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Items: 11


Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse.

Filograna R, Koolmeister C, Upadhyay M, Pajak A, Clemente P, Wibom R, Simard ML, Wredenberg A, Freyer C, Stewart JB, Larsson NG.

Sci Adv. 2019 Apr 3;5(4):eaav9824. doi: 10.1126/sciadv.aav9824. eCollection 2019 Apr.


Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo.

Gammage PA, Viscomi C, Simard ML, Costa ASH, Gaude E, Powell CA, Van Haute L, McCann BJ, Rebelo-Guiomar P, Cerutti R, Zhang L, Rebar EJ, Zeviani M, Frezza C, Stewart JB, Minczuk M.

Nat Med. 2018 Nov;24(11):1691-1695. doi: 10.1038/s41591-018-0165-9. Epub 2018 Sep 24.


A novel histochemistry assay to assess and quantify focal cytochrome c oxidase deficiency.

Simard ML, Mourier A, Greaves LC, Taylor RW, Stewart JB.

J Pathol. 2018 Jul;245(3):311-323. doi: 10.1002/path.5084. Epub 2018 May 14.


Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria.

Matic S, Jiang M, Nicholls TJ, Uhler JP, Dirksen-Schwanenland C, Polosa PL, Simard ML, Li X, Atanassov I, Rackham O, Filipovska A, Stewart JB, Falkenberg M, Larsson NG, Milenkovic D.

Nat Commun. 2018 Mar 23;9(1):1202. doi: 10.1038/s41467-018-03552-x.


A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease.

Kauppila JHK, Baines HL, Bratic A, Simard ML, Freyer C, Mourier A, Stamp C, Filograna R, Larsson NG, Greaves LC, Stewart JB.

Cell Rep. 2016 Sep 13;16(11):2980-2990. doi: 10.1016/j.celrep.2016.08.037.


Emergent and nonemergent nonbowel torsion: spectrum of imaging and clinical findings.

Lubner MG, Simard ML, Peterson CM, Bhalla S, Pickhardt PJ, Menias CO.

Radiographics. 2013 Jan-Feb;33(1):155-73. doi: 10.1148/rg.331125016. Review.


NG2 and NG2-positive cells delineate focal cerebral infarct demarcation in rats.

Claus HL, Walberer M, Simard ML, Emig B, Muesken SM, Rueger MA, Fink GR, Schroeter M.

Neuropathology. 2013 Feb;33(1):30-8. doi: 10.1111/j.1440-1789.2012.01322.x. Epub 2012 May 29.


Dynamics of neuroinflammation in the macrosphere model of arterio-arterial embolic focal ischemia: an approximation to human stroke patterns.

Walberer M, Rueger MA, Simard ML, Emig B, Jander S, Fink GR, Schroeter M.

Exp Transl Stroke Med. 2010 Dec 20;2(1):22. doi: 10.1186/2040-7378-2-22.


Noninvasive imaging of endogenous neural stem cell mobilization in vivo using positron emission tomography.

Rueger MA, Backes H, Walberer M, Neumaier B, Ullrich R, Simard ML, Emig B, Fink GR, Hoehn M, Graf R, Schroeter M.

J Neurosci. 2010 May 5;30(18):6454-60. doi: 10.1523/JNEUROSCI.6092-09.2010.


LDL receptor deficiency results in decreased cell proliferation and presynaptic bouton density in the murine hippocampus.

Mulder M, Koopmans G, Wassink G, Al Mansouri G, Simard ML, Havekes LM, Prickaerts J, Blokland A.

Neurosci Res. 2007 Nov;59(3):251-6. Epub 2007 Jul 17.


Natalizumab effects on immune cell responses in multiple sclerosis.

Niino M, Bodner C, Simard ML, Alatab S, Gano D, Kim HJ, Trigueiro M, Racicot D, Guérette C, Antel JP, Fournier A, Grand'Maison F, Bar-Or A.

Ann Neurol. 2006 May;59(5):748-54. Erratum in: Ann Neurol. 2006 Jun;59(6):990.


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