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SCING-Spinal Cord Injury Neuroprotection with Glyburide: a pilot, open-label, multicentre, prospective evaluation of oral glyburide in patients with acute traumatic spinal cord injury in the USA.

Minnema AJ, Mehta A, Boling WW, Schwab J, Simard JM, Farhadi HF.

BMJ Open. 2019 Oct 10;9(10):e031329. doi: 10.1136/bmjopen-2019-031329.


Intravenous Glibenclamide Reduces Lesional Water Uptake in Large Hemispheric Infarction.

Vorasayan P, Bevers MB, Beslow LA, Sze G, Molyneaux BJ, Hinson HE, Simard JM, von Kummer R, Sheth KN, Kimberly WT.

Stroke. 2019 Sep 20:STROKEAHA119026036. doi: 10.1161/STROKEAHA.119.026036. [Epub ahead of print]


Utility of the Hijdra Sum Score in Predicting Risk of Aneurysm in Patients With Subarachnoid Hemorrhage: A Single-Center Experience With 550 Patients.

Kole MJ, Shea P, Albrecht JS, Cannarsa GJ, Wessell AP, Miller TR, Jindal G, Gandhi D, Aldrich EF, Simard JM.

Neurosurgery. 2019 Sep 9. pii: nyz346. doi: 10.1093/neuros/nyz346. [Epub ahead of print]


Magnetic Resonance Imaging Pilot Study of Intravenous Glyburide in Traumatic Brain Injury.

Eisenberg HM, Shenton ME, Pasternak O, Simard JM, Okonkwo DO, Aldrich C, He F, Jain S, Hayman EG.

J Neurotrauma. 2019 Aug 27. doi: 10.1089/neu.2019.6538. [Epub ahead of print]


Efficacy of Ultra-Early (< 12 h), Early (12-24 h), and Late (>24-138.5 h) Surgery with Magnetic Resonance Imaging-Confirmed Decompression in American Spinal Injury Association Impairment Scale Grades A, B, and C Cervical Spinal Cord Injury.

Aarabi B, Akhtar-Danesh N, Chryssikos T, Shanmuganathan K, Schwartzbauer GT, Simard JM, Olexa J, Sansur CA, Crandall KM, Mushlin H, Kole MJ, Le EJ, Wessell AP, Pratt N, Cannarsa G, Lomangino C, Scarboro M, Aresco C, Oliver J, Caffes N, Carbine S, Mori K.

J Neurotrauma. 2019 Aug 1. doi: 10.1089/neu.2019.6606. [Epub ahead of print]


Chronic pain after blast-induced traumatic brain injury in awake rats.

Uddin O, Studlack PE, Parihar S, Keledjian K, Cruz A, Farooq T, Shin N, Gerzanich V, Simard JM, Keller A.

Neurobiol Pain. 2019 Apr 2;6:100030. doi: 10.1016/j.ynpai.2019.100030. eCollection 2019 Aug-Dec.


Minimally Invasive Surgery for Spontaneous Cerebellar Hemorrhage: A Multicenter Study.

Khattar NK, Fortuny EM, Wessell AP, John KD, Bak E, Adams SW, Meyer KS, Schirmer CM, Simard JM, Neimat JS, Ding D, James RF.

World Neurosurg. 2019 Sep;129:e35-e39. doi: 10.1016/j.wneu.2019.04.164. Epub 2019 Apr 28.


Pipeline embolization device diameter is an important factor determining the efficacy of flow diversion treatment of small intracranial saccular aneurysms.

Kole MJ, Miller TR, Cannarsa G, Wessell A, Jones S, Le E, Jindal G, Aldrich F, Simard JM, Gandhi D.

J Neurointerv Surg. 2019 Oct;11(10):1004-1008. doi: 10.1136/neurintsurg-2019-014792. Epub 2019 Mar 29.


Winners, losers, and controls.

Simard JM.

Neurology. 2019 Apr 9;92(15):689-690. doi: 10.1212/WNL.0000000000007257. Epub 2019 Mar 20. No abstract available.


Bursting at the Seams: Molecular Mechanisms Mediating Astrocyte Swelling.

Lafrenaye AD, Simard JM.

Int J Mol Sci. 2019 Jan 15;20(2). pii: E330. doi: 10.3390/ijms20020330. Review.


Effect of IV glyburide on adjudicated edema endpoints in the GAMES-RP Trial.

Kimberly WT, Bevers MB, von Kummer R, Demchuk AM, Romero JM, Elm JJ, Hinson HE, Molyneaux BJ, Simard JM, Sheth KN.

Neurology. 2018 Dec 4;91(23):e2163-e2169. doi: 10.1212/WNL.0000000000006618. Epub 2018 Nov 16.


Pipeline Diameter Significantly Impacts the Long-Term Fate of Jailed Side Branches during Treatment of Intracranial Aneurysms.

Miller TR, Kole MJ, Le EJ, Cannarsa G, Jones S, Wessell AP, Jindal G, Aldrich EF, Simard JM, Gandhi D.

AJNR Am J Neuroradiol. 2018 Dec;39(12):2270-2277. doi: 10.3174/ajnr.A5863. Epub 2018 Nov 1.


Blast-induced brain injury in rats leads to transient vestibulomotor deficits and persistent orofacial pain.

Studlack PE, Keledjian K, Farooq T, Akintola T, Gerzanich V, Simard JM, Keller A.

Brain Inj. 2018;32(13-14):1866-1878. doi: 10.1080/02699052.2018.1536282. Epub 2018 Oct 22.


Extent of Spinal Cord Decompression in Motor Complete (American Spinal Injury Association Impairment Scale Grades A and B) Traumatic Spinal Cord Injury Patients: Post-Operative Magnetic Resonance Imaging Analysis of Standard Operative Approaches.

Aarabi B, Olexa J, Chryssikos T, Galvagno SM, Hersh DS, Wessell A, Sansur C, Schwartzbauer G, Crandall K, Shanmuganathan K, Simard JM, Mushlin H, Kole M, Le E, Pratt N, Cannarsa G, Lomangino CD, Scarboro M, Aresco C, Curry B.

J Neurotrauma. 2019 Mar 19;36(6):862-876. doi: 10.1089/neu.2018.5834. Epub 2018 Oct 9.


Sulfonylurea Receptor 1, Transient Receptor Potential Cation Channel Subfamily M Member 4, and KIR6.2:Role in Hemorrhagic Progression of Contusion.

Gerzanich V, Stokum JA, Ivanova S, Woo SK, Tsymbalyuk O, Sharma A, Akkentli F, Imran Z, Aarabi B, Sahuquillo J, Simard JM.

J Neurotrauma. 2019 Apr 1;36(7):1060-1079. doi: 10.1089/neu.2018.5986. Epub 2018 Oct 4.


Profile of intravenous glyburide for the prevention of cerebral edema following large hemispheric infarction: evidence to date.

King ZA, Sheth KN, Kimberly WT, Simard JM.

Drug Des Devel Ther. 2018 Aug 15;12:2539-2552. doi: 10.2147/DDDT.S150043. eCollection 2018. Review.


Pathophysiology and treatment of cerebral edema in traumatic brain injury.

Jha RM, Kochanek PM, Simard JM.

Neuropharmacology. 2019 Feb;145(Pt B):230-246. doi: 10.1016/j.neuropharm.2018.08.004. Epub 2018 Aug 4. Review.


Correction: Cerebral microbleeds in a neonatal rat model.

Theriault BC, Woo SK, Karimy JK, Keledjian K, Stokum JA, Sarkar A, Coksaygan T, Ivanova S, Gerzanich V, Simard JM.

PLoS One. 2018 Jul 31;13(7):e0201831. doi: 10.1371/journal.pone.0201831. eCollection 2018.


A sustained systemic inflammatory response syndrome is associated with shunt-dependent hydrocephalus after aneurysmal subarachnoid hemorrhage.

Wessell AP, Kole MJ, Cannarsa G, Oliver J, Jindal G, Miller T, Gandhi D, Parikh G, Badjatia N, Aldrich EF, Simard JM.

J Neurosurg. 2018 Jun 1:1-8. doi: 10.3171/2018.1.JNS172925. [Epub ahead of print]


Long-Term Outcomes in Patients Aged ≤70 Years With Intravenous Glyburide From the Phase II GAMES-RP Study of Large Hemispheric Infarction: An Exploratory Analysis.

Sheth KN, Petersen NH, Cheung K, Elm JJ, Hinson HE, Molyneaux BJ, Beslow LA, Sze GK, Simard JM, Kimberly WT.

Stroke. 2018 Jun;49(6):1457-1463. doi: 10.1161/STROKEAHA.117.020365. Epub 2018 May 22.


Continuous infusion of low-dose unfractionated heparin after aneurysmal subarachnoid hemorrhage: a preliminary study of cognitive outcomes.

James RF, Khattar NK, Aljuboori ZS, Page PS, Shao EY, Carter LM, Meyer KS, Daniels MW, Craycroft J, Gaughen JR, Chaudry MI, Rai SN, Everhart DE, Simard JM.

J Neurosurg. 2018 May 11:1-8. doi: 10.3171/2017.11.JNS17894. [Epub ahead of print]


Kir6.2, the Pore-Forming Subunit of ATP-Sensitive K+ Channels, Is Overexpressed in Human Posttraumatic Brain Contusions.

Castro L, Noelia M, Vidal-Jorge M, Sánchez-Ortiz D, Gándara D, Martínez-Saez E, Cicuéndez M, Poca MA, Simard JM, Sahuquillo J.

J Neurotrauma. 2018 Jul 24. doi: 10.1089/neu.2017.5619. [Epub ahead of print]


Simplified and robust one-step radiosynthesis of [18 F]DCFPyL via direct radiofluorination and cartridge-based purification.

Dornan MH, Simard JM, Leblond A, Juneau D, Delouya G, Saad F, Ménard C, DaSilva JN.

J Labelled Comp Radiopharm. 2018 May 2. doi: 10.1002/jlcr.3632. [Epub ahead of print]


Mannitol and Hypertonic Saline Reduce Swelling and Modulate Inflammatory Markers in a Rat Model of Intracerebral Hemorrhage.

Schreibman DL, Hong CM, Keledjian K, Ivanova S, Tsymbalyuk S, Gerzanich V, Simard JM.

Neurocrit Care. 2018 Oct;29(2):253-263. doi: 10.1007/s12028-018-0535-7.


SUR1-TRPM4 channel activation and phasic secretion of MMP-9 induced by tPA in brain endothelial cells.

Gerzanich V, Kwon MS, Woo SK, Ivanov A, Simard JM.

PLoS One. 2018 Apr 4;13(4):e0195526. doi: 10.1371/journal.pone.0195526. eCollection 2018.


Selective Vulnerability of the Foramen Magnum in a Rat Blast Traumatic Brain Injury Model.

Hayman E, Keledjian K, Stokum JA, Pampori A, Gerzanich V, Simard JM.

J Neurotrauma. 2018 Sep 1;35(17):2136-2142. doi: 10.1089/neu.2017.5435. Epub 2018 Jun 5.


Reply to "Comments on the Cerebral Edema After CPR: A Therapeutic Target Following Cardiac Arrest?"

Hayman E, Simard JM.

Neurocrit Care. 2018 Apr;28(2):261. doi: 10.1007/s12028-018-0511-2. No abstract available.


Cross-species transcriptional analysis reveals conserved and host-specific neoplastic processes in mammalian glioma.

Connolly NP, Shetty AC, Stokum JA, Hoeschele I, Siegel MB, Miller CR, Kim AJ, Ho CY, Davila E, Simard JM, Devine SE, Rossmeisl JH, Holland EC, Winkles JA, Woodworth GF.

Sci Rep. 2018 Jan 19;8(1):1180. doi: 10.1038/s41598-018-19451-6.


Toward the Development of a Flexible Mesoscale MRI-compatible Neurosurgical Continuum Robot.

Kim Y, Cheng SS, Diakite M, Gullapalli RP, Simard JM, Desai JP.

IEEE Trans Robot. 2017 Dec;33(6):1386-1397. doi: 10.1109/TRO.2017.2719035. Epub 2017 Jul 27.


Pharmacological induced target temperature management after cardiac arrest: the capsaicinoids.

Simard JM, Jia X, Gerzanich V.

Neural Regen Res. 2017 Oct;12(10):1623-1624. doi: 10.4103/1673-5374.217334. No abstract available.


TRPM4 and the Emperor.

Simard JM, Gerzanich V.

Channels (Austin). 2018 Jan 1;12(1):174-175. doi: 10.1080/19336950.2017.1398967. No abstract available.


Cerebral Edema After Cardiopulmonary Resuscitation: A Therapeutic Target Following Cardiac Arrest?

Hayman EG, Patel AP, Kimberly WT, Sheth KN, Simard JM.

Neurocrit Care. 2018 Jun;28(3):276-287. doi: 10.1007/s12028-017-0474-8. Review.


α-Endosulfine (ARPP-19e) Expression in a Rat Model of Stroke.

Mehta RI, Tsymbalyuk N, Ivanova S, Stokum JA, Woo K, Gerzanich V, Simard JM.

J Neuropathol Exp Neurol. 2017 Oct 1;76(10):898-907. doi: 10.1093/jnen/nlx074.


SUR1-TRPM4 and AQP4 form a heteromultimeric complex that amplifies ion/water osmotic coupling and drives astrocyte swelling.

Stokum JA, Kwon MS, Woo SK, Tsymbalyuk O, Vennekens R, Gerzanich V, Simard JM.

Glia. 2018 Jan;66(1):108-125. doi: 10.1002/glia.23231. Epub 2017 Sep 14.


Direct versus indirect actions of ghrelin on hypothalamic NPY neurons.

Hashiguchi H, Sheng Z, Routh V, Gerzanich V, Simard JM, Bryan J.

PLoS One. 2017 Sep 6;12(9):e0184261. doi: 10.1371/journal.pone.0184261. eCollection 2017.


Salutary effects of glibenclamide during the chronic phase of murine experimental autoimmune encephalomyelitis.

Gerzanich V, Makar TK, Guda PR, Kwon MS, Stokum JA, Woo SK, Ivanova S, Ivanov A, Mehta RI, Morris AB, Bryan J, Bever CT, Simard JM.

J Neuroinflammation. 2017 Sep 2;14(1):177. doi: 10.1186/s12974-017-0953-z.


Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus.

Karimy JK, Zhang J, Kurland DB, Theriault BC, Duran D, Stokum JA, Furey CG, Zhou X, Mansuri MS, Montejo J, Vera A, DiLuna ML, Delpire E, Alper SL, Gunel M, Gerzanich V, Medzhitov R, Simard JM, Kahle KT.

Nat Med. 2017 Aug;23(8):997-1003. doi: 10.1038/nm.4361. Epub 2017 Jul 10.


Glibenclamide pretreatment protects against chronic memory dysfunction and glial activation in rat cranial blast traumatic brain injury.

Stokum JA, Keledjian K, Hayman E, Karimy JK, Pampori A, Imran Z, Woo SK, Gerzanich V, Simard JM.

Behav Brain Res. 2017 Aug 30;333:43-53. doi: 10.1016/j.bbr.2017.06.038. Epub 2017 Jun 27.


High Compliance with Scheduled Nimodipine Is Associated with Better Outcome in Aneurysmal Subarachnoid Hemorrhage Patients Cotreated with Heparin Infusion.

Wessell A, Kole MJ, Badjatia N, Parikh G, Albrecht JS, Schreibman DL, Simard JM.

Front Neurol. 2017 Jun 9;8:268. doi: 10.3389/fneur.2017.00268. eCollection 2017.


Heparin and Heparin-Derivatives in Post-Subarachnoid Hemorrhage Brain Injury: A Multimodal Therapy for a Multimodal Disease.

Hayman EG, Patel AP, James RF, Simard JM.

Molecules. 2017 May 2;22(5). pii: E724. doi: 10.3390/molecules22050724. Review.


Intramedullary Lesion Length on Postoperative Magnetic Resonance Imaging is a Strong Predictor of ASIA Impairment Scale Grade Conversion Following Decompressive Surgery in Cervical Spinal Cord Injury.

Aarabi B, Sansur CA, Ibrahimi DM, Simard JM, Hersh DS, Le E, Diaz C, Massetti J, Akhtar-Danesh N.

Neurosurgery. 2017 Apr 1;80(4):610-620. doi: 10.1093/neuros/nyw053.


Genetically engineered rat gliomas: PDGF-driven tumor initiation and progression in tv-a transgenic rats recreate key features of human brain cancer.

Connolly NP, Stokum JA, Schneider CS, Ozawa T, Xu S, Galisteo R, Castellani RJ, Kim AJ, Simard JM, Winkles JA, Holland EC, Woodworth GF.

PLoS One. 2017 Mar 30;12(3):e0174557. doi: 10.1371/journal.pone.0174557. eCollection 2017.


Development of a Meso-Scale SMA-Based Torsion Actuator for Image-Guided Procedures.

Sheng J, Gandhi D, Gullapalli R, Simard JM, Desai JP.

IEEE Trans Robot. 2017 Feb;33(1):240-248. doi: 10.1109/TRO.2016.2623348. Epub 2016 Dec 1.


Cerebral microbleeds in a neonatal rat model.

Theriault BC, Woo SK, Karimy JK, Keledjian K, Stokum JA, Sarkar A, Coksaygan T, Ivanova S, Gerzanich V, Simard JM.

PLoS One. 2017 Feb 3;12(2):e0171163. doi: 10.1371/journal.pone.0171163. eCollection 2017. Erratum in: PLoS One. 2018 Jul 31;13(7):e0201831.


Characterization of cytopathic factors through genome-wide analysis of the Zika viral proteins in fission yeast.

Li G, Poulsen M, Fenyvuesvolgyi C, Yashiroda Y, Yoshida M, Simard JM, Gallo RC, Zhao RY.

Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):E376-E385. doi: 10.1073/pnas.1619735114. Epub 2017 Jan 3.


Mechanisms of Global Cerebral Edema Formation in Aneurysmal Subarachnoid Hemorrhage.

Hayman EG, Wessell A, Gerzanich V, Sheth KN, Simard JM.

Neurocrit Care. 2017 Apr;26(2):301-310. doi: 10.1007/s12028-016-0354-7. Review.


Decompressive Craniectomy in Neurocritical Care.

Hayman EG, Kurland DB, Grunwald Z, Urday S, Sheth KN, Simard JM.

Semin Neurol. 2016 Dec;36(6):508-519. Epub 2016 Dec 1. Review.


Perihematomal Edema Expansion Rates and Patient Outcomes in Deep and Lobar Intracerebral Hemorrhage.

Grunwald Z, Beslow LA, Urday S, Vashkevich A, Ayres A, Greenberg SM, Goldstein JN, Leasure A, Shi FD, Kahle KT, Battey TW, Simard JM, Rosand J, Kimberly WT, Sheth KN.

Neurocrit Care. 2017 Apr;26(2):205-212. doi: 10.1007/s12028-016-0321-3.


Inducible nitric oxide synthase (NOS-2) in subarachnoid hemorrhage: Regulatory mechanisms and therapeutic implications.

Iqbal S, Hayman EG, Hong C, Stokum JA, Kurland DB, Gerzanich V, Simard JM.

Brain Circ. 2016;2(1):8-19.


Safety and efficacy of intravenous glyburide on brain swelling after large hemispheric infarction (GAMES-RP): a randomised, double-blind, placebo-controlled phase 2 trial.

Sheth KN, Elm JJ, Molyneaux BJ, Hinson H, Beslow LA, Sze GK, Ostwaldt AC, Del Zoppo GJ, Simard JM, Jacobson S, Kimberly WT.

Lancet Neurol. 2016 Oct;15(11):1160-9. doi: 10.1016/S1474-4422(16)30196-X. Epub 2016 Aug 23.


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