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Items: 1 to 50 of 1035

1.

Imaging Advances in Chronic Obstructive Pulmonary Disease: Insights from COPDGene.

Bhatt SP, Washko GR, Hoffman EA, Newell JD Jr, Bodduluri S, Diaz AA, Galban CJ, Silverman EK, San José Estépar R, Lynch DA; COPDGene Investigators.

Am J Respir Crit Care Med. 2018 Oct 10. doi: 10.1164/rccm.201807-1351SO. [Epub ahead of print]

PMID:
30304637
2.

Effect of in utero hydroxychloroquine exposure on the development of cutaneous neonatal lupus erythematosus.

Barsalou J, Costedoat-Chalumeau N, Berhanu A, Fors-Nieves C, Shah U, Brown P, Laskin CA, Morel N, Levesque K, Buyon JP, Silverman ED, Izmirly PM.

Ann Rheum Dis. 2018 Oct 8. pii: annrheumdis-2018-213718. doi: 10.1136/annrheumdis-2018-213718. [Epub ahead of print]

PMID:
30297329
3.

Integration of Molecular Interactome and Targeted Interaction Analysis to Identify a COPD Disease Network Module.

Sharma A, Kitsak M, Cho MH, Ameli A, Zhou X, Jiang Z, Crapo JD, Beaty TH, Menche J, Bakke PS, Santolini M, Silverman EK.

Sci Rep. 2018 Sep 27;8(1):14439. doi: 10.1038/s41598-018-32173-z.

4.

Establishing Surrogate Kidney Endpoints for Lupus Nephritis Clinical Trials: Development and Validation of a Novel Approach to Predict Future Kidney Outcomes.

Mackay M, Dall'Era M, Fishbein J, Kalunian K, Lesser M, Sanchez Guerrero J, Levy DM, Silverman E, Petri M, Arriens C, Lewis EJ, Korbet SM, Conti F, Tesar V, Hruskova Z, Borba EF, Bonfa E, Chan TM, Rathi M, Gupta KL, Jha V, Hasni S, West MR, Silverman E, Solomons N, Houssiau FA, Romera Diaz J, Mejia-Vilet J, Rovin BH.

Arthritis Rheumatol. 2018 Sep 17. doi: 10.1002/art.40724. [Epub ahead of print]

PMID:
30225865
5.

Persistent Disease Activity Remains a Burden for Patients with Systemic Lupus Erythematosus.

Peschken CA, Wang Y, Abrahamowicz M, Pope J, Silverman E, Sayani A, Iczkovitz S, Ross J, Zummer M, Tucker L, Pineau C, Levy D, Hudson M, Hitchon CA, Huber AM, Smith CD, Avina-Zubieta A, Arbillaga H, Chédeville G, Wynant W, Fortin PR; CaNIOS 1000 Faces Investigators.

J Rheumatol. 2018 Sep 15. pii: jrheum.171454. doi: 10.3899/jrheum.171454. [Epub ahead of print]

PMID:
30219771
6.

GWAS and systems biology analysis of depressive symptoms among smokers from the COPDGene cohort.

Heinzman JT, Hoth KF, Cho MH, Sakornsakolpat P, Regan EA, Make BJ, Kinney GL, Wamboldt FS, Holm KE, Bormann N, Robles J, Kim V, Iyer AS, Silverman EK, Crapo JD, Han S, Potash JB, Shinozaki G; COPDGene Investigators.

J Affect Disord. 2019 Jan 15;243:16-22. doi: 10.1016/j.jad.2018.09.003. Epub 2018 Sep 7.

PMID:
30219690
7.

Backlash Against Copay Accumulators.

Silverman E.

Manag Care. 2018 Sep;27(9):15.

8.

Lift Then Shift: Thyrotoxic Periodic Paralysis.

Silverman E, Haber LA, Geha RM.

Am J Med. 2018 Sep 7. pii: S0002-9343(18)30843-X. doi: 10.1016/j.amjmed.2018.08.015. [Epub ahead of print] No abstract available.

PMID:
30201247
9.

Canadian Rheumatology Association Recommendations for the Assessment and Monitoring of Systemic Lupus Erythematosus.

Keeling SO, Alabdurubalnabi Z, Avina-Zubieta A, Barr S, Bergeron L, Bernatsky S, Bourre-Tessier J, Clarke A, Baril-Dionne A, Dutz J, Ensworth S, Fifi-Mah A, Fortin PR, Gladman DD, Haaland D, Hanly JG, Hiraki LT, Hussein S, Legault K, Levy D, Lim L, Matsos M, McDonald EG, Medina-Rosas J, Pardo Pardi J, Peschken C, Pineau C, Pope J, Rader T, Reynolds J, Silverman E, Tselios K, Suitner M, Urowitz M, Touma Z, Vinet E, Santesso N.

J Rheumatol. 2018 Oct;45(10):1426-1439. doi: 10.3899/jrheum.171459. Epub 2018 Sep 1.

10.

Integrative epigenomic analysis in differentiated human primary bronchial epithelial cells exposed to cigarette smoke.

Glass K, Thibault D, Guo F, Mitchel JA, Pham B, Qiu W, Li Y, Jiang Z, Castaldi PJ, Silverman EK, Raby B, Park JA, Yuan GC, Zhou X.

Sci Rep. 2018 Aug 24;8(1):12750. doi: 10.1038/s41598-018-30781-3.

11.

Serologic features of cohorts with variable genetic risk for systemic lupus erythematosus.

Bhattacharya J, Pappas K, Toz B, Aranow C, Mackay M, Gregersen PK, Doumbo O, Traore AK, Lesser ML, McMahon M, Utset T, Silverman E, Levy D, McCune WJ, Jolly M, Wallace D, Weisman M, Romero-Diaz J, Diamond B.

Mol Med. 2018 Jun 1;24(1):24. doi: 10.1186/s10020-018-0019-4.

12.

Moving Beyond Collaboration: A Model for Enhancing Social Work's Organizational Empathy.

Silverman E.

Soc Work. 2018 Oct 1;63(4):297-304. doi: 10.1093/sw/swy034.

PMID:
30113662
13.

Identification of Functional Variants in the FAM13A COPD GWAS Locus by Massively Parallel Reporter Assays.

Castaldi PJ, Guo F, Qiao D, Du F, Naing ZZC, Li Y, Pham B, Mikkelsen TS, Cho MH, Silverman EK, Zhou X.

Am J Respir Crit Care Med. 2018 Aug 4. doi: 10.1164/rccm.201802-0337OC. [Epub ahead of print]

PMID:
30079747
14.

Whole exome sequencing analysis in severe chronic obstructive pulmonary disease.

Qiao D, Ameli A, Prokopenko D, Chen H, Kho AT, Parker MM, Morrow J, Hobbs BD, Liu Y, Beaty TH, Crapo JD, Barnes KC, Nickerson DA, Bamshad M, Hersh CP, Lomas DA, Agusti A, Make BJ, Calverley PMA, Donner CF, Wouters EF, Vestbo J, Paré PD, Levy RD, Rennard SI, Tal-Singer R, Spitz MR, Sharma A, Ruczinski I, Lange C, Silverman EK, Cho MH; NHLBI Exome Sequencing Project, University of Washington Center for Mendelian Genomics, Lung GO, COPDGene Investigators.

Hum Mol Genet. 2018 Jul 27. doi: 10.1093/hmg/ddy269. [Epub ahead of print]

PMID:
30060175
15.

Distribution, temporal stability and association with all-cause mortality of the 2017 GOLD groups in the ECLIPSE cohort.

Faner R, Noell G, Badia JR, López-Giraldo A, Bakke P, Silverman EK, Tal-Singer R, Agustí A.

Respir Med. 2018 Aug;141:14-19. doi: 10.1016/j.rmed.2018.06.015. Epub 2018 Jun 19.

PMID:
30053959
16.

Evolution of Traumatic Parenchymal Intracranial Hematomas (ICHs): Comparison of Hematoma and Edema Components.

Wilkes S, McCormack E, Kenney K, Stephens B, Passo R, Harburg L, Silverman E, Moore C, Bogoslovsky T, Pham D, Diaz-Arrastia R.

Front Neurol. 2018 Jul 4;9:527. doi: 10.3389/fneur.2018.00527. eCollection 2018.

17.

Nevada Pushes For Transparency On Diabetes Drug Prices.

Silverman E.

Manag Care. 2018 Jun;27(6):18.

18.

Rare Variants in Known Susceptibility Loci and Their Contribution to Risk of Lung Cancer.

Liu Y, Lusk CM, Cho MH, Silverman EK, Qiao D, Zhang R, Scheurer ME, Kheradmand F, Wheeler DA, Tsavachidis S, Armstrong G, Zhu D, Wistuba II, Chow CB, Behrens C, Pikielny CW, Neslund-Dudas C, Pinney SM, Anderson M, Kupert E, Bailey-Wilson J, Gaba C, Mandal D, You M, de Andrade M, Yang P, Field JK, Liloglou T, Davies M, Lissowska J, Swiatkowska B, Zaridze D, Mukeriya A, Janout V, Holcatova I, Mates D, Milosavljevic S, Scelo G, Brennan P, McKay J, Liu G, Hung RJ, Christiani DC, Schwartz AG, Amos CI, Spitz MR.

J Thorac Oncol. 2018 Oct;13(10):1483-1495. doi: 10.1016/j.jtho.2018.06.016. Epub 2018 Jul 4.

PMID:
29981437
19.

Controllability in an islet specific regulatory network identifies the transcriptional factor NFATC4, which regulates Type 2 Diabetes associated genes.

Sharma A, Halu A, Decano JL, Padi M, Liu YY, Prasad RB, Fadista J, Santolini M, Menche J, Weiss ST, Vidal M, Silverman EK, Aikawa M, Barabási AL, Groop L, Loscalzo J.

NPJ Syst Biol Appl. 2018 Jul 3;4:25. doi: 10.1038/s41540-018-0057-0. eCollection 2018.

20.

Whole Genome Sequencing in Severe Chronic Obstructive Pulmonary Disease.

Prokopenko D, Sakornsakolpat P, Loehlein Fier H, Qiao D, Parker MM, McDonald MN, Manichaikul A, Rich SS, Barr RG, Williams CJ, Brantly ML, Lange C, Beaty TH, Crapo JD, Silverman EK, Cho MH; COPDGene Investigators, NHLBI TOPMed Investigators.

Am J Respir Cell Mol Biol. 2018 Jun 27. doi: 10.1165/rcmb.2018-0088OC. [Epub ahead of print]

PMID:
29949718
21.

Genome-wide assessment of gene-by-smoking interactions in COPD.

Park B, Koo SM, An J, Lee M, Kang HY, Qiao D, Cho MH, Sung J, Silverman EK, Yang HJ, Won S.

Sci Rep. 2018 Jun 18;8(1):9319. doi: 10.1038/s41598-018-27463-5.

22.

A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locus.

Patel Z, Lu X, Miller D, Forney CR, Lee J, Lynch A, Schroeder C, Parks L, Magnusen AF, Chen X, Pujato M, Maddox A, Zoller EE, Namjou B, Brunner HI, Henrickson M, Huggins JL, Williams AH, Ziegler JT, Comeau ME, Marion MC, Glenn SB, Adler A, Shen N, Nath SK, Stevens AM, Freedman BI, Pons-Estel BA, Tsao BP, Jacob CO, Kamen DL, Brown EE, Gilkeson GS, Alarcón GS, Martin J, Reveille JD, Anaya JM, James JA, Sivils KL, Criswell LA, Vilá LM, Petri M, Scofield RH, Kimberly RP, Edberg JC, Ramsey-Goldman R, Bang SY, Lee HS, Bae SC, Boackle SA, Cunninghame Graham D, Vyse TJ, Merrill JT, Niewold TB, Ainsworth HC, Silverman ED, Weisman MH, Wallace DJ, Raj P, Guthridge JM, Gaffney PM, Kelly JA, Alarcón-Riquelme ME, Langefeld CD, Wakeland EK, Kaufman KM, Weirauch MT, Harley JB, Kottyan LC.

Hum Mol Genet. 2018 Apr 18. doi: 10.1093/hmg/ddy140. [Epub ahead of print]

PMID:
29912393
23.

Longitudinal Phenotypes and Mortality in Preserved Ratio Impaired Spirometry in the COPDGene Study.

Wan ES, Fortis S, Regan EA, Hokanson J, Han MK, Casaburi R, Make BJ, Crapo JD, DeMeo DL, Silverman EK; COPDGene Investigators .

Am J Respir Crit Care Med. 2018 Jun 6. doi: 10.1164/rccm.201804-0663OC. [Epub ahead of print]

PMID:
29874098
24.

Identification of Chronic Obstructive Pulmonary Disease Axes That Predict All-Cause Mortality: The COPDGene Study.

Kinney GL, Santorico SA, Young KA, Cho MH, Castaldi PJ, San José Estépar R, Ross JC, Dy JG, Make BJ, Regan EA, Lynch DA, Everett DC, Lutz SM, Silverman EK, Washko GR, Crapo JD, Hokanson JE; COPDGene Investigators.

Am J Epidemiol. 2018 Oct 1;187(10):2109-2116. doi: 10.1093/aje/kwy087.

PMID:
29771274
25.

Common and rare variants genetic association analysis of cigarettes per day among ever smokers in COPD cases and controls.

Lutz SM, Frederiksen B, Begum F, McDonald ML, Cho MH, Hobbs B, Parker MM, DeMeo DL, Hersh CP, Eringher M, Young K, Jiang L, Foreman MG, Kinney GL, Make BJ, Lomas DA, Bakke P, Gulsvik A, Crapo JD, Silverman EK, Beaty TH, Hokanson JE; ECLIPSE and COPDGene Investigators.

Nicotine Tob Res. 2018 May 15. doi: 10.1093/ntr/nty095. [Epub ahead of print]

PMID:
29767774
26.

Kymriah: A Sign of More Difficult Decisions To Come.

Silverman E.

Manag Care. 2018 May;27(5):17.

27.

CT-based Visual Classification of Emphysema: Association with Mortality in the COPDGene Study.

Lynch DA, Moore CM, Wilson C, Nevrekar D, Jennermann T, Humphries SM, Austin JHM, Grenier PA, Kauczor HU, Han MK, Regan EA, Make BJ, Bowler RP, Beaty TH, Curran-Everett D, Hokanson JE, Curtis JL, Silverman EK, Crapo JD; Genetic Epidemiology of COPD (COPDGene) Investigators.

Radiology. 2018 Sep;288(3):859-866. doi: 10.1148/radiol.2018172294. Epub 2018 May 15.

PMID:
29762095
28.

Do Programs for Runaway and Homeless Youth Work? A Qualitative Exploration From the Perspectives of Youth Clients in Diverse Settings.

Gwadz M, Freeman RM, Kutnick AH, Silverman E, Ritchie AS, Cleland CM, Leonard NR, Srinagesh A, Powlovich J, Bolas J.

Front Public Health. 2018 Apr 19;6:112. doi: 10.3389/fpubh.2018.00112. eCollection 2018.

29.

Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary disease.

Yun JH, Lamb A, Chase R, Singh D, Parker MM, Saferali A, Vestbo J, Tal-Singer R, Castaldi PJ, Silverman EK, Hersh CP; COPDGene and ECLIPSE Investigators.

J Allergy Clin Immunol. 2018 Jun;141(6):2037-2047.e10. doi: 10.1016/j.jaci.2018.04.010. Epub 2018 Apr 28.

PMID:
29709670
30.

WISARD: workbench for integrated superfast association studies for related datasets.

Lee S, Choi S, Qiao D, Cho M, Silverman EK, Park T, Won S.

BMC Med Genomics. 2018 Apr 20;11(Suppl 2):39. doi: 10.1186/s12920-018-0345-y.

31.

Phosphodiesterase-5 inhibition potentiates cerebrovascular reactivity in chronic traumatic brain injury.

Kenney K, Amyot F, Moore C, Haber M, Turtzo LC, Shenouda C, Silverman E, Gong Y, Qu BX, Harburg L, Wassermann EM, Lu H, Diaz-Arrastia R.

Ann Clin Transl Neurol. 2018 Mar 7;5(4):418-428. doi: 10.1002/acn3.541. eCollection 2018 Apr.

32.

Longitudinal Modeling of Lung Function Trajectories in Smokers with and without Chronic Obstructive Pulmonary Disease.

Ross JC, Castaldi PJ, Cho MH, Hersh CP, Rahaghi FN, Sánchez-Ferrero GV, Parker MM, Litonjua AA, Sparrow D, Dy JG, Silverman EK, Washko GR, San José Estépar R.

Am J Respir Crit Care Med. 2018 Oct 15;198(8):1033-1042. doi: 10.1164/rccm.201707-1405OC.

PMID:
29671603
33.

Hedgehog pathway mutations drive oncogenic transformation in high-risk T-cell acute lymphoblastic leukemia.

Burns MA, Liao ZW, Yamagata N, Pouliot GP, Stevenson KE, Neuberg DS, Thorner AR, Ducar M, Silverman EA, Hunger SP, Loh ML, Winter SS, Dunsmore KP, Wood B, Devidas M, Harris MH, Silverman LB, Sallan SE, Gutierrez A.

Leukemia. 2018 Oct;32(10):2126-2137. doi: 10.1038/s41375-018-0097-x. Epub 2018 Mar 20.

34.

Functional Assays to Screen and Dissect Genomic Hits: Doubling Down on the National Investment in Genomic Research.

Musunuru K, Bernstein D, Cole FS, Khokha MK, Lee FS, Lin S, McDonald TV, Moskowitz IP, Quertermous T, Sankaran VG, Schwartz DA, Silverman EK, Zhou X, Hasan AAK, Luo XJ.

Circ Genom Precis Med. 2018 Apr;11(4):e002178. doi: 10.1161/CIRCGEN.118.002178. Review.

PMID:
29654098
35.

Pectoralis muscle area and mortality in smokers without airflow obstruction.

Diaz AA, Martinez CH, Harmouche R, Young TP, McDonald ML, Ross JC, Han ML, Bowler R, Make B, Regan EA, Silverman EK, Crapo J, Boriek AM, Kinney GL, Hokanson JE, Estepar RSJ, Washko GR.

Respir Res. 2018 Apr 10;19(1):62. doi: 10.1186/s12931-018-0771-6.

36.

Vascular Abnormalities within Normal Appearing Tissue in Chronic Traumatic Brain Injury.

Haber M, Amyot F, Kenney K, Meredith-Duliba T, Moore C, Silverman E, Podell J, Chou YY, Pham DL, Butman J, Lu H, Diaz-Arrastia R, Sandsmark D.

J Neurotrauma. 2018 Oct 1;35(19):2250-2258. doi: 10.1089/neu.2018.5684. Epub 2018 Jun 7.

PMID:
29609518
37.

Integrative genomics identifies new genes associated with severe COPD and emphysema.

Sakornsakolpat P, Morrow JD, Castaldi PJ, Hersh CP, Bossé Y, Silverman EK, Manichaikul A, Cho MH.

Respir Res. 2018 Mar 22;19(1):46. doi: 10.1186/s12931-018-0744-9.

38.

Development of neoplasms in pediatric patients with rheumatic disease exposed to anti-tumor necrosis factor therapies: a single Centre retrospective study.

Okihiro A, Hasija R, Fung L, Cameron B, Feldman BM, Laxer R, Schneider R, Silverman E, Spiegel L, Yeung RSM, Tse SML.

Pediatr Rheumatol Online J. 2018 Mar 14;16(1):17. doi: 10.1186/s12969-018-0233-1.

39.

CT measurements of central pulmonary vasculature as predictors of severe exacerbation in COPD.

Rho JY, Lynch DA, Suh YJ, Nah JW, Zach JA, Schroeder JD, Cox CW, Bowler RP, Fenster BE, Dransfield MT, Wells JM, Hokanson JE, Curran-Everett D, Williams A, Han MK, Crapo JD, Silverman EK.

Medicine (Baltimore). 2018 Jan;97(3):e9542. doi: 10.1097/MD.0000000000009542.

40.

Emphysema and extrapulmonary tissue loss in COPD: a multi-organ loss of tissue phenotype.

Celli BR, Locantore N, Tal-Singer R, Riley J, Miller B, Vestbo J, Yates JC, Silverman EK, Owen CA, Divo M, Pinto-Plata V, Wouters EFM, Faner R, Agusti A; ECLIPSE Study Investigators.

Eur Respir J. 2018 Feb 7;51(2). pii: 1702146. doi: 10.1183/13993003.02146-2017. Print 2018 Feb.

PMID:
29437944
41.

Features, Treatment, and Outcomes of Macrophage Activation Syndrome in Childhood-Onset Systemic Lupus Erythematosus.

Borgia RE, Gerstein M, Levy DM, Silverman ED, Hiraki LT.

Arthritis Rheumatol. 2018 Apr;70(4):616-624. doi: 10.1002/art.40417. Epub 2018 Mar 2.

PMID:
29342508
42.

Ensemble genomic analysis in human lung tissue identifies novel genes for chronic obstructive pulmonary disease.

Morrow JD, Cho MH, Platig J, Zhou X, DeMeo DL, Qiu W, Celli B, Marchetti N, Criner GJ, Bueno R, Washko GR, Glass K, Quackenbush J, Silverman EK, Hersh CP.

Hum Genomics. 2018 Jan 15;12(1):1. doi: 10.1186/s40246-018-0132-z.

43.

Human Lung DNA Methylation Quantitative Trait Loci Colocalize with Chronic Obstructive Pulmonary Disease Genome-Wide Association Loci.

Morrow JD, Glass K, Cho MH, Hersh CP, Pinto-Plata V, Celli B, Marchetti N, Criner G, Bueno R, Washko G, Choi AMK, Quackenbush J, Silverman EK, DeMeo DL.

Am J Respir Crit Care Med. 2018 May 15;197(10):1275-1284. doi: 10.1164/rccm.201707-1434OC.

PMID:
29313708
44.

Asthma Is a Risk Factor for Respiratory Exacerbations Without Increased Rate of Lung Function Decline: Five-Year Follow-up in Adult Smokers From the COPDGene Study.

Hayden LP, Hardin ME, Qiu W, Lynch DA, Strand MJ, van Beek EJ, Crapo JD, Silverman EK, Hersh CP; COPDGene Investigators(∗).

Chest. 2018 Feb;153(2):368-377. doi: 10.1016/j.chest.2017.11.038. Epub 2017 Dec 15.

PMID:
29248621
45.

Chest computed tomography-derived low fat-free mass index and mortality in COPD.

McDonald MN, Diaz AA, Rutten E, Lutz SM, Harmouche R, San Jose Estepar R, Kinney G, Hokanson JE, Gower BA, Wouters EFM, Rennard SI, Hersh CP, Casaburi R, Dransfield MT, Silverman EK, Washko GR.

Eur Respir J. 2017 Dec 14;50(6). pii: 1701134. doi: 10.1183/13993003.01134-2017. Print 2017 Dec.

PMID:
29242259
46.

Severe COPD cases from Korea, Poland, and USA have substantial differences in respiratory symptoms and other respiratory illnesses.

Kim WJ, Yim JJ, Kim DK, Lee MG, Fuhlbrigge AL, Sliwinski P, Hawrylkiewicz I, Wan ES, Cho MH, Silverman EK.

Int J Chron Obstruct Pulmon Dis. 2017 Nov 30;12:3415-3423. doi: 10.2147/COPD.S145908. eCollection 2017.

47.

Estimating drivers of cell state transitions using gene regulatory network models.

Schlauch D, Glass K, Hersh CP, Silverman EK, Quackenbush J.

BMC Syst Biol. 2017 Dec 13;11(1):139. doi: 10.1186/s12918-017-0517-y.

48.

Systemic Markers of Adaptive and Innate Immunity Are Associated with Chronic Obstructive Pulmonary Disease Severity and Spirometric Disease Progression.

Halper-Stromberg E, Yun JH, Parker MM, Singer RT, Gaggar A, Silverman EK, Leach S, Bowler RP, Castaldi PJ.

Am J Respir Cell Mol Biol. 2018 Apr;58(4):500-509. doi: 10.1165/rcmb.2017-0373OC.

PMID:
29206476
49.

Psychometric Properties of Voice Activity Participation Profile-Persian Version (VAPPP).

Faham M, Anaraki ZG, Ahmadi A, Ebadi A, Silverman EP.

J Voice. 2018 Sep;32(5):643.e11-643.e15. doi: 10.1016/j.jvoice.2017.07.021.

PMID:
29100714
50.

Quantifying Laryngopharyngeal Reflux in Singers: Perceptual and Objective Findings.

Lloyd AT, Ruddy BH, Silverman E, Lewis VM, Lehman JJ.

Biomed Res Int. 2017;2017:3918214. doi: 10.1155/2017/3918214. Epub 2017 Sep 19.

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