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Zika Virus Production Is Resistant to RNase L Antiviral Activity.

Whelan JN, Li Y, Silverman RH, Weiss SR.

J Virol. 2019 Jul 30;93(16). pii: e00313-19. doi: 10.1128/JVI.00313-19. Print 2019 Aug 15.


OAS-RNase L innate immune pathway mediates the cytotoxicity of a DNA-demethylating drug.

Banerjee S, Gusho E, Gaughan C, Dong B, Gu X, Holvey-Bates E, Talukdar M, Li Y, Weiss SR, Sicheri F, Saunthararajah Y, Stark GR, Silverman RH.

Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):5071-5076. doi: 10.1073/pnas.1815071116. Epub 2019 Feb 27.


Ultrasound Imaging and Measurement of Choroidal Blood Flow.

Urs R, Ketterling JA, Yu ACH, Lloyd HO, Yiu BYS, Silverman RH.

Transl Vis Sci Technol. 2018 Sep 4;7(5):5. doi: 10.1167/tvst.7.5.5. eCollection 2018.


IFNL4-ΔG Allele Is Associated with an Interferon Signature in Tumors and Survival of African-American Men with Prostate Cancer.

Tang W, Wallace TA, Yi M, Magi-Galluzzi C, Dorsey TH, Onabajo OO, Obajemu A, Jordan SV, Loffredo CA, Stephens RM, Silverman RH, Stark GR, Klein EA, Prokunina-Olsson L, Ambs S.

Clin Cancer Res. 2018 Nov 1;24(21):5471-5481. doi: 10.1158/1078-0432.CCR-18-1060. Epub 2018 Jul 16.


Treatment of Macular Degeneration with Sildenafil: Results of a Two-Year Trial.

Coleman DJ, Lee W, Chang S, Silverman RH, Lloyd HO, Daly S, Tsang SH.

Ophthalmologica. 2018;240(1):45-54. doi: 10.1159/000486105. Epub 2018 Apr 25.


Improved High-Frequency Ultrasound Corneal Biometric Accuracy by Micrometer-Resolution Acoustic-Property Maps of the Cornea.

Rohrbach D, Silverman RH, Chun D, Lloyd HO, Urs R, Mamou J.

Transl Vis Sci Technol. 2018 Apr 11;7(2):21. doi: 10.1167/tvst.7.2.21. eCollection 2018 Apr.


A novel mechanism of RNase L inhibition: Theiler's virus L* protein prevents 2-5A from binding to RNase L.

Drappier M, Jha BK, Stone S, Elliott R, Zhang R, Vertommen D, Weiss SR, Silverman RH, Michiels T.

PLoS Pathog. 2018 Apr 13;14(4):e1006989. doi: 10.1371/journal.ppat.1006989. eCollection 2018 Apr.


In Vivo Elasticity Mapping of Posterior Ocular Layers Using Acoustic Radiation Force Optical Coherence Elastography.

Qu Y, He Y, Saidi A, Xin Y, Zhou Y, Zhu J, Ma T, Silverman RH, Minckler DS, Zhou Q, Chen Z.

Invest Ophthalmol Vis Sci. 2018 Jan 1;59(1):455-461. doi: 10.1167/iovs.17-22971.


A frequency-domain non-contact photoacoustic microscope based on an adaptive interferometer.

George D, Lloyd H, Silverman RH, Chitnis PV.

J Biophotonics. 2018 Jun;11(6):e201700278. doi: 10.1002/jbio.201700278. Epub 2018 Feb 26.


High-speed, high-frequency ultrasound, in utero vector-flow imaging of mouse embryos.

Ketterling JA, Aristizábal O, Yiu BYS, Turnbull DH, Phoon CKL, Yu ACH, Silverman RH.

Sci Rep. 2017 Nov 30;7(1):16658. doi: 10.1038/s41598-017-16933-x.


Gene Therapy Restores Mfrp and Corrects Axial Eye Length.

Velez G, Tsang SH, Tsai YT, Hsu CW, Gore A, Abdelhakim AH, Mahajan M, Silverman RH, Sparrow JR, Bassuk AG, Mahajan VB.

Sci Rep. 2017 Nov 23;7(1):16151. doi: 10.1038/s41598-017-16275-8.


Material Properties of Human Ocular Tissue at 7-µm Resolution.

Rohrbach D, Ito K, Lloyd HO, Silverman RH, Yoshida K, Yamaguchi T, Mamou J.

Ultrason Imaging. 2017 Sep;39(5):313-325. doi: 10.1177/0161734617713498. Epub 2017 Jul 5.


Ribonuclease L mediates the cell-lethal phenotype of double-stranded RNA editing enzyme ADAR1 deficiency in a human cell line.

Li Y, Banerjee S, Goldstein SA, Dong B, Gaughan C, Rath S, Donovan J, Korennykh A, Silverman RH, Weiss SR.

Elife. 2017 Mar 31;6. pii: e25687. doi: 10.7554/eLife.25687.


In vivo imaging of ocular blood flow using high-speed ultrasound.

Ketterling JA, Urs R, Silverman RH.

IEEE Int Ultrason Symp. 2016 Sep;2016. doi: 10.1109/ULTSYM.2016.7728578. Epub 2016 Nov 3.


Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication.

Kindler E, Gil-Cruz C, Spanier J, Li Y, Wilhelm J, Rabouw HH, Züst R, Hwang M, V'kovski P, Stalder H, Marti S, Habjan M, Cervantes-Barragan L, Elliot R, Karl N, Gaughan C, van Kuppeveld FJ, Silverman RH, Keller M, Ludewig B, Bergmann CC, Ziebuhr J, Weiss SR, Kalinke U, Thiel V.

PLoS Pathog. 2017 Feb 3;13(2):e1006195. doi: 10.1371/journal.ppat.1006195. eCollection 2017 Feb.


Lineage A Betacoronavirus NS2 Proteins and the Homologous Torovirus Berne pp1a Carboxy-Terminal Domain Are Phosphodiesterases That Antagonize Activation of RNase L.

Goldstein SA, Thornbrough JM, Zhang R, Jha BK, Li Y, Elliott R, Quiroz-Figueroa K, Chen AI, Silverman RH, Weiss SR.

J Virol. 2017 Feb 14;91(5). pii: e02201-16. doi: 10.1128/JVI.02201-16. Print 2017 Mar 1.


Combined tomography and epithelial thickness mapping for diagnosis of keratoconus.

Silverman RH, Urs R, RoyChoudhury A, Archer TJ, Gobbe M, Reinstein DZ.

Eur J Ophthalmol. 2017 Mar 10;27(2):129-134. doi: 10.5301/ejo.5000850. Epub 2016 Aug 8.


Focused ultrasound in ophthalmology.

Silverman RH.

Clin Ophthalmol. 2016 Sep 27;10:1865-1875. eCollection 2016. Review.


Ultrafast Ultrasound Imaging of Ocular Anatomy and Blood Flow.

Urs R, Ketterling JA, Silverman RH.

Invest Ophthalmol Vis Sci. 2016 Jul 1;57(8):3810-6. doi: 10.1167/iovs.16-19538.


A Novel Quantitative 500-MHz Acoustic Microscopy System for Ophthalmologic Tissues.

Rohrbach D, Jakob A, Lloyd HO, Tretbar SH, Silverman RH, Mamou J.

IEEE Trans Biomed Eng. 2017 Mar;64(3):715-724. doi: 10.1109/TBME.2016.2573682. Epub 2016 May 26.


Middle East Respiratory Syndrome Coronavirus NS4b Protein Inhibits Host RNase L Activation.

Thornbrough JM, Jha BK, Yount B, Goldstein SA, Li Y, Elliott R, Sims AC, Baric RS, Silverman RH, Weiss SR.

MBio. 2016 Mar 29;7(2):e00258. doi: 10.1128/mBio.00258-16.


Comparison of very-high-frequency ultrasound and spectral-domain optical coherence tomography corneal and epithelial thickness maps.

Urs R, Lloyd HO, Reinstein DZ, Silverman RH.

J Cataract Refract Surg. 2016 Jan;42(1):95-101. doi: 10.1016/j.jcrs.2015.07.038.


Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses.

Li Y, Banerjee S, Wang Y, Goldstein SA, Dong B, Gaughan C, Silverman RH, Weiss SR.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2241-6. doi: 10.1073/pnas.1519657113. Epub 2016 Feb 8. Erratum in: Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12573.


Crystal structure of the mouse hepatitis virus ns2 phosphodiesterase domain that antagonizes RNase L activation.

Sui B, Huang J, Jha BK, Yin P, Zhou M, Fu ZF, Silverman RH, Weiss SR, Peng G, Zhao L.

J Gen Virol. 2016 Apr;97(4):880-6. doi: 10.1099/jgv.0.000395. Epub 2016 Jan 11.


Activation of RNase L by Murine Coronavirus in Myeloid Cells Is Dependent on Basal Oas Gene Expression and Independent of Virus-Induced Interferon.

Birdwell LD, Zalinger ZB, Li Y, Wright PW, Elliott R, Rose KM, Silverman RH, Weiss SR.

J Virol. 2016 Jan 6;90(6):3160-72. doi: 10.1128/JVI.03036-15.


Detection of Keratoconus in Clinically and Algorithmically Topographically Normal Fellow Eyes Using Epithelial Thickness Analysis.

Reinstein DZ, Archer TJ, Urs R, Gobbe M, RoyChoudhury A, Silverman RH.

J Refract Surg. 2015 Nov;31(11):736-44. doi: 10.3928/1081597X-20151021-02.


RNase L is a negative regulator of cell migration.

Banerjee S, Li G, Li Y, Gaughan C, Baskar D, Parker Y, Lindner DJ, Weiss SR, Silverman RH.

Oncotarget. 2015 Dec 29;6(42):44360-72. doi: 10.18632/oncotarget.6246.


No Evidence for Association of SCO2 Heterozygosity with High-Grade Myopia or Other Diseases with Possible Mitochondrial Dysfunction.

Piekutowska-Abramczuk D, Kocyła-Karczmarewicz B, Małkowska M, Łuczak S, Iwanicka-Pronicka K, Siegmund S, Yang H, Wen Q, Hoang QV, Silverman RH, Kowalski P, Szczypińska O, Czornak K, Zimowski J, Płoski R, Pilch J, Ciara E, Zaremba J, Krajewska-Walasek M, Schon EA, Pronicka E.

JIMD Rep. 2016;27:63-8. doi: 10.1007/8904_2015_468. Epub 2015 Oct 2.


Comparison of Corneal Epithelial Thickness Measurement Between Fourier-Domain OCT and Very High-Frequency Digital Ultrasound.

Reinstein DZ, Yap TE, Archer TJ, Gobbe M, Silverman RH.

J Refract Surg. 2015 Jul;31(7):438-45. doi: 10.3928/1081597X-20150623-01.


Fine-resolution maps of acoustic properties at 250 MHz of unstained fixed murine retinal layers.

Rohrbach D, Lloyd HO, Silverman RH, Mamou J.

J Acoust Soc Am. 2015 May;137(5):EL381-7. doi: 10.1121/1.4916790.


Structural basis for 2'-5'-oligoadenylate binding and enzyme activity of a viral RNase L antagonist.

Ogden KM, Hu L, Jha BK, Sankaran B, Weiss SR, Silverman RH, Patton JT, Prasad BV.

J Virol. 2015 Jul;89(13):6633-45.


RNase L activates the NLRP3 inflammasome during viral infections.

Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Núñez G, Silverman RH.

Cell Host Microbe. 2015 Apr 8;17(4):466-77. doi: 10.1016/j.chom.2015.02.010. Epub 2015 Mar 26.


Caps off to poxviruses.

Silverman RH.

Cell Host Microbe. 2015 Mar 11;17(3):287-289. doi: 10.1016/j.chom.2015.02.013.


Ultrasound-based quantification of vitreous floaters correlates with contrast sensitivity and quality of life.

Mamou J, Wa CA, Yee KM, Silverman RH, Ketterling JA, Sadun AA, Sebag J.

Invest Ophthalmol Vis Sci. 2015 Jan 22;56(3):1611-7. doi: 10.1167/iovs.14-15414.


RNase L targets distinct sites in influenza A virus RNAs.

Cooper DA, Banerjee S, Chakrabarti A, García-Sastre A, Hesselberth JR, Silverman RH, Barton DJ.

J Virol. 2015 Mar;89(5):2764-76. doi: 10.1128/JVI.02953-14. Epub 2014 Dec 24.


Cytosolic double-stranded RNA activates the NLRP3 inflammasome via MAVS-induced membrane permeabilization and K+ efflux.

Franchi L, Eigenbrod T, Muñoz-Planillo R, Ozkurede U, Kim YG, Arindam C, Gale M Jr, Silverman RH, Colonna M, Akira S, Núñez G.

J Immunol. 2014 Oct 15;193(8):4214-4222. doi: 10.4049/jimmunol.1400582. Epub 2014 Sep 15.


Acoustic radiation force for noninvasive evaluation of corneal biomechanical changes induced by cross-linking therapy.

Urs R, Lloyd HO, Silverman RH.

J Ultrasound Med. 2014 Aug;33(8):1417-26. doi: 10.7863/ultra.33.8.1417.


Murine AKAP7 has a 2',5'-phosphodiesterase domain that can complement an inactive murine coronavirus ns2 gene.

Gusho E, Zhang R, Jha BK, Thornbrough JM, Dong B, Gaughan C, Elliott R, Weiss SR, Silverman RH.

MBio. 2014 Jul 1;5(4):e01312-14. doi: 10.1128/mBio.01312-14.


Viral phosphodiesterases that antagonize double-stranded RNA signaling to RNase L by degrading 2-5A.

Silverman RH, Weiss SR.

J Interferon Cytokine Res. 2014 Jun;34(6):455-63. doi: 10.1089/jir.2014.0007. Review.


Cell-type-specific effects of RNase L on viral induction of beta interferon.

Banerjee S, Chakrabarti A, Jha BK, Weiss SR, Silverman RH.

MBio. 2014 Feb 25;5(2):e00856-14. doi: 10.1128/mBio.00856-14.


Epithelial remodeling as basis for machine-based identification of keratoconus.

Silverman RH, Urs R, Roychoudhury A, Archer TJ, Gobbe M, Reinstein DZ.

Invest Ophthalmol Vis Sci. 2014 Mar 13;55(3):1580-7. doi: 10.1167/iovs.13-12578.


Ribonuclease L and metal-ion-independent endoribonuclease cleavage sites in host and viral RNAs.

Cooper DA, Jha BK, Silverman RH, Hesselberth JR, Barton DJ.

Nucleic Acids Res. 2014 Apr;42(8):5202-16. doi: 10.1093/nar/gku118. Epub 2014 Feb 5.


Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity.

Huang H, Zeqiraj E, Dong B, Jha BK, Duffy NM, Orlicky S, Thevakumaran N, Talukdar M, Pillon MC, Ceccarelli DF, Wan LC, Juang YC, Mao DY, Gaughan C, Brinton MA, Perelygin AA, Kourinov I, Guarné A, Silverman RH, Sicheri F.

Mol Cell. 2014 Jan 23;53(2):221-34. doi: 10.1016/j.molcel.2013.12.025.


RNase L restricts the mobility of engineered retrotransposons in cultured human cells.

Zhang A, Dong B, Doucet AJ, Moldovan JB, Moran JV, Silverman RH.

Nucleic Acids Res. 2014 Apr;42(6):3803-20. doi: 10.1093/nar/gkt1308. Epub 2013 Dec 25.


Role of ribonuclease L in viral pathogen-associated molecular pattern/influenza virus and cigarette smoke-induced inflammation and remodeling.

Zhou Y, Kang MJ, Jha BK, Silverman RH, Lee CG, Elias JA.

J Immunol. 2013 Sep 1;191(5):2637-46. doi: 10.4049/jimmunol.1300082. Epub 2013 Aug 2.


Homologous 2',5'-phosphodiesterases from disparate RNA viruses antagonize antiviral innate immunity.

Zhang R, Jha BK, Ogden KM, Dong B, Zhao L, Elliott R, Patton JT, Silverman RH, Weiss SR.

Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13114-9. doi: 10.1073/pnas.1306917110. Epub 2013 Jul 22.


Evasion of antiviral innate immunity by Theiler's virus L* protein through direct inhibition of RNase L.

Sorgeloos F, Jha BK, Silverman RH, Michiels T.

PLoS Pathog. 2013;9(6):e1003474. doi: 10.1371/journal.ppat.1003474. Epub 2013 Jun 27.


Potential pitfalls in measuring the thickness of small choroidal melanocytic tumors with ultrasonography.

Mrejen S, Fung AT, Silverman RH, Kendall C, Freund KB.

Retina. 2013 Jul-Aug;33(7):1293-9. doi: 10.1097/IAE.0b013e318296f681. No abstract available.


Age-related macular degeneration: choroidal ischaemia?

Coleman DJ, Silverman RH, Rondeau MJ, Lloyd HO, Khanifar AA, Chan RV.

Br J Ophthalmol. 2013 Aug;97(8):1020-3. doi: 10.1136/bjophthalmol-2013-303143. Epub 2013 Jun 5.


Suppression of antiviral innate immunity by sunitinib enhances oncolytic virotherapy.

Jha BK, Dong B, Nguyen CT, Polyakova I, Silverman RH.

Mol Ther. 2013 Sep;21(9):1749-57. doi: 10.1038/mt.2013.112. Epub 2013 Jun 4.

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