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The lysolipid transporter Mfsd2a regulates lipogenesis in the developing brain.

Chan JP, Wong BH, Chin CF, Galam DLA, Foo JC, Wong LC, Ghosh S, Wenk MR, Cazenave-Gassiot A, Silver DL.

PLoS Biol. 2018 Aug 3;16(8):e2006443. doi: 10.1371/journal.pbio.2006443. eCollection 2018 Aug.


Progenitor Hyperpolarization Regulates the Sequential Generation of Neuronal Subtypes in the Developing Neocortex.

Vitali I, Fièvre S, Telley L, Oberst P, Bariselli S, Frangeul L, Baumann N, McMahon JJ, Klingler E, Bocchi R, Kiss JZ, Bellone C, Silver DL, Jabaudon D.

Cell. 2018 Aug 23;174(5):1264-1276.e15. doi: 10.1016/j.cell.2018.06.036. Epub 2018 Jul 26.


Thrombospondin receptor α2δ-1 promotes synaptogenesis and spinogenesis via postsynaptic Rac1.

Risher WC, Kim N, Koh S, Choi JE, Mitev P, Spence EF, Pilaz LJ, Wang D, Feng G, Silver DL, Soderling SH, Yin HH, Eroglu C.

J Cell Biol. 2018 Oct 1;217(10):3747-3765. doi: 10.1083/jcb.201802057. Epub 2018 Jul 27.


Homozygous mutation in MFSD2A, encoding a lysolipid transporter for docosahexanoic acid, is associated with microcephaly and hypomyelination.

Harel T, Quek DQY, Wong BH, Cazenave-Gassiot A, Wenk MR, Fan H, Berger I, Shmueli D, Shaag A, Silver DL, Elpeleg O, Edvardson S.

Neurogenetics. 2018 Jul 24. doi: 10.1007/s10048-018-0556-6. [Epub ahead of print]


Fat storage-inducing transmembrane protein 2 (FIT2) is less abundant in type 2 diabetes, and regulates triglyceride accumulation and insulin sensitivity in adipocytes.

Agrawal M, Yeo CR, Shabbir A, Chhay V, Silver DL, Magkos F, Vidal-Puig A, Toh SA.

FASEB J. 2018 Jul 18:fj201701321RR. doi: 10.1096/fj.201701321RR. [Epub ahead of print]


LRH-1 regulates hepatic lipid homeostasis and maintains arachidonoyl phospholipid pools critical for phospholipid diversity.

Miranda DA, Krause WC, Cazenave-Gassiot A, Suzawa M, Escusa H, Foo JC, Shihadih DS, Stahl A, Fitch M, Nyangau E, Hellerstein M, Wenk MR, Silver DL, Ingraham HA.

JCI Insight. 2018 Mar 8;3(5). pii: 96151. doi: 10.1172/jci.insight.96151. [Epub ahead of print]


A Fluorescent Cell-Based System for Imaging Zika Virus Infection in Real-Time.

McFadden MJ, Mitchell-Dick A, Vazquez C, Roder AE, Labagnara KF, McMahon JJ, Silver DL, Horner SM.

Viruses. 2018 Feb 24;10(2). pii: E95. doi: 10.3390/v10020095.


Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets.

Vu TM, Ishizu AN, Foo JC, Toh XR, Zhang F, Whee DM, Torta F, Cazenave-Gassiot A, Matsumura T, Kim S, Toh SES, Suda T, Silver DL, Wenk MR, Nguyen LN.

Nature. 2017 Oct 26;550(7677):524-528. doi: 10.1038/nature24053. Epub 2017 Oct 18.


VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma.

Yao X, Tan J, Lim KJ, Koh J, Ooi WF, Li Z, Huang D, Xing M, Chan YS, Qu JZ, Tay ST, Wijaya G, Lam YN, Hong JH, Lee-Lim AP, Guan P, Ng MSW, He CZ, Lin JS, Nandi T, Qamra A, Xu C, Myint SS, Davies JOJ, Goh JY, Loh G, Tan BC, Rozen SG, Yu Q, Tan IBH, Cheng CWS, Li S, Chang KTE, Tan PH, Silver DL, Lezhava A, Steger G, Hughes JR, Teh BT, Tan P.

Cancer Discov. 2017 Nov;7(11):1284-1305. doi: 10.1158/2159-8290.CD-17-0375. Epub 2017 Sep 11.


Enhancing our brains: Genomic mechanisms underlying cortical evolution.

Mitchell C, Silver DL.

Semin Cell Dev Biol. 2018 Apr;76:23-32. doi: 10.1016/j.semcdb.2017.08.045. Epub 2017 Aug 31. Review.


RNA on the brain: emerging layers of post-transcriptional regulation in cerebral cortex development.

Lennox AL, Mao H, Silver DL.

Wiley Interdiscip Rev Dev Biol. 2018 Jan;7(1). doi: 10.1002/wdev.290. Epub 2017 Aug 24. Review.


Relationship Between the American Academy of Pediatrics and Infant Formula Companies.

Sharfstein JM, Silver DL.

JAMA Pediatr. 2017 Jul 1;171(7):613-614. doi: 10.1001/jamapediatrics.2017.1257. No abstract available.


EIF4A3 deficient human iPSCs and mouse models demonstrate neural crest defects that underlie Richieri-Costa-Pereira syndrome.

Miller EE, Kobayashi GS, Musso CM, Allen M, Ishiy FAA, de Caires LC Jr, Goulart E, Griesi-Oliveira K, Zechi-Ceide RM, Richieri-Costa A, Bertola DR, Passos-Bueno MR, Silver DL.

Hum Mol Genet. 2017 Jun 15;26(12):2177-2191. doi: 10.1093/hmg/ddx078.


Moving messages in the developing brain-emerging roles for mRNA transport and local translation in neural stem cells.

Pilaz LJ, Silver DL.

FEBS Lett. 2017 Jun;591(11):1526-1539. doi: 10.1002/1873-3468.12626. Epub 2017 Apr 6. Review.


A mutation of EPT1 (SELENOI) underlies a new disorder of Kennedy pathway phospholipid biosynthesis.

Ahmed MY, Al-Khayat A, Al-Murshedi F, Al-Futaisi A, Chioza BA, Pedro Fernandez-Murray J, Self JE, Salter CG, Harlalka GV, Rawlins LE, Al-Zuhaibi S, Al-Azri F, Al-Rashdi F, Cazenave-Gassiot A, Wenk MR, Al-Salmi F, Patton MA, Silver DL, Baple EL, McMaster CR, Crosby AH.

Brain. 2017 Mar 1;140(3):547-554. doi: 10.1093/brain/aww318.


Dynamic mRNA Transport and Local Translation in Radial Glial Progenitors of the Developing Brain.

Pilaz LJ, Lennox AL, Rouanet JP, Silver DL.

Curr Biol. 2016 Dec 19;26(24):3383-3392. doi: 10.1016/j.cub.2016.10.040. Epub 2016 Dec 1.


Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Causes p53-Mediated Microcephaly.

Mao H, McMahon JJ, Tsai YH, Wang Z, Silver DL.

PLoS Genet. 2016 Sep 12;12(9):e1006282. doi: 10.1371/journal.pgen.1006282. eCollection 2016 Sep.


The exon junction complex in neural development and neurodevelopmental disease.

McMahon JJ, Miller EE, Silver DL.

Int J Dev Neurosci. 2016 Dec;55:117-123. doi: 10.1016/j.ijdevneu.2016.03.006. Epub 2016 Apr 9. Review.


Mfsd2a Is a Transporter for the Essential ω-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development.

Wong BH, Chan JP, Cazenave-Gassiot A, Poh RW, Foo JC, Galam DL, Ghosh S, Nguyen LN, Barathi VA, Yeo SW, Luu CD, Wenk MR, Silver DL.

J Biol Chem. 2016 May 13;291(20):10501-14. doi: 10.1074/jbc.M116.721340. Epub 2016 Mar 22.


Structural Insights into the Transport Mechanism of the Human Sodium-dependent Lysophosphatidylcholine Transporter MFSD2A.

Quek DQ, Nguyen LN, Fan H, Silver DL.

J Biol Chem. 2016 Apr 29;291(18):9383-94. doi: 10.1074/jbc.M116.721035. Epub 2016 Mar 4.


Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin.

Singh SK, Stogsdill JA, Pulimood NS, Dingsdale H, Kim YH, Pilaz LJ, Kim IH, Manhaes AC, Rodrigues WS Jr, Pamukcu A, Enustun E, Ertuz Z, Scheiffele P, Soderling SH, Silver DL, Ji RR, Medina AE, Eroglu C.

Cell. 2016 Jan 14;164(1-2):183-196. doi: 10.1016/j.cell.2015.11.034.


Prolonged Mitosis of Neural Progenitors Alters Cell Fate in the Developing Brain.

Pilaz LJ, McMahon JJ, Miller EE, Lennox AL, Suzuki A, Salmon E, Silver DL.

Neuron. 2016 Jan 6;89(1):83-99. doi: 10.1016/j.neuron.2015.12.007.


Genomic divergence and brain evolution: How regulatory DNA influences development of the cerebral cortex.

Silver DL.

Bioessays. 2016 Feb;38(2):162-71. doi: 10.1002/bies.201500108. Epub 2015 Dec 7. Review.


Postnatal Deletion of Fat Storage-inducing Transmembrane Protein 2 (FIT2/FITM2) Causes Lethal Enteropathy.

Goh VJ, Tan JS, Tan BC, Seow C, Ong WY, Lim YC, Sun L, Ghosh S, Silver DL.

J Biol Chem. 2015 Oct 16;290(42):25686-99. doi: 10.1074/jbc.M115.676700. Epub 2015 Aug 24.


Post-transcriptional regulation in corticogenesis: how RNA-binding proteins help build the brain.

Pilaz LJ, Silver DL.

Wiley Interdiscip Rev RNA. 2015 Sep-Oct;6(5):501-15. doi: 10.1002/wrna.1289. Epub 2015 Jun 18. Review.


Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome.

Guemez-Gamboa A, Nguyen LN, Yang H, Zaki MS, Kara M, Ben-Omran T, Akizu N, Rosti RO, Rosti B, Scott E, Schroth J, Copeland B, Vaux KK, Cazenave-Gassiot A, Quek DQ, Wong BH, Tan BC, Wenk MR, Gunel M, Gabriel S, Chi NC, Silver DL, Gleeson JG.

Nat Genet. 2015 Jul;47(7):809-13. doi: 10.1038/ng.3311. Epub 2015 May 25.


A partially inactivating mutation in the sodium-dependent lysophosphatidylcholine transporter MFSD2A causes a non-lethal microcephaly syndrome.

Alakbarzade V, Hameed A, Quek DQ, Chioza BA, Baple EL, Cazenave-Gassiot A, Nguyen LN, Wenk MR, Ahmad AQ, Sreekantan-Nair A, Weedon MN, Rich P, Patton MA, Warner TT, Silver DL, Crosby AH.

Nat Genet. 2015 Jul;47(7):814-7. doi: 10.1038/ng.3313. Epub 2015 May 25.


Rbm8a haploinsufficiency disrupts embryonic cortical development resulting in microcephaly.

Mao H, Pilaz LJ, McMahon JJ, Golzio C, Wu D, Shi L, Katsanis N, Silver DL.

J Neurosci. 2015 May 6;35(18):7003-18. doi: 10.1523/JNEUROSCI.0018-15.2015.


Human-chimpanzee differences in a FZD8 enhancer alter cell-cycle dynamics in the developing neocortex.

Boyd JL, Skove SL, Rouanet JP, Pilaz LJ, Bepler T, Gordân R, Wray GA, Silver DL.

Curr Biol. 2015 Mar 16;25(6):772-779. doi: 10.1016/j.cub.2015.01.041. Epub 2015 Feb 19.


Astrocytes refine cortical connectivity at dendritic spines.

Risher WC, Patel S, Kim IH, Uezu A, Bhagat S, Wilton DK, Pilaz LJ, Singh Alvarado J, Calhan OY, Silver DL, Stevens B, Calakos N, Soderling SH, Eroglu C.

Elife. 2014 Dec 17;3. doi: 10.7554/eLife.04047.


A novel splice-site mutation in ALS2 establishes the diagnosis of juvenile amyotrophic lateral sclerosis in a family with early onset anarthria and generalized dystonias.

Siddiqi S, Foo JN, Vu A, Azim S, Silver DL, Mansoor A, Tay SK, Abbasi S, Hashmi AH, Janjua J, Khalid S, Tai ES, Yeo GW, Khor CC.

PLoS One. 2014 Dec 4;9(12):e113258. doi: 10.1371/journal.pone.0113258. eCollection 2014.


CCAAT/enhancer binding protein α predicts poorer prognosis and prevents energy starvation-induced cell death in hepatocellular carcinoma.

Lu GD, Ang YH, Zhou J, Tamilarasi J, Yan B, Lim YC, Srivastava S, Salto-Tellez M, Hui KM, Shen HM, Nguyen LN, Tan BC, Silver DL, Hooi SC.

Hepatology. 2015 Mar;61(3):965-78. doi: 10.1002/hep.27593. Epub 2015 Jan 30.


Cytosolic lipid droplets: from mechanisms of fat storage to disease.

Gross DA, Silver DL.

Crit Rev Biochem Mol Biol. 2014 Jul-Aug;49(4):304-26. doi: 10.3109/10409238.2014.931337. Review.


MicroRNAs are required for the feature maintenance and differentiation of brown adipocytes.

Kim HJ, Cho H, Alexander R, Patterson HC, Gu M, Lo KA, Xu D, Goh VJ, Nguyen LN, Chai X, Huang CX, Kovalik JP, Ghosh S, Trajkovski M, Silver DL, Lodish H, Sun L.

Diabetes. 2014 Dec;63(12):4045-56. doi: 10.2337/db14-0466. Epub 2014 Jul 9.


Live imaging of mitosis in the developing mouse embryonic cortex.

Pilaz LJ, Silver DL.

J Vis Exp. 2014 Jun 4;(88). doi: 10.3791/51298.


Recent advances in understanding proteins involved in lipid droplet formation, growth and fusion.

Tan JS, Seow CJ, Goh VJ, Silver DL.

J Genet Genomics. 2014 May 20;41(5):251-9. doi: 10.1016/j.jgg.2014.03.003. Epub 2014 Mar 19. Review.


Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid.

Nguyen LN, Ma D, Shui G, Wong P, Cazenave-Gassiot A, Zhang X, Wenk MR, Goh EL, Silver DL.

Nature. 2014 May 22;509(7501):503-6. doi: 10.1038/nature13241. Epub 2014 May 14.


Generation of a Magoh conditional allele in mice.

McMahon JJ, Shi L, Silver DL.

Genesis. 2014 Aug;52(8):752-8. doi: 10.1002/dvg.22788. Epub 2014 May 9.


Fat storage-inducing transmembrane protein 2 is required for normal fat storage in adipose tissue.

Miranda DA, Kim JH, Nguyen LN, Cheng W, Tan BC, Goh VJ, Tan JS, Yaligar J, Kn BP, Velan SS, Wang H, Silver DL.

J Biol Chem. 2014 Apr 4;289(14):9560-72. doi: 10.1074/jbc.M114.547687. Epub 2014 Feb 11.


The lipid droplet as a potential therapeutic target in NAFLD.

Goh VJ, Silver DL.

Semin Liver Dis. 2013 Nov;33(4):312-20. doi: 10.1055/s-0033-1358521. Epub 2013 Nov 12. Review.


Deficiency of asparagine synthetase causes congenital microcephaly and a progressive form of encephalopathy.

Ruzzo EK, Capo-Chichi JM, Ben-Zeev B, Chitayat D, Mao H, Pappas AL, Hitomi Y, Lu YF, Yao X, Hamdan FF, Pelak K, Reznik-Wolf H, Bar-Joseph I, Oz-Levi D, Lev D, Lerman-Sagie T, Leshinsky-Silver E, Anikster Y, Ben-Asher E, Olender T, Colleaux L, Décarie JC, Blaser S, Banwell B, Joshi RB, He XP, Patry L, Silver RJ, Dobrzeniecka S, Islam MS, Hasnat A, Samuels ME, Aryal DK, Rodriguiz RM, Jiang YH, Wetsel WC, McNamara JO, Rouleau GA, Silver DL, Lancet D, Pras E, Mitchell GA, Michaud JL, Goldstein DB.

Neuron. 2013 Oct 16;80(2):429-41. doi: 10.1016/j.neuron.2013.08.013.


Purification of integral membrane proteins and lipid-binding assays.

Gross DA, Silver DL.

Methods Cell Biol. 2013;116:191-211. doi: 10.1016/B978-0-12-408051-5.00010-3.


Genetic interaction screens identify a role for hedgehog signaling in Drosophila border cell migration.

Geisbrecht ER, Sawant K, Su Y, Liu ZC, Silver DL, Burtscher A, Wang X, Zhu AJ, McDonald JA.

Dev Dyn. 2013 May;242(5):414-31. doi: 10.1002/dvdy.23926. Epub 2013 Feb 8.


The EJC component Magoh regulates proliferation and expansion of neural crest-derived melanocytes.

Silver DL, Leeds KE, Hwang HW, Miller EE, Pavan WJ.

Dev Biol. 2013 Mar 15;375(2):172-81. doi: 10.1016/j.ydbio.2013.01.004. Epub 2013 Jan 18.


Major facilitator superfamily domain-containing protein 2a (MFSD2A) has roles in body growth, motor function, and lipid metabolism.

Berger JH, Charron MJ, Silver DL.

PLoS One. 2012;7(11):e50629. doi: 10.1371/journal.pone.0050629. Epub 2012 Nov 29.


Inhibition of Candida parapsilosis fatty acid synthase (Fas2) induces mitochondrial cell death in serum.

Nguyen LN, Cesar GV, Le GT, Silver DL, Nimrichter L, Nosanchuk JD.

PLoS Pathog. 2012;8(8):e1002879. doi: 10.1371/journal.ppat.1002879. Epub 2012 Aug 30.


SCS3 and YFT2 link transcription of phospholipid biosynthetic genes to ER stress and the UPR.

Moir RD, Gross DA, Silver DL, Willis IM.

PLoS Genet. 2012 Aug;8(8):e1002890. doi: 10.1371/journal.pgen.1002890. Epub 2012 Aug 23.


Analysis of the IJCNN 2011 UTL challenge.

Guyon I, Dror G, Lemaire V, Silver DL, Taylor G, Aha DW.

Neural Netw. 2012 Aug;32:174-8. doi: 10.1016/j.neunet.2012.02.010. Epub 2012 Feb 14.


Direct binding of triglyceride to fat storage-inducing transmembrane proteins 1 and 2 is important for lipid droplet formation.

Gross DA, Zhan C, Silver DL.

Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19581-6. doi: 10.1073/pnas.1110817108. Epub 2011 Nov 21.

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