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Items: 1 to 50 of 67

1.

Translational outcomes in a full gene deletion of ubiquitin protein ligase E3A rat model of Angelman syndrome.

Berg EL, Pride MC, Petkova SP, Lee RD, Copping NA, Shen Y, Adhikari A, Fenton TA, Pedersen LR, Noakes LS, Nieman BJ, Lerch JP, Harris S, Born HA, Peters MM, Deng P, Cameron DL, Fink KD, Beitnere U, O'Geen H, Anderson AE, Dindot SV, Nash KR, Weeber EJ, Wöhr M, Ellegood J, Segal DJ, Silverman JL.

Transl Psychiatry. 2020 Jan 27;10(1):39. doi: 10.1038/s41398-020-0720-2.

PMID:
32066685
2.

Generation of a Novel Rat Model of Angelman Syndrome with a Complete Ube3a Gene Deletion.

Dodge A, Peters MM, Greene HE, Dietrick C, Botelho R, Chung D, Willman J, Nenninger AW, Ciarlone S, Kamath SG, Houdek P, Sumová A, Anderson AE, Dindot SV, Berg EL, O'Geen H, Segal DJ, Silverman JL, Weeber EJ, Nash KR.

Autism Res. 2020 Jan 21. doi: 10.1002/aur.2267. [Epub ahead of print]

PMID:
31961493
3.

Genetic backgrounds have unique seizure response profiles and behavioral outcomes following convulsant administration.

Copping NA, Adhikari A, Petkova SP, Silverman JL.

Epilepsy Behav. 2019 Dec;101(Pt A):106547. doi: 10.1016/j.yebeh.2019.106547. Epub 2019 Nov 4.

PMID:
31698263
4.

Imprinting effects of UBE3A loss on synaptic gene networks and Wnt signaling pathways.

Lopez SJ, Laufer BI, Beitnere U, Berg EL, Silverman JL, O'Geen H, Segal DJ, LaSalle JM.

Hum Mol Genet. 2019 Nov 15;28(22):3842-3852. doi: 10.1093/hmg/ddz221.

PMID:
31625566
5.

Pathogenic WDFY3 variants cause neurodevelopmental disorders and opposing effects on brain size.

Le Duc D, Giulivi C, Hiatt SM, Napoli E, Panoutsopoulos A, Harlan De Crescenzo A, Kotzaeridou U, Syrbe S, Anagnostou E, Azage M, Bend R, Begtrup A, Brown NJ, Büttner B, Cho MT, Cooper GM, Doering JH, Dubourg C, Everman DB, Hildebrand MS, Santos FJR, Kellam B, Keller-Ramey J, Lemke JR, Liu S, Niyazov D, Payne K, Person R, Quélin C, Schnur RE, Smith BT, Strober J, Walker S, Wallis M, Walsh L, Yang S, Yuen RKC, Ziegler A, Sticht H, Pride MC, Orosco L, Martínez-Cerdeño V, Silverman JL, Crawley JN, Scherer SW, Zarbalis KS, Jamra R.

Brain. 2019 Sep 1;142(9):2617-2630. doi: 10.1093/brain/awz198. Erratum in: Brain. 2019 Nov 1;142(11):e63.

PMID:
31327001
6.

Persistent behavior deficits, neuroinflammation, and oxidative stress in a rat model of acute organophosphate intoxication.

Guignet M, Dhakal K, Flannery BM, Hobson BA, Zolkowska D, Dhir A, Bruun DA, Li S, Wahab A, Harvey DJ, Silverman JL, Rogawski MA, Lein PJ.

Neurobiol Dis. 2020 Jan;133:104431. doi: 10.1016/j.nbd.2019.03.019. Epub 2019 Mar 21. Review.

7.

Genetic mutations in Ca2+ signaling alter dendrite morphology and social approach in juvenile mice.

Keil KP, Sethi S, Wilson MD, Silverman JL, Pessah IN, Lein PJ.

Genes Brain Behav. 2019 Jan;18(1):e12526. doi: 10.1111/gbb.12526. Epub 2018 Nov 6.

8.

Autism-specific maternal autoantibodies produce behavioral abnormalities in an endogenous antigen-driven mouse model of autism.

Jones KL, Pride MC, Edmiston E, Yang M, Silverman JL, Crawley JN, Van de Water J.

Mol Psychiatry. 2018 Jun 28. doi: 10.1038/s41380-018-0126-1. [Epub ahead of print]

9.

Cognitive deficits in the Snord116 deletion mouse model for Prader-Willi syndrome.

Adhikari A, Copping NA, Onaga B, Pride MC, Coulson RL, Yang M, Yasui DH, LaSalle JM, Silverman JL.

Neurobiol Learn Mem. 2019 Nov;165:106874. doi: 10.1016/j.nlm.2018.05.011. Epub 2018 May 23. Review.

10.

Autistic traits in epilepsy models: Why, when and how?

Velíšková J, Silverman JL, Benson M, Lenck-Santini PP.

Epilepsy Res. 2018 Aug;144:62-70. doi: 10.1016/j.eplepsyres.2018.05.009. Epub 2018 May 18. Review.

11.

Behavioral and neuroanatomical approaches in models of neurodevelopmental disorders: opportunities for translation.

Silverman JL, Ellegood J.

Curr Opin Neurol. 2018 Apr;31(2):126-133. doi: 10.1097/WCO.0000000000000537. Review.

12.

Sex Differences in the Effects of a Kappa Opioid Receptor Antagonist in the Forced Swim Test.

Laman-Maharg A, Williams AV, Zufelt MD, Minie VA, Ramos-Maciel S, Hao R, Ordoñes Sanchez E, Copeland T, Silverman JL, Leigh A, Snyder R, Carroll FI, Fennell TR, Trainor BC.

Front Pharmacol. 2018 Feb 14;9:93. doi: 10.3389/fphar.2018.00093. eCollection 2018.

13.

SynDIG4/Prrt1 Is Required for Excitatory Synapse Development and Plasticity Underlying Cognitive Function.

Matt L, Kirk LM, Chenaux G, Speca DJ, Puhger KR, Pride MC, Qneibi M, Haham T, Plambeck KE, Stern-Bach Y, Silverman JL, Crawley JN, Hell JW, Díaz E.

Cell Rep. 2018 Feb 27;22(9):2246-2253. doi: 10.1016/j.celrep.2018.02.026.

14.

Developmental social communication deficits in the Shank3 rat model of phelan-mcdermid syndrome and autism spectrum disorder.

Berg EL, Copping NA, Rivera JK, Pride MC, Careaga M, Bauman MD, Berman RF, Lein PJ, Harony-Nicolas H, Buxbaum JD, Ellegood J, Lerch JP, Wöhr M, Silverman JL.

Autism Res. 2018 Apr;11(4):587-601. doi: 10.1002/aur.1925. Epub 2018 Jan 29.

15.

mGluR5 Modulation of Behavioral and Epileptic Phenotypes in a Mouse Model of Tuberous Sclerosis Complex.

Kelly E, Schaeffer SM, Dhamne SC, Lipton JO, Lindemann L, Honer M, Jaeschke G, Super CE, Lammers SH, Modi ME, Silverman JL, Dreier JR, Kwiatkowski DJ, Rotenberg A, Sahin M.

Neuropsychopharmacology. 2018 May;43(6):1457-1465. doi: 10.1038/npp.2017.295. Epub 2017 Dec 5.

16.

Neuronal overexpression of Ube3a isoform 2 causes behavioral impairments and neuroanatomical pathology relevant to 15q11.2-q13.3 duplication syndrome.

Copping NA, Christian SGB, Ritter DJ, Islam MS, Buscher N, Zolkowska D, Pride MC, Berg EL, LaSalle JM, Ellegood J, Lerch JP, Reiter LT, Silverman JL, Dindot SV.

Hum Mol Genet. 2017 Oct 15;26(20):3995-4010. doi: 10.1093/hmg/ddx289.

17.

Germline Chd8 haploinsufficiency alters brain development in mouse.

Gompers AL, Su-Feher L, Ellegood J, Copping NA, Riyadh MA, Stradleigh TW, Pride MC, Schaffler MD, Wade AA, Catta-Preta R, Zdilar I, Louis S, Kaushik G, Mannion BJ, Plajzer-Frick I, Afzal V, Visel A, Pennacchio LA, Dickel DE, Lerch JP, Crawley JN, Zarbalis KS, Silverman JL, Nord AS.

Nat Neurosci. 2017 Aug;20(8):1062-1073. doi: 10.1038/nn.4592. Epub 2017 Jun 26.

18.

Replicable in vivo physiological and behavioral phenotypes of the Shank3B null mutant mouse model of autism.

Dhamne SC, Silverman JL, Super CE, Lammers SHT, Hameed MQ, Modi ME, Copping NA, Pride MC, Smith DG, Rotenberg A, Crawley JN, Sahin M.

Mol Autism. 2017 Jun 15;8:26. doi: 10.1186/s13229-017-0142-z. eCollection 2017.

19.

Methodological Considerations for Optimizing and Validating Behavioral Assays.

Sukoff Rizzo SJ, Silverman JL.

Curr Protoc Mouse Biol. 2016 Dec 1;6(4):364-379. doi: 10.1002/cpmo.17.

20.

Persistent neuroinflammation and cognitive impairment in a rat model of acute diisopropylfluorophosphate intoxication.

Flannery BM, Bruun DA, Rowland DJ, Banks CN, Austin AT, Kukis DL, Li Y, Ford BD, Tancredi DJ, Silverman JL, Cherry SR, Lein PJ.

J Neuroinflammation. 2016 Oct 12;13(1):267.

21.

Behavioral Phenotyping of Juvenile Long-Evans and Sprague-Dawley Rats: Implications for Preclinical Models of Autism Spectrum Disorders.

Ku KM, Weir RK, Silverman JL, Berman RF, Bauman MD.

PLoS One. 2016 Jun 28;11(6):e0158150. doi: 10.1371/journal.pone.0158150. eCollection 2016.

22.

Translational Mouse Models of Autism: Advancing Toward Pharmacological Therapeutics.

Kazdoba TM, Leach PT, Yang M, Silverman JL, Solomon M, Crawley JN.

Curr Top Behav Neurosci. 2016;28:1-52. doi: 10.1007/7854_2015_5003. Review.

23.

Touchscreen learning deficits and normal social approach behavior in the Shank3B model of Phelan-McDermid Syndrome and autism.

Copping NA, Berg EL, Foley GM, Schaffler MD, Onaga BL, Buscher N, Silverman JL, Yang M.

Neuroscience. 2017 Mar 14;345:155-165. doi: 10.1016/j.neuroscience.2016.05.016. Epub 2016 May 14.

24.

Normal Performance of Fmr1 Mice on a Touchscreen Delayed Nonmatching to Position Working Memory Task.

Leach PT, Hayes J, Pride M, Silverman JL, Crawley JN.

eNeuro. 2016 Mar 15;3(1). pii: ENEURO.0143-15.2016. doi: 10.1523/ENEURO.0143-15.2016. eCollection 2016 Jan-Feb.

25.

Hippocampal Transcriptomic and Proteomic Alterations in the BTBR Mouse Model of Autism Spectrum Disorder.

Daimon CM, Jasien JM, Wood WH 3rd, Zhang Y, Becker KG, Silverman JL, Crawley JN, Martin B, Maudsley S.

Front Physiol. 2015 Nov 24;6:324. doi: 10.3389/fphys.2015.00324. eCollection 2015.

26.

GABAB Receptor Agonist R-Baclofen Reverses Social Deficits and Reduces Repetitive Behavior in Two Mouse Models of Autism.

Silverman JL, Pride MC, Hayes JE, Puhger KR, Butler-Struben HM, Baker S, Crawley JN.

Neuropsychopharmacology. 2015 Aug;40(9):2228-39. doi: 10.1038/npp.2015.66. Epub 2015 Mar 10.

27.

Modeling fragile X syndrome in the Fmr1 knockout mouse.

Kazdoba TM, Leach PT, Silverman JL, Crawley JN.

Intractable Rare Dis Res. 2014 Nov;3(4):118-33. doi: 10.5582/irdr.2014.01024. Review.

28.

Behavioral assessment of NIH Swiss mice acutely intoxicated with tetramethylenedisulfotetramine.

Flannery BM, Silverman JL, Bruun DA, Puhger KR, McCoy MR, Hammock BD, Crawley JN, Lein PJ.

Neurotoxicol Teratol. 2015 Jan-Feb;47:36-45. doi: 10.1016/j.ntt.2014.10.008. Epub 2014 Nov 8.

29.

Long-term exposure to intranasal oxytocin in a mouse autism model.

Bales KL, Solomon M, Jacob S, Crawley JN, Silverman JL, Larke RH, Sahagun E, Puhger KR, Pride MC, Mendoza SP.

Transl Psychiatry. 2014 Nov 11;4:e480. doi: 10.1038/tp.2014.117.

30.

Chronic desipramine treatment rescues depression-related, social and cognitive deficits in Engrailed-2 knockout mice.

Brielmaier J, Senerth JM, Silverman JL, Matteson PG, Millonig JH, DiCicco-Bloom E, Crawley JN.

Genes Brain Behav. 2014 Mar;13(3):286-298.

31.

The promising trajectory of autism therapeutics discovery.

Silverman JL, Crawley JN.

Drug Discov Today. 2014 Jul;19(7):838-44. doi: 10.1016/j.drudis.2013.12.007. Epub 2013 Dec 18. Review.

PMID:
24362109
32.

Cognitive abilities on transitive inference using a novel touchscreen technology for mice.

Silverman JL, Gastrell PT, Karras MN, Solomon M, Crawley JN.

Cereb Cortex. 2015 May;25(5):1133-42. doi: 10.1093/cercor/bht293. Epub 2013 Nov 28.

33.

Mutations in the cytoplasmic tail of herpes simplex virus 1 gH reduce the fusogenicity of gB in transfected cells.

Silverman JL, Heldwein EE.

J Virol. 2013 Sep;87(18):10139-47. doi: 10.1128/JVI.01760-13. Epub 2013 Jul 10.

34.

Absence of deficits in social behaviors and ultrasonic vocalizations in later generations of mice lacking neuroligin4.

Ey E, Yang M, Katz AM, Woldeyohannes L, Silverman JL, Leblond CS, Faure P, Torquet N, Le Sourd AM, Bourgeron T, Crawley JN.

Genes Brain Behav. 2012 Nov;11(8):928-941. doi: 10.1111/j.1601-183X.2012.00849.x. Epub 2012 Oct 10.

35.

Influence of stimulant-induced hyperactivity on social approach in the BTBR mouse model of autism.

Silverman JL, Babineau BA, Oliver CF, Karras MN, Crawley JN.

Neuropharmacology. 2013 May;68:210-22. doi: 10.1016/j.neuropharm.2012.07.042. Epub 2012 Aug 8.

36.

Autism-relevant social abnormalities and cognitive deficits in engrailed-2 knockout mice.

Brielmaier J, Matteson PG, Silverman JL, Senerth JM, Kelly S, Genestine M, Millonig JH, DiCicco-Bloom E, Crawley JN.

PLoS One. 2012;7(7):e40914. doi: 10.1371/journal.pone.0040914. Epub 2012 Jul 19.

37.

Developmental delays and reduced pup ultrasonic vocalizations but normal sociability in mice lacking the postsynaptic cell adhesion protein neuroligin2.

Wöhr M, Silverman JL, Scattoni ML, Turner SM, Harris MJ, Saxena R, Crawley JN.

Behav Brain Res. 2013 Aug 15;251:50-64. doi: 10.1016/j.bbr.2012.07.024. Epub 2012 Jul 20.

38.

AMPAKINE enhancement of social interaction in the BTBR mouse model of autism.

Silverman JL, Oliver CF, Karras MN, Gastrell PT, Crawley JN.

Neuropharmacology. 2013 Jan;64:268-82. doi: 10.1016/j.neuropharm.2012.07.013. Epub 2012 Jul 16.

39.

Membrane requirement for folding of the herpes simplex virus 1 gB cytodomain suggests a unique mechanism of fusion regulation.

Silverman JL, Greene NG, King DS, Heldwein EE.

J Virol. 2012 Aug;86(15):8171-84. doi: 10.1128/JVI.00932-12. Epub 2012 May 23.

40.

Reduced excitatory neurotransmission and mild autism-relevant phenotypes in adolescent Shank3 null mutant mice.

Yang M, Bozdagi O, Scattoni ML, Wöhr M, Roullet FI, Katz AM, Abrams DN, Kalikhman D, Simon H, Woldeyohannes L, Zhang JY, Harris MJ, Saxena R, Silverman JL, Buxbaum JD, Crawley JN.

J Neurosci. 2012 May 9;32(19):6525-41. doi: 10.1523/JNEUROSCI.6107-11.2012.

41.

Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism.

Silverman JL, Smith DG, Rizzo SJ, Karras MN, Turner SM, Tolu SS, Bryce DK, Smith DL, Fonseca K, Ring RH, Crawley JN.

Sci Transl Med. 2012 Apr 25;4(131):131ra51. doi: 10.1126/scitranslmed.3003501.

42.

Low sociability in BTBR T+tf/J mice is independent of partner strain.

Yang M, Abrams DN, Zhang JY, Weber MD, Katz AM, Clarke AM, Silverman JL, Crawley JN.

Physiol Behav. 2012 Dec 5;107(5):649-62. doi: 10.1016/j.physbeh.2011.12.025. Epub 2012 Jan 8.

43.

Working memory deficits, increased anxiety-like traits, and seizure susceptibility in BDNF overexpressing mice.

Papaleo F, Silverman JL, Aney J, Tian Q, Barkan CL, Chadman KK, Crawley JN.

Learn Mem. 2011 Jul 26;18(8):534-44. doi: 10.1101/lm.2213711. Print 2011 Aug.

44.

Automated three-chambered social approach task for mice.

Yang M, Silverman JL, Crawley JN.

Curr Protoc Neurosci. 2011 Jul;Chapter 8:Unit 8.26. doi: 10.1002/0471142301.ns0826s56.

45.

Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication.

Bozdagi O, Sakurai T, Papapetrou D, Wang X, Dickstein DL, Takahashi N, Kajiwara Y, Yang M, Katz AM, Scattoni ML, Harris MJ, Saxena R, Silverman JL, Crawley JN, Zhou Q, Hof PR, Buxbaum JD.

Mol Autism. 2010 Dec 17;1(1):15. doi: 10.1186/2040-2392-1-15.

46.

Low stress reactivity and neuroendocrine factors in the BTBR T+tf/J mouse model of autism.

Silverman JL, Yang M, Turner SM, Katz AM, Bell DB, Koenig JI, Crawley JN.

Neuroscience. 2010 Dec 29;171(4):1197-208. doi: 10.1016/j.neuroscience.2010.09.059. Epub 2010 Oct 1.

47.

Sociability and motor functions in Shank1 mutant mice.

Silverman JL, Turner SM, Barkan CL, Tolu SS, Saxena R, Hung AY, Sheng M, Crawley JN.

Brain Res. 2011 Mar 22;1380:120-37. doi: 10.1016/j.brainres.2010.09.026. Epub 2010 Sep 21.

48.

Behavioural phenotyping assays for mouse models of autism.

Silverman JL, Yang M, Lord C, Crawley JN.

Nat Rev Neurosci. 2010 Jul;11(7):490-502. doi: 10.1038/nrn2851. Review.

49.

Repetitive self-grooming behavior in the BTBR mouse model of autism is blocked by the mGluR5 antagonist MPEP.

Silverman JL, Tolu SS, Barkan CL, Crawley JN.

Neuropsychopharmacology. 2010 Mar;35(4):976-89. doi: 10.1038/npp.2009.201. Epub 2009 Dec 23.

50.

Fusion-deficient insertion mutants of herpes simplex virus type 1 glycoprotein B adopt the trimeric postfusion conformation.

Silverman JL, Sharma S, Cairns TM, Heldwein EE.

J Virol. 2010 Feb;84(4):2001-12. doi: 10.1128/JVI.01791-09. Epub 2009 Nov 25.

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