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Tryptophane-kynurenine pathway in the remote ischemic conditioning mechanism.

Bakhta O, Pascaud A, Dieu X, Beaumont J, Kouassi Nzoughet J, Kamel R, Croyal M, Tamareille S, Simard G, Chao de la Barca JM, Reynier P, Prunier F, Mirebeau-Prunier D.

Basic Res Cardiol. 2020 Jan 10;115(2):13. doi: 10.1007/s00395-019-0770-x.


Metabolomics reveals highly regional specificity of cerebral sexual dimorphism in mice.

Chabrun F, Dieu X, Rousseau G, Chupin S, Letournel F, Procaccio V, Bonneau D, Lenaers G, Simard G, Mirebeau-Prunier D, Chao de la Barca JM, Reynier P.

Prog Neurobiol. 2020 Jan;184:101698. doi: 10.1016/j.pneurobio.2019.101698. Epub 2019 Sep 23.


Plasma homocysteine concentration in privately owned healthy adult cats: assessment of biological determinants and establishment of a reference interval.

Drut A, Soetart N, Bertin C, Le Corff E, Berder C, Thorin C, Nguyen P, Simard G, Mallem MY.

J Feline Med Surg. 2019 Aug 19:1098612X19868549. doi: 10.1177/1098612X19868549. [Epub ahead of print]


Lipidomics Reveals Triacylglycerol Accumulation Due to Impaired Fatty Acid Flux in Opa1-Disrupted Fibroblasts.

Bocca C, Kane MS, Veyrat-Durebex C, Nzoughet JK, Chao de la Barca JM, Chupin S, Alban J, Procaccio V, Bonneau D, Simard G, Lenaers G, Reynier P, Chevrollier A.

J Proteome Res. 2019 Jul 5;18(7):2779-2790. doi: 10.1021/acs.jproteome.9b00081. Epub 2019 Jun 14.


Nicotinamide Deficiency in Primary Open-Angle Glaucoma.

Kouassi Nzoughet J, Chao de la Barca JM, Guehlouz K, Leruez S, Coulbault L, Allouche S, Bocca C, Muller J, Amati-Bonneau P, Gohier P, Bonneau D, Simard G, Milea D, Lenaers G, Procaccio V, Reynier P.

Invest Ophthalmol Vis Sci. 2019 Jun 3;60(7):2509-2514. doi: 10.1167/iovs.19-27099.


The Metabolomic Signature of Opa1 Deficiency in Rat Primary Cortical Neurons Shows Aspartate/Glutamate Depletion and Phospholipids Remodeling.

Chao de la Barca JM, Arrázola MS, Bocca C, Arnauné-Pelloquin L, Iuliano O, Tcherkez G, Lenaers G, Simard G, Belenguer P, Reynier P.

Sci Rep. 2019 Apr 15;9(1):6107. doi: 10.1038/s41598-019-42554-7.


Metabolomic Profiling of Aqueous Humor in Glaucoma Points to Taurine and Spermine Deficiency: Findings from the Eye-D Study.

Buisset A, Gohier P, Leruez S, Muller J, Amati-Bonneau P, Lenaers G, Bonneau D, Simard G, Procaccio V, Annweiler C, Milea D, Reynier P, Chao de la Barca JM.

J Proteome Res. 2019 Mar 1;18(3):1307-1315. doi: 10.1021/acs.jproteome.8b00915. Epub 2019 Feb 11.


Metabolomics signatures of a subset of RET variants according to their oncogenic risk level.

Veyrat-Durebex C, Bouzamondo N, Le Mao M, Chao de la Barca JM, Bris C, Dieu X, Simard G, Gadras C, Tessier L, Drui D, Borson-Chazot F, Barlier A, Reynier P, Prunier-Mirebeau D.

Endocr Relat Cancer. 2019 Mar 1;26(3):379-389. doi: 10.1530/ERC-18-0314.


Alagille syndrome: a case report.

Benabed Y, Chaillou E, Denis MC, Simard G, Reynier P, Homedan C.

Ann Biol Clin (Paris). 2018 Dec 1;76(6):675-680. doi: 10.1684/abc.2018.1399.


Phenotyping of circulating extracellular vesicles (EVs) in obesity identifies large EVs as functional conveyors of Macrophage Migration Inhibitory Factor.

Amosse J, Durcin M, Malloci M, Vergori L, Fleury A, Gagnadoux F, Dubois S, Simard G, Boursier J, Hue O, Martinez MC, Andriantsitohaina R, Le Lay S.

Mol Metab. 2018 Dec;18:134-142. doi: 10.1016/j.molmet.2018.10.001. Epub 2018 Oct 9.


A serum metabolomics signature of hypothermia fatalities involving arginase activity, tryptophan content, and phosphatidylcholine saturation.

Rousseau G, Chao de la Barca JM, Rougé-Maillart C, Teresiński G, Jousset N, Dieu X, Chabrun F, Prunier-Mirabeau D, Simard G, Reynier P, Palmiere C.

Int J Legal Med. 2019 May;133(3):889-898. doi: 10.1007/s00414-018-1937-y. Epub 2018 Sep 18.


A Metabolomics Profiling of Glaucoma Points to Mitochondrial Dysfunction, Senescence, and Polyamines Deficiency.

Leruez S, Marill A, Bresson T, de Saint Martin G, Buisset A, Muller J, Tessier L, Gadras C, Verny C, Gohier P, Amati-Bonneau P, Lenaers G, Bonneau D, Simard G, Milea D, Procaccio V, Reynier P, Chao de la Barca JM.

Invest Ophthalmol Vis Sci. 2018 Sep 4;59(11):4355-4361. doi: 10.1167/iovs.18-24938.


The Metabolomic Bioenergetic Signature of Opa1-Disrupted Mouse Embryonic Fibroblasts Highlights Aspartate Deficiency.

Bocca C, Kane MS, Veyrat-Durebex C, Chupin S, Alban J, Kouassi Nzoughet J, Le Mao M, Chao de la Barca JM, Amati-Bonneau P, Bonneau D, Procaccio V, Lenaers G, Simard G, Chevrollier A, Reynier P.

Sci Rep. 2018 Aug 1;8(1):11528. doi: 10.1038/s41598-018-29972-9.


Extracellular Vesicles: Mechanisms in Human Health and Disease.

Malloci M, Perdomo L, Veerasamy M, Andriantsitohaina R, Simard G, Martínez MC.

Antioxid Redox Signal. 2019 Feb 20;30(6):813-856. doi: 10.1089/ars.2017.7265. Epub 2018 Apr 30.


A redox-sensitive signaling pathway mediates pro-angiogenic effect of chlordecone via estrogen receptor activation.

Alabed Alibrahim E, Andriantsitohaina R, Hardonnière K, Soleti R, Faure S, Simard G.

Int J Biochem Cell Biol. 2018 Apr;97:83-97. doi: 10.1016/j.biocel.2018.02.008. Epub 2018 Feb 13.


A Plasma Metabolomic Signature of the Exfoliation Syndrome Involves Amino Acids, Acylcarnitines, and Polyamines.

Leruez S, Bresson T, Chao de la Barca JM, Marill A, de Saint Martin G, Buisset A, Muller J, Tessier L, Gadras C, Verny C, Amati-Bonneau P, Lenaers G, Gohier P, Bonneau D, Simard G, Milea D, Procaccio V, Reynier P.

Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):1025-1032. doi: 10.1167/iovs.17-23055.


Maternal protein restriction during lactation induces early and lasting plasma metabolomic and hepatic lipidomic signatures of the offspring in a rodent programming model.

Martin Agnoux A, El Ghaziri A, Moyon T, Pagniez A, David A, Simard G, Parnet P, Qannari EM, Darmaun D, Antignac JP, Alexandre-Gouabau MC.

J Nutr Biochem. 2018 May;55:124-141. doi: 10.1016/j.jnutbio.2017.11.009. Epub 2017 Dec 10.


A Plasma Metabolomic Signature Involving Purine Metabolism in Human Optic Atrophy 1 (OPA1)-Related Disorders.

Bocca C, Kouassi Nzoughet J, Leruez S, Amati-Bonneau P, Ferré M, Kane MS, Veyrat-Durebex C, Chao de la Barca JM, Chevrollier A, Homedan C, Verny C, Miléa D, Procaccio V, Simard G, Bonneau D, Lenaers G, Reynier P.

Invest Ophthalmol Vis Sci. 2018 Jan 1;59(1):185-195. doi: 10.1167/iovs.17-23027.


Lipidomics Reveals Cerebrospinal-Fluid Signatures of ALS.

Blasco H, Veyrat-Durebex C, Bocca C, Patin F, Vourc'h P, Kouassi Nzoughet J, Lenaers G, Andres CR, Simard G, Corcia P, Reynier P.

Sci Rep. 2017 Dec 15;7(1):17652. doi: 10.1038/s41598-017-17389-9.


Metabolomics and Lipidomics Profiling of a Combined Mitochondrial Plus Endoplasmic Reticulum Fraction of Human Fibroblasts: A Robust Tool for Clinical Studies.

Veyrat-Durebex C, Bocca C, Chupin S, Kouassi Nzoughet J, Simard G, Lenaers G, Reynier P, Blasco H.

J Proteome Res. 2018 Jan 5;17(1):745-750. doi: 10.1021/acs.jproteome.7b00637. Epub 2017 Nov 14.


Targeted metabolomics reveals reduced levels of polyunsaturated choline plasmalogens and a smaller dimethylarginine/arginine ratio in the follicular fluid of patients with a diminished ovarian reserve.

de la Barca JMC, Boueilh T, Simard G, Boucret L, Ferré-L'Hotellier V, Tessier L, Gadras C, Bouet PE, Descamps P, Procaccio V, Reynier P, May-Panloup P.

Hum Reprod. 2017 Nov 1;32(11):2269-2278. doi: 10.1093/humrep/dex303.


5-Oxoprolinuria in hyperammonemic encephalopathy: Coincidence or worsening factor?

Rousseau G, Signolet I, Denis MC, Chao de la Barca JM, Mahieu R, Letournel F, Reynier P, Simard G.

Clin Biochem. 2017 Dec;50(18):1115-1117. doi: 10.1016/j.clinbiochem.2017.09.025. Epub 2017 Sep 30. No abstract available.


Myoadenylate deaminase deficiency: a frequent cause of muscle pain A case detected by exercise testing.

Lim L, Palayer M, Bruneau A, Letournel F, Le Maréchal C, Simard G, Reynier P, Homedan C, Nadaj-Pakleza A.

Ann Biol Clin (Paris). 2017 Aug 1;75(4):445-449. doi: 10.1684/abc.2017.1253.


Retinal metabolic events in preconditioning light stress as revealed by wide-spectrum targeted metabolomics.

de la Barca JMC, Huang NT, Jiao H, Tessier L, Gadras C, Simard G, Natoli R, Tcherkez G, Reynier P, Valter K.

Metabolomics. 2017;13(3):22. doi: 10.1007/s11306-016-1156-9. Epub 2017 Jan 20.


Targeted Metabolomics Reveals Early Dominant Optic Atrophy Signature in Optic Nerves of Opa1delTTAG/+ Mice.

Chao de la Barca JM, Simard G, Sarzi E, Chaumette T, Rousseau G, Chupin S, Gadras C, Tessier L, Ferré M, Chevrollier A, Desquiret-Dumas V, Gueguen N, Leruez S, Verny C, Miléa D, Bonneau D, Amati-Bonneau P, Procaccio V, Hamel C, Lenaers G, Reynier P, Prunier-Mirebeau D.

Invest Ophthalmol Vis Sci. 2017 Feb 1;58(2):812-820. doi: 10.1167/iovs.16-21116.


A Nontargeted UHPLC-HRMS Metabolomics Pipeline for Metabolite Identification: Application to Cardiac Remote Ischemic Preconditioning.

Kouassi Nzoughet J, Bocca C, Simard G, Prunier-Mirebeau D, Chao de la Barca JM, Bonneau D, Procaccio V, Prunier F, Lenaers G, Reynier P.

Anal Chem. 2017 Feb 7;89(3):2138-2146. doi: 10.1021/acs.analchem.6b04912. Epub 2017 Jan 6.


Clinical and biological specificity of beta-thalassemia intermedia: a case report.

Girard JM, Drevin G, Brasme JF, Pissard S, Reynier P, Simard G, Denis MC.

Ann Biol Clin (Paris). 2016 Dec 1;74(6):688-692.


Metabolic Signature of Remote Ischemic Preconditioning Involving a Cocktail of Amino Acids and Biogenic Amines.

Chao de la Barca JM, Bakhta O, Kalakech H, Simard G, Tamareille S, Catros V, Callebert J, Gadras C, Tessier L, Reynier P, Prunier F, Mirebeau-Prunier D.

J Am Heart Assoc. 2016 Sep 24;5(9). pii: e003891.


The metabolomic signature of Leber's hereditary optic neuropathy reveals endoplasmic reticulum stress.

Chao de la Barca JM, Simard G, Amati-Bonneau P, Safiedeen Z, Prunier-Mirebeau D, Chupin S, Gadras C, Tessier L, Gueguen N, Chevrollier A, Desquiret-Dumas V, Ferré M, Bris C, Kouassi Nzoughet J, Bocca C, Leruez S, Verny C, Miléa D, Bonneau D, Lenaers G, Martinez MC, Procaccio V, Reynier P.

Brain. 2016 Nov 1;139(11):2864-2876. doi: 10.1093/brain/aww222.


Recurrent Isolated Neonatal Hemolytic Anemia: Think About Glutathione Synthetase Deficiency.

Signolet I, Chenouard R, Oca F, Barth M, Reynier P, Denis MC, Simard G.

Pediatrics. 2016 Sep;138(3). pii: e20154324. doi: 10.1542/peds.2015-4324.


Temporal Cross Talk Between Endoplasmic Reticulum and Mitochondria Regulates Oxidative Stress and Mediates Microparticle-Induced Endothelial Dysfunction.

Safiedeen Z, Rodríguez-Gómez I, Vergori L, Soleti R, Vaithilingam D, Douma I, Agouni A, Leiber D, Dubois S, Simard G, Zibara K, Andriantsitohaina R, Martínez MC.

Antioxid Redox Signal. 2017 Jan 1;26(1):15-27. doi: 10.1089/ars.2016.6771. Epub 2016 Aug 19.


[Regulators in access to anticancer drugs in Canada].

Côté A, Keating B, Parent M, Simard G.

Sante Publique. 2015 Jul-Aug;27(4):515-27. French.


Delphinidin Inhibits Tumor Growth by Acting on VEGF Signalling in Endothelial Cells.

Keravis T, Favot L, Abusnina AA, Anton A, Justiniano H, Soleti R, Alabed Alibrahim E, Simard G, Andriantsitohaina R, Lugnier C.

PLoS One. 2015 Dec 22;10(12):e0145291. doi: 10.1371/journal.pone.0145291. eCollection 2015.


Type I hyperlipidaemia caused by lipoprotein lipase deficiency in a nurseling: the role of the clinical laboratory in processing biological samples and contributing to the diagnosis and therapeutic follow-up of patients.

Girard JM, Debailleul PA, Chaillou E, Benlian P, Larcher F, Simard G, Reynier P, Homedan C.

Ann Biol Clin (Paris). 2015 Sep-Oct;73(5):581-6. doi: 10.1684/abc.2015.1075.


Mitochondrial energetic defects in muscle and brain of a Hmbs-/- mouse model of acute intermittent porphyria.

Homedan C, Schmitt C, Laafi J, Gueguen N, Desquiret-Dumas V, Lenglet H, Karim Z, Gouya L, Deybach JC, Simard G, Puy H, Malthièry Y, Reynier P.

Hum Mol Genet. 2015 Sep 1;24(17):5015-23. doi: 10.1093/hmg/ddv222. Epub 2015 Jun 12.


[Metabolome and mass spectrometry: new biomedical analysis perspectives].

Chao De La Barca JM, Mirebeau-Prunier D, Moal V, Reynier P, Garnotel R, Simard G.

Ann Biol Clin (Paris). 2015 Jan-Feb;73(1):126-30. doi: 10.1684/abc.2014.1020. Review. French.


Oxidative stress and metabolic pathologies: from an adipocentric point of view.

Le Lay S, Simard G, Martinez MC, Andriantsitohaina R.

Oxid Med Cell Longev. 2014;2014:908539. doi: 10.1155/2014/908539. Epub 2014 Jul 20. Review.


Time window-dependent effect of perinatal maternal protein restriction on insulin sensitivity and energy substrate oxidation in adult male offspring.

Agnoux AM, Antignac JP, Simard G, Poupeau G, Darmaun D, Parnet P, Alexandre-Gouabau MC.

Am J Physiol Regul Integr Comp Physiol. 2014 Jul 15;307(2):R184-97.


Delphinidin inhibits VEGF induced-mitochondrial biogenesis and Akt activation in endothelial cells.

Duluc L, Jacques C, Soleti R, Andriantsitohaina R, Simard G.

Int J Biochem Cell Biol. 2014 Aug;53:9-14. doi: 10.1016/j.biocel.2014.03.030. Epub 2014 Apr 30.


Maternal supplementation with n-3 long chain polyunsaturated fatty acids during perinatal period alleviates the metabolic syndrome disturbances in adult hamster pups fed a high-fat diet after weaning.

Kasbi-Chadli F, Boquien CY, Simard G, Ulmann L, Mimouni V, Leray V, Meynier A, Ferchaud-Roucher V, Champ M, Nguyen P, Ouguerram K.

J Nutr Biochem. 2014 Jul;25(7):726-33. doi: 10.1016/j.jnutbio.2014.03.003. Epub 2014 Mar 22.


Creatine and guanidinoacetate reference values in a French population.

Joncquel-Chevalier Curt M, Cheillan D, Briand G, Salomons GS, Mention-Mulliez K, Dobbelaere D, Cuisset JM, Lion-François L, Des Portes V, Chabli A, Valayannopoulos V, Benoist JF, Pinard JM, Simard G, Douay O, Deiva K, Tardieu M, Afenjar A, Héron D, Rivier F, Chabrol B, Prieur F, Cartault F, Pitelet G, Goldenberg A, Bekri S, Gerard M, Delorme R, Porchet N, Vianey-Saban C, Vamecq J.

Mol Genet Metab. 2013 Nov;110(3):263-7. doi: 10.1016/j.ymgme.2013.09.005. Epub 2013 Sep 16.


Aromatic L-amino acid decarboxylase deficiency is a cause of long-fasting hypoglycemia.

Arnoux JB, Damaj L, Napuri S, Serre V, Hubert L, Cadoudal M, Simard G, Ceballos I, Christa L, de Lonlay P.

J Clin Endocrinol Metab. 2013 Nov;98(11):4279-84. doi: 10.1210/jc.2013-2740. Epub 2013 Sep 13.


Modulation of mitochondrial capacity and angiogenesis by red wine polyphenols via estrogen receptor, NADPH oxidase and nitric oxide synthase pathways.

Duluc L, Jacques C, Soleti R, Iacobazzi F, Simard G, Andriantsitohaina R.

Int J Biochem Cell Biol. 2013 Apr;45(4):783-91. doi: 10.1016/j.biocel.2013.01.007. Epub 2013 Jan 16.


Screening for primary creatine deficiencies in French patients with unexplained neurological symptoms.

Cheillan D, Joncquel-Chevalier Curt M, Briand G, Salomons GS, Mention-Mulliez K, Dobbelaere D, Cuisset JM, Lion-François L, Portes VD, Chabli A, Valayannopoulos V, Benoist JF, Pinard JM, Simard G, Douay O, Deiva K, Afenjar A, Héron D, Rivier F, Chabrol B, Prieur F, Cartault F, Pitelet G, Goldenberg A, Bekri S, Gerard M, Delorme R, Tardieu M, Porchet N, Vianey-Saban C, Vamecq J.

Orphanet J Rare Dis. 2012 Dec 13;7:96. doi: 10.1186/1750-1172-7-96.


Large electronic bandwidth in solution-processable pyrene crystals: the role of close-packed crystal structure.

Provencher F, Bérubé N, Laprade JF, Simard G, Tant J, de Halleux V, Geerts Y, Silva C, Côté M.

J Chem Phys. 2012 Jul 21;137(3):034706.


Mitochondria as potential targets of flavonoids: focus on adipocytes and endothelial cells.

Duluc L, Soleti R, Clere N, Andriantsitohaina R, Simard G.

Curr Med Chem. 2012;19(26):4462-74. Review.


Systems biology of antioxidants.

Andriantsitohaina R, Duluc L, García-Rodríguez JC, Gil-del Valle L, Guevara-Garcia M, Simard G, Soleti R, Su DF, Velásquez-Pérez L, Wilson JX, Laher I.

Clin Sci (Lond). 2012 Aug 1;123(3):173-92. doi: 10.1042/CS20110643. Review.


Propionyl-L-carnitine corrects metabolic and cardiovascular alterations in diet-induced obese mice and improves liver respiratory chain activity.

Mingorance C, Duluc L, Chalopin M, Simard G, Ducluzeau PH, Herrera MD, Alvarez de Sotomayor M, Andriantsitohaina R.

PLoS One. 2012;7(3):e34268. doi: 10.1371/journal.pone.0034268. Epub 2012 Mar 23.


Barth syndrome in a female patient.

Cosson L, Toutain A, Simard G, Kulik W, Matyas G, Guichet A, Blasco H, Maakaroun-Vermesse Z, Vaillant MC, Le Caignec C, Chantepie A, Labarthe F.

Mol Genet Metab. 2012 May;106(1):115-20. doi: 10.1016/j.ymgme.2012.01.015. Epub 2012 Jan 24.


Regulation of hepatic mitochondrial metabolism in response to a high fat diet: a longitudinal study in rats.

Flamment M, Rieusset J, Vidal H, Simard G, Malthièry Y, Fromenty B, Ducluzeau PH.

J Physiol Biochem. 2012 Sep;68(3):335-44. doi: 10.1007/s13105-012-0145-3. Epub 2012 Jan 26.


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