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Items: 1 to 50 of 137

1.

Janus kinase 2 activation mechanisms revealed by analysis of suppressing mutations.

Hammarén HM, Virtanen AT, Abraham BG, Peussa H, Hubbard SR, Silvennoinen O.

J Allergy Clin Immunol. 2018 Aug 6. pii: S0091-6749(18)31129-1. doi: 10.1016/j.jaci.2018.07.022. [Epub ahead of print]

PMID:
30092288
2.

The regulation of JAKs in cytokine signaling and its breakdown in disease.

Hammarén HM, Virtanen AT, Raivola J, Silvennoinen O.

Cytokine. 2018 Apr 20. pii: S1043-4666(18)30127-3. doi: 10.1016/j.cyto.2018.03.041. [Epub ahead of print] Review.

3.

Proprotein convertase enzyme FURIN is upregulated in primary Sjögren's syndrome.

Ranta N, Valli A, Grönholm A, Silvennoinen O, Isomäki P, Pesu M, Pertovaara M.

Clin Exp Rheumatol. 2018 May-Jun;36 Suppl 112(3):47-50. Epub 2018 Feb 21.

4.

Oncoprotein Tudor-SN is a key determinant providing survival advantage under DNA damaging stress.

Fu X, Zhang C, Meng H, Zhang K, Shi L, Cao C, Wang Y, Su C, Xin L, Ren Y, Zhang W, Sun X, Ge L, Silvennoinen O, Yao Z, Yang X, Yang J.

Cell Death Differ. 2018 Sep;25(9):1625-1637. doi: 10.1038/s41418-018-0068-9. Epub 2018 Feb 19.

PMID:
29459768
5.

Identification and Characterization of JAK2 Pseudokinase Domain Small Molecule Binders.

Puleo DE, Kucera K, Hammarén HM, Ungureanu D, Newton AS, Silvennoinen O, Jorgensen WL, Schlessinger J.

ACS Med Chem Lett. 2017 May 17;8(6):618-621. doi: 10.1021/acsmedchemlett.7b00153. eCollection 2017 Jun 8.

6.

An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation.

Saarimäki-Vire J, Balboa D, Russell MA, Saarikettu J, Kinnunen M, Keskitalo S, Malhi A, Valensisi C, Andrus C, Eurola S, Grym H, Ustinov J, Wartiovaara K, Hawkins RD, Silvennoinen O, Varjosalo M, Morgan NG, Otonkoski T.

Cell Rep. 2017 Apr 11;19(2):281-294. doi: 10.1016/j.celrep.2017.03.055.

7.

Cytokine-induced STAT1 activation is increased in patients with primary Sjögren's syndrome.

Pertovaara M, Silvennoinen O, Isomäki P.

Clin Immunol. 2016 Apr;165:60-7. doi: 10.1016/j.clim.2016.03.010. Epub 2016 Mar 17.

PMID:
26995659
8.

Nucleotide-binding mechanisms in pseudokinases.

Hammarén HM, Virtanen AT, Silvennoinen O.

Biosci Rep. 2015 Nov 20;36(1):e00282. doi: 10.1042/BSR20150226. Review.

9.

Structural and Functional Characterization of the JH2 Pseudokinase Domain of JAK Family Tyrosine Kinase 2 (TYK2).

Min X, Ungureanu D, Maxwell S, Hammarén H, Thibault S, Hillert EK, Ayres M, Greenfield B, Eksterowicz J, Gabel C, Walker N, Silvennoinen O, Wang Z.

J Biol Chem. 2015 Nov 6;290(45):27261-70. doi: 10.1074/jbc.M115.672048. Epub 2015 Sep 10.

10.

Targeting the Inactive Conformation of JAK2 in Hematological Malignancies.

Silvennoinen O, Hubbard SR.

Cancer Cell. 2015 Jul 13;28(1):1-2. doi: 10.1016/j.ccell.2015.06.010.

11.

ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation.

Hammarén HM, Ungureanu D, Grisouard J, Skoda RC, Hubbard SR, Silvennoinen O.

Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4642-7. doi: 10.1073/pnas.1423201112. Epub 2015 Mar 30.

12.

Molecular insights into regulation of JAK2 in myeloproliferative neoplasms.

Silvennoinen O, Hubbard SR.

Blood. 2015 May 28;125(22):3388-92. doi: 10.1182/blood-2015-01-621110. Epub 2015 Mar 30. Review.

13.

STAT-5 is activated constitutively in T cells, B cells and monocytes from patients with primary Sjögren's syndrome.

Pertovaara M, Silvennoinen O, Isomäki P.

Clin Exp Immunol. 2015 Jul;181(1):29-38. doi: 10.1111/cei.12614. Epub 2015 Apr 23.

14.

Tudor staphylococcal nuclease (Tudor-SN), a novel regulator facilitating G1/S phase transition, acting as a co-activator of E2F-1 in cell cycle regulation.

Su C, Zhang C, Tecle A, Fu X, He J, Song J, Zhang W, Sun X, Ren Y, Silvennoinen O, Yao Z, Yang X, Wei M, Yang J.

J Biol Chem. 2015 Mar 13;290(11):7208-20. doi: 10.1074/jbc.M114.625046. Epub 2015 Jan 27.

15.

Poly(A)(+) mRNA-binding protein Tudor-SN regulates stress granules aggregation dynamics.

Gao X, Fu X, Song J, Zhang Y, Cui X, Su C, Ge L, Shao J, Xin L, Saarikettu J, Mei M, Yang X, Wei M, Silvennoinen O, Yao Z, He J, Yang J.

FEBS J. 2015 Mar;282(5):874-90. doi: 10.1111/febs.13186. Epub 2015 Jan 26.

16.

The activity of JAK-STAT pathways in rheumatoid arthritis: constitutive activation of STAT3 correlates with interleukin 6 levels.

Isomäki P, Junttila I, Vidqvist KL, Korpela M, Silvennoinen O.

Rheumatology (Oxford). 2015 Jun;54(6):1103-13. doi: 10.1093/rheumatology/keu430. Epub 2014 Nov 17.

PMID:
25406356
17.

The JH2 domain and SH2-JH2 linker regulate JAK2 activity: A detailed kinetic analysis of wild type and V617F mutant kinase domains.

Sanz Sanz A, Niranjan Y, Hammarén H, Ungureanu D, Ruijtenbeek R, Touw IP, Silvennoinen O, Hilhorst R.

Biochim Biophys Acta. 2014 Oct;1844(10):1835-41. doi: 10.1016/j.bbapap.2014.07.003. Epub 2014 Aug 7.

PMID:
25107665
18.

Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase.

Shan Y, Gnanasambandan K, Ungureanu D, Kim ET, Hammarén H, Yamashita K, Silvennoinen O, Shaw DE, Hubbard SR.

Nat Struct Mol Biol. 2014 Jul;21(7):579-84. doi: 10.1038/nsmb.2849. Epub 2014 Jun 11.

19.

Human Tudor staphylococcal nuclease (Tudor-SN) protein modulates the kinetics of AGTR1-3'UTR granule formation.

Gao X, Shi X, Fu X, Ge L, Zhang Y, Su C, Yang X, Silvennoinen O, Yao Z, He J, Wei M, Yang J.

FEBS Lett. 2014 Jun 13;588(13):2154-61. doi: 10.1016/j.febslet.2014.04.045. Epub 2014 May 8.

20.

Tudor-SN, a novel coactivator of peroxisome proliferator-activated receptor γ protein, is essential for adipogenesis.

Duan Z, Zhao X, Fu X, Su C, Xin L, Saarikettu J, Yang X, Yao Z, Silvennoinen O, Wei M, Yang J.

J Biol Chem. 2014 Mar 21;289(12):8364-74. doi: 10.1074/jbc.M113.523456. Epub 2014 Feb 12.

21.

Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses.

Varghese LN, Ungureanu D, Liau NP, Young SN, Laktyushin A, Hammaren H, Lucet IS, Nicola NA, Silvennoinen O, Babon JJ, Murphy JM.

Biochem J. 2014 Mar 1;458(2):395-405. doi: 10.1042/BJ20131516.

22.

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties.

Murphy JM, Zhang Q, Young SN, Reese ML, Bailey FP, Eyers PA, Ungureanu D, Hammaren H, Silvennoinen O, Varghese LN, Chen K, Tripaydonis A, Jura N, Fukuda K, Qin J, Nimchuk Z, Mudgett MB, Elowe S, Gee CL, Liu L, Daly RJ, Manning G, Babon JJ, Lucet IS.

Biochem J. 2014 Jan 15;457(2):323-34. doi: 10.1042/BJ20131174.

23.

The transcriptional co-activator SND1 is a novel regulator of alternative splicing in prostate cancer cells.

Cappellari M, Bielli P, Paronetto MP, Ciccosanti F, Fimia GM, Saarikettu J, Silvennoinen O, Sette C.

Oncogene. 2014 Jul 17;33(29):3794-802. doi: 10.1038/onc.2013.360. Epub 2013 Sep 2.

PMID:
23995791
24.

Analysis of steady-state Förster resonance energy transfer data by avoiding pitfalls: interaction of JAK2 tyrosine kinase with N-methylanthraniloyl nucleotides.

Niranjan Y, Ungureanu D, Hammarén H, Sanz-Sanz A, Westphal AH, Borst JW, Silvennoinen O, Hilhorst R.

Anal Biochem. 2013 Nov 15;442(2):213-22. doi: 10.1016/j.ab.2013.07.020. Epub 2013 Jul 23.

PMID:
23891636
25.

New insights into the structure and function of the pseudokinase domain in JAK2.

Silvennoinen O, Ungureanu D, Niranjan Y, Hammaren H, Bandaranayake R, Hubbard SR.

Biochem Soc Trans. 2013 Aug;41(4):1002-7. doi: 10.1042/BST20130005. Review.

PMID:
23863170
26.

Comparative analysis of targeted differentiation of human induced pluripotent stem cells (hiPSCs) and human embryonic stem cells reveals variability associated with incomplete transgene silencing in retrovirally derived hiPSC lines.

Toivonen S, Ojala M, Hyysalo A, Ilmarinen T, Rajala K, Pekkanen-Mattila M, Äänismaa R, Lundin K, Palgi J, Weltner J, Trokovic R, Silvennoinen O, Skottman H, Narkilahti S, Aalto-Setälä K, Otonkoski T.

Stem Cells Transl Med. 2013 Feb;2(2):83-93. doi: 10.5966/sctm.2012-0047. Epub 2013 Jan 22.

27.

Expression analysis of Tudor-SN protein in mouse tissues.

Fashe T, Saarikettu J, Isomäki P, Yang J, Silvennoinen O.

Tissue Cell. 2013 Feb;45(1):21-31. doi: 10.1016/j.tice.2012.09.001. Epub 2012 Oct 12.

PMID:
23068188
28.

Structure-function analysis indicates that sumoylation modulates DNA-binding activity of STAT1.

Grönholm J, Vanhatupa S, Ungureanu D, Väliaho J, Laitinen T, Valjakka J, Silvennoinen O.

BMC Biochem. 2012 Oct 8;13:20. doi: 10.1186/1471-2091-13-20.

29.

JAK Kinases in Health and Disease: An Update.

Laurence A, Pesu M, Silvennoinen O, O'Shea J.

Open Rheumatol J. 2012;6:232-44. doi: 10.2174/1874312901206010232. Epub 2012 Sep 7.

30.

Cell model of catecholaminergic polymorphic ventricular tachycardia reveals early and delayed afterdepolarizations.

Kujala K, Paavola J, Lahti A, Larsson K, Pekkanen-Mattila M, Viitasalo M, Lahtinen AM, Toivonen L, Kontula K, Swan H, Laine M, Silvennoinen O, Aalto-Setälä K.

PLoS One. 2012;7(9):e44660. doi: 10.1371/journal.pone.0044660. Epub 2012 Sep 4.

31.

Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F.

Bandaranayake RM, Ungureanu D, Shan Y, Shaw DE, Silvennoinen O, Hubbard SR.

Nat Struct Mol Biol. 2012 Aug;19(8):754-9. doi: 10.1038/nsmb.2348. Epub 2012 Jul 22.

32.

Tudor staphylococcal nuclease (Tudor-SN) participates in small ribonucleoprotein (snRNP) assembly via interacting with symmetrically dimethylated Sm proteins.

Gao X, Zhao X, Zhu Y, He J, Shao J, Su C, Zhang Y, Zhang W, Saarikettu J, Silvennoinen O, Yao Z, Yang J.

J Biol Chem. 2012 May 25;287(22):18130-41. doi: 10.1074/jbc.M111.311852. Epub 2012 Apr 9.

33.

Th17 cells in multiple sclerosis express higher levels of JAK2, which increases their surface expression of IFN-γR2.

Conti L, De Palma R, Rolla S, Boselli D, Rodolico G, Kaur S, Silvennoinen O, Niccolai E, Amedei A, Ivaldi F, Clerico M, Contessa G, Uccelli A, Durelli L, Novelli F.

J Immunol. 2012 Feb 1;188(3):1011-8. doi: 10.4049/jimmunol.1004013. Epub 2012 Jan 4.

34.

Not4 enhances JAK/STAT pathway-dependent gene expression in Drosophila and in human cells.

Grönholm J, Kaustio M, Myllymäki H, Kallio J, Saarikettu J, Kronhamn J, Valanne S, Silvennoinen O, Rämet M.

FASEB J. 2012 Mar;26(3):1239-50. doi: 10.1096/fj.11-195875. Epub 2011 Dec 8.

PMID:
22159038
35.

Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture.

Lahti AL, Kujala VJ, Chapman H, Koivisto AP, Pekkanen-Mattila M, Kerkelä E, Hyttinen J, Kontula K, Swan H, Conklin BR, Yamanaka S, Silvennoinen O, Aalto-Setälä K.

Dis Model Mech. 2012 Mar;5(2):220-30. doi: 10.1242/dmm.008409. Epub 2011 Nov 3.

36.

The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling.

Ungureanu D, Wu J, Pekkala T, Niranjan Y, Young C, Jensen ON, Xu CF, Neubert TA, Skoda RC, Hubbard SR, Silvennoinen O.

Nat Struct Mol Biol. 2011 Aug 14;18(9):971-6. doi: 10.1038/nsmb.2099.

37.

Defense of zebrafish embryos against Streptococcus pneumoniae infection is dependent on the phagocytic activity of leukocytes.

Rounioja S, Saralahti A, Rantala L, Parikka M, Henriques-Normark B, Silvennoinen O, Rämet M.

Dev Comp Immunol. 2012 Feb;36(2):342-8. doi: 10.1016/j.dci.2011.05.008. Epub 2011 May 31.

PMID:
21658407
38.

Analysis of Jak2 catalytic function by peptide microarrays: the role of the JH2 domain and V617F mutation.

Sanz A, Ungureanu D, Pekkala T, Ruijtenbeek R, Touw IP, Hilhorst R, Silvennoinen O.

PLoS One. 2011 Apr 18;6(4):e18522. doi: 10.1371/journal.pone.0018522.

39.

PTB-associated splicing factor (PSF) functions as a repressor of STAT6-mediated Ig epsilon gene transcription by recruitment of HDAC1.

Dong L, Zhang X, Fu X, Zhang X, Gao X, Zhu M, Wang X, Yang Z, Jensen ON, Saarikettu J, Yao Z, Silvennoinen O, Yang J.

J Biol Chem. 2011 Feb 4;286(5):3451-9. doi: 10.1074/jbc.M110.168377. Epub 2010 Nov 24.

40.

Tudor-SN interacts with and co-localizes with G3BP in stress granules under stress conditions.

Gao X, Ge L, Shao J, Su C, Zhao H, Saarikettu J, Yao X, Yao Z, Silvennoinen O, Yang J.

FEBS Lett. 2010 Aug 20;584(16):3525-32. doi: 10.1016/j.febslet.2010.07.022. Epub 2010 Jul 17.

41.

Eye transformer is a negative regulator of Drosophila JAK/STAT signaling.

Kallio J, Myllymäki H, Grönholm J, Armstrong M, Vanha-aho LM, Mäkinen L, Silvennoinen O, Valanne S, Rämet M.

FASEB J. 2010 Nov;24(11):4467-79. doi: 10.1096/fj.10-162784. Epub 2010 Jul 12.

PMID:
20624926
42.

Sumoylation of Drosophila transcription factor STAT92E.

Grönholm J, Ungureanu D, Vanhatupa S, Rämet M, Silvennoinen O.

J Innate Immun. 2010;2(6):618-24. doi: 10.1159/000318676. Epub 2010 Jul 12.

43.

Monoclonal antibodies against human Tudor-SN.

Saarikettu J, Ovod V, Vuoksio M, Grönholm J, Yang J, Silvennoinen O.

Hybridoma (Larchmt). 2010 Jun;29(3):231-6. doi: 10.1089/hyb.2009.0114.

PMID:
20568998
44.

Genome-wide RNA interference in Drosophila cells identifies G protein-coupled receptor kinase 2 as a conserved regulator of NF-kappaB signaling.

Valanne S, Myllymäki H, Kallio J, Schmid MR, Kleino A, Murumägi A, Airaksinen L, Kotipelto T, Kaustio M, Ulvila J, Esfahani SS, Engström Y, Silvennoinen O, Hultmark D, Parikka M, Rämet M.

J Immunol. 2010 Jun 1;184(11):6188-98. doi: 10.4049/jimmunol.1000261. Epub 2010 Apr 26.

45.

Expression of IL-10 family cytokines in rheumatoid arthritis: elevated levels of IL-19 in the joints.

Alanärä T, Karstila K, Moilanen T, Silvennoinen O, Isomäki P.

Scand J Rheumatol. 2010 Mar;39(2):118-26. doi: 10.3109/03009740903170823.

PMID:
20001767
46.

Tudor staphylococcal nuclease is an evolutionarily conserved component of the programmed cell death degradome.

Sundström JF, Vaculova A, Smertenko AP, Savenkov EI, Golovko A, Minina E, Tiwari BS, Rodriguez-Nieto S, Zamyatnin AA Jr, Välineva T, Saarikettu J, Frilander MJ, Suarez MF, Zavialov A, Ståhl U, Hussey PJ, Silvennoinen O, Sundberg E, Zhivotovsky B, Bozhkov PV.

Nat Cell Biol. 2009 Nov;11(11):1347-54. doi: 10.1038/ncb1979. Epub 2009 Oct 11.

PMID:
19820703
47.

p100 increases AT1R expression through interaction with AT1R 3'-UTR.

Paukku K, Kalkkinen N, Silvennoinen O, Kontula KK, Lehtonen JY.

Nucleic Acids Res. 2008 Aug;36(13):4474-87. doi: 10.1093/nar/gkn411. Epub 2008 Jul 4.

48.

MAPK-induced Ser727 phosphorylation promotes SUMOylation of STAT1.

Vanhatupa S, Ungureanu D, Paakkunainen M, Silvennoinen O.

Biochem J. 2008 Jan 1;409(1):179-85.

PMID:
17897103
49.

The expression of SOCS is altered in rheumatoid arthritis.

Isomäki P, Alanärä T, Isohanni P, Lagerstedt A, Korpela M, Moilanen T, Visakorpi T, Silvennoinen O.

Rheumatology (Oxford). 2007 Oct;46(10):1538-46. Epub 2007 Aug 27.

PMID:
17726036
50.

The multifunctional human p100 protein 'hooks' methylated ligands.

Shaw N, Zhao M, Cheng C, Xu H, Saarikettu J, Li Y, Da Y, Yao Z, Silvennoinen O, Yang J, Liu ZJ, Wang BC, Rao Z.

Nat Struct Mol Biol. 2007 Aug;14(8):779-84. Epub 2007 Jul 15.

PMID:
17632523

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