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Items: 26


A distinct biomolecular profile identifies monoclonal mast cell disorders in patients with idiopathic anaphylaxis.

Carter MC, Desai A, Komarow HD, Bai Y, Clayton ST, Clark AS, Ruiz-Esteves KN, Long LM, Cantave D, Wilson TM, Scott LM, Simakova O, Jung MY, Hahn J, Maric I, Metcalfe DD.

J Allergy Clin Immunol. 2018 Jan;141(1):180-188.e3. doi: 10.1016/j.jaci.2017.05.036. Epub 2017 Jun 16.


Monoclonal gammopathy-associated pure red cell aplasia.

Korde N, Zhang Y, Loeliger K, Poon A, Simakova O, Zingone A, Costello R, Childs R, Noel P, Silver S, Kwok M, Mo C, Young N, Landgren O, Sloand E, Maric I.

Br J Haematol. 2016 Jun;173(6):876-83. doi: 10.1111/bjh.14012. Epub 2016 Mar 21.


Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits.

Acosta-Alvear D, Cho MY, Wild T, Buchholz TJ, Lerner AG, Simakova O, Hahn J, Korde N, Landgren O, Maric I, Choudhary C, Walter P, Weissman JS, Kampmann M.

Elife. 2015 Sep 1;4:e08153. doi: 10.7554/eLife.08153.


York platelet syndrome is a CRAC channelopathy due to gain-of-function mutations in STIM1.

Markello T, Chen D, Kwan JY, Horkayne-Szakaly I, Morrison A, Simakova O, Maric I, Lozier J, Cullinane AR, Kilo T, Meister L, Pakzad K, Bone W, Chainani S, Lee E, Links A, Boerkoel C, Fischer R, Toro C, White JG, Gahl WA, Gunay-Aygun M.

Mol Genet Metab. 2015 Mar;114(3):474-82. doi: 10.1016/j.ymgme.2014.12.307. Epub 2014 Dec 24.


Episodic angioedema with eosinophilia (Gleich syndrome) is a multilineage cell cycling disorder.

Khoury P, Herold J, Alpaugh A, Dinerman E, Holland-Thomas N, Stoddard J, Gurprasad S, Maric I, Simakova O, Schwartz LB, Fong J, Lee CC, Xi L, Wang Z, Raffeld M, Klion AD.

Haematologica. 2015 Mar;100(3):300-7. doi: 10.3324/haematol.2013.091264. Epub 2014 Dec 19.


Mastocytosis associated with a rare germline KIT K509I mutation displays a well-differentiated mast cell phenotype.

Chan EC, Bai Y, Kirshenbaum AS, Fischer ER, Simakova O, Bandara G, Scott LM, Wisch LB, Cantave D, Carter MC, Lewis JC, Noel P, Maric I, Gilfillan AM, Metcalfe DD, Wilson TM.

J Allergy Clin Immunol. 2014 Jul;134(1):178-87. doi: 10.1016/j.jaci.2013.12.1090. Epub 2014 Feb 28.


The eosinophil surface receptor epidermal growth factor-like module containing mucin-like hormone receptor 1 (EMR1): a novel therapeutic target for eosinophilic disorders.

Legrand F, Tomasevic N, Simakova O, Lee CC, Wang Z, Raffeld M, Makiya MA, Palath V, Leung J, Baer M, Yarranton G, Maric I, Bebbington C, Klion AD.

J Allergy Clin Immunol. 2014 May;133(5):1439-47, 1447.e1-8. doi: 10.1016/j.jaci.2013.11.041. Epub 2014 Feb 13.


KIT GNNK splice variants: expression in systemic mastocytosis and influence on the activating potential of the D816V mutation in mast cells.

Chan EC, Bai Y, Bandara G, Simakova O, Brittain E, Scott L, Dyer KD, Klion AD, Maric I, Gilfillan AM, Metcalfe DD, Wilson TM.

Exp Hematol. 2013 Oct;41(10):870-881.e2. doi: 10.1016/j.exphem.2013.05.005. Epub 2013 Jun 4.


Oxygen-assisted hydroxymatairesinol dehydrogenation: a selective secondary-alcohol oxidation over a gold catalyst.

Prestianni A, Ferrante F, Simakova OA, Duca D, Murzin DY.

Chemistry. 2013 Apr 2;19(14):4577-85. doi: 10.1002/chem.201202957. Epub 2013 Feb 5.


Targeting the KIT activating switch control pocket: a novel mechanism to inhibit neoplastic mast cell proliferation and mast cell activation.

Bai Y, Bandara G, Ching Chan E, Maric I, Simakova O, Bandara SN, Lu WP, Wise SC, Flynn DL, Metcalfe DD, Gilfillan AM, Wilson TM.

Leukemia. 2013 Feb;27(2):278-85. doi: 10.1038/leu.2012.218. Epub 2012 Jul 31. Review.


MicroRNA profiling of follicular lymphoma identifies microRNAs related to cell proliferation and tumor response.

Wang W, Corrigan-Cummins M, Hudson J, Maric I, Simakova O, Neelapu SS, Kwak LW, Janik JE, Gause B, Jaffe ES, Calvo KR.

Haematologica. 2012 Apr;97(4):586-94. doi: 10.3324/haematol.2011.048132. Epub 2011 Nov 18.


mTORC1 and mTORC2 differentially regulate homeostasis of neoplastic and non-neoplastic human mast cells.

Smrz D, Kim MS, Zhang S, Mock BA, Smrzová S, DuBois W, Simakova O, Maric I, Wilson TM, Metcalfe DD, Gilfillan AM.

Blood. 2011 Dec 22;118(26):6803-13. doi: 10.1182/blood-2011-06-359984. Epub 2011 Nov 3.


IL-5 receptor α levels in patients with marked eosinophilia or mastocytosis.

Wilson TM, Maric I, Shukla J, Brown M, Santos C, Simakova O, Khoury P, Fay MP, Kozhich A, Kolbeck R, Metcalfe DD, Klion AD.

J Allergy Clin Immunol. 2011 Nov;128(5):1086-92.e1-3. doi: 10.1016/j.jaci.2011.05.032. Epub 2011 Jul 16.


Fluorescent analysis of the cell-selective Alzheimer's disease aβ Peptide surface membrane binding: influence of membrane components.

Simakova O, Arispe NJ.

Int J Alzheimers Dis. 2011;2011:917629. doi: 10.4061/2011/917629. Epub 2011 Jun 8.


Carbon nanotubes activate store-operated calcium entry in human blood platelets.

Lacerda SH, Semberova J, Holada K, Simakova O, Hudson SD, Simak J.

ACS Nano. 2011 Jul 26;5(7):5808-13. doi: 10.1021/nn2015369. Epub 2011 Jun 8.


Clonal analysis of NRAS activating mutations in KIT-D816V systemic mastocytosis.

Wilson TM, Maric I, Simakova O, Bai Y, Chan EC, Olivares N, Carter M, Maric D, Robyn J, Metcalfe DD.

Haematologica. 2011 Mar;96(3):459-63. doi: 10.3324/haematol.2010.031690. Epub 2010 Dec 6.


Carbon nanotubes activate blood platelets by inducing extracellular Ca2+ influx sensitive to calcium entry inhibitors.

Semberova J, De Paoli Lacerda SH, Simakova O, Holada K, Gelderman MP, Simak J.

Nano Lett. 2009 Sep;9(9):3312-7. doi: 10.1021/nl901603k.


Annexin-A7 protects normal prostate cells and induces distinct patterns of RB-associated cytotoxicity in androgen-sensitive and -resistant prostate cancer cells.

Torosyan Y, Simakova O, Naga S, Mezhevaya K, Leighton X, Diaz J, Huang W, Pollard H, Srivastava M.

Int J Cancer. 2009 Dec 1;125(11):2528-39. doi: 10.1002/ijc.24592.


Small molecule blockers of the Alzheimer Abeta calcium channel potently protect neurons from Abeta cytotoxicity.

Diaz JC, Simakova O, Jacobson KA, Arispe N, Pollard HB.

Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3348-53. doi: 10.1073/pnas.0813355106. Epub 2009 Feb 9.


Adverse effects of fullerenes on endothelial cells: fullerenol C60(OH)24 induced tissue factor and ICAM-I membrane expression and apoptosis in vitro.

Gelderman MP, Simakova O, Clogston JD, Patri AK, Siddiqui SF, Vostal AC, Simak J.

Int J Nanomedicine. 2008;3(1):59-68.


Heart failure drug digitoxin induces calcium uptake into cells by forming transmembrane calcium channels.

Arispe N, Diaz JC, Simakova O, Pollard HB.

Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2610-5. doi: 10.1073/pnas.0712270105. Epub 2008 Feb 12.


Abeta ion channels. Prospects for treating Alzheimer's disease with Abeta channel blockers.

Arispe N, Diaz JC, Simakova O.

Biochim Biophys Acta. 2007 Aug;1768(8):1952-65. Epub 2007 Mar 24. Review.


Hsc70 and Hsp70 interact with phosphatidylserine on the surface of PC12 cells resulting in a decrease of viability.

Arispe N, Doh M, Simakova O, Kurganov B, De Maio A.

FASEB J. 2004 Nov;18(14):1636-45.


Inhibition of Smad5 in human hematopoietic progenitors blocks erythroid differentiation induced by BMP4.

Fuchs O, Simakova O, Klener P, Cmejlova J, Zivny J, Zavadil J, Stopka T.

Blood Cells Mol Dis. 2002 Mar-Apr;28(2):221-33.


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