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Items: 45

1.

Local anti-inflammatory activity: Topical formulation containing Kalanchoe brasiliensis and Kalanchoe pinnata leaf aqueous extract.

de Araújo ERD, Félix-Silva J, Xavier-Santos JB, Fernandes JM, Guerra GCB, de Araújo AA, Araújo DFS, de Santis Ferreira L, da Silva Júnior AA, Fernandes-Pedrosa MF, Zucolotto SM.

Biomed Pharmacother. 2019 Mar 8;113:108721. doi: 10.1016/j.biopha.2019.108721. [Epub ahead of print]

2.

Potent and Broad-Spectrum Antimicrobial Activity of Analogs from the Scorpion Peptide Stigmurin.

Amorim-Carmo B, Daniele-Silva A, Parente AMS, Furtado AA, Carvalho E, Oliveira JWF, Santos ECG, Silva MS, Silva SRB, Silva-Júnior AA, Monteiro NK, Fernandes-Pedrosa MF.

Int J Mol Sci. 2019 Jan 31;20(3). pii: E623. doi: 10.3390/ijms20030623.

3.

Tailoring structural properties of spray-dried methotrexate-loaded poly (lactic acid)/poloxamer microparticle blends.

de Oliveira EG, Machado PRL, Farias KJS, da Costa TR, Melo DMA, Lacerda AF, de Freitas Fernandes-Pedrosa M, Cornélio AM, da Silva-Junior AA.

J Mater Sci Mater Med. 2019 Jan 8;30(1):12. doi: 10.1007/s10856-018-6214-6.

PMID:
30617752
4.

Improving Encapsulation of Hydrophilic Chloroquine Diphosphate into Biodegradable Nanoparticles: A Promising Approach against Herpes Virus Simplex-1 Infection.

Lima TLC, Feitosa RC, Dos Santos-Silva E, Dos Santos-Silva AM, Siqueira EMDS, Machado PRL, Cornélio AM, do Egito EST, Fernandes-Pedrosa MF, Farias KJS, da Silva-Júnior AA.

Pharmaceutics. 2018 Dec 3;10(4). pii: E255. doi: 10.3390/pharmaceutics10040255.

5.

Tailoring microstructural, drug release properties, and antichagasic efficacy of biocompatible oil-in-water benznidazol-loaded nanoemulsions.

Streck L, Sarmento VHV, de Menezes RPRPB, Fernandes-Pedrosa MF, Martins AMC, da Silva-Júnior AA.

Int J Pharm. 2019 Jan 30;555:36-48. doi: 10.1016/j.ijpharm.2018.11.041. Epub 2018 Nov 15.

PMID:
30448310
6.

Metformin Hydrochloride-Loaded PLGA Nanoparticle in Periodontal Disease Experimental Model Using Diabetic Rats.

Pereira ASBF, Brito GAC, Lima MLS, Silva Júnior AAD, Silva EDS, de Rezende AA, Bortolin RH, Galvan M, Pirih FQ, Araújo Júnior RF, Medeiros CACX, Guerra GCB, Araújo AA.

Int J Mol Sci. 2018 Nov 6;19(11). pii: E3488. doi: 10.3390/ijms19113488.

7.

A biotechnological approach to immunotherapy: Antivenom against Crotalus durissus cascavella snake venom produced from biodegradable nanoparticles.

Gláucia-Silva F, Torres-Rêgo M, Rocha Soares KS, Damasceno IZ, Tambourgi DV, Silva-Júnior AAD, Fernandes-Pedrosa MF.

Int J Biol Macromol. 2018 Dec;120(Pt B):1917-1924. doi: 10.1016/j.ijbiomac.2018.09.203. Epub 2018 Oct 1.

PMID:
30287370
8.

Development of an effective and safe topical anti-inflammatory gel containing Jatropha gossypiifolia leaf extract: Results from a pre-clinical trial in mice.

Xavier-Santos JB, Félix-Silva J, Passos JGR, Gomes JAS, Fernandes JM, Garcia VB, de Araujo-Junior RF, Zucolotto SM, Silva-Junior AA, Fernandes-Pedrosa MF.

J Ethnopharmacol. 2018 Dec 5;227:268-278. doi: 10.1016/j.jep.2018.09.007. Epub 2018 Sep 6.

PMID:
30195567
9.

Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial.

Palhano-Fontes F, Barreto D, Onias H, Andrade KC, Novaes MM, Pessoa JA, Mota-Rolim SA, Osório FL, Sanches R, Dos Santos RG, Tófoli LF, de Oliveira Silveira G, Yonamine M, Riba J, Santos FR, Silva-Junior AA, Alchieri JC, Galvão-Coelho NL, Lobão-Soares B, Hallak JEC, Arcoverde E, Maia-de-Oliveira JP, Araújo DB.

Psychol Med. 2019 Mar;49(4):655-663. doi: 10.1017/S0033291718001356. Epub 2018 Jun 15.

10.

Analogs of the Scorpion Venom Peptide Stigmurin: Structural Assessment, Toxicity, and Increased Antimicrobial Activity.

Parente AMS, Daniele-Silva A, Furtado AA, Melo MA, Lacerda AF, Queiroz M, Moreno C, Santos E, Rocha HAO, Barbosa EG, Carvalho E, Silva-Júnior AA, Silva MS, Fernandes-Pedrosa MF.

Toxins (Basel). 2018 Apr 18;10(4). pii: E161. doi: 10.3390/toxins10040161.

11.

Antivenom Production against Bothrops jararaca and Bothrops erythromelas Snake Venoms Using Cross-Linked Chitosan Nanoparticles as an Immunoadjuvant.

Soares KSR, Gláucia-Silva F, Daniele-Silva A, Torres-Rêgo M, Araújo NK, Menezes YAS, Damasceno IZ, Tambourgi DV, da Silva-Júnior AA, Fernandes-Pedrosa MF.

Toxins (Basel). 2018 Apr 16;10(4). pii: E158. doi: 10.3390/toxins10040158.

12.

Aspidosperma pyrifolium Has Anti-Inflammatory Properties: An Experimental Study in Mice with Peritonitis Induced by Tityus serrulatus Venom or Carrageenan.

Souza Lima MCJ, Oliveira Bitencourt MA, Furtado AA, Torres-Rêgo M, Siqueira EMDS, Oliveira RM, Oliveira Rocha HA, Ferreira Rocha KB, Silva-Júnior AAD, Zucolotto SM, Fernandes-Pedrosa MF.

Int J Mol Sci. 2017 Nov 11;18(11). pii: E2248. doi: 10.3390/ijms18112248.

13.

Comparison of two Jatropha species (Euphorbiaceae) used popularly to treat snakebites in Northeastern Brazil: Chemical profile, inhibitory activity against Bothrops erythromelas venom and antibacterial activity.

Félix-Silva J, Gomes JAS, Fernandes JM, Moura AKC, Menezes YAS, Santos ECG, Tambourgi DV, Silva-Junior AA, Zucolotto SM, Fernandes-Pedrosa MF.

J Ethnopharmacol. 2018 Mar 1;213:12-20. doi: 10.1016/j.jep.2017.11.002. Epub 2017 Nov 4.

PMID:
29113958
14.

Medicinal Plants for the Treatment of Local Tissue Damage Induced by Snake Venoms: An Overview from Traditional Use to Pharmacological Evidence.

Félix-Silva J, Silva-Junior AA, Zucolotto SM, Fernandes-Pedrosa MF.

Evid Based Complement Alternat Med. 2017;2017:5748256. doi: 10.1155/2017/5748256. Epub 2017 Aug 21. Review.

15.

Monitoring structural features, biocompatibility and biological efficacy of gamma-irradiated methotrexate-loaded spray-dried microparticles.

de Oliveira AR, Mesquita PC, Machado PRL, Farias KJS, de Almeida YMB, Fernandes-Pedrosa MF, Cornélio AM, do Egito EST, da Silva-Júnior AA.

Mater Sci Eng C Mater Biol Appl. 2017 Nov 1;80:438-448. doi: 10.1016/j.msec.2017.06.013. Epub 2017 Jun 17.

PMID:
28866185
16.

Designing structural features of novel benznidazole-loaded cationic nanoparticles for inducing slow drug release and improvement of biological efficacy.

Dos Santos-Silva AM, de Caland LB, de S L Oliveira ALC, de Araújo-Júnior RF, Fernandes-Pedrosa MF, Cornélio AM, da Silva-Júnior AA.

Mater Sci Eng C Mater Biol Appl. 2017 Sep 1;78:978-987. doi: 10.1016/j.msec.2017.04.053. Epub 2017 Apr 27.

PMID:
28576075
17.

Structure and in vitro activities of a Copper II-chelating anionic peptide from the venom of the scorpion Tityus stigmurus.

Melo MMA, Daniele-Silva A, Teixeira DG, Estrela AB, Melo KRT, Oliveira VS, Rocha HAO, Ferreira LS, Pontes DL, Lima JPMS, Silva-Júnior AA, Barbosa EG, Carvalho E, Fernandes-Pedrosa MF.

Peptides. 2017 Aug;94:91-98. doi: 10.1016/j.peptides.2017.05.009. Epub 2017 May 26.

18.

Evaluation of toxic, cytotoxic and genotoxic effects of phytol and its nanoemulsion.

Islam MT, Streck L, de Alencar MV, Cardoso Silva SW, da Conceição Machado K, da Conceição Machado K, Gomes Júnior AL, Paz MF, da Mata AM, de Castro E Sousa JM, da Costa Junior JS, Lins Rolim HM, da Silva-Junior AA, de Carvalho Melo-Cavalcante AA.

Chemosphere. 2017 Jun;177:93-101. doi: 10.1016/j.chemosphere.2017.02.145. Epub 2017 Mar 3.

PMID:
28284120
19.

Inhibition of local effects induced by Bothrops erythromelas snake venom: Assessment of the effectiveness of Brazilian polyvalent bothropic antivenom and aqueous leaf extract of Jatropha gossypiifolia.

Félix-Silva J, Gomes JA, Xavier-Santos JB, Passos JG, Silva-Junior AA, Tambourgi DV, Fernandes-Pedrosa MF.

Toxicon. 2017 Jan;125:74-83. doi: 10.1016/j.toxicon.2016.11.260. Epub 2016 Nov 25.

20.

Aqueous Leaf Extract of Jatropha mollissima (Pohl) Bail Decreases Local Effects Induced by Bothropic Venom.

Gomes JA, Félix-Silva J, Morais Fernandes J, Geraldo Amaral J, Lopes NP, Tabosa do Egito ES, da Silva-Júnior AA, Maria Zucolotto S, Fernandes-Pedrosa MF.

Biomed Res Int. 2016;2016:6101742. Epub 2016 Oct 26.

21.

Stigmurin and TsAP-2 from Tityus stigmurus scorpion venom: Assessment of structure and therapeutic potential in experimental sepsis.

Daniele-Silva A, Machado RJ, Monteiro NK, Estrela AB, Santos EC, Carvalho E, Araújo Júnior RF, Melo-Silveira RF, Rocha HA, Silva-Júnior AA, Fernandes-Pedrosa MF.

Toxicon. 2016 Oct;121:10-21. doi: 10.1016/j.toxicon.2016.08.016. Epub 2016 Aug 24.

22.

Anti-inflammatory activity of aqueous extract and bioactive compounds identified from the fruits of Hancornia speciosa Gomes (Apocynaceae).

Torres-Rêgo M, Furtado AA, Bitencourt MA, Lima MC, Andrade RC, Azevedo EP, Soares Tda C, Tomaz JC, Lopes NP, da Silva-Júnior AA, Zucolotto SM, Fernandes-Pedrosa Mde F.

BMC Complement Altern Med. 2016 Aug 5;16:275. doi: 10.1186/s12906-016-1259-x.

23.

Supramolecular aggregates of oligosaccharides with co-solvents in ternary systems for the solubilizing approach of triamcinolone.

de Medeiros ASA, Zoppi A, Barbosa EG, Oliveira JIN, Fernandes-Pedrosa MF, Longhi MR, da Silva-Júnior AA.

Carbohydr Polym. 2016 Oct 20;151:1040-1051. doi: 10.1016/j.carbpol.2016.06.044. Epub 2016 Jun 14.

24.

Aqueous extract from Ipomoea asarifolia (Convolvulaceae) leaves and its phenolic compounds have anti-inflammatory activity in murine models of edema, peritonitis and air-pouch inflammation.

Furtado AA, Torres-Rêgo M, Lima MCJS, Bitencourt MAO, Estrela AB, Souza da Silva N, da Silva Siqueira EM, Tomaz JC, Lopes NP, Silva-Júnior AA, Zucolotto SM, Fernandes-Pedrosa MF.

J Ethnopharmacol. 2016 Nov 4;192:225-235. doi: 10.1016/j.jep.2016.07.048. Epub 2016 Jul 19.

25.

Phase Transitions of Isotropic to Anisotropic Biocompatible Lipid-Based Drug Delivery Systems Overcoming Insoluble Benznidazole Loading.

Streck L, Sarmento VH, Machado PR, Farias KJ, Fernandes-Pedrosa MF, da Silva-Júnior AA.

Int J Mol Sci. 2016 Jun 30;17(7). pii: E981. doi: 10.3390/ijms17070981.

26.

Characterization of TistH, a multifunctional peptide from the scorpion Tityus stigmurus: Structure, cytotoxicity and antimicrobial activity.

Machado RJ, Estrela AB, Nascimento AK, Melo MM, Torres-Rêgo M, Lima EO, Rocha HA, Carvalho E, Silva-Junior AA, Fernandes-Pedrosa MF.

Toxicon. 2016 Sep 1;119:362-70. doi: 10.1016/j.toxicon.2016.06.002. Epub 2016 Jun 3.

27.

New Trends on Antineoplastic Therapy Research: Bullfrog (Rana catesbeiana Shaw) Oil Nanostructured Systems.

Amaral-Machado L, Xavier-Júnior FH, Rutckeviski R, Morais AR, Alencar ÉN, Dantas TR, Cruz AK, Genre J, da Silva-Junior AA, Pedrosa MF, Rocha HA, Egito ES.

Molecules. 2016 Apr 30;21(5). pii: E585. doi: 10.3390/molecules21050585.

28.

Development and Characterization of a Microemulsion System Containing Amphotericin B with Potential Ocular Applications.

da Silveira WL, Damasceno BP, Ferreira LF, Ribeiro IL, Silva KS, Silva AL, Giannini MJ, da Silva-Júnior AA, de Oliveira AG, do Egito ES.

Curr Drug Deliv. 2016;13(6):982-93.

PMID:
26549650
29.

Homology modeling, vasorelaxant and bradykinin-potentiating activities of a novel hypotensin found in the scorpion venom from Tityus stigmurus.

Machado RJ, Junior LG, Monteiro NK, Silva-Júnior AA, Portaro FC, Barbosa EG, Braga VA, Fernandes-Pedrosa MF.

Toxicon. 2015 Jul;101:11-8. doi: 10.1016/j.toxicon.2015.04.003. Epub 2015 Apr 28.

30.

Structural characterization of a novel peptide with antimicrobial activity from the venom gland of the scorpion Tityus stigmurus: Stigmurin.

de Melo ET, Estrela AB, Santos EC, Machado PR, Farias KJ, Torres TM, Carvalho E, Lima JP, Silva-Júnior AA, Barbosa EG, Fernandes-Pedrosa Mde F.

Peptides. 2015 Jun;68:3-10. doi: 10.1016/j.peptides.2015.03.003. Epub 2015 Mar 22.

31.

The prevalence and impact of headache in Brazil.

Queiroz LP, Silva Junior AA.

Headache. 2015 Feb;55 Suppl 1:32-8. doi: 10.1111/head.12511. Epub 2015 Feb 6. Review.

PMID:
25659407
32.

In vitro anticoagulant and antioxidant activities of Jatropha gossypiifolia L. (Euphorbiaceae) leaves aiming therapeutical applications.

Félix-Silva J, Souza T, Camara RB, Cabral B, Silva-Júnior AA, Rebecchi IM, Zucolotto SM, Rocha HA, Fernandes-Pedrosa Mde F.

BMC Complement Altern Med. 2014 Oct 20;14:405. doi: 10.1186/1472-6882-14-405.

33.

Triethanolamine stabilization of methotrexate-β-cyclodextrin interactions in ternary complexes.

Barbosa JA, Zoppi A, Quevedo MA, de Melo PN, de Medeiros AS, Streck L, de Oliveira AR, Fernandes-Pedrosa MF, Longhi MR, da Silva-Júnior AA.

Int J Mol Sci. 2014 Sep 25;15(9):17077-99. doi: 10.3390/ijms150917077.

34.

Aqueous leaf extract of Jatropha gossypiifolia L. (Euphorbiaceae) inhibits enzymatic and biological actions of Bothrops jararaca snake venom.

Félix-Silva J, Souza T, Menezes YA, Cabral B, Câmara RB, Silva-Junior AA, Rocha HA, Rebecchi IM, Zucolotto SM, Fernandes-Pedrosa MF.

PLoS One. 2014 Aug 15;9(8):e104952. doi: 10.1371/journal.pone.0104952. eCollection 2014.

35.

Neutralizing effects of Mimosa tenuiflora extracts against inflammation caused by Tityus serrulatus scorpion venom.

Bitencourt MA, de Souza Lima MC, Torres-Rêgo M, Fernandes JM, da Silva-Júnior AA, Tambourgi DV, Zucolotto SM, de Freitas Fernandes-Pedrosa M.

Biomed Res Int. 2014;2014:378235. doi: 10.1155/2014/378235. Epub 2014 Jun 11.

36.

Ipomoea asarifolia neutralizes inflammation induced by Tityus serrulatus scorpion venom.

Lima MC, Bitencourt MA, Furtado AA, Oliveira Rocha HA, Oliveira RM, da Silva-Júnior AA, Tabosa do Egito ES, Tambourgi DV, Zucolotto SM, Fernandes-Pedrosa Mde F.

J Ethnopharmacol. 2014 May 14;153(3):890-5. doi: 10.1016/j.jep.2014.03.060. Epub 2014 Apr 2.

PMID:
24704487
37.

Protein-rich fraction of Cnidoscolus urens (L.) Arthur leaves: enzymatic characterization and procoagulant and fibrinogenolytic activities.

de Menezes YA, Félix-Silva J, da Silva-Júnior AA, Rebecchi IM, de Oliveira AS, Uchoa AF, Fernandes-Pedrosa Mde F.

Molecules. 2014 Mar 21;19(3):3552-69. doi: 10.3390/molecules19033552.

38.

Temporomandibular disorders and chronic daily headaches in the community and in specialty care.

da Silva Junior AA, Krymchantowski AV, Gomes JB, Leite FM, Alves BM, Lara RP, Gómez RS, Teixeira AL.

Headache. 2013 Sep;53(8):1350-5. doi: 10.1111/head.12130. Epub 2013 May 15.

PMID:
23676083
39.

Profiling the resting venom gland of the scorpion Tityus stigmurus through a transcriptomic survey.

Almeida DD, Scortecci KC, Kobashi LS, Agnez-Lima LF, Medeiros SR, Silva-Junior AA, Junqueira-de-Azevedo Ide L, Fernandes-Pedrosa Mde F.

BMC Genomics. 2012 Aug 1;13:362.

40.

Prevalence and burden of headaches as assessed by the health family program.

Silva Junior AA, Bigal M, Vasconcelos LP, Rodrigues J, Gomez RS, Krymchantowski AV, Moreira Filho P, Teixeira AL.

Headache. 2012 Mar;52(3):483-90. doi: 10.1111/j.1526-4610.2012.02090.x. Epub 2012 Feb 21. Erratum in: Headache. 2012 May;52(5):861.

PMID:
22352696
41.

A curious maneuver for glossopharyngeal neuralgic pain relief.

Vale TC, da Silva-Júnior AA, Gomez RS, Teixeira AL.

Headache. 2011 Nov-Dec;51(10):1540-1. doi: 10.1111/j.1526-4610.2011.01969.x. Epub 2011 Aug 3. No abstract available.

PMID:
21812774
42.

Relative frequency of headache types: a longitudinal study in the tertiary care.

Silva-Júnior AA, Faleiros BE, Santos TM, Gómez RS, Teixeira AL.

Arq Neuropsiquiatr. 2010 Dec;68(6):878-81.

43.

Structure and viscoelastic behavior of pharmaceutical biocompatible anionic microemulsions containing the antitumoral drug compound doxorubicin.

Formariz TP, Chiavacci LA, Scarpa MV, Silva-Júnior AA, Egito ES, Terrugi CH, Franzini CM, Sarmento VH, Oliveira AG.

Colloids Surf B Biointerfaces. 2010 May 1;77(1):47-53. doi: 10.1016/j.colsurfb.2010.01.004. Epub 2010 Jan 14.

PMID:
20133113
44.

Obsessive compulsive disorder and migraine: case report, diagnosis and therapeutic approach.

Vasconcelos LP, Silva MC, Costa EA, da Silva Júnior AA, Gómez RS, Teixeira AL.

J Headache Pain. 2008 Dec;9(6):397-400. doi: 10.1007/s10194-008-0069-z. Epub 2008 Sep 19.

45.

Doxorubicin biocompatible O/W microemulsion stabilized by mixed surfactant containing soya phosphatidylcholine.

Formariz TP, Sarmento VH, Silva-Junior AA, Scarpa MV, Santilli CV, Oliveira AG.

Colloids Surf B Biointerfaces. 2006 Aug 1;51(1):54-61. Epub 2006 May 16.

PMID:
16814997

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