.

J Biol Chem. 2012 Aug 10;287(33):28169-79. doi: 10.1074/jbc.M111.332106. Epub 2012 May 14.


α-Amylase inhibitors: a review of raw material and isolated compounds from plant source.

Sales PM, Souza PM, Simeoni LA, Silveira D.

J Pharm Pharm Sci. 2012;15(1):141-83. Review.


TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells.

Warnecke N, Poltorak M, Kowtharapu BS, Arndt B, Stone JC, Schraven B, Simeoni L.

EMBO Rep. 2012 Apr;13(4):386-91. doi: 10.1038/embor.2012.17.


Inhibitory activity of α-amylase and α-glucosidase by plant extracts from the Brazilian cerrado.

Souza PM, Sales PM, Simeoni LA, Silva EC, Silveira D, Magalhães Pde O.

Planta Med. 2012 Mar;78(4):393-9. doi: 10.1055/s-0031-1280404. Epub 2011 Dec 1.


The transmembrane adaptor protein SIT inhibits TCR-mediated signaling.

Arndt B, Krieger T, Kalinski T, Thielitz A, Reinhold D, Roessner A, Schraven B, Simeoni L.

PLoS One. 2011;6(9):e23761. doi: 10.1371/journal.pone.0023761. Epub 2011 Sep 21.


Cardiopulmonary resuscitation monitoring for EMT volunteers: a two year evaluation of practice.

Segal N, Camus N, Laborie JM, Simeoni L, Deschamps J, Kossorotoff L, Cassan P.

Resuscitation. 2012 Jan;83(1):e13-4. doi: 10.1016/j.resuscitation.2011.08.012. Epub 2011 Aug 27. No abstract available. Erratum in: Resuscitation. 2012 Oct;83(10:e205. Nicolas, Segal [corrected to Segal, Nicolas]; Nicolas, Camus [corrected to Camus, Nicolas]; Jean Marc, Laborie [corrected to Laborie, Jean Marc]; Laurent, Simeoni [corrected to Simeoni, Laurent]; Jérôme, Deschamps [corrected to Deschamps, Jérôme]; Laur.


Helix 12 dynamics and thyroid hormone receptor activity: experimental and molecular dynamics studies of Ile280 mutants.

Souza PC, Barra GB, Velasco LF, Ribeiro IC, Simeoni LA, Togashi M, Webb P, Neves FA, Skaf MS, Martínez L, Polikarpov I.

J Mol Biol. 2011 Oct 7;412(5):882-93. doi: 10.1016/j.jmb.2011.04.014. Epub 2011 Apr 21.


Cytotoxic effect of tobacco extracts on human oral squamous cell carcinoma cell-line.

Elias ST, Diniz J, Almeida RS, Alvarenga N, Simeoni LA, Silveira D, Ferro E, Guerra EN, Motoyama AB.

Oral Oncol. 2010 Dec;46(12):869-73. doi: 10.1016/j.oraloncology.2010.09.008. Epub 2010 Oct 23.


Src homology 2-domain containing leukocyte-specific phosphoprotein of 76 kDa is mandatory for TCR-mediated inside-out signaling, but dispensable for CXCR4-mediated LFA-1 activation, adhesion, and migration of T cells.

Horn J, Wang X, Reichardt P, Stradal TE, Warnecke N, Simeoni L, Gunzer M, Yablonski D, Schraven B, Kliche S.

J Immunol. 2009 Nov 1;183(9):5756-67. doi: 10.4049/jimmunol.0900649. Epub 2009 Oct 7.


Adenosine regulates CD8 T-cell priming by inhibition of membrane-proximal T-cell receptor signalling.

Linnemann C, Schildberg FA, Schurich A, Diehl L, Hegenbarth SI, Endl E, Lacher S, Müller CE, Frey J, Simeoni L, Schraven B, Stabenow D, Knolle PA.

Immunology. 2009 Sep;128(1 Suppl):e728-37. doi: 10.1111/j.1365-2567.2009.03075.x. Epub 2009 Feb 9.


A novel mutation of thyroid hormone receptor beta (I431V) impairs corepressor release, and induces thyroid hormone resistance syndrome.

Ferreira Azevedo M, Barra GB, Medeiros LD, Simeoni LA, Naves LA, Neves Fde A.

Arq Bras Endocrinol Metabol. 2008 Nov;52(8):1304-12.


SIT and TRIM determine T cell fate in the thymus.

Koelsch U, Schraven B, Simeoni L.

J Immunol. 2008 Nov 1;181(9):5930-9.


Control of lymphocyte development and activation by negative regulatory transmembrane adapter proteins.

Simeoni L, Lindquist JA, Smida M, Witte V, Arndt B, Schraven B.

Immunol Rev. 2008 Aug;224:215-28. doi: 10.1111/j.1600-065X.2008.00656.x. Review.


Dynamics of proximal signaling events after TCR/CD8-mediated induction of proliferation or apoptosis in mature CD8+ T cells.

Wang X, Simeoni L, Lindquist JA, Saez-Rodriguez J, Ambach A, Gilles ED, Kliche S, Schraven B.

J Immunol. 2008 May 15;180(10):6703-12.


Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms.

Bleicher L, Aparicio R, Nunes FM, Martinez L, Gomes Dias SM, Figueira AC, Santos MA, Venturelli WH, da Silva R, Donate PM, Neves FA, Simeoni LA, Baxter JD, Webb P, Skaf MS, Polikarpov I.

BMC Struct Biol. 2008 Jan 31;8:8. doi: 10.1186/1472-6807-8-8.


Regulation of T cell homeostasis by the transmembrane adaptor protein SIT.

Posevitz V, Arndt B, Krieger T, Warnecke N, Schraven B, Simeoni L.

J Immunol. 2008 Feb 1;180(3):1634-42.


Inhibitors of dipeptidyl peptidase IV-like activity mediate antifibrotic effects in normal and keloid-derived skin fibroblasts.

Thielitz A, Vetter RW, Schultze B, Wrenger S, Simeoni L, Ansorge S, Neubert K, Faust J, Lindenlaub P, Gollnick HP, Reinhold D.

J Invest Dermatol. 2008 Apr;128(4):855-66. Epub 2007 Oct 18.

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