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Items: 33


An Overview of Immunotherapeutic Approaches Against Canine Visceral Leishmaniasis: What Has Been Tested on Dogs and a New Perspective on Improving Treatment Efficacy.

Gonçalves AAM, Leite JC, Resende LA, Mariano RMDS, Silveira P, Melo-Júnior OAO, Ribeiro HS, de Oliveira DS, Soares DF, Santos TAP, Marques AF, Galdino AS, Martins-Filho OA, Dutra WO, da Silveira-Lemos D, Giunchetti RC.

Front Cell Infect Microbiol. 2019 Dec 18;9:427. doi: 10.3389/fcimb.2019.00427. eCollection 2019. Review.


Canine visceral leishmaniasis biomarkers and their employment in vaccines.

Giunchetti RC, Silveira P, Resende LA, Leite JC, Melo-Júnior OAO, Rodrigues-Alves ML, Costa LM, Lair DF, Chaves VR, Soares IDS, de Mendonça LZ, Lanna MF, Ribeiro HS, Maia-Gonçalves AA, Santos TAP, Roatt BM, Aguiar-Soares RDO, Vitoriano-Souza J, das Dores Moreira N, Mathias FAS, Cardoso JMO, Coura-Vital W, Galdino AS, Viana KF, Martins-Filho OA, Silveira-Lemos DD, Dutra WO, Reis AB.

Vet Parasitol. 2019 Jul;271:87-97. doi: 10.1016/j.vetpar.2019.05.006. Epub 2019 May 20. Review.


Clinical-pathological and immunological biomarkers in dogs with atopic dermatitis.

Martins GC, de Oliveira Melo Júnior OA, Botoni LS, Nogueira MM, da Costa Val AP, Blanco BS, Dutra WO, Giunchetti RC, Melo MM, da Silveira Lemos D.

Vet Immunol Immunopathol. 2018 Nov;205:58-64. doi: 10.1016/j.vetimm.2018.10.009. Epub 2018 Oct 23.


Fcγ-RI, Fcγ-RII and IL-10 as predictive biomarkers for post-therapeutic cicatrization time in monocytes from cutaneous leishmaniasis patients.

Rodrigues-Alves ML, Melo-Júnior OAO, Coelho-Dos-Reis JG, Pascoal-Xavier MA, Alves-Costa H, Reis CA, Dutra WO, Silva RE, Senna MCR, Faria AC, Medeiros NI, Gomes JAS, Silveira-Lemos D, Martins-Filho OA, Teixeira-Carvalho A, Costa-Silva MF, Giunchetti RC, Peruhype-Magalhães V.

Parasite Immunol. 2018 Aug;40(8):e12565. doi: 10.1111/pim.12565. Epub 2018 Jul 8.


Regulatory monocytes in helminth infections: insights from the modulation during human hookworm infection.

Passos LS, Gazzinelli-Guimarães PH, Oliveira Mendes TA, Guimarães AC, Silveira Lemos DD, Ricci ND, Gonçalves R, Bartholomeu DC, Fujiwara RT, Bueno LL.

BMC Infect Dis. 2017 Apr 8;17(1):253. doi: 10.1186/s12879-017-2366-0.


Baccharis trimera inhibits reactive oxygen species production through PKC and down-regulation p47 phox phosphorylation of NADPH oxidase in SK Hep-1 cells.

de Araújo GR, Rabelo AC, Meira JS, Rossoni-Júnior JV, Castro-Borges W, Guerra-Sá R, Batista MA, Silveira-Lemos DD, Souza GH, Brandão GC, Chaves MM, Costa DC.

Exp Biol Med (Maywood). 2017 Feb;242(3):333-343. doi: 10.1177/1535370216672749. Epub 2016 Oct 7.


Multicomponent LBSap vaccine displays immunological and parasitological profiles similar to those of Leish-Tec® and Leishmune® vaccines against visceral leishmaniasis.

de Mendonça LZ, Resende LA, Lanna MF, Aguiar-Soares RD, Roatt BM, Castro RA, Batista MA, Silveira-Lemos D, Gomes Jde A, Fujiwara RT, Rezende SA, Martins-Filho OA, Corrêa-Oliveira R, Dutra WO, Reis AB, Giunchetti RC.

Parasit Vectors. 2016 Aug 30;9:472. doi: 10.1186/s13071-016-1752-6.


Impact of LbSapSal Vaccine in Canine Immunological and Parasitological Features before and after Leishmania chagasi-Challenge.

Resende LA, Aguiar-Soares RD, Gama-Ker H, Roatt BM, Mendonça LZ, Alves ML, Silveira-Lemos Dd, Corrêa-Oliveira R, Martins-Filho OA, Araújo MS, Fujiwara RT, Gontijo NF, Reis AB, Giunchetti RC.

PLoS One. 2016 Aug 24;11(8):e0161169. doi: 10.1371/journal.pone.0161169. eCollection 2016.


Application of rapid in vitro co-culture system of macrophages and T-cell subsets to assess the immunogenicity of dogs vaccinated with live attenuated Leishmania donovani centrin deleted parasites (LdCen-/-).

Viana KF, Fiuza JA, Gannavaram S, Dey R, Selvapandiyan A, Bartholomeu DC, da Silveira-Lemos D, Bueno LL, Dutra WO, Fujiwara RT, Nakhasi HL, Giunchetti RC.

Parasit Vectors. 2016 Apr 30;9:250. doi: 10.1186/s13071-016-1528-z.


Setting the proportion of CD4+ and CD8+ T-cells co-cultured with canine macrophages infected with Leishmania chagasi.

Viana KF, Aguiar-Soares RD, Ker HG, Resende LA, Souza-Fagundes EM, Dutra WO, Fujiwara RT, da Silveira-Lemos D, Sant'Ana Rde C, Wardini AB, Araújo MS, Martins-Filho OA, Reis AB, Giunchetti RC.

Vet Parasitol. 2015 Jul 30;211(3-4):124-32. doi: 10.1016/j.vetpar.2015.05.025. Epub 2015 Jun 3.


Etiological treatment of Chagas disease patients with benznidazole lead to a sustained pro-inflammatory profile counterbalanced by modulatory events.

Campi-Azevedo AC, Gomes JA, Teixeira-Carvalho A, Silveira-Lemos D, Vitelli-Avelar DM, Sathler-Avelar R, Peruhype-Magalhães V, Béla SR, Silvestre KF, Batista MA, Schachnik NC, Correa-Oliveira R, Eloi-Santos SM, Martins-Filho OA.

Immunobiology. 2015 May;220(5):564-74. doi: 10.1016/j.imbio.2014.12.006. Epub 2015 Jan 8.


Association of liposome-encapsulated trivalent antimonial with ascorbic acid: an effective and safe strategy in the treatment of experimental visceral leishmaniasis.

Castro RA, Silva-Barcellos NM, Licio CS, Souza JB, Souza-Testasicca MC, Ferreira FM, Batista MA, Silveira-Lemos D, Moura SL, Frézard F, Rezende SA.

PLoS One. 2014 Aug 8;9(8):e104055. doi: 10.1371/journal.pone.0104055. eCollection 2014.


Cellular immunophenotypic profile in the splenic compartment during canine visceral leishmaniasis.

Reis AB, Teixeira-Carvalho A, Giunchetti RC, Roatt BM, Coura-Vital W, Nicolato Rde C, Silveira-Lemos D, Corrêa-Oliveira R, Martins-Filho OA.

Vet Immunol Immunopathol. 2014 Feb 15;157(3-4):190-6. doi: 10.1016/j.vetimm.2013.11.005. Epub 2013 Nov 28.


Association of water extract of green propolis and liposomal meglumine antimoniate in the treatment of experimental visceral leishmaniasis.

Ferreira FM, Castro RA, Batista MA, Rossi FM, Silveira-Lemos D, Frézard F, Moura SA, Rezende SA.

Parasitol Res. 2014 Feb;113(2):533-43. doi: 10.1007/s00436-013-3685-8. Epub 2013 Nov 30.


Cytokine and nitric oxide patterns in dogs immunized with LBSap vaccine, before and after experimental challenge with Leishmania chagasi plus saliva of Lutzomyia longipalpis.

Resende LA, Roatt BM, Aguiar-Soares RD, Viana KF, Mendonça LZ, Lanna MF, Silveira-Lemos D, Corrêa-Oliveira R, Martins-Filho OA, Fujiwara RT, Carneiro CM, Reis AB, Giunchetti RC.

Vet Parasitol. 2013 Dec 6;198(3-4):371-81. doi: 10.1016/j.vetpar.2013.09.011. Epub 2013 Sep 23.


Evaluation of a prototype flow cytometry test for serodiagnosis of canine visceral leishmaniasis.

Ker HG, Coura-Vital W, Aguiar-Soares RD, Roatt BM, das Dores Moreira N, Carneiro CM, Machado EM, Teixeira-Carvalho A, Martins-Filho OA, Giunchetti RC, Araújo MS, Coelho EA, da Silveira-Lemos D, Reis AB.

Clin Vaccine Immunol. 2013 Dec;20(12):1792-8. doi: 10.1128/CVI.00575-13. Epub 2013 Oct 9.


Analysis using canine peripheral blood for establishing in vitro conditions for monocyte differentiation into macrophages for Leishmania chagasi infection and T-cell subset purification.

Viana KF, Aguiar-Soares RD, Roatt BM, Resende LA, da Silveira-Lemos D, Corrêa-Oliveira R, Martins-Filho OA, Moura SL, Zanini MS, Araújo MS, Reis AB, Giunchetti RC.

Vet Parasitol. 2013 Nov 15;198(1-2):62-71. doi: 10.1016/j.vetpar.2013.08.014. Epub 2013 Aug 22.


Effect of the preservative and temperature conditions on the stability of Leishmania infantum promastigotes antigens applied in a flow cytometry diagnostic method for canine visceral leishmaniasis.

Gama Ker H, Dian de Oliveira Aguiar-Soares R, Mendes Roatt B, das Dores Moreira N, Coura-Vital W, Martins Carneiro C, Teixeira-Carvalho A, Martins-Filho OA, Cordeiro Giunchetti R, da Silveira-Lemos D, Barbosa Reis A.

Diagn Microbiol Infect Dis. 2013 Aug;76(4):470-6. doi: 10.1016/j.diagmicrobio.2013.04.007. Epub 2013 May 29.


Cytokine Pattern of T Lymphocytes in Acute Schistosomiasis mansoni Patients following Treated Praziquantel Therapy.

Silveira-Lemos D, Fernandes Costa-Silva M, Cardoso de Oliveira Silveira A, Azevedo Batista M, Alves Oliveira-Fraga L, Soares Silveira AM, Barbosa Alvarez MC, Martins-Filho OA, Gazzinelli G, Corrêa-Oliveira R, Teixeira-Carvalho A.

J Parasitol Res. 2013;2013:909134. doi: 10.1155/2013/909134. Epub 2013 Jan 20.


17DD and 17D-213/77 yellow fever substrains trigger a balanced cytokine profile in primary vaccinated children.

Campi-Azevedo AC, de Araújo-Porto LP, Luiza-Silva M, Batista MA, Martins MA, Sathler-Avelar R, da Silveira-Lemos D, Camacho LA, de Menezes Martins R, de Lourdes de Sousa Maia M, Farias RH, da Silva Freire M, Galler R, Homma A, Ribeiro JG, Lemos JA, Auxiliadora-Martins M, Caldas IR, Elói-Santos SM, Teixeira-Carvalho A, Martins-Filho OA.

PLoS One. 2012;7(12):e49828. doi: 10.1371/journal.pone.0049828. Epub 2012 Dec 10.


Distinct pattern of immunophenotypic features of innate and adaptive immunity as a putative signature of clinical and laboratorial status of patients with localized cutaneous leishmaniasis.

Freitas-Teixeira PM, Silveira-Lemos D, Giunchetti RC, Baratta-Masini A, Mayrink W, Peruhype-Magalhães V, Rocha RD, Campi-Azevedo AC, Teixeira-Carvalho A, Martins-Filho OA.

Scand J Immunol. 2012 Oct;76(4):421-32. doi: 10.1111/j.1365-3083.2012.02748.x.


Higher expression of CCL2, CCL4, CCL5, CCL21, and CXCL8 chemokines in the skin associated with parasite density in canine visceral leishmaniasis.

Menezes-Souza D, Guerra-Sá R, Carneiro CM, Vitoriano-Souza J, Giunchetti RC, Teixeira-Carvalho A, Silveira-Lemos D, Oliveira GC, Corrêa-Oliveira R, Reis AB.

PLoS Negl Trop Dis. 2012;6(4):e1566. doi: 10.1371/journal.pntd.0001566. Epub 2012 Apr 10.


Impaired phagocytic capacity driven by downregulation of major phagocytosis-related cell surface molecules elicits an overall modulatory cytokine profile in neutrophils and monocytes from the indeterminate clinical form of Chagas disease.

Gomes JA, Campi-Azevedo AC, Teixeira-Carvalho A, Silveira-Lemos D, Vitelli-Avelar D, Sathler-Avelar R, Peruhype-Magalhães V, Silvestre KF, Batista MA, Schachnik NC, Correa-Oliveira R, Eloi-Santos S, Martins-Filho OA.

Immunobiology. 2012 Oct;217(10):1005-16. doi: 10.1016/j.imbio.2012.01.014. Epub 2012 Jan 20.


Cytokine signatures of innate and adaptive immunity in 17DD yellow fever vaccinated children and its association with the level of neutralizing antibody.

Luiza-Silva M, Campi-Azevedo AC, Batista MA, Martins MA, Avelar RS, da Silveira Lemos D, Bastos Camacho LA, de Menezes Martins R, de Lourdes de Sousa Maia M, Guedes Farias RH, da Silva Freire M, Galler R, Homma A, Leite Ribeiro JG, Campos Lemos JA, Auxiliadora-Martins M, Eloi-Santos SM, Teixeira-Carvalho A, Martins-Filho OA.

J Infect Dis. 2011 Sep 15;204(6):873-83. doi: 10.1093/infdis/jir439.


Characterization of main cytokine sources from the innate and adaptive immune responses following primary 17DD yellow fever vaccination in adults.

Silva ML, Martins MA, Espírito-Santo LR, Campi-Azevedo AC, Silveira-Lemos D, Ribeiro JG, Homma A, Kroon EG, Teixeira-Carvalho A, Elói-Santos SM, Martins-Filho OA.

Vaccine. 2011 Jan 10;29(3):583-92. doi: 10.1016/j.vaccine.2010.08.046. Epub 2010 Aug 21.


Rural tourism: a risk factor for schistosomiasis transmission in Brazil.

Enk MJ, Amaral GL, Costa e Silva MF, Silveira-Lemos D, Teixeira-Carvalho A, Martins-Filho OA, Correa-Oliveira R, Gazinnelli G, Coelho PM, Massara CL.

Mem Inst Oswaldo Cruz. 2010 Jul;105(4):537-40.


Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni.

Silveira-Lemos D, Teixeira-Carvalho A, Martins-Filho OA, Souza-Soares AL, Castro-Silva P, Costa-Silva MF, Guimarães PH, Ferraz HB, Oliveira-Fraga LA, Teixeira MM, Corrêa-Oliveira R.

Mem Inst Oswaldo Cruz. 2010 Jul;105(4):380-6.


Clinical and immunological insights on severe, adverse neurotropic and viscerotropic disease following 17D yellow fever vaccination.

Silva ML, Espírito-Santo LR, Martins MA, Silveira-Lemos D, Peruhype-Magalhães V, Caminha RC, de Andrade Maranhão-Filho P, Auxiliadora-Martins M, de Menezes Martins R, Galler R, da Silva Freire M, Marcovistz R, Homma A, Teuwen DE, Elói-Santos SM, Andrade MC, Teixeira-Carvalho A, Martins-Filho OA.

Clin Vaccine Immunol. 2010 Jan;17(1):118-26. doi: 10.1128/CVI.00369-09. Epub 2009 Nov 11.


Protective effect of ions against cell death induced by acid stress in Saccharomyces.

Sant'Ana GS, Paes LS, Paiva AF, Fietto LG, Totola AH, Trópia MJ, Silveira-Lemos D, Lucas C, Fietto JL, Brandão RL, Castro IM.

FEMS Yeast Res. 2009 Aug;9(5):701-12. doi: 10.1111/j.1567-1364.2009.00523.x. Epub 2009 May 16.


Eosinophil activation status, cytokines and liver fibrosis in Schistosoma mansoni infected patients.

Silveira-Lemos D, Teixeira-Carvalho A, Martins-Filho OA, Alves Oliveira LF, Costa-Silva MF, Matoso LF, de Souza LJ, Gazzinelli A, Corrêa-Oliveira R.

Acta Trop. 2008 Nov-Dec;108(2-3):150-9. doi: 10.1016/j.actatropica.2008.04.006. Epub 2008 Apr 15.


Cytokines, chemokine receptors, CD4+CD25HIGH+ T-cells and clinical forms of human schistosomiasis.

Teixeira-Carvalho A, Martins-Filho OA, Peruhype-Magalhães V, Silveira-Lemos D, Malaquias LC, Oliveira LF, Silveira AM, Gazzinelli A, Gazzinelli G, Corrêa-Oliveira R.

Acta Trop. 2008 Nov-Dec;108(2-3):139-49. doi: 10.1016/j.actatropica.2008.04.010. Epub 2008 Apr 18.


Antigenicity of a whole parasite vaccine as promising candidate against canine leishmaniasis.

Giunchetti RC, Reis AB, da Silveira-Lemos D, Martins-Filho OA, Corrêa-Oliveira R, Bethony J, Vale AM, da Silva Quetz J, Bueno LL, França-Silva JC, Nascimento E, Mayrink W, Fujiwara RT.

Res Vet Sci. 2008 Aug;85(1):106-12. Epub 2007 Oct 22.


High expression of co-stimulatory and adhesion molecules are observed on eosinophils during human Schistosoma mansoni infection.

Silveira-Lemos D, Teixeira-Carvalho A, Martins-Filho OA, Oliveira LF, Corrêa-Oliveira R.

Mem Inst Oswaldo Cruz. 2006 Sep;101 Suppl 1:345-51.

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