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Engineered Interspecies Amino Acid Cross-Feeding Increases Population Evenness in a Synthetic Bacterial Consortium.

Ziesack M, Gibson T, Oliver JKW, Shumaker AM, Hsu BB, Riglar DT, Giessen TW, DiBenedetto NV, Bry L, Way JC, Silver PA, Gerber GK.

mSystems. 2019 Aug 13;4(4). pii: e00352-19. doi: 10.1128/mSystems.00352-19.


Large protein organelles form a new iron sequestration system with high storage capacity.

Giessen TW, Orlando BJ, Verdegaal AA, Chambers MG, Gardener J, Bell DC, Birrane G, Liao M, Silver PA.

Elife. 2019 Jul 8;8. pii: e46070. doi: 10.7554/eLife.46070.


Early-Career Scientists Shaping the World.

Cristea IM, Dorrestein PC, Eisen JA, Gilbert JA, Huber JA, Jansson JK, Knight R, Pollard KS, Raes J, Silver PA, Webster NS, Xu J.

mSystems. 2019 May 7;4(3). pii: e00196-19. doi: 10.1128/mSystems.00196-19. No abstract available.


Synthetic Gene Circuits Enable Systems-Level Biosensor Trigger Discovery at the Host-Microbe Interface.

Naydich AD, Nangle SN, Bues JJ, Trivedi D, Nissar N, Inniss MC, Niederhuber MJ, Way JC, Silver PA, Riglar DT.

mSystems. 2019 Jun 11;4(4). pii: e00125-19. doi: 10.1128/mSystems.00125-19.


Dynamic Modulation of the Gut Microbiota and Metabolome by Bacteriophages in a Mouse Model.

Hsu BB, Gibson TE, Yeliseyev V, Liu Q, Lyon L, Bry L, Silver PA, Gerber GK.

Cell Host Microbe. 2019 Jun 12;25(6):803-814.e5. doi: 10.1016/j.chom.2019.05.001. Epub 2019 Jun 4.


Interleukin 22 ameliorates neuropathology and protects from central nervous system autoimmunity.

Mattapallil MJ, Kielczewski JL, Zárate-Bladés CR, St Leger AJ, Raychaudhuri K, Silver PB, Jittayasothorn Y, Chan CC, Caspi RR.

J Autoimmun. 2019 Aug;102:65-76. doi: 10.1016/j.jaut.2019.04.017. Epub 2019 May 9.


Beyond the Four Bases: A Home Run for Synthetic Epigenetic Control?

Chang TZ, Kuo J, Silver PA.

Mol Cell. 2019 Apr 4;74(1):5-7. doi: 10.1016/j.molcel.2019.03.016.


AS101 ameliorates experimental autoimmune uveitis by regulating Th1 and Th17 responses and inducing Treg cells.

Bing SJ, Shemesh I, Chong WP, Horai R, Jittayasothorn Y, Silver PB, Sredni B, Caspi RR.

J Autoimmun. 2019 Jun;100:52-61. doi: 10.1016/j.jaut.2019.02.006. Epub 2019 Mar 8.


Identification of a Fifth Antibacterial Toxin Produced by a Single Bacteroides fragilis Strain.

Shumaker AM, Laclare McEneany V, Coyne MJ, Silver PA, Comstock LE.

J Bacteriol. 2019 Mar 26;201(8). pii: e00577-18. doi: 10.1128/JB.00577-18. Print 2019 Apr 15.


Harnessing undomesticated life.

Libby EA, Silver PA.

Nat Microbiol. 2019 Feb;4(2):212-213. doi: 10.1038/s41564-018-0355-8. No abstract available.


A Synthetic System That Senses Candida albicans and Inhibits Virulence Factors.

Tscherner M, Giessen TW, Markey L, Kumamoto CA, Silver PA.

ACS Synth Biol. 2019 Feb 15;8(2):434-444. doi: 10.1021/acssynbio.8b00457. Epub 2019 Jan 16.


Escherichia coli NGF-1, a Genetically Tractable, Efficiently Colonizing Murine Gut Isolate.

Ziesack M, Karrenbelt MAP, Bues J, Schaefer E, Silver P, Way J.

Microbiol Resour Announc. 2018 Dec 6;7(22). pii: e01416-18. doi: 10.1128/MRA.01416-18. eCollection 2018 Dec.


Rational Design of Evolutionarily Stable Microbial Kill Switches.

Stirling F, Bitzan L, O'Keefe S, Redfield E, Oliver JWK, Way J, Silver PA.

Mol Cell. 2018 Oct 18;72(2):395. doi: 10.1016/j.molcel.2018.10.002. No abstract available.


Quorum Sensing Can Be Repurposed To Promote Information Transfer between Bacteria in the Mammalian Gut.

Kim S, Kerns SJ, Ziesack M, Bry L, Gerber GK, Way JC, Silver PA.

ACS Synth Biol. 2018 Sep 21;7(9):2270-2281. doi: 10.1021/acssynbio.8b00271. Epub 2018 Aug 31.


Mammalian Cells Engineered To Produce New Steroids.

Spady ES, Wyche TP, Rollins NJ, Clardy J, Way JC, Silver PA.

Chembiochem. 2018 Sep 4;19(17):1827-1833. doi: 10.1002/cbic.201800214. Epub 2018 Jul 26.


Prokaryotic nanocompartments form synthetic organelles in a eukaryote.

Lau YH, Giessen TW, Altenburg WJ, Silver PA.

Nat Commun. 2018 Apr 3;9(1):1311. doi: 10.1038/s41467-018-03768-x.


Chimeric Fatty Acyl-Acyl Carrier Protein Thioesterases Provide Mechanistic Insight into Enzyme Specificity and Expression.

Ziesack M, Rollins N, Shah A, Dusel B, Webster G, Silver PA, Way JC.

Appl Environ Microbiol. 2018 May 1;84(10). pii: e02868-17. doi: 10.1128/AEM.02868-17. Print 2018 May 15.


STAT-3-independent production of IL-17 by mouse innate-like αβ T cells controls ocular infection.

St Leger AJ, Hansen AM, Karauzum H, Horai R, Yu CR, Laurence A, Mayer-Barber KD, Silver P, Villasmil R, Egwuagu C, Datta SK, Caspi RR.

J Exp Med. 2018 Apr 2;215(4):1079-1090. doi: 10.1084/jem.20170369. Epub 2018 Feb 28.


Engineering bacteria for diagnostic and therapeutic applications.

Riglar DT, Silver PA.

Nat Rev Microbiol. 2018 Apr;16(4):214-225. doi: 10.1038/nrmicro.2017.172. Epub 2018 Feb 5. Review.


Frequent Versus Infrequent Monitoring of Endotracheal Tube Cuff Pressures.

Letvin A, Kremer P, Silver PC, Samih N, Reed-Watts P, Kollef MH.

Respir Care. 2018 May;63(5):495-501. doi: 10.4187/respcare.05926. Epub 2018 Jan 30.


Rational Design of Evolutionarily Stable Microbial Kill Switches.

Stirling F, Bitzan L, O'Keefe S, Redfield E, Oliver JWK, Way J, Silver PA.

Mol Cell. 2017 Nov 16;68(4):686-697.e3. doi: 10.1016/j.molcel.2017.10.033. Erratum in: Mol Cell. 2018 Oct 18;72(2):395.


Biological-inorganic hybrid systems as a generalized platform for chemical production.

Nangle SN, Sakimoto KK, Silver PA, Nocera DG.

Curr Opin Chem Biol. 2017 Dec;41:107-113. doi: 10.1016/j.cbpa.2017.10.023. Epub 2017 Nov 12. Review.


Synthetic genome recoding: new genetic codes for new features.

Kuo J, Stirling F, Lau YH, Shulgina Y, Way JC, Silver PA.

Curr Genet. 2018 Apr;64(2):327-333. doi: 10.1007/s00294-017-0754-z. Epub 2017 Oct 5. Review.


Superresolution microscopy of the β-carboxysome reveals a homogeneous matrix.

Niederhuber MJ, Lambert TJ, Yapp C, Silver PA, Polka JK.

Mol Biol Cell. 2017 Oct 1;28(20):2734-2745. doi: 10.1091/mbc.E17-01-0069. Epub 2017 Aug 9.


Complex cellular logic computation using ribocomputing devices.

Green AA, Kim J, Ma D, Silver PA, Collins JJ, Yin P.

Nature. 2017 Aug 3;548(7665):117-121. doi: 10.1038/nature23271. Epub 2017 Jul 26.


An Ocular Commensal Protects against Corneal Infection by Driving an Interleukin-17 Response from Mucosal γδ T Cells.

St Leger AJ, Desai JV, Drummond RA, Kugadas A, Almaghrabi F, Silver P, Raychaudhuri K, Gadjeva M, Iwakura Y, Lionakis MS, Caspi RR.

Immunity. 2017 Jul 18;47(1):148-158.e5. doi: 10.1016/j.immuni.2017.06.014. Epub 2017 Jul 11.


Ambient nitrogen reduction cycle using a hybrid inorganic-biological system.

Liu C, Sakimoto KK, Colón BC, Silver PA, Nocera DG.

Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):6450-6455. doi: 10.1073/pnas.1706371114. Epub 2017 Jun 6.


Engineered bacteria can function in the mammalian gut long-term as live diagnostics of inflammation.

Riglar DT, Giessen TW, Baym M, Kerns SJ, Niederhuber MJ, Bronson RT, Kotula JW, Gerber GK, Way JC, Silver PA.

Nat Biotechnol. 2017 Jul;35(7):653-658. doi: 10.1038/nbt.3879. Epub 2017 May 29.


Large-scale recoding of a bacterial genome by iterative recombineering of synthetic DNA.

Lau YH, Stirling F, Kuo J, Karrenbelt MAP, Chan YA, Riesselman A, Horton CA, Schäfer E, Lips D, Weinstock MT, Gibson DG, Way JC, Silver PA.

Nucleic Acids Res. 2017 Jun 20;45(11):6971-6980. doi: 10.1093/nar/gkx415.


13C-Labeling the carbon-fixation pathway of a highly efficient artificial photosynthetic system.

Liu C, Nangle SN, Colón BC, Silver PA, Nocera DG.

Faraday Discuss. 2017 Jun 2;198:529-537. doi: 10.1039/c6fd00231e.


Widespread distribution of encapsulin nanocompartments reveals functional diversity.

Giessen TW, Silver PA.

Nat Microbiol. 2017 Mar 6;2:17029. doi: 10.1038/nmicrobiol.2017.29.


Preparation of Protein-containing Extracts from Microbiota-rich Intestinal Contents.

Dillenburg-Pilla P, Zárate-Bladés CR, Silver PB, Horai R, Caspi RR.

Bio Protoc. 2016 Sep 20;6(18). pii: e1936.


Synthetic photosynthetic consortia define interactions leading to robustness and photoproduction.

Hays SG, Yan LLW, Silver PA, Ducat DC.

J Biol Eng. 2017 Jan 23;11:4. doi: 10.1186/s13036-017-0048-5. eCollection 2017.


Engineering carbon fixation with artificial protein organelles.

Giessen TW, Silver PA.

Curr Opin Biotechnol. 2017 Aug;46:42-50. doi: 10.1016/j.copbio.2017.01.004. Epub 2017 Jan 23. Review.


Efficient size-independent chromosome delivery from yeast to cultured cell lines.

Brown DM, Chan YA, Desai PJ, Grzesik P, Oldfield LM, Vashee S, Way JC, Silver PA, Glass JI.

Nucleic Acids Res. 2017 Apr 20;45(7):e50. doi: 10.1093/nar/gkw1252.


A Respiratory Therapist Disease Management Program for Subjects Hospitalized With COPD.

Silver PC, Kollef MH, Clinkscale D, Watts P, Kidder R, Eads B, Bennett D, Lora C, Quartaro M.

Respir Care. 2017 Jan;62(1):1-9. doi: 10.4187/respcare.05030. Epub 2016 Nov 29.


Engineering Genetically-Encoded Mineralization and Magnetism via Directed Evolution.

Liu X, Lopez PA, Giessen TW, Giles M, Way JC, Silver PA.

Sci Rep. 2016 Nov 29;6:38019. doi: 10.1038/srep38019.


Impact of monitoring endotracheal tube cuff leak pressure on postextubation stridor in children.

Schneider J, Mulale U, Yamout S, Pollard S, Silver P.

J Crit Care. 2016 Dec;36:173-177. doi: 10.1016/j.jcrc.2016.06.033. Epub 2016 Jul 9.


Using Pleth Variability as a Triage Tool for Children With Obstructive Airway Disease in a Pediatric Emergency Department.

Brandwein A, Patel K, Kline M, Silver P, Gangadharan S.

Pediatr Emerg Care. 2018 Oct;34(10):702-705. doi: 10.1097/PEC.0000000000000887.


A Catalytic Nanoreactor Based on in Vivo Encapsulation of Multiple Enzymes in an Engineered Protein Nanocompartment.

Giessen TW, Silver PA.

Chembiochem. 2016 Oct 17;17(20):1931-1935. doi: 10.1002/cbic.201600431. Epub 2016 Sep 14.


Synthetic Lipid-Containing Scaffolds Enhance Production by Colocalizing Enzymes.

Myhrvold C, Polka JK, Silver PA.

ACS Synth Biol. 2016 Dec 16;5(12):1396-1403. Epub 2016 Aug 3.


Creating Single-Copy Genetic Circuits.

Lee JW, Gyorgy A, Cameron DE, Pyenson N, Choi KR, Way JC, Silver PA, Del Vecchio D, Collins JJ.

Mol Cell. 2016 Jul 21;63(2):329-336. doi: 10.1016/j.molcel.2016.06.006. Epub 2016 Jul 14.


Converting a Natural Protein Compartment into a Nanofactory for the Size-Constrained Synthesis of Antimicrobial Silver Nanoparticles.

Giessen TW, Silver PA.

ACS Synth Biol. 2016 Dec 16;5(12):1497-1504. Epub 2016 Jun 17.


Building Spatial Synthetic Biology with Compartments, Scaffolds, and Communities.

Polka JK, Hays SG, Silver PA.

Cold Spring Harb Perspect Biol. 2016 Aug 1;8(8). pii: a024018. doi: 10.1101/cshperspect.a024018. Review.


Water splitting-biosynthetic system with CO₂ reduction efficiencies exceeding photosynthesis.

Liu C, Colón BC, Ziesack M, Silver PA, Nocera DG.

Science. 2016 Jun 3;352(6290):1210-3. doi: 10.1126/science.aaf5039.


GENOME ENGINEERING. The Genome Project-Write.

Boeke JD, Church G, Hessel A, Kelley NJ, Arkin A, Cai Y, Carlson R, Chakravarti A, Cornish VW, Holt L, Isaacs FJ, Kuiken T, Lajoie M, Lessor T, Lunshof J, Maurano MT, Mitchell LA, Rine J, Rosser S, Sanjana NE, Silver PA, Valle D, Wang H, Way JC, Yang L.

Science. 2016 Jul 8;353(6295):126-7. doi: 10.1126/science.aaf6850. Epub 2016 Jun 2. No abstract available.


Use of a Shared Canister Protocol for the Delivery of Metered-Dose Inhalers in Mechanically Ventilated Subjects.

Gowan M, Bushwitz J, Watts P, Silver PC, Jackson M, Hampton N, Kollef MH.

Respir Care. 2016 Oct;61(10):1285-92. doi: 10.4187/respcare.04550. Epub 2016 May 3.


Targeted erythropoietin selectively stimulates red blood cell expansion in vivo.

Burrill DR, Vernet A, Collins JJ, Silver PA, Way JC.

Proc Natl Acad Sci U S A. 2016 May 10;113(19):5245-50. doi: 10.1073/pnas.1525388113. Epub 2016 Apr 25.


An Analysis of the Daily Work-Rounding Process in a Pediatric Intensive Care Unit.

Gangadharan S, Belpanno B, Silver P.

J Healthc Qual. 2017 Mar/Apr;39(2):122-127. doi: 10.1097/JHQ.0000000000000024.


Mincle Activation and the Syk/Card9 Signaling Axis Are Central to the Development of Autoimmune Disease of the Eye.

Lee EJ, Brown BR, Vance EE, Snow PE, Silver PB, Heinrichs D, Lin X, Iwakura Y, Wells CA, Caspi RR, Rosenzweig HL.

J Immunol. 2016 Apr 1;196(7):3148-58. doi: 10.4049/jimmunol.1502355. Epub 2016 Feb 26.

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