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Secretion of functionally active complement factor H related protein 5 (FHR5) by primary tumour cells derived from Glioblastoma Multiforme patients.

DeCordova S, Abdelgany A, Murugaiah V, Pathan AA, Nayak A, Walker T, Shastri A, Alrokayan SH, Khan HA, Singh SK, De Pennington N, Sim RB, Kishore U.

Immunobiology. 2019 Sep;224(5):625-631. doi: 10.1016/j.imbio.2019.07.006. Epub 2019 Aug 5.


Enterococcus faecalis Escapes Complement-Mediated Killing via Recruitment of Complement Factor H.

Ali YM, Sim RB, Schwaeble W, Shaaban MI.

J Infect Dis. 2019 Aug 9;220(6):1061-1070. doi: 10.1093/infdis/jiz226.


Complement Dependent and Independent Interaction Between Bovine Conglutinin and Mycobacterium bovis BCG: Implications in Bovine Tuberculosis.

Mehmood A, Kouser L, Kaur A, Holmskov U, Al-Ahdal MN, Sim RB, Kishore U, Tsolaki AG.

Front Immunol. 2019 Feb 5;9:3159. doi: 10.3389/fimmu.2018.03159. eCollection 2018.


Recombinant chemotaxis inhibitory protein of Staphylococcus aureus (CHIPS) protects against LPS-induced lung injury in mice.

Ali YM, Abd El-Aziz AM, Mabrook M, Shabaan AA, Sim RB, Hassan R.

Clin Immunol. 2018 Dec;197:27-33. doi: 10.1016/j.clim.2018.08.009. Epub 2018 Aug 23.


Human Properdin Modulates Macrophage: Mycobacterium bovis BCG Interaction via Thrombospondin Repeats 4 and 5.

Al-Mozaini MA, Tsolaki AG, Abdul-Aziz M, Abozaid SM, Al-Ahdal MN, Pathan AA, Murugaiah V, Makarov EM, Kaur A, Sim RB, Kishore U, Kouser L.

Front Immunol. 2018 May 8;9:533. doi: 10.3389/fimmu.2018.00533. eCollection 2018.


Human Properdin Opsonizes Nanoparticles and Triggers a Potent Pro-inflammatory Response by Macrophages without Involving Complement Activation.

Kouser L, Paudyal B, Kaur A, Stenbeck G, Jones LA, Abozaid SM, Stover CM, Flahaut E, Sim RB, Kishore U.

Front Immunol. 2018 Feb 12;9:131. doi: 10.3389/fimmu.2018.00131. eCollection 2018.


Serine proteases of the complement lectin pathway and their genetic variations in ischaemic stroke.

Tsakanova G, Stepanyan A, Nahapetyan K, Sim RB, Arakelyan A, Boyajyan A.

J Clin Pathol. 2018 Feb;71(2):141-147. doi: 10.1136/jclinpath-2017-204403. Epub 2017 Jul 18.


Potential influences of complement factor H in autoimmune inflammatory and thrombotic disorders.

Ferluga J, Kouser L, Murugaiah V, Sim RB, Kishore U.

Mol Immunol. 2017 Apr;84:84-106. doi: 10.1016/j.molimm.2017.01.015. Epub 2017 Feb 16. Review.


Lectin pathway effector enzyme mannan-binding lectin-associated serine protease-2 can activate native complement C3 in absence of C4 and/or C2.

Yaseen S, Demopulos G, Dudler T, Yabuki M, Wood CL, Cummings WJ, Tjoelker LW, Fujita T, Sacks S, Garred P, Andrew P, Sim RB, Lachmann PJ, Wallis R, Lynch N, Schwaeble WJ.

FASEB J. 2017 May;31(5):2210-2219. doi: 10.1096/fj.201601306R. Epub 2017 Feb 10.


Pulmonary surfactant protein SP-D opsonises carbon nanotubes and augments their phagocytosis and subsequent pro-inflammatory immune response.

Pondman KM, Paudyal B, Sim RB, Kaur A, Kouser L, Tsolaki AG, Jones LA, Salvador-Morales C, Khan HA, Ten Haken B, Stenbeck G, Kishore U.

Nanoscale. 2017 Jan 19;9(3):1097-1109. doi: 10.1039/c6nr08807d.


Complement research in the 18th-21st centuries: Progress comes with new technology.

Sim RB, Schwaeble W, Fujita T.

Immunobiology. 2016 Oct;221(10):1037-45. doi: 10.1016/j.imbio.2016.06.011. Epub 2016 Jun 15. Review.


Complement Deposition on Nanoparticles Can Modulate Immune Responses by Macrophage, B and T Cells.

Pondman KM, Tsolaki AG, Paudyal B, Shamji MH, Switzer A, Pathan AA, Abozaid SM, Ten Haken B, Stenbeck G, Sim RB, Kishore U.

J Biomed Nanotechnol. 2016 Jan;12(1):197-216.


Complement factor H interferes with Mycobacterium bovis BCG entry into macrophages and modulates the pro-inflammatory cytokine response.

Abdul-Aziz M, Tsolaki AG, Kouser L, Carroll MV, Al-Ahdal MN, Sim RB, Kishore U.

Immunobiology. 2016 Sep;221(9):944-52. doi: 10.1016/j.imbio.2016.05.011. Epub 2016 May 24.


A recombinant two-module form of human properdin is an inhibitor of the complement alternative pathway.

Kouser L, Abdul-Aziz M, Tsolaki AG, Singhal D, Schwaeble WJ, Urban BC, Khan HA, Sim RB, Kishore U.

Mol Immunol. 2016 May;73:76-87. doi: 10.1016/j.molimm.2016.03.005. Epub 2016 Apr 6.


Complement factor H in its alternative identity as adrenomedullin-binding protein 1.

Sim RB, Ferluga J, Al-Rashidi H, Abbow H, Schwaeble W, Kishore U.

Mol Immunol. 2015 Nov;68(1):45-8. doi: 10.1016/j.molimm.2015.06.006. Review.


Innate immune humoral factors, C1q and factor H, with differential pattern recognition properties, alter macrophage response to carbon nanotubes.

Pondman KM, Pednekar L, Paudyal B, Tsolaki AG, Kouser L, Khan HA, Shamji MH, Ten Haken B, Stenbeck G, Sim RB, Kishore U.

Nanomedicine. 2015 Nov;11(8):2109-18. doi: 10.1016/j.nano.2015.06.009. Epub 2015 Jul 11.


European Union funded project on the development of a whole complement deficiency screening ELISA-A story of success and an exceptional manager: Mohamed R. Daha.

Würzner R, Tedesco F, Garred P, Mollnes TE, Truedsson L, Turner MW, Sommarin Y, Wieslander J, Sim RB.

Mol Immunol. 2015 Nov;68(1):63-6. doi: 10.1016/j.molimm.2015.05.003. Epub 2015 May 23. Review.


Low-dose recombinant properdin provides substantial protection against Streptococcus pneumoniae and Neisseria meningitidis infection.

Ali YM, Hayat A, Saeed BM, Haleem KS, Alshamrani S, Kenawy HI, Ferreira VP, Saggu G, Buchberger A, Lachmann PJ, Sim RB, Goundis D, Andrew PW, Lynch NJ, Schwaeble WJ.

Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5301-6. doi: 10.1073/pnas.1401011111. Epub 2014 Mar 24.


A potential anti-coagulant role of complement factor H.

Ferluga J, Kishore U, Sim RB.

Mol Immunol. 2014 Jun;59(2):188-93. doi: 10.1016/j.molimm.2014.02.012. Epub 2014 Mar 13.


Complement activation by carbon nanotubes and its influence on the phagocytosis and cytokine response by macrophages.

Pondman KM, Sobik M, Nayak A, Tsolaki AG, Jäkel A, Flahaut E, Hampel S, Ten Haken B, Sim RB, Kishore U.

Nanomedicine. 2014 Aug;10(6):1287-99. doi: 10.1016/j.nano.2014.02.010. Epub 2014 Mar 6.


Human L-ficolin, a recognition molecule of the lectin activation pathway of complement, activates complement by binding to pneumolysin, the major toxin of Streptococcus pneumoniae.

Ali YM, Kenawy HI, Muhammad A, Sim RB, Andrew PW, Schwaeble WJ.

PLoS One. 2013 Dec 12;8(12):e82583. doi: 10.1371/journal.pone.0082583. eCollection 2013.


Purification, quantification, and functional analysis of Complement Factor H.

Yu BB, Moffatt BE, Fedorova M, Villiers CG, Arnold JN, Du E, Swinkels A, Li MC, Ryan A, Sim RB.

Methods Mol Biol. 2014;1100:207-23. doi: 10.1007/978-1-62703-724-2_17.


Structural insight on the recognition of surface-bound opsonins by the integrin I domain of complement receptor 3.

Bajic G, Yatime L, Sim RB, Vorup-Jensen T, Andersen GR.

Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16426-31. doi: 10.1073/pnas.1311261110. Epub 2013 Sep 24.


Genetic influences on plasma CFH and CFHR1 concentrations and their role in susceptibility to age-related macular degeneration.

Ansari M, McKeigue PM, Skerka C, Hayward C, Rudan I, Vitart V, Polasek O, Armbrecht AM, Yates JR, Vatavuk Z, Bencic G, Kolcic I, Oostra BA, Van Duijn CM, Campbell S, Stanton CM, Huffman J, Shu X, Khan JC, Shahid H, Harding SP, Bishop PN, Deary IJ, Moore AT, Dhillon B, Rudan P, Zipfel PF, Sim RB, Hastie ND, Campbell H, Wright AF.

Hum Mol Genet. 2013 Dec 1;22(23):4857-69. doi: 10.1093/hmg/ddt336. Epub 2013 Jul 19.


Ligands and receptors of lung surfactant proteins SP-A and SP-D.

Jakel A, Qaseem AS, Kishore U, Sim RB.

Front Biosci (Landmark Ed). 2013 Jun 1;18:1129-40. Review.


Properdin and factor h: opposing players on the alternative complement pathway "see-saw".

Kouser L, Abdul-Aziz M, Nayak A, Stover CM, Sim RB, Kishore U.

Front Immunol. 2013 Apr 23;4:93. doi: 10.3389/fimmu.2013.00093. eCollection 2013.


The complement system of the goat: haemolytic assays and isolation of major proteins.

Moreno-Indias I, Dodds AW, Argüello A, Castro N, Sim RB.

BMC Vet Res. 2012 Jun 26;8:91. doi: 10.1186/1746-6148-8-91.


Effect of functionalization of carbon nanotubes with psychosine on complement activation and protein adsorption.

Rybak-Smith MJ, Tripisciano C, Borowiak-Palen E, Lamprecht C, Sim RB.

J Biomed Nanotechnol. 2011 Dec;7(6):830-9.


Human complement Factor H modulates C1q-mediated phagocytosis of apoptotic cells.

Kang YH, Urban BC, Sim RB, Kishore U.

Immunobiology. 2012 Apr;217(4):455-64. doi: 10.1016/j.imbio.2011.10.008. Epub 2011 Oct 23.


Chemical labelling of active serum thioester proteins for quantification.

Holm L, Ackland GL, Edwards MR, Breckenridge RA, Sim RB, Offer J.

Immunobiology. 2012 Feb;217(2):256-64. doi: 10.1016/j.imbio.2011.07.021. Epub 2011 Jul 23.


Factor H as a regulator of the classical pathway activation.

Kishore U, Sim RB.

Immunobiology. 2012 Feb;217(2):162-8. doi: 10.1016/j.imbio.2011.07.024. Epub 2011 Jul 23.


Structures of the rat complement regulator CrrY.

Roversi P, Johnson S, Caesar JJ, McLean F, Leath KJ, Tsiftsoglou SA, Morgan BP, Harris CL, Sim RB, Lea SM.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Jul 1;67(Pt 7):739-43. doi: 10.1107/S1744309111016551. Epub 2011 Jun 23.


Structural basis for complement factor I control and its disease-associated sequence polymorphisms.

Roversi P, Johnson S, Caesar JJ, McLean F, Leath KJ, Tsiftsoglou SA, Morgan BP, Harris CL, Sim RB, Lea SM.

Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12839-44. doi: 10.1073/pnas.1102167108. Epub 2011 Jul 18.


Improvement of the expression and purification of Mycobacterium tuberculosis arylamine N-acetyltransferase (TBNAT) a potential target for novel anti-tubercular agents.

Abuhammad A, Lack N, Schweichler J, Staunton D, Sim RB, Sim E.

Protein Expr Purif. 2011 Dec;80(2):246-52. doi: 10.1016/j.pep.2011.06.021. Epub 2011 Jul 13.


Complement in health and disease.

Carroll MV, Sim RB.

Adv Drug Deliv Rev. 2011 Sep 16;63(12):965-75. doi: 10.1016/j.addr.2011.06.005. Epub 2011 Jun 16. Review.


Complement activation by carbon nanotubes.

Rybak-Smith MJ, Sim RB.

Adv Drug Deliv Rev. 2011 Sep 16;63(12):1031-41. doi: 10.1016/j.addr.2011.05.012. Epub 2011 Jun 12. Review.


Interactions of complement proteins C1q and factor H with lipid A and Escherichia coli: further evidence that factor H regulates the classical complement pathway.

Tan LA, Yang AC, Kishore U, Sim RB.

Protein Cell. 2011 Apr;2(4):320-32. doi: 10.1007/s13238-011-1029-y. Epub 2011 May 15.


Complement factor I in health and disease.

Nilsson SC, Sim RB, Lea SM, Fremeaux-Bacchi V, Blom AM.

Mol Immunol. 2011 Aug;48(14):1611-20. doi: 10.1016/j.molimm.2011.04.004. Epub 2011 Apr 29. Review.


Understanding the laminated layer of larval Echinococcus II: immunology.

Díaz A, Casaravilla C, Allen JE, Sim RB, Ferreira AM.

Trends Parasitol. 2011 Jun;27(6):264-73. doi: 10.1016/ Epub 2011 Mar 2. Review.


Surface properties: Immune attack on nanoparticles.

Sim RB, Wallis R.

Nat Nanotechnol. 2011 Feb;6(2):80-1. doi: 10.1038/nnano.2011.4. No abstract available.


Surface-bound myeloperoxidase is a ligand for recognition of late apoptotic neutrophils by human lung surfactant proteins A and D.

Jäkel A, Clark H, Reid KB, Sim RB.

Protein Cell. 2010 Jun;1(6):563-72. doi: 10.1007/s13238-010-0076-0. Epub 2010 Jul 7.


Specific interaction of hepatitis C virus glycoproteins with mannan binding lectin inhibits virus entry.

Brown KS, Keogh MJ, Owsianka AM, Adair R, Patel AH, Arnold JN, Ball JK, Sim RB, Tarr AW, Hickling TP.

Protein Cell. 2010 Jul;1(7):664-74. doi: 10.1007/s13238-010-0088-9. Epub 2010 Jul 29.


Identification of four novel DC-SIGN ligands on Mycobacterium bovis BCG.

Carroll MV, Sim RB, Bigi F, Jäkel A, Antrobus R, Mitchell DA.

Protein Cell. 2010 Sep;1(9):859-70. doi: 10.1007/s13238-010-0101-3. Epub 2010 Oct 7.


Complement activation by phospholipids: the interplay of factor H and C1q.

Tan LA, Yu B, Sim FC, Kishore U, Sim RB.

Protein Cell. 2010 Nov;1(11):1033-49. doi: 10.1007/s13238-010-0125-8. Epub 2010 Dec 10.


High glucose disrupts oligosaccharide recognition function via competitive inhibition: a potential mechanism for immune dysregulation in diabetes mellitus.

Ilyas R, Wallis R, Soilleux EJ, Townsend P, Zehnder D, Tan BK, Sim RB, Lehnert H, Randeva HS, Mitchell DA.

Immunobiology. 2011 Jan-Feb;216(1-2):126-31. doi: 10.1016/j.imbio.2010.06.002. Epub 2010 Jul 1.


Impaired binding of the age-related macular degeneration-associated complement factor H 402H allotype to Bruch's membrane in human retina.

Clark SJ, Perveen R, Hakobyan S, Morgan BP, Sim RB, Bishop PN, Day AJ.

J Biol Chem. 2010 Sep 24;285(39):30192-202. doi: 10.1074/jbc.M110.103986. Epub 2010 Jul 26.


Filled and glycosylated carbon nanotubes for in vivo radioemitter localization and imaging.

Hong SY, Tobias G, Al-Jamal KT, Ballesteros B, Ali-Boucetta H, Lozano-Perez S, Nellist PD, Sim RB, Finucane C, Mather SJ, Green ML, Kostarelos K, Davis BG.

Nat Mater. 2010 Jun;9(6):485-90. doi: 10.1038/nmat2766. Epub 2010 May 16.


Activation of mannan-binding lectin-associated serine proteases leads to generation of a fibrin clot.

Gulla KC, Gupta K, Krarup A, Gal P, Schwaeble WJ, Sim RB, O'Connor CD, Hajela K.

Immunology. 2010 Apr;129(4):482-95. doi: 10.1111/j.1365-2567.2009.03200.x. Epub 2009 Dec 2.


Macrophage scavenger receptor A mediates adhesion to apolipoproteins A-I and E.

Neyen C, Plüddemann A, Roversi P, Thomas B, Cai L, van der Westhuyzen DR, Sim RB, Gordon S.

Biochemistry. 2009 Dec 22;48(50):11858-71. doi: 10.1021/bi9013769.


The human lung surfactant proteins A (SP-A) and D (SP-D) interact with apoptotic target cells by different binding mechanisms.

Jäkel A, Clark H, Reid KB, Sim RB.

Immunobiology. 2010 Jul;215(7):551-8. doi: 10.1016/j.imbio.2009.09.005. Epub 2009 Oct 31.


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