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Items: 1 to 50 of 76

1.

Interleukin-17A exacerbates disease severity in BALB/c mice susceptible to lung infection with Mycoplasma pulmonis.

Mize MT, Sun XL, Simecka JW.

Infect Immun. 2018 Jul 9. pii: IAI.00292-18. doi: 10.1128/IAI.00292-18. [Epub ahead of print]

PMID:
29986888
2.

Copper-tolfenamic acid: evaluation of stability and anti-cancer activity.

Hurtado M, Sankpal UT, Chhabra J, Brown DT, Maram R, Patel R, Gurung RK, Simecka J, Holder AA, Basha R.

Invest New Drugs. 2018 May 15. doi: 10.1007/s10637-018-0594-9. [Epub ahead of print]

PMID:
29761244
3.

Activity of Meropenem-Vaborbactam against Carbapenem-Resistant Enterobacteriaceae in a Murine Model of Pyelonephritis.

Weiss WJ, Pulse ME, Nguyen P, Peterson K, Silva J, Simecka JW, Valtierra D, Sabet M, Griffith DC.

Antimicrob Agents Chemother. 2017 Dec 21;62(1). pii: e01439-17. doi: 10.1128/AAC.01439-17. Print 2018 Jan.

4.

Association of Sp1 and survivin in epithelial ovarian cancer: Sp1 inhibitor and cisplatin, a novel combination for inhibiting epithelial ovarian cancer cell proliferation.

Sankpal UT, Ingersoll SB, Ahmad S, Holloway RW, Bhat VB, Simecka JW, Daniel L, Kariali E, Vishwanatha JK, Basha R.

Tumour Biol. 2016 Oct;37(10):14259-14269. Epub 2016 Aug 31.

PMID:
27581819
5.

Thiopurine Prodrugs Mediate Immunosuppressive Effects by Interfering with Rac1 Protein Function.

Shin JY, Wey M, Umutesi HG, Sun X, Simecka J, Heo J.

J Biol Chem. 2016 Jun 24;291(26):13699-714. doi: 10.1074/jbc.M115.694422. Epub 2016 May 9.

6.

Regulatory CD4+CD25+ T Cells Dampen Inflammatory Disease in Murine Mycoplasma Pneumonia and Promote IL-17 and IFN-γ Responses.

Odeh AN, Simecka JW.

PLoS One. 2016 May 13;11(5):e0155648. doi: 10.1371/journal.pone.0155648. eCollection 2016.

7.

Small molecule tolfenamic acid and dietary spice curcumin treatment enhances antiproliferative effect in pancreatic cancer cells via suppressing Sp1, disrupting NF-kB translocation to nucleus and cell cycle phase distribution.

Basha R, Connelly SF, Sankpal UT, Nagaraju GP, Patel H, Vishwanatha JK, Shelake S, Tabor-Simecka L, Shoji M, Simecka JW, El-Rayes B.

J Nutr Biochem. 2016 May;31:77-87. doi: 10.1016/j.jnutbio.2016.01.003. Epub 2016 Feb 10.

8.

Combination of tolfenamic acid and curcumin induces colon cancer cell growth inhibition through modulating specific transcription factors and reactive oxygen species.

Sankpal UT, Nagaraju GP, Gottipolu SR, Hurtado M, Jordan CG, Simecka JW, Shoji M, El-Rayes B, Basha R.

Oncotarget. 2016 Jan 19;7(3):3186-200. doi: 10.18632/oncotarget.6553.

9.

Antigen-pulsed bone marrow-derived and pulmonary dendritic cells promote Th2 cell responses and immunopathology in lungs during the pathogenesis of murine Mycoplasma pneumonia.

Dobbs NA, Zhou X, Pulse M, Hodge LM, Schoeb TR, Simecka JW.

J Immunol. 2014 Aug 1;193(3):1353-63. doi: 10.4049/jimmunol.1301772. Epub 2014 Jun 27.

10.

Interleukin-23 (IL-23) deficiency disrupts Th17 and Th1-related defenses against Streptococcus pneumoniae infection.

Kim BJ, Lee S, Berg RE, Simecka JW, Jones HP.

Cytokine. 2013 Oct;64(1):375-81. doi: 10.1016/j.cyto.2013.05.013. Epub 2013 Jun 14.

PMID:
23752068
11.

Perturbation of Staphylococcus aureus gene expression by the enoyl-acyl carrier protein reductase inhibitor AFN-1252.

Parsons JB, Kukula M, Jackson P, Pulse M, Simecka JW, Valtierra D, Weiss WJ, Kaplan N, Rock CO.

Antimicrob Agents Chemother. 2013 May;57(5):2182-90. doi: 10.1128/AAC.02307-12. Epub 2013 Mar 4.

12.

Dendritic cells are the major antigen presenting cells in inflammatory lesions of murine Mycoplasma respiratory disease.

Sun X, Jones HP, Dobbs N, Bodhankar S, Simecka JW.

PLoS One. 2013;8(2):e55984. doi: 10.1371/journal.pone.0055984. Epub 2013 Feb 4.

13.

Oral inoculation of young dairy calves with Mycoplasma bovis results in colonization of tonsils, development of otitis media and local immunity.

Maunsell F, Brown MB, Powe J, Ivey J, Woolard M, Love W, Simecka JW.

PLoS One. 2012;7(9):e44523. doi: 10.1371/journal.pone.0044523. Epub 2012 Sep 6.

14.

Corticotropin-releasing hormone receptor-1 and 2 activity produces divergent resistance against stress-induced pulmonary Streptococcus pneumoniae infection.

Kim BJ, Kayembe K, Simecka JW, Pulse M, Jones HP.

J Neuroimmunol. 2011 Aug 15;237(1-2):57-65. doi: 10.1016/j.jneuroim.2011.06.016. Epub 2011 Jul 20.

15.

Small molecule inhibitors of Staphylococcus aureus RnpA alter cellular mRNA turnover, exhibit antimicrobial activity, and attenuate pathogenesis.

Olson PD, Kuechenmeister LJ, Anderson KL, Daily S, Beenken KE, Roux CM, Reniere ML, Lewis TL, Weiss WJ, Pulse M, Nguyen P, Simecka JW, Morrison JM, Sayood K, Asojo OA, Smeltzer MS, Skaar EP, Dunman PM.

PLoS Pathog. 2011 Feb 10;7(2):e1001287. doi: 10.1371/journal.ppat.1001287.

16.

Pyruvate-enriched resuscitation protects hindlimb muscle from ischemia-reperfusion injury.

Flaherty DC, Hoxha B, Sun J, Gurji H, Simecka JW, Olivencia-Yurvati AH, Mallet RT.

Mil Med. 2010 Dec;175(12):1020-6.

PMID:
21265313
17.

Toll-like receptor 2 (TLR2) plays a major role in innate resistance in the lung against murine Mycoplasma.

Love W, Dobbs N, Tabor L, Simecka JW.

PLoS One. 2010 May 20;5(5):e10739. doi: 10.1371/journal.pone.0010739.

18.
19.

Pyruvate-fortified fluid resuscitation improves hemodynamic stability while suppressing systemic inflammation and myocardial oxidative stress after hemorrhagic shock.

Flaherty DC, Hoxha B, Sun J, Gurji H, Simecka JW, Mallet RT, Olivencia-Yurvati AH.

Mil Med. 2010 Mar;175(3):166-72.

PMID:
20358705
20.

Peri- and intra-operative management of the goat during acute surgical experimentation.

Flaherty DC, Hoxha B, Nelson S, Sun J, Gurji H, Simecka JW, Mallet RT, Olivencia-Yurvati AH, Daniels EQ.

Lab Anim (NY). 2010 Mar;39(3):80-5. doi: 10.1038/laban0310-80.

PMID:
20164949
21.

NK cells interfere with the generation of resistance against mycoplasma respiratory infection following nasal-pulmonary immunization.

Bodhankar S, Woolard MD, Sun X, Simecka JW.

J Immunol. 2009 Aug 15;183(4):2622-31. doi: 10.4049/jimmunol.0802180. Epub 2009 Jul 22.

22.

A novel IL-17-dependent mechanism of cross protection: respiratory infection with mycoplasma protects against a secondary listeria infection.

Sieve AN, Meeks KD, Bodhankar S, Lee S, Kolls JK, Simecka JW, Berg RE.

Eur J Immunol. 2009 Feb;39(2):426-38. doi: 10.1002/eji.200838726.

23.
24.

Hyperbaric oxygen treatment attenuates the pro-inflammatory and immune responses in apolipoprotein E knockout mice.

Kudchodkar B, Jones H, Simecka J, Dory L.

Clin Immunol. 2008 Sep;128(3):435-41. doi: 10.1016/j.clim.2008.05.004. Epub 2008 Jul 2.

25.

Abdominal lymphatic pump treatment increases leukocyte count and flux in thoracic duct lymph.

Hodge LM, King HH, Williams AG Jr, Reder SJ, Belavadi T, Simecka JW, Stoll ST, Downey HF.

Lymphat Res Biol. 2007;5(2):127-33.

PMID:
17935480
26.

Synthesis and antibacterial evaluation of a novel series of rifabutin-like spirorifamycins.

Kim IH, Combrink KD, Ma Z, Chapo K, Yan D, Renick P, Morris TW, Pulse M, Simecka JW, Ding CZ.

Bioorg Med Chem Lett. 2007 Mar 1;17(5):1181-4. Epub 2006 Dec 12.

PMID:
17189695
28.

NK cells in gamma-interferon-deficient mice suppress lung innate immunity against Mycoplasma spp.

Woolard MD, Hudig D, Tabor L, Ivey JA, Simecka JW.

Infect Immun. 2005 Oct;73(10):6742-51.

29.

IL-4-independent pathways exacerbate methacholine-induced airway hyperreactivity during mycoplasma respiratory disease.

Woolard MD, Hardy RD, Simecka JW.

J Allergy Clin Immunol. 2004 Sep;114(3):645-9.

PMID:
15356571
30.
31.
32.

Role of upper and lower respiratory tract immunity in resistance to Mycoplasma respiratory disease.

Hodge LM, Simecka JW.

J Infect Dis. 2002 Jul 15;186(2):290-4. Epub 2002 Jun 17.

PMID:
12134269
33.

Catabolite repression of Escherichia coli biofilm formation.

Jackson DW, Simecka JW, Romeo T.

J Bacteriol. 2002 Jun;184(12):3406-10.

34.
35.
36.

Biofilm formation and dispersal under the influence of the global regulator CsrA of Escherichia coli.

Jackson DW, Suzuki K, Oakford L, Simecka JW, Hart ME, Romeo T.

J Bacteriol. 2002 Jan;184(1):290-301.

38.

Variations in the surface proteins and restriction enzyme systems of Mycoplasma pulmonis in the respiratory tract of infected rats.

Gumulak-Smith J, Teachman A, Tu AH, Simecka JW, Lindsey JR, Dybvig K.

Mol Microbiol. 2001 May;40(4):1037-44.

39.

Positive regulation of motility and flhDC expression by the RNA-binding protein CsrA of Escherichia coli.

Wei BL, Brun-Zinkernagel AM, Simecka JW, Prüss BM, Babitzke P, Romeo T.

Mol Microbiol. 2001 Apr;40(1):245-56.

40.

Gender is a major factor in determining the severity of mycoplasma respiratory disease in mice.

Yancey AL, Watson HL, Cartner SC, Simecka JW.

Infect Immun. 2001 May;69(5):2865-71.

41.

Immunoglobulin A (IgA) responses and IgE-associated inflammation along the respiratory tract after mucosal but not systemic immunization.

Hodge LM, Marinaro M, Jones HP, McGhee JR, Kiyono H, Simecka JW.

Infect Immun. 2001 Apr;69(4):2328-38.

42.

Mucosal immunity of the gastrointestinal tract and oral tolerance.

Simecka JW.

Adv Drug Deliv Rev. 1998 Dec 1;34(2-3):235-259.

PMID:
10837680
43.

Mucosally induced immunoglobulin E-associated inflammation in the respiratory tract.

Simecka JW, Jackson RJ, Kiyono H, McGhee JR.

Infect Immun. 2000 Feb;68(2):672-9.

44.

Antibody responses after Sendai virus infection and their role in upper and lower respiratory tract disease in rats.

Liang SC, Simecka JW, Lindsey JR, Cassell GH, Davis JK.

Lab Anim Sci. 1999 Aug;49(4):385-94.

PMID:
10480643
45.
46.

Roles of innate and adaptive immunity in respiratory mycoplasmosis.

Cartner SC, Lindsey JR, Gibbs-Erwin J, Cassell GH, Simecka JW.

Infect Immun. 1998 Aug;66(8):3485-91.

47.

Adenoviral gene delivery elicits distinct pulmonary-associated T helper cell responses to the vector and to its transgene.

van Ginkel FW, McGhee JR, Liu C, Simecka JW, Yamamoto M, Frizzell RA, Sorscher EJ, Kiyono H, Pascual DW.

J Immunol. 1997 Jul 15;159(2):685-93.

PMID:
9218583
48.

Mucosal immunization with DNA encoding influenza hemagglutinin.

Ban EM, van Ginkel FW, Simecka JW, Kiyono H, Robinson HL, McGhee JR.

Vaccine. 1997 Jun;15(8):811-3. No abstract available.

PMID:
9234521
49.

Resistance to mycoplasmal lung disease in mice is a complex genetic trait.

Cartner SC, Simecka JW, Briles DE, Cassell GH, Lindsey JR.

Infect Immun. 1996 Dec;64(12):5326-31.

50.

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