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Items: 1 to 50 of 106

1.

Reframing the Biological Basis of Neuroprotection Using Functional Genomics: Differentially Weighted, Time-Dependent Multifactor Pathogenesis of Human Ischemic Brain Damage.

Kofke WA, Ren Y, Augoustides JG, Li H, Nathanson K, Siman R, Meng QC, Bu W, Yandrawatthana S, Kositratna G, Kim C, Bavaria JE.

Front Neurol. 2018 Jun 26;9:497. doi: 10.3389/fneur.2018.00497. eCollection 2018.

2.

SNTF immunostaining reveals previously undetected axonal pathology in traumatic brain injury.

Johnson VE, Stewart W, Weber MT, Cullen DK, Siman R, Smith DH.

Acta Neuropathol. 2016 Jan;131(1):115-35. doi: 10.1007/s00401-015-1506-0. Epub 2015 Nov 20.

3.

The mTOR Inhibitor Rapamycin Mitigates Perforant Pathway Neurodegeneration and Synapse Loss in a Mouse Model of Early-Stage Alzheimer-Type Tauopathy.

Siman R, Cocca R, Dong Y.

PLoS One. 2015 Nov 5;10(11):e0142340. doi: 10.1371/journal.pone.0142340. eCollection 2015.

4.

Serum SNTF Increases in Concussed Professional Ice Hockey Players and Relates to the Severity of Postconcussion Symptoms.

Siman R, Shahim P, Tegner Y, Blennow K, Zetterberg H, Smith DH.

J Neurotrauma. 2015 Sep 1;32(17):1294-300. doi: 10.1089/neu.2014.3698. Epub 2015 May 14.

5.

Evidence That the Blood Biomarker SNTF Predicts Brain Imaging Changes and Persistent Cognitive Dysfunction in Mild TBI Patients.

Siman R, Giovannone N, Hanten G, Wilde EA, McCauley SR, Hunter JV, Li X, Levin HS, Smith DH.

Front Neurol. 2013 Nov 18;4:190. doi: 10.3389/fneur.2013.00190. eCollection 2013.

6.

A rapid gene delivery-based mouse model for early-stage Alzheimer disease-type tauopathy.

Siman R, Lin YG, Malthankar-Phatak G, Dong Y.

J Neuropathol Exp Neurol. 2013 Nov;72(11):1062-71. doi: 10.1097/NEN.0000000000000006.

7.

Amyloid deposition and advanced age fails to induce Alzheimer's type progression in a double knock-in mouse model.

Malthankar-Phatak GH, Lin YG, Giovannone N, Siman R.

Aging Dis. 2012 Apr;3(2):141-55. Epub 2011 Jul 28.

8.

Mechanisms of calpain mediated proteolysis of voltage gated sodium channel α-subunits following in vitro dynamic stretch injury.

von Reyn CR, Mott RE, Siman R, Smith DH, Meaney DF.

J Neurochem. 2012 Jun;121(5):793-805. doi: 10.1111/j.1471-4159.2012.07735.x. Epub 2012 Apr 12.

9.

Evidence that a panel of neurodegeneration biomarkers predicts vasospasm, infarction, and outcome in aneurysmal subarachnoid hemorrhage.

Siman R, Giovannone N, Toraskar N, Frangos S, Stein SC, Levine JM, Kumar MA.

PLoS One. 2011;6(12):e28938. doi: 10.1371/journal.pone.0028938. Epub 2011 Dec 9.

10.

Combination therapy prevents amyloid-dependent and -independent structural changes.

Malthankar-Phatak G, Poplawski S, Toraskar N, Siman R.

Neurobiol Aging. 2012 Jul;33(7):1273-83. doi: 10.1016/j.neurobiolaging.2010.12.007. Epub 2011 Jan 22.

11.

A panel of neuron-enriched proteins as markers for traumatic brain injury in humans.

Siman R, Toraskar N, Dang A, McNeil E, McGarvey M, Plaum J, Maloney E, Grady MS.

J Neurotrauma. 2009 Nov;26(11):1867-77. doi: 10.1089/neu.2009.0882.

12.

Calpain mediates proteolysis of the voltage-gated sodium channel alpha-subunit.

von Reyn CR, Spaethling JM, Mesfin MN, Ma M, Neumar RW, Smith DH, Siman R, Meaney DF.

J Neurosci. 2009 Aug 19;29(33):10350-6. doi: 10.1523/JNEUROSCI.2339-09.2009.

13.

Biomarker evidence for mild central nervous system injury after surgically-induced circulation arrest.

Siman R, Roberts VL, McNeil E, Dang A, Bavaria JE, Ramchandren S, McGarvey M.

Brain Res. 2008 Jun 5;1213:1-11. doi: 10.1016/j.brainres.2008.03.034. Epub 2008 Apr 1.

14.

Temporal profiles of cytoskeletal protein loss following traumatic axonal injury in mice.

Serbest G, Burkhardt MF, Siman R, Raghupathi R, Saatman KE.

Neurochem Res. 2007 Dec;32(12):2006-14. Epub 2007 Mar 31.

PMID:
17401646
15.
16.

Behaviour of a full-scale expanded bed reactor with overlaid anaerobic and aerobic zones for domestic wastewater treatment.

Mendonça NM, Siman RR, Niciura CL, Campos JR.

Water Sci Technol. 2006;54(2):269-75.

PMID:
16939112
17.

Traumatic mechanical injury to the hippocampus in vitro causes regional caspase-3 and calpain activation that is influenced by NMDA receptor subunit composition.

DeRidder MN, Simon MJ, Siman R, Auberson YP, Raghupathi R, Meaney DF.

Neurobiol Dis. 2006 Apr;22(1):165-76. Epub 2005 Dec 13.

PMID:
16356733
18.

Caspase-mediated cell death predominates following engraftment of neural progenitor cells into traumatically injured rat brain.

Bakshi A, Keck CA, Koshkin VS, LeBold DG, Siman R, Snyder EY, McIntosh TK.

Brain Res. 2005 Dec 14;1065(1-2):8-19. Epub 2005 Nov 23.

PMID:
16309635
19.
20.

Novel surrogate markers for acute brain damage: cerebrospinal fluid levels corrrelate with severity of ischemic neurodegeneration in the rat.

Siman R, Zhang C, Roberts VL, Pitts-Kiefer A, Neumar RW.

J Cereb Blood Flow Metab. 2005 Nov;25(11):1433-44.

PMID:
15902199
21.

Neuroprotection with delayed initiation of prolonged hypothermia after in vitro transient global brain ischemia.

Lawrence EJ, Dentcheva E, Curtis KM, Roberts VL, Siman R, Neumar RW.

Resuscitation. 2005 Mar;64(3):383-8.

PMID:
15733770
22.

Developmental status of neurons selectively vulnerable to rapidly triggered post-ischemic caspase activation.

Chen Z, Kontonotas D, Friedmann D, Pitts-Kiefer A, Frederick JR, Siman R, Neumar RW.

Neurosci Lett. 2005 Mar 16;376(3):166-70. Epub 2004 Dec 10.

PMID:
15721215
23.
24.

Stirred anaerobic sequencing batch reactor containing immobilized biomass: a behavior study when submitted to different fill times.

Borges AC, Siman RR, Rodrigues JA, Ratusznei SM, Zaiat M, Foresti E, Borzani W.

Water Sci Technol. 2004;49(11-12):311-8.

PMID:
15303756
25.

Influence of organic loading on an anaerobic sequencing biofilm batch reactor (ASBBR) as a function of cycle period and wastewater concentration.

Siman RR, Borges AC, Ratusznei SM, Rodrigues JA, Zaiat M, Foresti E, Borzani W.

J Environ Manage. 2004 Sep;72(4):241-7.

PMID:
15294356
26.

Long-term accumulation of amyloid-beta, beta-secretase, presenilin-1, and caspase-3 in damaged axons following brain trauma.

Chen XH, Siman R, Iwata A, Meaney DF, Trojanowski JQ, Smith DH.

Am J Pathol. 2004 Aug;165(2):357-71.

27.

Proteins released from degenerating neurons are surrogate markers for acute brain damage.

Siman R, McIntosh TK, Soltesz KM, Chen Z, Neumar RW, Roberts VL.

Neurobiol Dis. 2004 Jul;16(2):311-20.

PMID:
15193288
28.

Activation of calpain-1 in myelin and microglia in the white matter of the aged rhesus monkey.

Hinman JD, Duce JA, Siman RA, Hollander W, Abraham CR.

J Neurochem. 2004 Apr;89(2):430-41.

29.

A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations.

Marambaud P, Wen PH, Dutt A, Shioi J, Takashima A, Siman R, Robakis NK.

Cell. 2003 Sep 5;114(5):635-45.

30.

Calpain facilitates the neuron death induced by 3-nitropropionic acid and contributes to the necrotic morphology.

Pang Z, Bondada V, Sengoku T, Siman R, Geddes JW.

J Neuropathol Exp Neurol. 2003 Jun;62(6):633-43.

PMID:
12834108
31.
32.

Cross-talk between calpain and caspase proteolytic systems during neuronal apoptosis.

Neumar RW, Xu YA, Gada H, Guttmann RP, Siman R.

J Biol Chem. 2003 Apr 18;278(16):14162-7. Epub 2003 Feb 7.

33.

Comparison of calpain and caspase activities in the adult rat brain after transient forebrain ischemia.

Zhang C, Siman R, Xu YA, Mills AM, Frederick JR, Neumar RW.

Neurobiol Dis. 2002 Aug;10(3):289-05.

PMID:
12270691
34.

Selective, reversible caspase-3 inhibitor is neuroprotective and reveals distinct pathways of cell death after neonatal hypoxic-ischemic brain injury.

Han BH, Xu D, Choi J, Han Y, Xanthoudakis S, Roy S, Tam J, Vaillancourt J, Colucci J, Siman R, Giroux A, Robertson GS, Zamboni R, Nicholson DW, Holtzman DM.

J Biol Chem. 2002 Aug 16;277(33):30128-36. Epub 2002 Jun 10.

36.

FAD mutant PS-1 gene-targeted mice: increased A beta 42 and A beta deposition without APP overproduction.

Flood DG, Reaume AG, Dorfman KS, Lin YG, Lang DM, Trusko SP, Savage MJ, Annaert WG, De Strooper B, Siman R, Scott RW.

Neurobiol Aging. 2002 May-Jun;23(3):335-48.

PMID:
11959395
37.
38.

Calpain activity in the rat brain after transient forebrain ischemia.

Neumar RW, Meng FH, Mills AM, Xu YA, Zhang C, Welsh FA, Siman R.

Exp Neurol. 2001 Jul;170(1):27-35.

PMID:
11421581
39.

Caspase-3 activation in oligodendrocytes from the myelin-deficient rat.

Beesley JS, Lavy L, Eraydin NB, Siman R, Grinspan JB.

J Neurosci Res. 2001 May 15;64(4):371-9.

PMID:
11340644
42.

Evidence that Wallerian degeneration and localized axon degeneration induced by local neurotrophin deprivation do not involve caspases.

Finn JT, Weil M, Archer F, Siman R, Srinivasan A, Raff MC.

J Neurosci. 2000 Feb 15;20(4):1333-41.

43.

Presenilin-1 P264L knock-in mutation: differential effects on abeta production, amyloid deposition, and neuronal vulnerability.

Siman R, Reaume AG, Savage MJ, Trusko S, Lin YG, Scott RW, Flood DG.

J Neurosci. 2000 Dec 1;20(23):8717-26.

44.

P2-achiral, P'-extended alpha-ketoamide inhibitors of calpain I.

Chatterjee S, Dunn D, Tao M, Wells G, Gu ZQ, Bihovsky R, Ator MA, Siman R, Mallamo JP.

Bioorg Med Chem Lett. 1999 Aug 16;9(16):2371-4.

PMID:
10476871
45.
46.

Rank-order of potencies for inhibition of the secretion of abeta40 and abeta42 suggests that both are generated by a single gamma-secretase.

Durkin JT, Murthy S, Husten EJ, Trusko SP, Savage MJ, Rotella DP, Greenberg BD, Siman R.

J Biol Chem. 1999 Jul 16;274(29):20499-504.

47.

The role of calpain-mediated spectrin proteolysis in traumatically induced axonal injury.

Büki A, Siman R, Trojanowski JQ, Povlishock JT.

J Neuropathol Exp Neurol. 1999 Apr;58(4):365-75.

PMID:
10218632
48.

Cyclosporin A limits calcium-induced axonal damage following traumatic brain injury.

Okonkwo DO, Büki A, Siman R, Povlishock JT.

Neuroreport. 1999 Feb 5;10(2):353-8.

PMID:
10203334
50.

Glutamate receptor antagonists inhibit calpain-mediated cytoskeletal proteolysis in focal cerebral ischemia.

Minger SL, Geddes JW, Holtz ML, Craddock SD, Whiteheart SW, Siman RG, Pettigrew LC.

Brain Res. 1998 Nov 9;810(1-2):181-99.

PMID:
9813316

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