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Modification of HDL by reactive aldehydes alters select cardioprotective functions of HDL in macrophages.

Schill RL, Knaack DA, Powers HR, Chen Y, Yang M, Schill DJ, Silverstein RL, Sahoo D.

FEBS J. 2019 Aug 6. doi: 10.1111/febs.15034. [Epub ahead of print]


CD36 and ERK5 link dyslipidemia to apoptotic-like platelet procoagulant function.

Yang M, Silverstein RL.

Curr Opin Hematol. 2019 Sep;26(5):357-365. doi: 10.1097/MOH.0000000000000522.


CD36 signaling in vascular redox stress.

Yang M, Silverstein RL.

Free Radic Biol Med. 2019 May 20;136:159-171. doi: 10.1016/j.freeradbiomed.2019.02.021. Epub 2019 Feb 27. Review.


Platelets inhibit apoptotic lung epithelial cell death and protect mice against infection-induced lung injury.

Bain W, Olonisakin T, Yu M, Qu Y, Hulver M, Xiong Z, Li H, Pilewski J, Mallampalli RK, Nouraie M, Ray A, Ray P, Cheng Z, Shanks RMQ, St Croix C, Silverstein RL, Lee JS.

Blood Adv. 2019 Feb 12;3(3):432-445. doi: 10.1182/bloodadvances.2018026286.


CD36 Enhances Vascular Smooth Muscle Cell Proliferation and Development of Neointimal Hyperplasia.

Yue H, Febbraio M, Klenotic PA, Kennedy DJ, Wu Y, Chen S, Gohara AF, Li O, Belcher A, Kuang B, McIntyre TM, Silverstein RL, Li W.

Arterioscler Thromb Vasc Biol. 2019 Feb;39(2):263-275. doi: 10.1161/ATVBAHA.118.312186.


Platelet CD36 signaling through ERK5 promotes caspase-dependent procoagulant activity and fibrin deposition in vivo.

Yang M, Kholmukhamedov A, Schulte ML, Cooley BC, Scoggins NO, Wood JP, Cameron SJ, Morrell CN, Jobe SM, Silverstein RL.

Blood Adv. 2018 Nov 13;2(21):2848-2861. doi: 10.1182/bloodadvances.2018025411.


Platelet metabolism meets thrombosis.

Chen Y, Silverstein RL.

Blood. 2018 Sep 13;132(11):1089-1091. doi: 10.1182/blood-2018-08-865600. No abstract available.


Oxidized Lipid Uptake by Scavenger Receptor CD36 (Cluster of Differentiation 36) Modulates Endothelial Surface Properties and May Contribute to Atherogenesis.

Silverstein RL.

Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):4-5. doi: 10.1161/ATVBAHA.117.310351. No abstract available.


Cardiotonic Steroids Stimulate Macrophage Inflammatory Responses Through a Pathway Involving CD36, TLR4, and Na/K-ATPase.

Chen Y, Huang W, Yang M, Xin G, Cui W, Xie Z, Silverstein RL.

Arterioscler Thromb Vasc Biol. 2017 Aug;37(8):1462-1469. doi: 10.1161/ATVBAHA.117.309444. Epub 2017 Jun 15.


Linking Metabolic Dysfunction to Atherosclerosis Via Activation of Macrophage CD36 Gene Transcription by Retinol Binding Protein-4.

Silverstein RL.

Circulation. 2017 Apr 4;135(14):1355-1356. doi: 10.1161/CIRCULATIONAHA.117.027505. No abstract available.


Platelet CD36 promotes thrombosis by activating redox sensor ERK5 in hyperlipidemic conditions.

Yang M, Cooley BC, Li W, Chen Y, Vasquez-Vivar J, Scoggins NO, Cameron SJ, Morrell CN, Silverstein RL.

Blood. 2017 May 25;129(21):2917-2927. doi: 10.1182/blood-2016-11-750133. Epub 2017 Mar 23.


Diet-induced obesity links to ER positive breast cancer progression via LPA/PKD-1-CD36 signaling-mediated microvascular remodeling.

Dong L, Yuan Y, Opansky C, Chen Y, Aguilera-Barrantes I, Wu S, Yuan R, Cao Q, Cheng YC, Sahoo D, Silverstein RL, Ren B.

Oncotarget. 2017 Apr 4;8(14):22550-22562. doi: 10.18632/oncotarget.15123.


CD36 Provides Host Protection Against Klebsiella pneumoniae Intrapulmonary Infection by Enhancing Lipopolysaccharide Responsiveness and Macrophage Phagocytosis.

Olonisakin TF, Li H, Xiong Z, Kochman EJ, Yu M, Qu Y, Hulver M, Kolls JK, St Croix C, Doi Y, Nguyen MH, Shanks RM, Mallampalli RK, Kagan VE, Ray A, Silverstein RL, Ray P, Lee JS.

J Infect Dis. 2016 Dec 15;214(12):1865-1875. Epub 2016 Sep 28.


Circulating protein Z concentration, PROZ variants, and unexplained cerebral infarction in young and middle-aged adults.

Zhang L, Segal AZ, Leifer D, Silverstein RL, Gerber LM, Devereux RB, Kizer JR.

Thromb Haemost. 2017 Jan 5;117(1):149-157. doi: 10.1160/TH16-04-0277. Epub 2016 Sep 29.


Metabolic Manipulation to Put the Brakes on Platelet Activation: A Potential Novel Pharmacologic Approach to Atherothrombosis.

Silverstein RL.

Arterioscler Thromb Vasc Biol. 2016 Oct;36(10):2031-2. doi: 10.1161/ATVBAHA.116.308218. No abstract available.


LPA/PKD-1-FoxO1 Signaling Axis Mediates Endothelial Cell CD36 Transcriptional Repression and Proangiogenic and Proarteriogenic Reprogramming.

Ren B, Best B, Ramakrishnan DP, Walcott BP, Storz P, Silverstein RL.

Arterioscler Thromb Vasc Biol. 2016 Jun;36(6):1197-208. doi: 10.1161/ATVBAHA.116.307421. Epub 2016 Mar 24.


Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk.

Zhu W, Gregory JC, Org E, Buffa JA, Gupta N, Wang Z, Li L, Fu X, Wu Y, Mehrabian M, Sartor RB, McIntyre TM, Silverstein RL, Tang WHW, DiDonato JA, Brown JM, Lusis AJ, Hazen SL.

Cell. 2016 Mar 24;165(1):111-124. doi: 10.1016/j.cell.2016.02.011. Epub 2016 Mar 10.


Extracellular Vesicles Activate a CD36-Dependent Signaling Pathway to Inhibit Microvascular Endothelial Cell Migration and Tube Formation.

Ramakrishnan DP, Hajj-Ali RA, Chen Y, Silverstein RL.

Arterioscler Thromb Vasc Biol. 2016 Mar;36(3):534-44. doi: 10.1161/ATVBAHA.115.307085. Epub 2016 Jan 28.


Atherothrombosis: Seeing Red?

Simon DI, Silverstein RL.

Circulation. 2015 Nov 17;132(20):1860-2. doi: 10.1161/CIRCULATIONAHA.115.019259. Epub 2015 Oct 14. No abstract available.


Oxidized LDL-bound CD36 recruits an Na⁺/K⁺-ATPase-Lyn complex in macrophages that promotes atherosclerosis.

Chen Y, Kennedy DJ, Ramakrishnan DP, Yang M, Huang W, Li Z, Xie Z, Chadwick AC, Sahoo D, Silverstein RL.

Sci Signal. 2015 Sep 8;8(393):ra91. doi: 10.1126/scisignal.aaa9623. Erratum in: Sci Signal. 2015 Oct 6;8(397):er7.


The interface of inflammation and subclinical atherosclerosis in granulomatosis with polyangiitis (Wegener's): a preliminary study.

Hajj-Ali RA, Major J, Langford C, Hoffman GS, Clark T, Zhang L, Sun Z, Silverstein RL.

Transl Res. 2015 Oct;166(4):366-74. doi: 10.1016/j.trsl.2015.04.001. Epub 2015 Apr 13.


Disabling the platelet's brakes to promote thrombosis.

Silverstein RL.

Blood. 2015 Apr 23;125(17):2591-3. doi: 10.1182/blood-2015-03-630822.


Acrolein impairs the cholesterol transport functions of high density lipoproteins.

Chadwick AC, Holme RL, Chen Y, Thomas MJ, Sorci-Thomas MG, Silverstein RL, Pritchard KA Jr, Sahoo D.

PLoS One. 2015 Apr 7;10(4):e0123138. doi: 10.1371/journal.pone.0123138. eCollection 2015.


Thrombospondin-1 restrains neutrophil granule serine protease function and regulates the innate immune response during Klebsiella pneumoniae infection.

Zhao Y, Olonisakin TF, Xiong Z, Hulver M, Sayeed S, Yu MT, Gregory AD, Kochman EJ, Chen BB, Mallampalli RK, Sun M, Silverstein RL, Stolz DB, Shapiro SD, Ray A, Ray P, Lee JS.

Mucosal Immunol. 2015 Jul;8(4):896-905. doi: 10.1038/mi.2014.120. Epub 2014 Dec 10.


Thymidine phosphorylase participates in platelet signaling and promotes thrombosis.

Li W, Gigante A, Perez-Perez MJ, Yue H, Hirano M, McIntyre TM, Silverstein RL.

Circ Res. 2014 Dec 5;115(12):997-1006. doi: 10.1161/CIRCRESAHA.115.304591. Epub 2014 Oct 6.


Hyper-inflammation and skin destruction mediated by rosiglitazone activation of macrophages in IL-6 deficiency.

Das LM, Rosenjack J, Au L, Galle PS, Hansen MB, Cathcart MK, McCormick TS, Cooper KD, Silverstein RL, Lu KQ.

J Invest Dermatol. 2015 Feb;135(2):389-399. doi: 10.1038/jid.2014.375. Epub 2014 Sep 3.


Exosome poly-ubiquitin inhibits platelet activation, downregulates CD36 and inhibits pro-atherothombotic cellular functions.

Srikanthan S, Li W, Silverstein RL, McIntyre TM.

J Thromb Haemost. 2014 Nov;12(11):1906-17. doi: 10.1111/jth.12712. Epub 2014 Oct 13.


Platelet CD36 links not only α-granule-derived proteins to thrombus stability but also metabolic and oxidant stress to a prothrombotic phenotype.

Silverstein RL.

Arterioscler Thromb Vasc Biol. 2014 Jun;34(6):1120-1. doi: 10.1161/ATVBAHA.114.303687. No abstract available.


Cancer stem cell-specific scavenger receptor CD36 drives glioblastoma progression.

Hale JS, Otvos B, Sinyuk M, Alvarado AG, Hitomi M, Stoltz K, Wu Q, Flavahan W, Levison B, Johansen ML, Schmitt D, Neltner JM, Huang P, Ren B, Sloan AE, Silverstein RL, Gladson CL, DiDonato JA, Brown JM, McIntyre T, Hazen SL, Horbinski C, Rich JN, Lathia JD.

Stem Cells. 2014 Jul;32(7):1746-58. doi: 10.1002/stem.1716.


Platelet-derived S100 family member myeloid-related protein-14 regulates thrombosis.

Wang Y, Fang C, Gao H, Bilodeau ML, Zhang Z, Croce K, Liu S, Morooka T, Sakuma M, Nakajima K, Yoneda S, Shi C, Zidar D, Andre P, Stephens G, Silverstein RL, Hogg N, Schmaier AH, Simon DI.

J Clin Invest. 2014 May;124(5):2160-71. Epub 2014 Apr 1.


Proteasome proteolysis supports stimulated platelet function and thrombosis.

Gupta N, Li W, Willard B, Silverstein RL, McIntyre TM.

Arterioscler Thromb Vasc Biol. 2014 Jan;34(1):160-8. doi: 10.1161/ATVBAHA.113.302116. Epub 2013 Oct 31.


Lipopolysaccharide stimulates platelets through an IL-1β autocrine loop.

Brown GT, Narayanan P, Li W, Silverstein RL, McIntyre TM.

J Immunol. 2013 Nov 15;191(10):5196-203. doi: 10.4049/jimmunol.1300354. Epub 2013 Sep 30.


Thrombospondin-1 triggers macrophage IL-10 production and promotes resolution of experimental lung injury.

Zhao Y, Xiong Z, Lechner EJ, Klenotic PA, Hamburg BJ, Hulver M, Khare A, Oriss T, Mangalmurti N, Chan Y, Zhang Y, Ross MA, Stolz DB, Rosengart MR, Pilewski J, Ray P, Ray A, Silverstein RL, Lee JS.

Mucosal Immunol. 2014 Mar;7(2):440-8. doi: 10.1038/mi.2013.63. Epub 2013 Sep 18.


Thrombospondin-1 modulates VEGF signaling via CD36 by recruiting SHP-1 to VEGFR2 complex in microvascular endothelial cells.

Chu LY, Ramakrishnan DP, Silverstein RL.

Blood. 2013 Sep 5;122(10):1822-32. doi: 10.1182/blood-2013-01-482315. Epub 2013 Jul 29.


Vav Guanine nucleotide exchange factors regulate atherosclerotic lesion development in mice.

Rahaman SO, Li W, Silverstein RL.

Arterioscler Thromb Vasc Biol. 2013 Sep;33(9):2053-7. doi: 10.1161/ATVBAHA.113.301414. Epub 2013 Jul 3.


Nicotine potentiates proatherogenic effects of oxLDL by stimulating and upregulating macrophage CD36 signaling.

Zhou MS, Chadipiralla K, Mendez AJ, Jaimes EA, Silverstein RL, Webster K, Raij L.

Am J Physiol Heart Circ Physiol. 2013 Aug 15;305(4):H563-74. doi: 10.1152/ajpheart.00042.2013. Epub 2013 Jun 7.


Molecular basis of antiangiogenic thrombospondin-1 type 1 repeat domain interactions with CD36.

Klenotic PA, Page RC, Li W, Amick J, Misra S, Silverstein RL.

Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1655-62. doi: 10.1161/ATVBAHA.113.301523. Epub 2013 May 2.


Loci influencing blood pressure identified using a cardiovascular gene-centric array.

Ganesh SK, Tragante V, Guo W, Guo Y, Lanktree MB, Smith EN, Johnson T, Castillo BA, Barnard J, Baumert J, Chang YP, Elbers CC, Farrall M, Fischer ME, Franceschini N, Gaunt TR, Gho JM, Gieger C, Gong Y, Isaacs A, Kleber ME, Mateo Leach I, McDonough CW, Meijs MF, Mellander O, Molony CM, Nolte IM, Padmanabhan S, Price TS, Rajagopalan R, Shaffer J, Shah S, Shen H, Soranzo N, van der Most PJ, Van Iperen EP, Van Setten J, Vonk JM, Zhang L, Beitelshees AL, Berenson GS, Bhatt DL, Boer JM, Boerwinkle E, Burkley B, Burt A, Chakravarti A, Chen W, Cooper-Dehoff RM, Curtis SP, Dreisbach A, Duggan D, Ehret GB, Fabsitz RR, Fornage M, Fox E, Furlong CE, Gansevoort RT, Hofker MH, Hovingh GK, Kirkland SA, Kottke-Marchant K, Kutlar A, Lacroix AZ, Langaee TY, Li YR, Lin H, Liu K, Maiwald S, Malik R; CARDIOGRAM, METASTROKE, Murugesan G, Newton-Cheh C, O'Connell JR, Onland-Moret NC, Ouwehand WH, Palmas W, Penninx BW, Pepine CJ, Pettinger M, Polak JF, Ramachandran VS, Ranchalis J, Redline S, Ridker PM, Rose LM, Scharnag H, Schork NJ, Shimbo D, Shuldiner AR, Srinivasan SR, Stolk RP, Taylor HA, Thorand B, Trip MD, van Duijn CM, Verschuren WM, Wijmenga C, Winkelmann BR, Wyatt S, Young JH, Boehm BO, Caulfield MJ, Chasman DI, Davidson KW, Doevendans PA, Fitzgerald GA, Gums JG, Hakonarson H, Hillege HL, Illig T, Jarvik GP, Johnson JA, Kastelein JJ, Koenig W; LifeLines Cohort Study, März W, Mitchell BD, Murray SS, Oldehinkel AJ, Rader DJ, Reilly MP, Reiner AP, Schadt EE, Silverstein RL, Snieder H, Stanton AV, Uitterlinden AG, van der Harst P, van der Schouw YT, Samani NJ, Johnson AD, Munroe PB, de Bakker PI, Zhu X, Levy D, Keating BJ, Asselbergs FW.

Hum Mol Genet. 2013 Apr 15;22(8):1663-78. doi: 10.1093/hmg/dds555. Epub 2013 Jan 8. Erratum in: Hum Mol Genet. 2013 Aug 15;22(16):3394-5. Van Setten, Jessic A [corrected to Van Setten, Jessica].


Ferric chloride-induced murine carotid arterial injury: A model of redox pathology.

Li W, McIntyre TM, Silverstein RL.

Redox Biol. 2013 Jan 26;1:50-5. doi: 10.1016/j.redox.2012.11.001. eCollection 2013.


CD36 and Na/K-ATPase-α1 form a proinflammatory signaling loop in kidney.

Kennedy DJ, Chen Y, Huang W, Viterna J, Liu J, Westfall K, Tian J, Bartlett DJ, Tang WH, Xie Z, Shapiro JI, Silverstein RL.

Hypertension. 2013 Jan;61(1):216-24. doi: 10.1161/HYPERTENSIONAHA.112.198770. Epub 2012 Nov 19.


Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

Asselbergs FW, Guo Y, van Iperen EP, Sivapalaratnam S, Tragante V, Lanktree MB, Lange LA, Almoguera B, Appelman YE, Barnard J, Baumert J, Beitelshees AL, Bhangale TR, Chen YD, Gaunt TR, Gong Y, Hopewell JC, Johnson T, Kleber ME, Langaee TY, Li M, Li YR, Liu K, McDonough CW, Meijs MF, Middelberg RP, Musunuru K, Nelson CP, O'Connell JR, Padmanabhan S, Pankow JS, Pankratz N, Rafelt S, Rajagopalan R, Romaine SP, Schork NJ, Shaffer J, Shen H, Smith EN, Tischfield SE, van der Most PJ, van Vliet-Ostaptchouk JV, Verweij N, Volcik KA, Zhang L, Bailey KR, Bailey KM, Bauer F, Boer JM, Braund PS, Burt A, Burton PR, Buxbaum SG, Chen W, Cooper-Dehoff RM, Cupples LA, deJong JS, Delles C, Duggan D, Fornage M, Furlong CE, Glazer N, Gums JG, Hastie C, Holmes MV, Illig T, Kirkland SA, Kivimaki M, Klein R, Klein BE, Kooperberg C, Kottke-Marchant K, Kumari M, LaCroix AZ, Mallela L, Murugesan G, Ordovas J, Ouwehand WH, Post WS, Saxena R, Scharnagl H, Schreiner PJ, Shah T, Shields DC, Shimbo D, Srinivasan SR, Stolk RP, Swerdlow DI, Taylor HA Jr, Topol EJ, Toskala E, van Pelt JL, van Setten J, Yusuf S, Whittaker JC, Zwinderman AH; LifeLines Cohort Study, Anand SS, Balmforth AJ, Berenson GS, Bezzina CR, Boehm BO, Boerwinkle E, Casas JP, Caulfield MJ, Clarke R, Connell JM, Cruickshanks KJ, Davidson KW, Day IN, de Bakker PI, Doevendans PA, Dominiczak AF, Hall AS, Hartman CA, Hengstenberg C, Hillege HL, Hofker MH, Humphries SE, Jarvik GP, Johnson JA, Kaess BM, Kathiresan S, Koenig W, Lawlor DA, März W, Melander O, Mitchell BD, Montgomery GW, Munroe PB, Murray SS, Newhouse SJ, Onland-Moret NC, Poulter N, Psaty B, Redline S, Rich SS, Rotter JI, Schunkert H, Sever P, Shuldiner AR, Silverstein RL, Stanton A, Thorand B, Trip MD, Tsai MY, van der Harst P, van der Schoot E, van der Schouw YT, Verschuren WM, Watkins H, Wilde AA, Wolffenbuttel BH, Whitfield JB, Hovingh GK, Ballantyne CM, Wijmenga C, Reilly MP, Martin NG, Wilson JG, Rader DJ, Samani NJ, Reiner AP, Hegele RA, Kastelein JJ, Hingorani AD, Talmud PJ, Hakonarson H, Elbers CC, Keating BJ, Drenos F.

Am J Hum Genet. 2012 Nov 2;91(5):823-38. doi: 10.1016/j.ajhg.2012.08.032. Epub 2012 Oct 11.


Context dependent role of the CD36--thrombospondin--histidine-rich glycoprotein axis in tumor angiogenesis and growth.

Hale JS, Li M, Sinyuk M, Jahnen-Dechent W, Lathia JD, Silverstein RL.

PLoS One. 2012;7(7):e40033. doi: 10.1371/journal.pone.0040033. Epub 2012 Jul 10.


Oxidized LDL/CD36 interaction induces loss of cell polarity and inhibits macrophage locomotion.

Park YM, Drazba JA, Vasanji A, Egelhoff T, Febbraio M, Silverstein RL.

Mol Biol Cell. 2012 Aug;23(16):3057-68. Epub 2012 Jun 20.


P2RY1 and P2RY12 polymorphisms and on-aspirin platelet reactivity in patients with coronary artery disease.

Timur AA, Murugesan G, Zhang L, Aung PP, Barnard J, Wang QK, Gaussem P, Silverstein RL, Bhatt DL, Kottke-Marchant K.

Int J Lab Hematol. 2012 Oct;34(5):473-83. doi: 10.1111/j.1751-553X.2012.01420.x. Epub 2012 May 10.


Insulin promotes macrophage foam cell formation: potential implications in diabetes-related atherosclerosis.

Park YM, R Kashyap S, A Major J, Silverstein RL.

Lab Invest. 2012 Aug;92(8):1171-80. doi: 10.1038/labinvest.2012.74. Epub 2012 Apr 23.


Advanced glycation end products induce a prothrombotic phenotype in mice via interaction with platelet CD36.

Zhu W, Li W, Silverstein RL.

Blood. 2012 Jun 21;119(25):6136-44. doi: 10.1182/blood-2011-10-387506. Epub 2012 Mar 19.


CD36 ectodomain phosphorylation blocks thrombospondin-1 binding: structure-function relationships and regulation by protein kinase C.

Chu LY, Silverstein RL.

Arterioscler Thromb Vasc Biol. 2012 Mar;32(3):760-7. doi: 10.1161/ATVBAHA.111.242511. Epub 2012 Jan 12.


"Refractory" resistant hypertension: new terminology for an old problem.

Ram CV, Silverstein RL.

J Clin Hypertens (Greenwich). 2012 Jan;14(1):5-6. doi: 10.1111/j.1751-7176.2011.00567.x. Epub 2011 Dec 7. No abstract available.


CD9 tetraspanin interacts with CD36 on the surface of macrophages: a possible regulatory influence on uptake of oxidized low density lipoprotein.

Huang W, Febbraio M, Silverstein RL.

PLoS One. 2011;6(12):e29092. doi: 10.1371/journal.pone.0029092. Epub 2011 Dec 21.


Teaching an old dog new tricks: potential antiatherothrombotic use for statins.

Silverstein RL.

J Clin Invest. 2012 Feb;122(2):478-81. doi: 10.1172/JCI61857. Epub 2012 Jan 3.

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