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Items: 1 to 50 of 55

1.

MicroRNA-181a regulates IFN-γ expression in effector CD8+ T cell differentiation.

Amado T, Amorim A, Enguita FJ, Romero PV, Inácio D, de Miranda MP, Winter SJ, Simas JP, Krueger A, Schmolka N, Silva-Santos B, Gomes AQ.

J Mol Med (Berl). 2020 Feb;98(2):309-320. doi: 10.1007/s00109-019-01865-y. Epub 2020 Jan 30.

2.

Vaccine protection against murid herpesvirus-4 is maintained when the priming virus lacks known latency genes.

Lawler C, Simas JP, Stevenson PG.

Immunol Cell Biol. 2020 Jan;98(1):67-78. doi: 10.1111/imcb.12299. Epub 2019 Nov 21.

PMID:
31630452
3.

In Vivo Persistence of Chimeric Virus after Substitution of the Kaposi's Sarcoma-Associated Herpesvirus LANA DNA Binding Domain with That of Murid Herpesvirus 4.

Pires de Miranda M, Quendera AP, McVey CE, Kaye KM, Simas JP.

J Virol. 2018 Oct 12;92(21). pii: e01251-18. doi: 10.1128/JVI.01251-18. Print 2018 Nov 1.

4.

Gammaherpesvirus Colonization of the Spleen Requires Lytic Replication in B Cells.

Lawler C, de Miranda MP, May J, Wyer O, Simas JP, Stevenson PG.

J Virol. 2018 Mar 14;92(7). pii: e02199-17. doi: 10.1128/JVI.02199-17. Print 2018 Apr 1.

5.

Cross-species conservation of episome maintenance provides a basis for in vivo investigation of Kaposi's sarcoma herpesvirus LANA.

Habison AC, de Miranda MP, Beauchemin C, Tan M, Cerqueira SA, Correia B, Ponnusamy R, Usherwood EJ, McVey CE, Simas JP, Kaye KM.

PLoS Pathog. 2017 Sep 14;13(9):e1006555. doi: 10.1371/journal.ppat.1006555. eCollection 2017 Sep.

6.

Response to commentary on "Identification of H-type BSE in Portugal".

Orge L, Simas JP.

Prion. 2016 Sep 2;10(5):343. No abstract available.

7.

Type I Interferons and NK Cells Restrict Gammaherpesvirus Lymph Node Infection.

Lawler C, Tan CS, Simas JP, Stevenson PG.

J Virol. 2016 Sep 29;90(20):9046-57. doi: 10.1128/JVI.01108-16. Print 2016 Oct 15.

8.

GLUT1-mediated glucose uptake plays a crucial role during Plasmodium hepatic infection.

Meireles P, Sales-Dias J, Andrade CM, Mello-Vieira J, Mancio-Silva L, Simas JP, Staines HM, Prudêncio M.

Cell Microbiol. 2017 Feb;19(2). doi: 10.1111/cmi.12646. Epub 2016 Aug 2.

9.

Latency-Associated Nuclear Antigen E3 Ubiquitin Ligase Activity Impacts Gammaherpesvirus-Driven Germinal Center B Cell Proliferation.

Cerqueira SA, Tan M, Li S, Juillard F, McVey CE, Kaye KM, Simas JP.

J Virol. 2016 Aug 12;90(17):7667-83. doi: 10.1128/JVI.00813-16. Print 2016 Sep 1.

10.

Effector γδ T Cell Differentiation Relies on Master but Not Auxiliary Th Cell Transcription Factors.

Barros-Martins J, Schmolka N, Fontinha D, Pires de Miranda M, Simas JP, Brok I, Ferreira C, Veldhoen M, Silva-Santos B, Serre K.

J Immunol. 2016 May 1;196(9):3642-52. doi: 10.4049/jimmunol.1501921. Epub 2016 Mar 18.

11.

Correction: Murid Gammaherpesvirus Latency-Associated Protein M2 Promotes the Formation of Conjugates between Transformed B Lymphoma Cells and T Helper Cells.

Fontinha D, Lopes FB, Marques S, Alenquer M, Simas JP.

PLoS One. 2015 Dec 22;10(12):e0145942. doi: 10.1371/journal.pone.0145942. eCollection 2015. No abstract available.

12.

Murid Gammaherpesvirus Latency-Associated Protein M2 Promotes the Formation of Conjugates between Transformed B Lymphoma Cells and T Helper Cells.

Fontinha D, Lopes FB, Marques S, Alenquer M, Simas JP.

PLoS One. 2015 Nov 6;10(11):e0142540. doi: 10.1371/journal.pone.0142540. eCollection 2015. Erratum in: PLoS One. 2015;10(12):e0145942. Alenquer, Marta [added].

13.

KSHV but not MHV-68 LANA induces a strong bend upon binding to terminal repeat viral DNA.

Ponnusamy R, Petoukhov MV, Correia B, Custodio TF, Juillard F, Tan M, Pires de Miranda M, Carrondo MA, Simas JP, Kaye KM, Svergun DI, McVey CE.

Nucleic Acids Res. 2015 Nov 16;43(20):10039-54. doi: 10.1093/nar/gkv987. Epub 2015 Sep 30.

14.

The Kaposi Sarcoma Herpesvirus Latency-associated Nuclear Antigen DNA Binding Domain Dorsal Positive Electrostatic Patch Facilitates DNA Replication and Episome Persistence.

Li S, Tan M, Juillard F, Ponnusamy R, Correia B, Simas JP, Carrondo MA, McVey CE, Kaye KM.

J Biol Chem. 2015 Nov 20;290(47):28084-96. doi: 10.1074/jbc.M115.674622. Epub 2015 Sep 29.

15.

Identification of H-type BSE in Portugal.

Orge L, Machado CG, Ramalho L, Carvalho R, Silva J, Almeida P, Tavares P, Ochoa C, Lima C, Pinto MJ, Simas JP.

Prion. 2015;9(1):22-8. doi: 10.1080/19336896.2014.997615. Epub 2015 Feb 10.

16.

Establishment of murine gammaherpesvirus latency in B cells is not a stochastic event.

Decalf J, Godinho-Silva C, Fontinha D, Marques S, Simas JP.

PLoS Pathog. 2014 Jul 31;10(7):e1004269. doi: 10.1371/journal.ppat.1004269. eCollection 2014 Jul.

17.

Defining immune engagement thresholds for in vivo control of virus-driven lymphoproliferation.

Godinho-Silva C, Marques S, Fontinha D, Veiga-Fernandes H, Stevenson PG, Simas JP.

PLoS Pathog. 2014 Jun 26;10(6):e1004220. doi: 10.1371/journal.ppat.1004220. eCollection 2014 Jun.

18.

Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity.

van de Pavert SA, Ferreira M, Domingues RG, Ribeiro H, Molenaar R, Moreira-Santos L, Almeida FF, Ibiza S, Barbosa I, Goverse G, Labão-Almeida C, Godinho-Silva C, Konijn T, Schooneman D, O'Toole T, Mizee MR, Habani Y, Haak E, Santori FR, Littman DR, Schulte-Merker S, Dzierzak E, Simas JP, Mebius RE, Veiga-Fernandes H.

Nature. 2014 Apr 3;508(7494):123-7. doi: 10.1038/nature13158. Epub 2014 Mar 19.

19.

Anthracyclines induce DNA damage response-mediated protection against severe sepsis.

Figueiredo N, Chora A, Raquel H, Pejanovic N, Pereira P, Hartleben B, Neves-Costa A, Moita C, Pedroso D, Pinto A, Marques S, Faridi H, Costa P, Gozzelino R, Zhao JL, Soares MP, Gama-Carvalho M, Martinez J, Zhang Q, Döring G, Grompe M, Simas JP, Huber TB, Baltimore D, Gupta V, Green DR, Ferreira JA, Moita LF.

Immunity. 2013 Nov 14;39(5):874-84. doi: 10.1016/j.immuni.2013.08.039. Epub 2013 Oct 31.

20.

Crystal structure of the gamma-2 herpesvirus LANA DNA binding domain identifies charged surface residues which impact viral latency.

Correia B, Cerqueira SA, Beauchemin C, Pires de Miranda M, Li S, Ponnusamy R, Rodrigues L, Schneider TR, Carrondo MA, Kaye KM, Simas JP, McVey CE.

PLoS Pathog. 2013;9(10):e1003673. doi: 10.1371/journal.ppat.1003673. Epub 2013 Oct 17.

21.

Stabilization of Myc through heterotypic poly-ubiquitination by mLANA is critical for γ-herpesvirus lymphoproliferation.

Rodrigues L, Popov N, Kaye KM, Simas JP.

PLoS Pathog. 2013;9(8):e1003554. doi: 10.1371/journal.ppat.1003554. Epub 2013 Aug 8.

22.

Role of Src homology domain binding in signaling complexes assembled by the murid γ-herpesvirus M2 protein.

Pires de Miranda M, Lopes FB, McVey CE, Bustelo XR, Simas JP.

J Biol Chem. 2013 Feb 8;288(6):3858-70. doi: 10.1074/jbc.M112.439810. Epub 2012 Dec 20.

23.

Murine gammaherpesvirus 68 LANA acts on terminal repeat DNA to mediate episome persistence.

Habison AC, Beauchemin C, Simas JP, Usherwood EJ, Kaye KM.

J Virol. 2012 Nov;86(21):11863-76. doi: 10.1128/JVI.01656-12. Epub 2012 Aug 22.

24.

CD8(+) T cells from mice transnuclear for a TCR that recognizes a single H-2K(b)-restricted MHV68 epitope derived from gB-ORF8 help control infection.

Sehrawat S, Kirak O, Koenig PA, Isaacson MK, Marques S, Bozkurt G, Simas JP, Jaenisch R, Ploegh HL.

Cell Rep. 2012 May 31;1(5):461-71. doi: 10.1016/j.celrep.2012.03.009. Epub 2012 Apr 26.

25.

T cell apoptosis and induction of Foxp3+ regulatory T cells underlie the therapeutic efficacy of CD4 blockade in experimental autoimmune encephalomyelitis.

Duarte J, Carrié N, Oliveira VG, Almeida C, Agua-Doce A, Rodrigues L, Simas JP, Mars LT, Graca L.

J Immunol. 2012 Aug 15;189(4):1680-8. doi: 10.4049/jimmunol.1201269. Epub 2012 Jul 16.

26.

Cutting edge: adaptive versus innate receptor signals selectively control the pool sizes of murine IFN-γ- or IL-17-producing γδ T cells upon infection.

Ribot JC, Chaves-Ferreira M, d'Orey F, Wencker M, Gonçalves-Sousa N, Decalf J, Simas JP, Hayday AC, Silva-Santos B.

J Immunol. 2010 Dec 1;185(11):6421-6425. doi: 10.4049/jimmunol.1002283. Epub 2010 Oct 29.

27.

Putative emergence of classical scrapie in a background of enzootic atypical scrapie.

Orge L, Oliveira A, Machado C, Lima C, Ochoa C, Silva J, Carvalho R, Tavares P, Almeida P, Ramos M, Pinto MJ, Simas JP.

J Gen Virol. 2010 Jun;91(Pt 6):1646-50. doi: 10.1099/vir.0.018879-0. Epub 2010 Feb 17.

PMID:
20164262
28.

Immune control of mammalian gamma-herpesviruses: lessons from murid herpesvirus-4.

Stevenson PG, Simas JP, Efstathiou S.

J Gen Virol. 2009 Oct;90(Pt 10):2317-30. doi: 10.1099/vir.0.013300-0. Epub 2009 Jul 15. Review.

PMID:
19605591
29.

Parainfluenza virus 5 genomes are located in viral cytoplasmic bodies whilst the virus dismantles the interferon-induced antiviral state of cells.

Carlos TS, Young DF, Schneider M, Simas JP, Randall RE.

J Gen Virol. 2009 Sep;90(Pt 9):2147-56. doi: 10.1099/vir.0.012047-0. Epub 2009 May 20.

30.

Termination of NF-kappaB activity through a gammaherpesvirus protein that assembles an EC5S ubiquitin-ligase.

Rodrigues L, Filipe J, Seldon MP, Fonseca L, Anrather J, Soares MP, Simas JP.

EMBO J. 2009 May 6;28(9):1283-95. doi: 10.1038/emboj.2009.74. Epub 2009 Mar 26.

31.

In vivo imaging of murid herpesvirus-4 infection.

Milho R, Smith CM, Marques S, Alenquer M, May JS, Gillet L, Gaspar M, Efstathiou S, Simas JP, Stevenson PG.

J Gen Virol. 2009 Jan;90(Pt 1):21-32. doi: 10.1099/vir.0.006569-0.

32.

A single CD8+ T cell epitope sets the long-term latent load of a murid herpesvirus.

Marques S, Alenquer M, Stevenson PG, Simas JP.

PLoS Pathog. 2008 Oct;4(10):e1000177. doi: 10.1371/journal.ppat.1000177. Epub 2008 Oct 10.

33.

The Gammaherpesvirus m2 protein manipulates the Fyn/Vav pathway through a multidocking mechanism of assembly.

Pires de Miranda M, Alenquer M, Marques S, Rodrigues L, Lopes F, Bustelo XR, Simas JP.

PLoS One. 2008 Feb 27;3(2):e1654. doi: 10.1371/journal.pone.0001654.

34.

Type I interferon inhibition and dendritic cell activation during gammaherpesvirus respiratory infection.

Weslow-Schmidt JL, Jewell NA, Mertz SE, Simas JP, Durbin JE, Flaño E.

J Virol. 2007 Sep;81(18):9778-89. Epub 2007 Jul 11.

35.

Activation of Vav by the gammaherpesvirus M2 protein contributes to the establishment of viral latency in B lymphocytes.

Rodrigues L, Pires de Miranda M, Caloca MJ, Bustelo XR, Simas JP.

J Virol. 2006 Jun;80(12):6123-35.

36.

Murine gamma-herpesvirus 68 latency protein M2 binds to Vav signaling proteins and inhibits B-cell receptor-induced cell cycle arrest and apoptosis in WEHI-231 B cells.

Madureira PA, Matos P, Soeiro I, Dixon LK, Simas JP, Lam EW.

J Biol Chem. 2005 Nov 11;280(45):37310-8. Epub 2005 Sep 2.

37.

Intrabodies targeting the Kaposi sarcoma-associated herpesvirus latency antigen inhibit viral persistence in lymphoma cells.

Corte-Real S, Collins C, Aires da Silva F, Simas JP, Barbas CF 3rd, Chang Y, Moore P, Goncalves J.

Blood. 2005 Dec 1;106(12):3797-802. Epub 2005 Aug 9.

38.

Murine gammaherpesvirus 68 bcl-2 homologue contributes to latency establishment in vivo.

de Lima BD, May JS, Marques S, Simas JP, Stevenson PG.

J Gen Virol. 2005 Jan;86(Pt 1):31-40.

PMID:
15604429
39.

Identification of putative atypical scrapie in sheep in Portugal.

Orge L, Galo A, Machado C, Lima C, Ochoa C, Silva J, Ramos M, Simas JP.

J Gen Virol. 2004 Nov;85(Pt 11):3487-91.

PMID:
15483267
41.

ORF73 of murine herpesvirus-68 is critical for the establishment and maintenance of latency.

Fowler P, Marques S, Simas JP, Efstathiou S.

J Gen Virol. 2003 Dec;84(Pt 12):3405-3416. doi: 10.1099/vir.0.19594-0.

PMID:
14645921
42.

Scrapie genetic susceptibility in Portuguese sheep breeds.

Orge L, Galo A, Sepúlveda N, Simas JP, Pires M.

Vet Rec. 2003 Oct 18;153(16):508. No abstract available.

PMID:
14601805
43.

Selective gene expression of latent murine gammaherpesvirus 68 in B lymphocytes.

Marques S, Efstathiou S, Smith KG, Haury M, Simas JP.

J Virol. 2003 Jul;77(13):7308-18.

44.

Disruption of CCL21-induced chemotaxis in vitro and in vivo by M3, a chemokine-binding protein encoded by murine gammaherpesvirus 68.

Jensen KK, Chen SC, Hipkin RW, Wiekowski MT, Schwarz MA, Chou CC, Simas JP, Alcami A, Lira SA.

J Virol. 2003 Jan;77(1):624-30.

45.

K3-mediated evasion of CD8(+) T cells aids amplification of a latent gamma-herpesvirus.

Stevenson PG, May JS, Smith XG, Marques S, Adler H, Koszinowski UH, Simas JP, Efstathiou S.

Nat Immunol. 2002 Aug;3(8):733-40. Epub 2002 Jul 8.

PMID:
12101398
46.
47.

Similarity of the lesion profile of BSE in Portuguese cattle to that described in British cattle.

Orge L, Simas JP, Fernandes AC, Ramos M, Galo A.

Vet Rec. 2000 Oct 21;147(17):486-8. No abstract available.

PMID:
11093402
48.

BSE in Portugal: anticipating the decline of an epidemic.

Donnelly CA, Santos R, Ramos M, Galo A, Simas JP.

J Epidemiol Biostat. 1999;4(4):277-83.

PMID:
10764241
49.

A broad spectrum secreted chemokine binding protein encoded by a herpesvirus.

Parry CM, Simas JP, Smith VP, Stewart CA, Minson AC, Efstathiou S, Alcami A.

J Exp Med. 2000 Feb 7;191(3):573-8.

50.

Analysis of murine gammaherpesvirus-68 transcription during lytic and latent infection.

Simas JP, Swann D, Bowden R, Efstathiou S.

J Gen Virol. 1999 Jan;80 ( Pt 1):75-82. doi: 10.1099/0022-1317-80-1-75.

PMID:
9934687

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