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Early adolescent nicotine exposure affects later-life hippocampal mu-opioid receptors activity and morphine reward but not physical dependence in male mice.

Kota D, Alajaji M, Bagdas D, Selley DE, Sim-Selley LJ, Damaj MI.

Pharmacol Biochem Behav. 2018 Oct;173:58-64. doi: 10.1016/j.pbb.2018.08.006. Epub 2018 Aug 17.


Differential Tolerance to FTY720-Induced Antinociception in Acute Thermal and Nerve Injury Mouse Pain Models: Role of Sphingosine-1-Phosphate Receptor Adaptation.

Sim-Selley LJ, Wilkerson JL, Burston JJ, Hauser KF, McLane V, Welch SP, Lichtman AH, Selley DE.

J Pharmacol Exp Ther. 2018 Sep;366(3):509-518. doi: 10.1124/jpet.118.248260. Epub 2018 Jun 26.


Δ9-Tetrahydrocannabinol Experience Influences ΔFosB and Downstream Gene Expression in Prefrontal Cortex.

Lazenka MF, Kang M, De DD, Selley DE, Sim-Selley LJ.

Cannabis Cannabinoid Res. 2017 Aug 1;2(1):224-234. doi: 10.1089/can.2017.0022. eCollection 2017.


Stratification of Cannabinoid 1 Receptor (CB1R) Agonist Efficacy: Manipulation of CB1R Density through Use of Transgenic Mice Reveals Congruence between In Vivo and In Vitro Assays.

Grim TW, Morales AJ, Gonek MM, Wiley JL, Thomas BF, Endres GW, Sim-Selley LJ, Selley DE, Negus SS, Lichtman AH.

J Pharmacol Exp Ther. 2016 Nov;359(2):329-339. Epub 2016 Aug 17.


Central HIV-1 Tat exposure elevates anxiety and fear conditioned responses of male mice concurrent with altered mu-opioid receptor-mediated G-protein activation and β-arrestin 2 activity in the forebrain.

Hahn YK, Paris JJ, Lichtman AH, Hauser KF, Sim-Selley LJ, Selley DE, Knapp PE.

Neurobiol Dis. 2016 Aug;92(Pt B):124-36. doi: 10.1016/j.nbd.2016.01.014. Epub 2016 Feb 1.


Early adolescent nicotine exposure affects later-life cocaine reward in mice.

Alajaji M, Lazenka MF, Kota D, Wise LE, Younis RM, Carroll FI, Levine A, Selley DE, Sim-Selley LJ, Damaj MI.

Neuropharmacology. 2016 Jun;105:308-317. doi: 10.1016/j.neuropharm.2016.01.032. Epub 2016 Jan 22.


Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.

Viader A, Blankman JL, Zhong P, Liu X, Schlosburg JE, Joslyn CM, Liu QS, Tomarchio AJ, Lichtman AH, Selley DE, Sim-Selley LJ, Cravatt BF.

Cell Rep. 2015 Aug 4;12(5):798-808. doi: 10.1016/j.celrep.2015.06.075. Epub 2015 Jul 23.


Role of Dopamine Type 1 Receptors and Dopamine- and cAMP-Regulated Phosphoprotein Mr 32 kDa in Δ9-Tetrahydrocannabinol-Mediated Induction of ΔFosB in the Mouse Forebrain.

Lazenka MF, Tomarchio AJ, Lichtman AH, Greengard P, Flajolet M, Selley DE, Sim-Selley LJ.

J Pharmacol Exp Ther. 2015 Sep;354(3):316-27. doi: 10.1124/jpet.115.224428. Epub 2015 Jun 22.


Full Fatty Acid Amide Hydrolase Inhibition Combined with Partial Monoacylglycerol Lipase Inhibition: Augmented and Sustained Antinociceptive Effects with Reduced Cannabimimetic Side Effects in Mice.

Ghosh S, Kinsey SG, Liu QS, Hruba L, McMahon LR, Grim TW, Merritt CR, Wise LE, Abdullah RA, Selley DE, Sim-Selley LJ, Cravatt BF, Lichtman AH.

J Pharmacol Exp Ther. 2015 Aug;354(2):111-20. doi: 10.1124/jpet.115.222851. Epub 2015 May 21.


Δ9-tetrahydrocannabinol and endocannabinoid degradative enzyme inhibitors attenuate intracranial self-stimulation in mice.

Wiebelhaus JM, Grim TW, Owens RA, Lazenka MF, Sim-Selley LJ, Abdullah RA, Niphakis MJ, Vann RE, Cravatt BF, Wiley JL, Negus SS, Lichtman AH.

J Pharmacol Exp Ther. 2015 Feb;352(2):195-207. doi: 10.1124/jpet.114.218677. Epub 2014 Nov 14.


Inhibition of monoacylglycerol lipase reduces nicotine withdrawal.

Muldoon PP, Chen J, Harenza JL, Abdullah RA, Sim-Selley LJ, Cravatt BF, Miles MF, Chen X, Lichtman AH, Damaj MI.

Br J Pharmacol. 2015 Feb;172(3):869-82. doi: 10.1111/bph.12948.


Delta FosB and AP-1-mediated transcription modulate cannabinoid CB₁ receptor signaling and desensitization in striatal and limbic brain regions.

Lazenka MF, David BG, Lichtman AH, Nestler EJ, Selley DE, Sim-Selley LJ.

Biochem Pharmacol. 2014 Oct 1;91(3):380-9. doi: 10.1016/j.bcp.2014.07.024. Epub 2014 Aug 2.


Mutation of putative GRK phosphorylation sites in the cannabinoid receptor 1 (CB1R) confers resistance to cannabinoid tolerance and hypersensitivity to cannabinoids in mice.

Morgan DJ, Davis BJ, Kearn CS, Marcus D, Cook AJ, Wager-Miller J, Straiker A, Myoga MH, Karduck J, Leishman E, Sim-Selley LJ, Czyzyk TA, Bradshaw HB, Selley DE, Mackie K.

J Neurosci. 2014 Apr 9;34(15):5152-63. doi: 10.1523/JNEUROSCI.3445-12.2014.


ΔFosB induction correlates inversely with CB₁ receptor desensitization in a brain region-dependent manner following repeated Δ⁹-THC administration.

Lazenka MF, Selley DE, Sim-Selley LJ.

Neuropharmacology. 2014 Feb;77:224-33. doi: 10.1016/j.neuropharm.2013.09.019. Epub 2013 Sep 30.


Sphingosine lysolipids in the CNS: endogenous cannabinoid antagonists or a parallel pain modulatory system?

Selley DE, Welch SP, Sim-Selley LJ.

Life Sci. 2013 Aug 14;93(5-6):187-93. doi: 10.1016/j.lfs.2013.06.004. Epub 2013 Jun 16. Review.


Sphingosine-1-phosphate receptors as emerging targets for treatment of pain.

Welch SP, Sim-Selley LJ, Selley DE.

Biochem Pharmacol. 2012 Dec 15;84(12):1551-62. doi: 10.1016/j.bcp.2012.08.010. Epub 2012 Aug 16. Review.


Brain regional differences in CB1 receptor adaptation and regulation of transcription.

Lazenka MF, Selley DE, Sim-Selley LJ.

Life Sci. 2013 Mar 19;92(8-9):446-52. doi: 10.1016/j.lfs.2012.08.023. Epub 2012 Aug 24. Review.


Statistical parametric mapping reveals regional alterations in cannabinoid CB1 receptor distribution and G-protein activation in the 3D reconstructed epileptic rat brain.

Sayers KW, Nguyen PT, Blair RE, Sim-Selley LJ, DeLorenzo RJ.

Epilepsia. 2012 May;53(5):897-907. doi: 10.1111/j.1528-1167.2012.03460.x. Epub 2012 Apr 17.


β-arrestin2 regulates cannabinoid CB1 receptor signaling and adaptation in a central nervous system region-dependent manner.

Nguyen PT, Schmid CL, Raehal KM, Selley DE, Bohn LM, Sim-Selley LJ.

Biol Psychiatry. 2012 Apr 15;71(8):714-24. doi: 10.1016/j.biopsych.2011.11.027. Epub 2012 Jan 20.


Effect of ΔFosB overexpression on opioid and cannabinoid receptor-mediated signaling in the nucleus accumbens.

Sim-Selley LJ, Cassidy MP, Sparta A, Zachariou V, Nestler EJ, Selley DE.

Neuropharmacology. 2011 Dec;61(8):1470-6. doi: 10.1016/j.neuropharm.2011.08.046. Epub 2011 Sep 3.


Chronic neuropathic pain in mice reduces μ-opioid receptor-mediated G-protein activity in the thalamus.

Hoot MR, Sim-Selley LJ, Selley DE, Scoggins KL, Dewey WL.

Brain Res. 2011 Aug 11;1406:1-7. doi: 10.1016/j.brainres.2011.06.023. Epub 2011 Jun 16.


Blockade of endocannabinoid hydrolytic enzymes attenuates precipitated opioid withdrawal symptoms in mice.

Ramesh D, Ross GR, Schlosburg JE, Owens RA, Abdullah RA, Kinsey SG, Long JZ, Nomura DK, Sim-Selley LJ, Cravatt BF, Akbarali HI, Lichtman AH.

J Pharmacol Exp Ther. 2011 Oct;339(1):173-85. doi: 10.1124/jpet.111.181370. Epub 2011 Jun 30.


delta(9)-Tetrahydrocannabinol-dependent mice undergoing withdrawal display impaired spatial memory.

Wise LE, Varvel SA, Selley DE, Wiebelhaus JM, Long KA, Middleton LS, Sim-Selley LJ, Lichtman AH.

Psychopharmacology (Berl). 2011 Oct;217(4):485-94. doi: 10.1007/s00213-011-2305-5. Epub 2011 May 11.


Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system.

Schlosburg JE, Blankman JL, Long JZ, Nomura DK, Pan B, Kinsey SG, Nguyen PT, Ramesh D, Booker L, Burston JJ, Thomas EA, Selley DE, Sim-Selley LJ, Liu QS, Lichtman AH, Cravatt BF.

Nat Neurosci. 2010 Sep;13(9):1113-9. doi: 10.1038/nn.2616. Epub 2010 Aug 22.


Regional enhancement of cannabinoid CB₁ receptor desensitization in female adolescent rats following repeated Delta-tetrahydrocannabinol exposure.

Burston JJ, Wiley JL, Craig AA, Selley DE, Sim-Selley LJ.

Br J Pharmacol. 2010 Sep;161(1):103-12. doi: 10.1111/j.1476-5381.2010.00870.x.


Cannabinoid CB1 receptor-interacting proteins: novel targets for central nervous system drug discovery?

Smith TH, Sim-Selley LJ, Selley DE.

Br J Pharmacol. 2010 Jun;160(3):454-66. doi: 10.1111/j.1476-5381.2010.00777.x. Review.


Statistical Parametric Mapping reveals ligand and region-specific activation of G-proteins by CB1 receptors and non-CB1 sites in the 3D reconstructed mouse brain.

Nguyen PT, Selley DE, Sim-Selley LJ.

Neuroimage. 2010 Oct 1;52(4):1243-51. doi: 10.1016/j.neuroimage.2010.04.259. Epub 2010 May 6.


Chronic constriction injury reduces cannabinoid receptor 1 activity in the rostral anterior cingulate cortex of mice.

Hoot MR, Sim-Selley LJ, Poklis JL, Abdullah RA, Scoggins KL, Selley DE, Dewey WL.

Brain Res. 2010 Jun 21;1339:18-25. doi: 10.1016/j.brainres.2010.03.105. Epub 2010 Apr 7.


FAAH-/- mice display differential tolerance, dependence, and cannabinoid receptor adaptation after delta 9-tetrahydrocannabinol and anandamide administration.

Falenski KW, Thorpe AJ, Schlosburg JE, Cravatt BF, Abdullah RA, Smith TH, Selley DE, Lichtman AH, Sim-Selley LJ.

Neuropsychopharmacology. 2010 Jul;35(8):1775-87. doi: 10.1038/npp.2010.44. Epub 2010 Mar 31.


Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo.

Long JZ, Nomura DK, Vann RE, Walentiny DM, Booker L, Jin X, Burston JJ, Sim-Selley LJ, Lichtman AH, Wiley JL, Cravatt BF.

Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20270-5. doi: 10.1073/pnas.0909411106. Epub 2009 Nov 16.


Sphingosine-1-phosphate receptors mediate neuromodulatory functions in the CNS.

Sim-Selley LJ, Goforth PB, Mba MU, Macdonald TL, Lynch KR, Milstien S, Spiegel S, Satin LS, Welch SP, Selley DE.

J Neurochem. 2009 Aug;110(4):1191-202. doi: 10.1111/j.1471-4159.2009.06202.x. Epub 2009 May 31.


Basic neuroanatomy and neuropharmacology of cannabinoids.

Breivogel CS, Sim-Selley LJ.

Int Rev Psychiatry. 2009 Apr;21(2):113-21. doi: 10.1080/09540260902782760. Review.


Antipsychotic-induced alterations in CB1 receptor-mediated G-protein signaling and in vivo pharmacology in rats.

Wiley JL, Kendler SH, Burston JJ, Howard DR, Selley DE, Sim-Selley LJ.

Neuropharmacology. 2008 Dec;55(7):1183-90. doi: 10.1016/j.neuropharm.2008.07.026. Epub 2008 Jul 30.


N-arachidonyl maleimide potentiates the pharmacological and biochemical effects of the endocannabinoid 2-arachidonylglycerol through inhibition of monoacylglycerol lipase.

Burston JJ, Sim-Selley LJ, Harloe JP, Mahadevan A, Razdan RK, Selley DE, Wiley JL.

J Pharmacol Exp Ther. 2008 Nov;327(2):546-53. doi: 10.1124/jpet.108.141382. Epub 2008 Aug 5.


Dose-related differences in the regional pattern of cannabinoid receptor adaptation and in vivo tolerance development to delta9-tetrahydrocannabinol.

McKinney DL, Cassidy MP, Collier LM, Martin BR, Wiley JL, Selley DE, Sim-Selley LJ.

J Pharmacol Exp Ther. 2008 Feb;324(2):664-73. Epub 2007 Oct 29.


Low dose combination of morphine and delta9-tetrahydrocannabinol circumvents antinociceptive tolerance and apparent desensitization of receptors.

Smith PA, Selley DE, Sim-Selley LJ, Welch SP.

Eur J Pharmacol. 2007 Oct 1;571(2-3):129-37. Epub 2007 Jun 12.


Region-dependent attenuation of mu opioid receptor-mediated G-protein activation in mouse CNS as a function of morphine tolerance.

Sim-Selley LJ, Scoggins KL, Cassidy MP, Smith LA, Dewey WL, Smith FL, Selley DE.

Br J Pharmacol. 2007 Aug;151(8):1324-33. Epub 2007 Jun 18.


Status epilepticus causes a long-lasting redistribution of hippocampal cannabinoid type 1 receptor expression and function in the rat pilocarpine model of acquired epilepsy.

Falenski KW, Blair RE, Sim-Selley LJ, Martin BR, DeLorenzo RJ.

Neuroscience. 2007 May 25;146(3):1232-44. Epub 2007 Apr 12.


Role of kappa and delta opioid receptors in mediating morphine-induced antinociception in morphine-tolerant infant rats.

Stoller DC, Sim-Selley LJ, Smith FL.

Brain Res. 2007 Apr 20;1142:28-36. Epub 2007 Jan 13.


Prolonged recovery rate of CB1 receptor adaptation after cessation of long-term cannabinoid administration.

Sim-Selley LJ, Schechter NS, Rorrer WK, Dalton GD, Hernandez J, Martin BR, Selley DE.

Mol Pharmacol. 2006 Sep;70(3):986-96. Epub 2006 Jun 7.


Pharmacological characterization of novel water-soluble cannabinoids.

Martin BR, Wiley JL, Beletskaya I, Sim-Selley LJ, Smith FL, Dewey WL, Cottney J, Adams J, Baker J, Hill D, Saha B, Zerkowski J, Mahadevan A, Razdan RK.

J Pharmacol Exp Ther. 2006 Sep;318(3):1230-9. Epub 2006 Jun 6.


Sphingosine and its analog, the immunosuppressant 2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol, interact with the CB1 cannabinoid receptor.

Paugh SW, Cassidy MP, He H, Milstien S, Sim-Selley LJ, Spiegel S, Selley DE.

Mol Pharmacol. 2006 Jul;70(1):41-50. Epub 2006 Mar 29.


An essential role for DeltaFosB in the nucleus accumbens in morphine action.

Zachariou V, Bolanos CA, Selley DE, Theobald D, Cassidy MP, Kelz MB, Shaw-Lutchman T, Berton O, Sim-Selley LJ, Dileone RJ, Kumar A, Nestler EJ.

Nat Neurosci. 2006 Feb;9(2):205-11. Epub 2006 Jan 15.


Mu and delta opioid-stimulated [35S]GTP gamma S binding in brain and spinal cord of polyarthritic rats.

Cichewicz DL, Cox ML, Welch SP, Selley DE, Sim-Selley LJ.

Eur J Pharmacol. 2004 Nov 3;504(1-2):33-8.


Mice with deficiency of G protein gamma3 are lean and have seizures.

Schwindinger WF, Giger KE, Betz KS, Stauffer AM, Sunderlin EM, Sim-Selley LJ, Selley DE, Bronson SK, Robishaw JD.

Mol Cell Biol. 2004 Sep;24(17):7758-68.


Long-term administration of Delta9-tetrahydrocannabinol desensitizes CB1-, adenosine A1-, and GABAB-mediated inhibition of adenylyl cyclase in mouse cerebellum.

Selley DE, Cassidy MP, Martin BR, Sim-Selley LJ.

Mol Pharmacol. 2004 Nov;66(5):1275-84. Epub 2004 Jul 30.


Signaling pathways involved in the development of cannabinoid tolerance.

Martin BR, Sim-Selley LJ, Selley DE.

Trends Pharmacol Sci. 2004 Jun;25(6):325-30. Review.


Regulation of cannabinoid CB1 receptors in the central nervous system by chronic cannabinoids.

Sim-Selley LJ.

Crit Rev Neurobiol. 2003;15(2):91-119. Review.


Essential role for RGS9 in opiate action.

Zachariou V, Georgescu D, Sanchez N, Rahman Z, DiLeone R, Berton O, Neve RL, Sim-Selley LJ, Selley DE, Gold SJ, Nestler EJ.

Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13656-61. Epub 2003 Oct 31.


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