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Evaluating Susceptibility to Pancreatic Cancer: ASCO Provisional Clinical Opinion.

Stoffel EM, McKernin SE, Brand R, Canto M, Goggins M, Moravek C, Nagarajan A, Petersen GM, Simeone DM, Yurgelun M, Khorana AA.

J Clin Oncol. 2018 Nov 20:JCO1801489. doi: 10.1200/JCO.18.01489. [Epub ahead of print]


Pancreatic Microtumors: A Novel 3D Ex Vivo Testing Platform.

Goodwin ML, Urs SK, Simeone DM.

Methods Mol Biol. 2019;1882:73-80. doi: 10.1007/978-1-4939-8879-2_7.


3-D Cell Culture System for Studying Invasion and Evaluating Therapeutics in Bladder Cancer.

Wang Y, Day ML, Simeone DM, Palmbos PL.

J Vis Exp. 2018 Sep 13;(139). doi: 10.3791/58345.


Cyclooxygenase-2 Influences Response to Cotargeting of MEK and CDK4/6 in a Subpopulation of Pancreatic Cancers.

Maust JD, Frankowski-McGregor CL, Bankhead A 3rd, Simeone DM, Sebolt-Leopold JS.

Mol Cancer Ther. 2018 Dec;17(12):2495-2506. doi: 10.1158/1535-7163.MCT-18-0082. Epub 2018 Sep 25.


Scalable Multiplexed Drug-Combination Screening Platforms Using 3D Microtumor Model for Precision Medicine.

Zhang Z, Chen YC, Urs S, Chen L, Simeone DM, Yoon E.

Small. 2018 Oct;14(42):e1703617. doi: 10.1002/smll.201703617. Epub 2018 Sep 21.


A model of defect cluster creation in fragmented cascades in metals based on morphological analysis.

De Backer A, Domain C, Becquart CS, Luneville L, Simeone D, Sand AE, Nordlund K.

J Phys Condens Matter. 2018 Oct 10;30(40):405701. doi: 10.1088/1361-648X/aadb4e. Epub 2018 Aug 20.


HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties.

Abel EV, Goto M, Magnuson B, Abraham S, Ramanathan N, Hotaling E, Alaniz AA, Kumar-Sinha C, Dziubinski ML, Urs S, Wang L, Shi J, Waghray M, Ljungman M, Crawford HC, Simeone DM.

Elife. 2018 Aug 3;7. pii: e33947. doi: 10.7554/eLife.33947.


SHP2 Inhibition Prevents Adaptive Resistance to MEK Inhibitors in Multiple Cancer Models.

Fedele C, Ran H, Diskin B, Wei W, Jen J, Geer MJ, Araki K, Ozerdem U, Simeone DM, Miller G, Neel BG, Tang KH.

Cancer Discov. 2018 Oct;8(10):1237-1249. doi: 10.1158/2159-8290.CD-18-0444. Epub 2018 Jul 25.


Irradiation-based design of mechanically resistant microstructures tuned via multiscale phase-field modeling.

Demange G, Dépinoy S, Lunéville L, Simeone D, Pontikis V.

Sci Rep. 2018 Jul 6;8(1):10237. doi: 10.1038/s41598-018-28685-3.


Characterization of Oxygen Defect Clusters in UO2+ x Using Neutron Scattering and PDF Analysis.

Ma Y, Garcia P, Lechelle J, Miard A, Desgranges L, Baldinozzi G, Simeone D, Fischer HE.

Inorg Chem. 2018 Jun 18;57(12):7064-7076. doi: 10.1021/acs.inorgchem.8b00750. Epub 2018 Jun 4.


Improving atomic displacement and replacement calculations with physically realistic damage models.

Nordlund K, Zinkle SJ, Sand AE, Granberg F, Averback RS, Stoller R, Suzudo T, Malerba L, Banhart F, Weber WJ, Willaime F, Dudarev SL, Simeone D.

Nat Commun. 2018 Mar 14;9(1):1084. doi: 10.1038/s41467-018-03415-5.


HIF1-alpha Regulates Acinar Cell Function and Response to Injury in Mouse Pancreas.

Park MJ, Iyer S, Xue X, Bragazzi Cunha J, Gu S, Moons D, Pipe SW, Williams JA, Simeone DM, Shah YM, Omary MB.

Gastroenterology. 2018 May;154(6):1630-1634.e3. doi: 10.1053/j.gastro.2018.01.037. Epub 2018 Feb 1.


Chronic exposure to high doses of selenium in the first trimester of pregnancy: Case report and brief literature review.

D'Oria L, Apicella M, De Luca C, Licameli A, Neri C, Pellegrino M, Simeone D, De Santis M.

Birth Defects Res. 2018 Mar 1;110(4):372-375. doi: 10.1002/bdr2.1148. Epub 2018 Jan 19. Review.


Understanding Local Structure versus Long-Range Structure: The Case of UO2.

Desgranges L, Ma Y, Garcia P, Baldinozzi G, Siméone D, Fischer HE.

Chemistry. 2018 Feb 9;24(9):2085-2088. doi: 10.1002/chem.201705674. Epub 2018 Jan 16.


An academic career in global surgery: a position paper from the Society of University Surgeons Committee on Academic Global Surgery.

Krishnaswami S, Stephens CQ, Yang GP, Nwomeh BC, Swaroop M, Nadler EP, Holterman AX, Simeone DM, Kingham TP, Merchant N, Orloff SL.

Surgery. 2018 Apr;163(4):954-960. doi: 10.1016/j.surg.2017.10.019. Epub 2017 Dec 15. Review.


Usp9x Promotes Survival in Human Pancreatic Cancer and Its Inhibition Suppresses Pancreatic Ductal Adenocarcinoma In Vivo Tumor Growth.

Pal A, Dziubinski M, Di Magliano MP, Simeone DM, Owens S, Thomas D, Peterson L, Potu H, Talpaz M, Donato NJ.

Neoplasia. 2018 Feb;20(2):152-164. doi: 10.1016/j.neo.2017.11.007. Epub 2017 Dec 14.


Epidemiology and pathogenesis of fulminant viral hepatitis in pregnant women.

Tosone G, Simeone D, Spera AM, Viceconte G, Bianco V, Orlando R.

Minerva Ginecol. 2018 Aug;70(4):480-486. doi: 10.23736/S0026-4784.17.04107-7. Epub 2017 Oct 9. Review.


High-Throughput Microfluidic Labyrinth for the Label-free Isolation of Circulating Tumor Cells.

Lin E, Rivera-Báez L, Fouladdel S, Yoon HJ, Guthrie S, Wieger J, Deol Y, Keller E, Sahai V, Simeone DM, Burness ML, Azizi E, Wicha MS, Nagrath S.

Cell Syst. 2017 Sep 27;5(3):295-304.e4. doi: 10.1016/j.cels.2017.08.012. Epub 2017 Sep 20.


An update on epidemiology of congenital rubella syndrome: how far from the World Health Organization goals?

Bianco V, Spera AM, Simeone D, Tosone G, Orlando R.

Minerva Med. 2017 Oct;108(5):483-485. doi: 10.23736/S0026-4806.17.05103-5. No abstract available.


Intricate disorder in defect fluorite/pyrochlore: a concord of chemistry and crystallography.

Simeone D, Thorogood GJ, Huo D, Luneville L, Baldinozzi G, Petricek V, Porcher F, Ribis J, Mazerolles L, Largeau L, Berar JF, Surble S.

Sci Rep. 2017 Jun 16;7(1):3727. doi: 10.1038/s41598-017-02787-w.


Near transferable phenomenological n-body potentials for noble metals.

Pontikis V, Baldinozzi G, Luneville L, Simeone D.

J Phys Condens Matter. 2017 Sep 6;29(35):355701. doi: 10.1088/1361-648X/aa7766. Epub 2017 Jun 6.


Microfluidic continuum sorting of sub-populations of tumor cells via surface antibody expression levels.

Jack R, Hussain K, Rodrigues D, Zeinali M, Azizi E, Wicha M, Simeone DM, Nagrath S.

Lab Chip. 2017 Mar 29;17(7):1349-1358. doi: 10.1039/c6lc01496h.


A Gastric Glycoform of MUC5AC Is a Biomarker of Mucinous Cysts of the Pancreas.

Sinha J, Cao Z, Dai J, Tang H, Partyka K, Hostetter G, Simeone DM, Feng Z, Allen PJ, Brand RE, Haab BB.

PLoS One. 2016 Dec 19;11(12):e0167070. doi: 10.1371/journal.pone.0167070. eCollection 2016.


What Is the Actual Local Crystalline Structure of Uranium Dioxide, UO2? A New Perspective for the Most Used Nuclear Fuel.

Desgranges L, Ma Y, Garcia P, Baldinozzi G, Siméone D, Fischer HE.

Inorg Chem. 2017 Jan 3;56(1):321-326. doi: 10.1021/acs.inorgchem.6b02111. Epub 2016 Dec 15.


Patterning in systems driven by nonlocal external forces.

Luneville L, Mallick K, Pontikis V, Simeone D.

Phys Rev E. 2016 Nov;94(5-1):052126. Epub 2016 Nov 16.


Tissue Classification Using Optical Spectroscopy Accurately Differentiates Cancer and Chronic Pancreatitis.

Wilson RH, Chandra M, Scheiman JM, Lee SY, Lee OE, McKenna BJ, Simeone DM, Taylor JM, Mycek MA.

Pancreas. 2017 Feb;46(2):244-251. doi: 10.1097/MPA.0000000000000732.


Ultra-Specific Isolation of Circulating Tumor Cells Enables Rare-Cell RNA Profiling.

Jack RM, Grafton MM, Rodrigues D, Giraldez MD, Griffith C, Cieslak R, Zeinali M, Kumar Sinha C, Azizi E, Wicha M, Tewari M, Simeone DM, Nagrath S.

Adv Sci (Weinh). 2016 Apr 18;3(9):1600063. eCollection 2016 Sep.


Pancreatic Cancer Chemoprevention Translational Workshop: Meeting Report.

Miller MS, Allen P, Brentnall TA, Goggins M, Hruban RH, Petersen GM, Rao CV, Whitcomb DC, Brand RE, Chari ST, Klein AP, Lubman DM, Rhim AD, Simeone DM, Wolpin BM, Umar A, Srivastava S, Steele VE, Rinaudo JA.

Pancreas. 2016 Sep;45(8):1080-91. doi: 10.1097/MPA.0000000000000705.


A phase I trial of cabozantinib and gemcitabine in advanced pancreatic cancer.

Zhen DB, Griffith KA, Ruch JM, Camphausen K, Savage JE, Kim EJ, Sahai V, Simeone DM, Zalupski MM.

Invest New Drugs. 2016 Dec;34(6):733-739. Epub 2016 Jul 21.


Structural Changes in the Local Environment of Uranium Atoms in the Three Phases of U4O9.

Desgranges L, Baldinozzi G, Simeone D, Fischer HE.

Inorg Chem. 2016 Aug 1;55(15):7485-91. doi: 10.1021/acs.inorgchem.6b00654. Epub 2016 Jul 20.


Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer.

Zhang Y, Velez-Delgado A, Mathew E, Li D, Mendez FM, Flannagan K, Rhim AD, Simeone DM, Beatty GL, Pasca di Magliano M.

Gut. 2017 Jan;66(1):124-136. doi: 10.1136/gutjnl-2016-312078. Epub 2016 Jul 8.


Opportunities and Challenges for Pancreatic Circulating Tumor Cells.

Nagrath S, Jack RM, Sahai V, Simeone DM.

Gastroenterology. 2016 Sep;151(3):412-26. doi: 10.1053/j.gastro.2016.05.052. Epub 2016 Jun 20. Review.


Localized Pancreatic Cancer: Multidisciplinary Management.

Coveler AL, Herman JM, Simeone DM, Chiorean EG.

Am Soc Clin Oncol Educ Book. 2016;35:e217-26. doi: 10.14694/EDBK_160827. Review.


GM-CSF Mediates Mesenchymal-Epithelial Cross-talk in Pancreatic Cancer.

Waghray M, Yalamanchili M, Dziubinski M, Zeinali M, Erkkinen M, Yang H, Schradle KA, Urs S, Pasca Di Magliano M, Welling TH, Palmbos PL, Abel EV, Sahai V, Nagrath S, Wang L, Simeone DM.

Cancer Discov. 2016 Aug;6(8):886-99. doi: 10.1158/2159-8290.CD-15-0947. Epub 2016 May 16.


Tunable Thermal-Sensitive Polymer-Graphene Oxide Composite for Efficient Capture and Release of Viable Circulating Tumor Cells.

Yoon HJ, Shanker A, Wang Y, Kozminsky M, Jin Q, Palanisamy N, Burness ML, Azizi E, Simeone DM, Wicha MS, Kim J, Nagrath S.

Adv Mater. 2016 Jun;28(24):4891-7. doi: 10.1002/adma.201600658. Epub 2016 Apr 26.


Narcotic Independence After Pancreatic Duct Stenting Predicts Narcotic Independence After Lateral Pancreaticojejunostomy for Chronic Pancreatitis.

Kwon RS, Young BE, Marsteller WF, Lawrence C, Wu BU, Lee LS, Mullady D, Klibansky DA, Gardner TB, Simeone DM.

Pancreas. 2016 Sep;45(8):1126-30. doi: 10.1097/MPA.0000000000000623.


Notch1 and Notch2 receptors regulate mouse and human gastric antral epithelial cell homoeostasis.

Gifford GB, Demitrack ES, Keeley TM, Tam A, La Cunza N, Dedhia PH, Spence JR, Simeone DM, Saotome I, Louvi A, Siebel CW, Samuelson LC.

Gut. 2017 Jun;66(6):1001-1011. doi: 10.1136/gutjnl-2015-310811. Epub 2016 Mar 1.


ATDC/TRIM29 Drives Invasive Bladder Cancer Formation through miRNA-Mediated and Epigenetic Mechanisms.

Palmbos PL, Wang L, Yang H, Wang Y, Leflein J, Ahmet ML, Wilkinson JE, Kumar-Sinha C, Ney GM, Tomlins SA, Daignault S, Kunju LP, Wu XR, Lotan Y, Liebert M, Ljungman ME, Simeone DM.

Cancer Res. 2015 Dec 1;75(23):5155-66. doi: 10.1158/0008-5472.CAN-15-0603. Epub 2015 Oct 15.


ATDC (Ataxia Telangiectasia Group D Complementing) Promotes Radioresistance through an Interaction with the RNF8 Ubiquitin Ligase.

Yang H, Palmbos PL, Wang L, Kim EH, Ney GM, Liu C, Prasad J, Misek DE, Yu X, Ljungman M, Simeone DM.

J Biol Chem. 2015 Nov 6;290(45):27146-57. doi: 10.1074/jbc.M115.665489. Epub 2015 Sep 17.


Definitive Chemoradiation With Full-dose Gemcitabine for Unresectable Pancreatic Cancer: Efficacy of Involved-Field Radiotherapy.

Zhou J, Fang CX, Shen J, Schipper MJ, Zalupski MM, Minter RM, Simeone DM, Hart D, Eagle T, Kimmel GW, Vainshtein J, Lawrence TS, Feng M.

Am J Clin Oncol. 2017 Oct;40(5):517-522. doi: 10.1097/COC.0000000000000200.


Bmi1 is required for the initiation of pancreatic cancer through an Ink4a-independent mechanism.

Bednar F, Schofield HK, Collins MA, Yan W, Zhang Y, Shyam N, Eberle JA, Almada LL, Olive KP, Bardeesy N, Fernandez-Zapico ME, Nakada D, Simeone DM, Morrison SJ, Pasca di Magliano M.

Carcinogenesis. 2015 Jul;36(7):730-8. doi: 10.1093/carcin/bgv058. Epub 2015 May 4.


Early detection of sporadic pancreatic cancer: summative review.

Chari ST, Kelly K, Hollingsworth MA, Thayer SP, Ahlquist DA, Andersen DK, Batra SK, Brentnall TA, Canto M, Cleeter DF, Firpo MA, Gambhir SS, Go VL, Hines OJ, Kenner BJ, Klimstra DS, Lerch MM, Levy MJ, Maitra A, Mulvihill SJ, Petersen GM, Rhim AD, Simeone DM, Srivastava S, Tanaka M, Vinik AI, Wong D.

Pancreas. 2015 Jul;44(5):693-712. doi: 10.1097/MPA.0000000000000368. Review.


Large-scale identification of core-fucosylated glycopeptide sites in pancreatic cancer serum using mass spectrometry.

Tan Z, Yin H, Nie S, Lin Z, Zhu J, Ruffin MT, Anderson MA, Simeone DM, Lubman DM.

J Proteome Res. 2015 Apr 3;14(4):1968-78. doi: 10.1021/acs.jproteome.5b00068. Epub 2015 Mar 9.


ATDC induces an invasive switch in KRAS-induced pancreatic tumorigenesis.

Wang L, Yang H, Abel EV, Ney GM, Palmbos PL, Bednar F, Zhang Y, Leflein J, Waghray M, Owens S, Wilkinson JE, Prasad J, Ljungman M, Rhim AD, Pasca di Magliano M, Simeone DM.

Genes Dev. 2015 Jan 15;29(2):171-83. doi: 10.1101/gad.253591.114.


CD44 regulates pancreatic cancer invasion through MT1-MMP.

Jiang W, Zhang Y, Kane KT, Collins MA, Simeone DM, di Magliano MP, Nguyen KT.

Mol Cancer Res. 2015 Jan;13(1):9-15. doi: 10.1158/1541-7786.MCR-14-0076. Epub 2015 Jan 7.


Expansion of CTCs from early stage lung cancer patients using a microfluidic co-culture model.

Zhang Z, Shiratsuchi H, Lin J, Chen G, Reddy RM, Azizi E, Fouladdel S, Chang AC, Lin L, Jiang H, Waghray M, Luker G, Simeone DM, Wicha MS, Beer DG, Ramnath N, Nagrath S.

Oncotarget. 2014 Dec 15;5(23):12383-97.


Quantitative analysis of single amino acid variant peptides associated with pancreatic cancer in serum by an isobaric labeling quantitative method.

Nie S, Yin H, Tan Z, Anderson MA, Ruffin MT, Simeone DM, Lubman DM.

J Proteome Res. 2014 Dec 5;13(12):6058-66. doi: 10.1021/pr500934u. Epub 2014 Nov 24.


Tumor-associated macrophages are a useful biomarker to predict recurrence after surgical resection of nonfunctional pancreatic neuroendocrine tumors.

Wei IH, Harmon CM, Arcerito M, Cheng DF, Minter RM, Simeone DM.

Ann Surg. 2014 Dec;260(6):1088-94. doi: 10.1097/SLA.0000000000000262.


A pilot study of diffusion-weighted MRI in patients undergoing neoadjuvant chemoradiation for pancreatic cancer.

Cuneo KC, Chenevert TL, Ben-Josef E, Feng MU, Greenson JK, Hussain HK, Simeone DM, Schipper MJ, Anderson MA, Zalupski MM, Al-Hawary M, Galban CJ, Rehemtulla A, Feng FY, Lawrence TS, Ross BD.

Transl Oncol. 2014 Oct 24;7(5):644-9. doi: 10.1016/j.tranon.2014.07.005. eCollection 2014 Oct.


Proteins associated with pancreatic cancer survival in patients with resectable pancreatic ductal adenocarcinoma.

Chen R, Dawson DW, Pan S, Ottenhof NA, de Wilde RF, Wolfgang CL, May DH, Crispin DA, Lai LA, Lay AR, Waghray M, Wang S, McIntosh MW, Simeone DM, Maitra A, Brentnall TA.

Lab Invest. 2015 Jan;95(1):43-55. doi: 10.1038/labinvest.2014.128. Epub 2014 Oct 27.

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