Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 55

1.

Participant Experiences in the Environmental Determinants of Diabetes in the Young Study: Common Reasons for Withdrawing.

Lernmark B, Lynch K, Baxter J, Roth R, Simell T, Smith L, Swartling U, Johnson SB; Teddy Study Group.

J Diabetes Res. 2016;2016:2720650. doi: 10.1155/2016/2720650. Epub 2015 Nov 22.

2.

Reduced β-cell function in early preclinical type 1 diabetes.

Koskinen MK, Helminen O, Matomäki J, Aspholm S, Mykkänen J, Mäkinen M, Simell V, Vähä-Mäkilä M, Simell T, Ilonen J, Knip M, Veijola R, Toppari J, Simell O.

Eur J Endocrinol. 2016 Mar;174(3):251-9. doi: 10.1530/EJE-15-0674. Epub 2015 Nov 30.

3.

Predicting Later Study Withdrawal in Participants Active in a Longitudinal Birth Cohort Study for 1 Year: The TEDDY Study.

Johnson SB, Lynch KF, Baxter J, Lernmark B, Roth R, Simell T, Smith L; TEDDY Study Group.

J Pediatr Psychol. 2016 Apr;41(3):373-83. doi: 10.1093/jpepsy/jsv092. Epub 2015 Sep 27.

4.

Serum proteomes distinguish children developing type 1 diabetes in a cohort with HLA-conferred susceptibility.

Moulder R, Bhosale SD, Erkkilä T, Laajala E, Salmi J, Nguyen EV, Kallionpää H, Mykkänen J, Vähä-Mäkilä M, Hyöty H, Veijola R, Ilonen J, Simell T, Toppari J, Knip M, Goodlett DR, Lähdesmäki H, Simell O, Lahesmaa R.

Diabetes. 2015 Jun;64(6):2265-78. doi: 10.2337/db14-0983. Epub 2015 Jan 23.

5.

Bacteroides dorei dominates gut microbiome prior to autoimmunity in Finnish children at high risk for type 1 diabetes.

Davis-Richardson AG, Ardissone AN, Dias R, Simell V, Leonard MT, Kemppainen KM, Drew JC, Schatz D, Atkinson MA, Kolaczkowski B, Ilonen J, Knip M, Toppari J, Nurminen N, Hyöty H, Veijola R, Simell T, Mykkänen J, Simell O, Triplett EW.

Front Microbiol. 2014 Dec 10;5:678. doi: 10.3389/fmicb.2014.00678. eCollection 2014.

6.

Maternal anxiety about a child's diabetes risk in the TEDDY study: the potential role of life stress, postpartum depression, and risk perception.

Roth R, Lynch K, Lernmark B, Baxter J, Simell T, Smith L, Swartling U, Ziegler AG, Johnson SB; TEDDY Study Group.

Pediatr Diabetes. 2015 Jun;16(4):287-98. doi: 10.1111/pedi.12168. Epub 2014 Aug 1.

7.

At high risk for early withdrawal: using a cumulative risk model to increase retention in the first year of the TEDDY study.

Johnson SB, Lynch KF, Lee HS, Smith L, Baxter J, Lernmark B, Roth R, Simell T; TEDDY Study Group.

J Clin Epidemiol. 2014 Jun;67(6):609-11. doi: 10.1016/j.jclinepi.2014.01.004. Epub 2014 Apr 13. No abstract available.

8.

Innate immune activity is detected prior to seroconversion in children with HLA-conferred type 1 diabetes susceptibility.

Kallionpää H, Elo LL, Laajala E, Mykkänen J, Ricaño-Ponce I, Vaarma M, Laajala TD, Hyöty H, Ilonen J, Veijola R, Simell T, Wijmenga C, Knip M, Lähdesmäki H, Simell O, Lahesmaa R.

Diabetes. 2014 Jul;63(7):2402-14. doi: 10.2337/db13-1775. Epub 2014 Feb 18.

9.

Factors associated with maternal-reported actions to prevent type 1 diabetes in the first year of the TEDDY study.

Smith LB, Lynch KF, Baxter J, Lernmark B, Roth R, Simell T, Johnson SB; TEDDY Study Group.

Diabetes Care. 2014 Feb;37(2):325-31. doi: 10.2337/dc13-0449. Epub 2013 Sep 16.

10.

Coxsackievirus B1 is associated with induction of β-cell autoimmunity that portends type 1 diabetes.

Laitinen OH, Honkanen H, Pakkanen O, Oikarinen S, Hankaniemi MM, Huhtala H, Ruokoranta T, Lecouturier V, André P, Harju R, Virtanen SM, Lehtonen J, Almond JW, Simell T, Simell O, Ilonen J, Veijola R, Knip M, Hyöty H.

Diabetes. 2014 Feb;63(2):446-55. doi: 10.2337/db13-0619. Epub 2013 Aug 23.

11.

Virus infections among young children--the first year of the INDIS study.

Simonen-Tikka ML, Klemola P, Suomenrinne S, Kaijalainen S, Söderström D, Savolainen-Kopra C, Näntö-Salonen K, Ilonen J, Simell T, Simell O, Roivainen M.

J Med Virol. 2013 Sep;85(9):1678-84. doi: 10.1002/jmv.23625. Epub 2013 Jun 21.

PMID:
23794481
12.

Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children.

Ziegler AG, Rewers M, Simell O, Simell T, Lempainen J, Steck A, Winkler C, Ilonen J, Veijola R, Knip M, Bonifacio E, Eisenbarth GS.

JAMA. 2013 Jun 19;309(23):2473-9. doi: 10.1001/jama.2013.6285.

13.

Differences in recruitment and early retention among ethnic minority participants in a large pediatric cohort: the TEDDY Study.

Baxter J, Vehik K, Johnson SB, Lernmark B, Roth R, Simell T; TEDDY Study Group.

Contemp Clin Trials. 2012 Jul;33(4):633-40. doi: 10.1016/j.cct.2012.03.009. Epub 2012 Mar 29.

14.

Early seroconversion and rapidly increasing autoantibody concentrations predict prepubertal manifestation of type 1 diabetes in children at genetic risk.

Parikka V, Näntö-Salonen K, Saarinen M, Simell T, Ilonen J, Hyöty H, Veijola R, Knip M, Simell O.

Diabetologia. 2012 Jul;55(7):1926-36. doi: 10.1007/s00125-012-2523-3. Epub 2012 Mar 23.

PMID:
22441569
15.

Reasons for Staying as a Participant in the Environmental Determinants of Diabetes in the Young (TEDDY) Longitudinal Study.

Lernmark B, Lynch K, Ballard L, Baxter J, Roth R, Simell T, Johnson SB.

J Clin Trials. 2012;2(2). pii: 1000114.

16.

Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes.

Brown CT, Davis-Richardson AG, Giongo A, Gano KA, Crabb DB, Mukherjee N, Casella G, Drew JC, Ilonen J, Knip M, Hyöty H, Veijola R, Simell T, Simell O, Neu J, Wasserfall CH, Schatz D, Atkinson MA, Triplett EW.

PLoS One. 2011;6(10):e25792. doi: 10.1371/journal.pone.0025792. Epub 2011 Oct 17.

17.

Impact of intranasal insulin on insulin antibody affinity and isotypes in young children with HLA-conferred susceptibility to type 1 diabetes.

Ryhänen SJ, Härkönen T, Siljander H, Näntö-Salonen K, Simell T, Hyöty H, Ilonen J, Veijola R, Simell O, Knip M.

Diabetes Care. 2011 Jun;34(6):1383-8. doi: 10.2337/dc10-1449. Epub 2011 Apr 22.

18.

Enrollment experiences in a pediatric longitudinal observational study: The Environmental Determinants of Diabetes in the Young (TEDDY) study.

Lernmark B, Johnson SB, Vehik K, Smith L, Ballard L, Baxter J, McLeod W, Roth R, Simell T.

Contemp Clin Trials. 2011 Jul;32(4):517-23. doi: 10.1016/j.cct.2011.03.009. Epub 2011 Mar 17.

19.

The Environmental Determinants of Diabetes in the Young (TEDDY) study: predictors of early study withdrawal among participants with no family history of type 1 diabetes.

Johnson SB, Lee HS, Baxter J, Lernmark B, Roth R, Simell T; TEDDY Study Group.

Pediatr Diabetes. 2011 May;12(3 Pt 1):165-71. doi: 10.1111/j.1399-5448.2010.00686.x. Epub 2010 Oct 28.

20.

Toward defining the autoimmune microbiome for type 1 diabetes.

Giongo A, Gano KA, Crabb DB, Mukherjee N, Novelo LL, Casella G, Drew JC, Ilonen J, Knip M, Hyöty H, Veijola R, Simell T, Simell O, Neu J, Wasserfall CH, Schatz D, Atkinson MA, Triplett EW.

ISME J. 2011 Jan;5(1):82-91. doi: 10.1038/ismej.2010.92. Epub 2010 Jul 8.

21.

Early suppression of immune response pathways characterizes children with prediabetes in genome-wide gene expression profiling.

Elo LL, Mykkänen J, Nikula T, Järvenpää H, Simell S, Aittokallio T, Hyöty H, Ilonen J, Veijola R, Simell T, Knip M, Simell O, Lahesmaa R.

J Autoimmun. 2010 Aug;35(1):70-6. doi: 10.1016/j.jaut.2010.03.001. Epub 2010 Mar 30.

PMID:
20356713
22.

Age at development of type 1 diabetes- and celiac disease-associated antibodies and clinical disease in genetically susceptible children observed from birth.

Simell S, Hoppu S, Simell T, Ståhlberg MR, Viander M, Routi T, Simell V, Veijola R, Ilonen J, Hyöty H, Knip M, Simell O.

Diabetes Care. 2010 Apr;33(4):774-9. doi: 10.2337/dc09-1217. Epub 2010 Jan 7.

23.

Predictive characteristics of diabetes-associated autoantibodies among children with HLA-conferred disease susceptibility in the general population.

Siljander HT, Simell S, Hekkala A, Lähde J, Simell T, Vähäsalo P, Veijola R, Ilonen J, Simell O, Knip M.

Diabetes. 2009 Dec;58(12):2835-42. doi: 10.2337/db08-1305. Epub 2009 Sep 15.

24.

From genetic risk awareness to overt type 1 diabetes: parental stress in a placebo-controlled prevention trial.

Goldstein E, Hermann R, Renfors TJ, Näntö-Salonen KM, Korhonen T, Kärkkäinen M, Veijola RK, Knip M, Simell TT, Simell OG.

Diabetes Care. 2009 Dec;32(12):2181-3. doi: 10.2337/dc09-0423. Epub 2009 Sep 14.

25.

Role of insulin autoantibody affinity as a predictive marker for type 1 diabetes in young children with HLA-conferred disease susceptibility.

Siljander H, Härkönen T, Hermann R, Simell S, Hekkala A, Salonsaari RT, Simell T, Simell O, Ilonen J, Veijola R, Knip M.

Diabetes Metab Res Rev. 2009 Oct;25(7):615-22. doi: 10.1002/dmrr.998.

PMID:
19637309
26.

Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes.

Oresic M, Simell S, Sysi-Aho M, Näntö-Salonen K, Seppänen-Laakso T, Parikka V, Katajamaa M, Hekkala A, Mattila I, Keskinen P, Yetukuri L, Reinikainen A, Lähde J, Suortti T, Hakalax J, Simell T, Hyöty H, Veijola R, Ilonen J, Lahesmaa R, Knip M, Simell O.

J Exp Med. 2008 Dec 22;205(13):2975-84. doi: 10.1084/jem.20081800. Epub 2008 Dec 15.

27.

Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial.

Näntö-Salonen K, Kupila A, Simell S, Siljander H, Salonsaari T, Hekkala A, Korhonen S, Erkkola R, Sipilä JI, Haavisto L, Siltala M, Tuominen J, Hakalax J, Hyöty H, Ilonen J, Veijola R, Simell T, Knip M, Simell O.

Lancet. 2008 Nov 15;372(9651):1746-55. doi: 10.1016/S0140-6736(08)61309-4. Epub 2008 Sep 22.

PMID:
18814906
28.

Fate of five celiac disease-associated antibodies during normal diet in genetically at-risk children observed from birth in a natural history study.

Simell S, Hoppu S, Hekkala A, Simell T, Ståhlberg MR, Viander M, Yrjänäinen H, Grönlund J, Markula P, Simell V, Knip M, Ilonen J, Hyöty H, Simell O.

Am J Gastroenterol. 2007 Sep;102(9):2026-35. Epub 2007 Jun 15.

PMID:
17573785
29.

Time-resolved fluorescence imaging of islet cell autoantibodies.

Vuorinen P, Rulli M, Kuusisto A, Simell S, Simell T, Vahlberg T, Ilonen J, Hyöty H, Knip M, Simell O.

Ann N Y Acad Sci. 2006 Oct;1079:226-8.

PMID:
17130559
30.

Parental reactions to information about increased genetic risk of type 1 diabetes mellitus in infants.

Simonen P, Korhonen T, Simell T, Keskinen P, Kärkkäinen M, Knip M, Ilonen J, Simell O.

Arch Pediatr Adolesc Med. 2006 Nov;160(11):1131-6.

PMID:
17088516
31.

The effects of type 1 diabetes and its long-term complications on physical and mental health status.

Hahl J, Hämäläinen H, Simell T, Simell O.

Pharmacoeconomics. 2006;24(6):559-69.

PMID:
16761904
32.

Natural history of transglutaminase autoantibodies and mucosal changes in children carrying HLA-conferred celiac disease susceptibility.

Simell S, Kupila A, Hoppu S, Hekkala A, Simell T, Ståhlberg MR, Viander M, Hurme T, Knip M, Ilonen J, Hyöty H, Simell O.

Scand J Gastroenterol. 2005 Oct;40(10):1182-91.

PMID:
16265775
33.

Dynamics of diabetes-associated autoantibodies in young children with human leukocyte antigen-conferred risk of type 1 diabetes recruited from the general population.

Kukko M, Kimpimäki T, Korhonen S, Kupila A, Simell S, Veijola R, Simell T, Ilonen J, Simell O, Knip M.

J Clin Endocrinol Metab. 2005 May;90(5):2712-7. Epub 2005 Feb 15.

PMID:
15872335
34.

Intranasally administered insulin intended for prevention of type 1 diabetes--a safety study in healthy adults.

Kupila A, Sipilä J, Keskinen P, Simell T, Knip M, Pulkki K, Simell O.

Diabetes Metab Res Rev. 2003 Sep-Oct;19(5):415-20.

PMID:
12951650
35.

Signs of beta-cell autoimmunity and HLA-defined diabetes susceptibility in the Finnish population: the sib cohort from the Type 1 Diabetes Prediction and Prevention Study.

Kukko M, Kimpimäki T, Kupila A, Korhonen S, Kulmala P, Savola K, Simell T, Keskinen P, Ilonen J, Simell O, Knip M.

Diabetologia. 2003 Jan;46(1):65-70. Epub 2002 Dec 18.

PMID:
12637984
36.

A simulation model for estimating direct costs of type 1 diabetes prevention.

Hahl J, Simell T, Kupila A, Keskinen P, Knip M, Ilonen J, Simell O.

Pharmacoeconomics. 2003;21(5):295-303.

PMID:
12627983
37.

First-phase insulin response in young healthy children at genetic and immunological risk for Type I diabetes.

Keskinen P, Korhonen S, Kupila A, Veijola R, Erkkilä S, Savolainen H, Arvilommi P, Simell T, Ilonen J, Knip M, Simell O.

Diabetologia. 2002 Dec;45(12):1639-48. Epub 2002 Oct 30.

PMID:
12488953
38.

A type 1 diabetes-related protein from wheat (Triticum aestivum). cDNA clone of a wheat storage globulin, Glb1, linked to islet damage.

MacFarlane AJ, Burghardt KM, Kelly J, Simell T, Simell O, Altosaar I, Scott FW.

J Biol Chem. 2003 Jan 3;278(1):54-63. Epub 2002 Oct 29.

39.

Natural history of beta-cell autoimmunity in young children with increased genetic susceptibility to type 1 diabetes recruited from the general population.

Kimpimäki T, Kulmala P, Savola K, Kupila A, Korhonen S, Simell T, Ilonen J, Simell O, Knip M.

J Clin Endocrinol Metab. 2002 Oct;87(10):4572-9.

PMID:
12364437
40.

Health-related quality of life in type 1 diabetes without or with symptoms of long-term complications.

Hahl J, Hämäläinen H, Sintonen H, Simell T, Arinen S, Simell O.

Qual Life Res. 2002 Aug;11(5):427-36.

PMID:
12113390
41.

Rotavirus infections and development of diabetes-associated autoantibodies during the first 2 years of life.

Blomqvist M, Juhela S, Erkkila S, Korhonen S, Simell T, Kupila A, Vaarala O, Simell O, Knip M, Ilonen J.

Clin Exp Immunol. 2002 Jun;128(3):511-5.

42.

Prevalence and fate of type 1 diabetes-associated autoantibodies in cord blood samples from newborn infants of non-diabetic mothers.

Hämäläinen AM, Ilonen J, Simell O, Savola K, Kulmala P, Kupila A, Simell T, Erkkola R, Koskela P, Knip M.

Diabetes Metab Res Rev. 2002 Jan-Feb;18(1):57-63.

PMID:
11921419
43.

Genetic risk determines the emergence of diabetes-associated autoantibodies in young children.

Kupila A, Keskinen P, Simell T, Erkkilä S, Arvilommi P, Korhonen S, Kimpimäki T, Sjöroos M, Ronkainen M, Ilonen J, Knip M, Simell O.

Diabetes. 2002 Mar;51(3):646-51.

44.

The first signs of beta-cell autoimmunity appear in infancy in genetically susceptible children from the general population: the Finnish Type 1 Diabetes Prediction and Prevention Study.

Kimpimäki T, Kupila A, Hämäläinen AM, Kukko M, Kulmala P, Savola K, Simell T, Keskinen P, Ilonen J, Simell O, Knip M.

J Clin Endocrinol Metab. 2001 Oct;86(10):4782-8.

PMID:
11600541
45.

Feasibility of genetic and immunological prediction of type I diabetes in a population-based birth cohort.

Kupila A, Muona P, Simell T, Arvilommi P, Savolainen H, Hämäläinen AM, Korhonen S, Kimpimäki T, Sjöroos M, Ilonen J, Knip M, Simell O; Juvenile Diabetes Research Foundation Centre for the Prevention of Type I Diabetes in Finland.

Diabetologia. 2001 Mar;44(3):290-7.

PMID:
11317658
46.

Enterovirus infection as a risk factor for beta-cell autoimmunity in a prospectively observed birth cohort: the Finnish Diabetes Prediction and Prevention Study.

Lönnrot M, Korpela K, Knip M, Ilonen J, Simell O, Korhonen S, Savola K, Muona P, Simell T, Koskela P, Hyöty H.

Diabetes. 2000 Aug;49(8):1314-8.

PMID:
10923631
47.

Costs of predicting IDDM.

Hahl J, Simell T, Ilonen J, Knip M, Simell O.

Diabetologia. 1998 Jan;41(1):79-85.

PMID:
9498634
48.

Longitudinal reproductive hormone profiles in infants: peak of inhibin B levels in infant boys exceeds levels in adult men.

Andersson AM, Toppari J, Haavisto AM, Petersen JH, Simell T, Simell O, Skakkebaek NE.

J Clin Endocrinol Metab. 1998 Feb;83(2):675-81.

PMID:
9467591
49.

Costs of insulin-dependent diabetes mellitus.

Simell TT, Sintonen H, Hahl J, Simell OG.

Pharmacoeconomics. 1996 Jan;9(1):24-38. Review.

PMID:
10160085
50.

Serum insulin profiles in consecutive children 2 years after the diagnosis of IDDM.

Simell T, Mäenpää J, Kaprio EA, Hakulinen A, Hakalax J, Sipilä I, Akerblom HK, Simell O.

Diabetologia. 1995 Jan;38(1):97-105.

PMID:
7744234

Supplemental Content

Loading ...
Support Center