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Items: 40

1.

Perspective on Antibacterial Lead Identification Challenges and the Role of Hypothesis-Driven Strategies.

McDowell LL, Quinn CL, Leeds JA, Silverman JA, Silver LL.

SLAS Discov. 2019 Apr;24(4):440-456. doi: 10.1177/2472555218818786.

PMID:
30890054
2.

Analysis of the clinical antibacterial and antituberculosis pipeline.

Theuretzbacher U, Gottwalt S, Beyer P, Butler M, Czaplewski L, Lienhardt C, Moja L, Paul M, Paulin S, Rex JH, Silver LL, Spigelman M, Thwaites GE, Paccaud JP, Harbarth S.

Lancet Infect Dis. 2019 Feb;19(2):e40-e50. doi: 10.1016/S1473-3099(18)30513-9. Epub 2018 Oct 15. Review.

PMID:
30337260
3.

What is an "ideal" antibiotic? Discovery challenges and path forward.

Singh SB, Young K, Silver LL.

Biochem Pharmacol. 2017 Jun 1;133:63-73. doi: 10.1016/j.bcp.2017.01.003. Epub 2017 Jan 10. Review.

PMID:
28087253
4.

Fosfomycin: Mechanism and Resistance.

Silver LL.

Cold Spring Harb Perspect Med. 2017 Feb 1;7(2). pii: a025262. doi: 10.1101/cshperspect.a025262. Review.

5.

Appropriate Targets for Antibacterial Drugs.

Silver LL.

Cold Spring Harb Perspect Med. 2016 Dec 1;6(12). pii: a030239. doi: 10.1101/cshperspect.a030239. Review.

6.

A Gestalt approach to Gram-negative entry.

Silver LL.

Bioorg Med Chem. 2016 Dec 15;24(24):6379-6389. doi: 10.1016/j.bmc.2016.06.044. Epub 2016 Jun 23. Review.

PMID:
27381365
7.

70th Anniversary Collection for the Microbiology Society: Journal of Medical Microbiology.

Mathee K, Silver LL, Tatke G.

J Med Microbiol. 2015 Dec;64(12):1457-1461. doi: 10.1099/jmm.0.000186.

PMID:
26689963
8.

Characterization of a Carbapenem-Hydrolyzing Enzyme, PoxB, in Pseudomonas aeruginosa PAO1.

Zincke D, Balasubramanian D, Silver LL, Mathee K.

Antimicrob Agents Chemother. 2015 Nov 30;60(2):936-45. doi: 10.1128/AAC.01807-15. Print 2016 Feb.

9.

Natural products as a source of drug leads to overcome drug resistance.

Silver LL.

Future Microbiol. 2015;10(11):1711-8. doi: 10.2217/fmb.15.67. Epub 2015 Oct 30. Review.

PMID:
26517443
10.

Antibacterials for any target.

Silver LL.

Nat Biotechnol. 2014 Nov;32(11):1102-4. doi: 10.1038/nbt.3060. No abstract available.

PMID:
25380445
11.

Viable screening targets related to the bacterial cell wall.

Silver LL.

Ann N Y Acad Sci. 2013 Jan;1277:29-53. doi: 10.1111/nyas.12006. Epub 2012 Dec 26. Review.

PMID:
23278681
12.

Multitarget ligands in antibacterial research: progress and opportunities.

East SP, Silver LL.

Expert Opin Drug Discov. 2013 Feb;8(2):143-56. doi: 10.1517/17460441.2013.743991. Epub 2012 Dec 19. Review.

PMID:
23252414
13.

Challenges of antibacterial discovery.

Silver LL.

Clin Microbiol Rev. 2011 Jan;24(1):71-109. doi: 10.1128/CMR.00030-10. Review.

14.

A persistent problem.

Silver LL.

J Med Microbiol. 2011 Mar;60(Pt 3):267-8. doi: 10.1099/jmm.0.029967-0. Epub 2011 Jan 6. No abstract available.

PMID:
21212149
15.

Are natural products still the best source for antibacterial discovery? The bacterial entry factor.

Silver LL.

Expert Opin Drug Discov. 2008 May;3(5):487-500. doi: 10.1517/17460441.3.5.487.

PMID:
23484922
16.

Multi-targeting by monotherapeutic antibacterials.

Silver LL.

Nat Rev Drug Discov. 2007 Jan;6(1):41-55. Review. Erratum in: Nat Rev Drug Discov. 2007 Feb;6(2):126.

PMID:
17159922
17.
18.

Platensimycin is a selective FabF inhibitor with potent antibiotic properties.

Wang J, Soisson SM, Young K, Shoop W, Kodali S, Galgoci A, Painter R, Parthasarathy G, Tang YS, Cummings R, Ha S, Dorso K, Motyl M, Jayasuriya H, Ondeyka J, Herath K, Zhang C, Hernandez L, Allocco J, Basilio A, Tormo JR, Genilloud O, Vicente F, Pelaez F, Colwell L, Lee SH, Michael B, Felcetto T, Gill C, Silver LL, Hermes JD, Bartizal K, Barrett J, Schmatz D, Becker JW, Cully D, Singh SB.

Nature. 2006 May 18;441(7091):358-61.

PMID:
16710421
19.

Discovery of FabH/FabF inhibitors from natural products.

Young K, Jayasuriya H, Ondeyka JG, Herath K, Zhang C, Kodali S, Galgoci A, Painter R, Brown-Driver V, Yamamoto R, Silver LL, Zheng Y, Ventura JI, Sigmund J, Ha S, Basilio A, Vicente F, Tormo JR, Pelaez F, Youngman P, Cully D, Barrett JF, Schmatz D, Singh SB, Wang J.

Antimicrob Agents Chemother. 2006 Feb;50(2):519-26.

20.

Does the cell wall of bacteria remain a viable source of targets for novel antibiotics?

Silver LL.

Biochem Pharmacol. 2006 Mar 30;71(7):996-1005. Epub 2005 Nov 14. Review.

PMID:
16290173
21.
22.

Outbreak of Klebsiella pneumoniae producing a new carbapenem-hydrolyzing class A beta-lactamase, KPC-3, in a New York Medical Center.

Woodford N, Tierno PM Jr, Young K, Tysall L, Palepou MF, Ward E, Painter RE, Suber DF, Shungu D, Silver LL, Inglima K, Kornblum J, Livermore DM.

Antimicrob Agents Chemother. 2004 Dec;48(12):4793-9.

23.

Determination of selectivity and efficacy of fatty acid synthesis inhibitors.

Kodali S, Galgoci A, Young K, Painter R, Silver LL, Herath KB, Singh SB, Cully D, Barrett JF, Schmatz D, Wang J.

J Biol Chem. 2005 Jan 14;280(2):1669-77. Epub 2004 Oct 29.

24.

Novel illudins from Coprinopsis episcopalis (syn. Coprinus episcopalis), and the distribution of illudin-like compounds among filamentous fungi.

Gonzalez del Val A, Platas G, Arenal F, Orihuela JC, Garcia M, Hernández P, Royo I, De Pedro N, Silver LL, Young K, Vicente MF, Pelaez F.

Mycol Res. 2003 Oct;107(Pt 10):1201-9.

PMID:
14635768
25.

Novel inhibitors of bacterial cell wall synthesis.

Silver LL.

Curr Opin Microbiol. 2003 Oct;6(5):431-8. Review.

PMID:
14572533
26.

Novel pyrazolo[3,4-d]pyrimidine-based inhibitors of Staphlococcus aureus DNA polymerase III: design, synthesis, and biological evaluation.

Ali A, Taylor GE, Ellsworth K, Harris G, Painter R, Silver LL, Young K.

J Med Chem. 2003 May 8;46(10):1824-30.

PMID:
12723946
27.

Direct interaction of a vancomycin derivative with bacterial enzymes involved in cell wall biosynthesis.

Sinha Roy R, Yang P, Kodali S, Xiong Y, Kim RM, Griffin PR, Onishi HR, Kohler J, Silver LL, Chapman K.

Chem Biol. 2001 Nov;8(11):1095-106.

28.

Design and synthesis of novel antibacterial agents with inhibitory activity against DNA polymerase III.

Ali A, Aster SD, Graham DW, Patel GF, Taylor GE, Tolman RL, Painter RE, Silver LL, Young K, Ellsworth K, Geissler W, Harris GS.

Bioorg Med Chem Lett. 2001 Aug 20;11(16):2185-8.

PMID:
11514166
29.

Inhibition of IMP-1 metallo-beta-lactamase and sensitization of IMP-1-producing bacteria by thioester derivatives.

Hammond GG, Huber JL, Greenlee ML, Laub JB, Young K, Silver LL, Balkovec JM, Pryor KD, Wu JK, Leiting B, Pompliano DL, Toney JH.

FEMS Microbiol Lett. 1999 Oct 15;179(2):289-96.

31.

Vancomycin derivatives that inhibit peptidoglycan biosynthesis without binding D-Ala-D-Ala.

Ge M, Chen Z, Onishi HR, Kohler J, Silver LL, Kerns R, Fukuzawa S, Thompson C, Kahne D.

Science. 1999 Apr 16;284(5413):507-11.

32.

Carbohydroxamido-oxazolidines: antibacterial agents that target lipid A biosynthesis.

Chen MH, Steiner MG, de Laszlo SE, Patchett AA, Anderson MS, Hyland SA, Onishi HR, Silver LL, Raetz CR.

Bioorg Med Chem Lett. 1999 Feb 8;9(3):313-8.

PMID:
10091675
33.

Antibacterial agents that inhibit lipid A biosynthesis.

Onishi HR, Pelak BA, Gerckens LS, Silver LL, Kahan FM, Chen MH, Patchett AA, Galloway SM, Hyland SA, Anderson MS, Raetz CR.

Science. 1996 Nov 8;274(5289):980-2.

PMID:
8875939
34.

The envA permeability/cell division gene of Escherichia coli encodes the second enzyme of lipid A biosynthesis. UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase.

Young K, Silver LL, Bramhill D, Cameron P, Eveland SS, Raetz CR, Hyland SA, Anderson MS.

J Biol Chem. 1995 Dec 22;270(51):30384-91.

35.

Discovery and development of new antibiotics: the problem of antibiotic resistance.

Silver LL, Bostian KA.

Antimicrob Agents Chemother. 1993 Mar;37(3):377-83. Review. No abstract available.

36.

Leakage of periplasmic enzymes from envA1 strains of Escherichia coli.

Young K, Silver LL.

J Bacteriol. 1991 Jun;173(12):3609-14.

37.
38.

Bacteriophage T4 gene 41 protein, required for the synthesis of RNA primers, is also a DNA helicase.

Venkatesan M, Silver LL, Nossal NG.

J Biol Chem. 1982 Oct 25;257(20):12426-34.

40.

DNA replication by bacteriophage T4 proteins: role of the DNA-delay gene 61 in the chain-initiation reaction.

Silver LL, Nossal NG.

Cold Spring Harb Symp Quant Biol. 1979;43 Pt 1:489-94. No abstract available.

PMID:
289458

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