Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 827

1.

Y balance test: Are we doing it right?

Fusco A, Giancotti GF, Fuchs PX, Wagner H, da Silva RA, Cortis C.

J Sci Med Sport. 2019 Sep 26. pii: S1440-2440(19)30824-2. doi: 10.1016/j.jsams.2019.09.016. [Epub ahead of print]

PMID:
31601458
2.

Quantification of pro-inflammatory cytokines and osteoclastogenesis markers in successful and failed orthodontic mini-implants.

Andrucioli MCD, Matsumoto MAN, Fukada SY, Saraiva MCP, Bergamo AZN, Romano FL, Silva RABD, Silva LABD, Nelson-Filho P.

J Appl Oral Sci. 2019 Oct 7;27:e20180476. doi: 10.1590/1678-7757-2018-0476. eCollection 2019.

3.

Dynamic Behavior of Dengue and Zika viruses NS1 protein reveals monomer-monomer interaction mechanisms and insights to rational drug design.

Gonçalves RL, de Lima Menezes G, Sussuchi L, Moreli ML, Mottin M, Andrade CH, Pereira M, da Silva RA.

J Biomol Struct Dyn. 2019 Oct 8:1-13. doi: 10.1080/07391102.2019.1677504. [Epub ahead of print] No abstract available.

PMID:
31594455
4.

Minimally interventive restorative care of teeth with Molar-Incisor Hypomineralization and open apex - a 24-month longitudinal study.

Gatón-Hernandéz P, Serrano CR, da Silva LAB, de ER, Castañeda, da Silva RAB, Pucinelli CM, Manton D, Ustrell-Torrent JM, Nelson-Filho P.

Int J Paediatr Dent. 2019 Oct 8. doi: 10.1111/ipd.12581. [Epub ahead of print]

PMID:
31593607
5.

Infection by Platynosomum illiciens (= P. fastosum) in domestic cats of Araguaína, Tocantins, northern Brazil.

Sobral MCGO, Sousa SAP, Ribeiro TMP, Galvão SR, Santos RM, Silva RAD, Reis TS, Dias FEF, Santos HD.

Rev Bras Parasitol Vet. 2019 Sep 30. pii: S1984-29612019005017103. doi: 10.1590/S1984-29612019070. [Epub ahead of print]

6.

Comparison of apical periodontitis repair in endodontic treatment with calcium hydroxide-dressing and aPDT.

Silva LABD, Lopes ZMS, Sá RC, Novaes Júnior AB, Romualdo PC, Lucisano MP, Nelson-Filho P, Silva RABD.

Braz Oral Res. 2019 Sep 26;33:e092. doi: 10.1590/1807-3107bor-2019.vol33.0092. eCollection 2019.

7.

How many balance task trials are needed to accurately assess postural control measures in older women?

Oliveira MR, Vieira ER, Gil AWO, Teixeira DC, Amorim CF, da Silva RA.

J Bodyw Mov Ther. 2019 Jul;23(3):594-597. doi: 10.1016/j.jbmt.2019.04.004. Epub 2019 Apr 12.

PMID:
31563376
8.

Depression, self-concept, future expectations and hope of people with HIV.

Patrício ACFA, Silva IBDN, Ferreira MAM, Rodrigues BFL, Silva RFD, Nascimento JAD, Silva RARD.

Rev Bras Enferm. 2019 Sep 16;72(5):1288-1294. doi: 10.1590/0034-7167-2018-0730. English, Portuguese.

9.

ICNP® Diagnoses of People Living with AIDS, and Empirical Indicators.

de Souza Neto VL, Costa RTDS, Costa DARDS, Belmiro SSDR, Lima MA, Silva RARD.

Rev Bras Enferm. 2019 Sep 16;72(5):1226-1234. doi: 10.1590/0034-7167-2017-0850. English, Portuguese.

10.

Construct validation: coping with HIV/AIDS in Primary Health Care.

Castro RR, Oliveira SS, Pereira IRBO, Santos WND, Fernandes SF, Silva RARD.

Rev Bras Enferm. 2019 Sep 16;72(5):1173-1181. doi: 10.1590/0034-7167-2018-0734. English, Portuguese.

11.

Prediction of MAYV peptide antigens for immunodiagnostic tests by immunoinformatics and molecular dynamics simulations.

Rodrigues RL, Menezes GL, Saivish MV, Costa VGD, Pereira M, Moreli ML, Silva RAD.

Sci Rep. 2019 Sep 16;9(1):13339. doi: 10.1038/s41598-019-50008-3.

12.

Association between body composition and inflammation: A central role of IL-17 and IL-10 in diabetic and hypertensive elderly women.

Ribeiro IS, Pereira ÍS, Santos DP, Lopes DS, Prado AO, Calado SPM, Gonçalves CV, Galantini MPL, Muniz IPR, Santos GS, Silva RAA.

Exp Gerontol. 2019 Sep 10;127:110734. doi: 10.1016/j.exger.2019.110734. [Epub ahead of print]

PMID:
31518664
13.

Modulation of the endogenous Annexin A1 in a cigarette smoke cessation model: Potential therapeutic target in reversing the damage caused by smoking?

Lebron ISL, da Silva LF, Paletta JT, da Silva RA, Sant'Ana M, Costa SS, Iyomasa-Pilon MM, Souza HR, Possebon L, Girol AP.

Pathol Res Pract. 2019 Oct;215(10):152614. doi: 10.1016/j.prp.2019.152614. Epub 2019 Aug 24.

PMID:
31500927
14.

Branched-chain amino acids do not improve muscle recovery from resistance exercise in untrained young adults.

Estoche JM, Jacinto JL, Roveratti MC, Gabardo JM, Buzzachera CF, de Oliveira EP, Ribeiro AS, da Silva RA, Aguiar AF.

Amino Acids. 2019 Sep;51(9):1387-1395. doi: 10.1007/s00726-019-02776-5. Epub 2019 Aug 29.

PMID:
31468208
15.

Topical photodynamic therapy with chloroaluminum phthalocyanine liposomes is as effective as systemic pentavalent antimony in the treatment of experimental cutaneous leishmaniasis.

Lopes SC, Silva RA, Novais MV, Coelho LD, Ferreira LA, Souza PE, Tedesco A, Azevedo RB, Aguiar MG, Oliveira MC.

Photodiagnosis Photodyn Ther. 2019 Aug 24. pii: S1572-1000(19)30226-1. doi: 10.1016/j.pdpdt.2019.08.020. [Epub ahead of print]

PMID:
31454712
16.

Terms of specialized nursing language for people with pressure injury.

Duarte FHDS, Santos WND, Silva FSD, Lima DM, Fernandes SF, Silva RARD.

Rev Bras Enferm. 2019 Aug 19;72(4):1028-1035. doi: 10.1590/0034-7167-2018-0492. English, Portuguese.

17.

Factors related to impaired comfort in chronic kidney disease patients on hemodialysis.

Melo GAA, Aguiar LL, Silva RA, Quirino GDS, Pinheiro AKB, Caetano JÁ.

Rev Bras Enferm. 2019 Aug 19;72(4):889-895. doi: 10.1590/0034-7167-2018-0120. English, Portuguese.

18.

[PROVISIONAL] Non-mosaic partial duplication 12p in a patient with dysmorphic characteristics and developmental delay.

Oliveira JS, Joaquim TM, Silva RABD, Souza DH, Martelli LR, Moretti-Ferreira D.

Genet Mol Biol. 2019 Aug 19. pii: S1415-47572019005034101. doi: 10.1590/1678-4685-GMB-2018-0285. [Epub ahead of print]

19.

Alendronate inhibits osteocyte apoptosis and inflammation via IL-6, inhibiting bone resorption in periapical lesions of ovariectomized rats.

Silva RAB, Sousa-Pereira AP, Lucisano MP, Romualdo PC, Paula-Silva FWG, Consolaro A, Silva LAB, Nelson-Filho P.

Int Endod J. 2019 Aug 19. doi: 10.1111/iej.13206. [Epub ahead of print]

PMID:
31429089
20.

Leptin polymorphism rs3828942: risk for anxiety disorders?

Salerno PSV, Bastos CR, Peres A, Ardais AP, Gazal M, Jansen K, Souza LDM, da Silva RA, Kaster MP, Lara DR, Ghisleni G.

Eur Arch Psychiatry Clin Neurosci. 2019 Aug 16. doi: 10.1007/s00406-019-01051-8. [Epub ahead of print]

PMID:
31420734
21.

Emotional and behavioral problems: a school-based study in southern Brazil.

Bach SL, Molina ML, Amaral PLD, Reyes AN, Jansen K, Silva RAD, Motta JVDS.

Trends Psychiatry Psychother. 2019 Aug 1. pii: S2237-60892019005008101. doi: 10.1590/2237-6089-2017-0119. [Epub ahead of print]

22.

Hernia recurrence inventory: inguinal hernia recurrence can be accurately assessed using patient-reported outcomes.

Tastaldi L, Barros PHF, Krpata DM, Prabhu AS, Rosenblatt S, Petro CC, Alkhatib H, Szutan LA, Silva RA, Olson MA, Stewart TG, Roll S, Rosen MJ, Poulose BK.

Hernia. 2019 Jul 29. doi: 10.1007/s10029-019-02000-z. [Epub ahead of print]

PMID:
31359209
23.

Implementation of a Brazilian Cardioprotective Nutritional (BALANCE) Program for improvement on quality of diet and secondary prevention of cardiovascular events: A randomized, multicenter trial.

Weber B, Bersch-Ferreira ÂC, Torreglosa CR, Marcadenti A, Lara ES, da Silva JT, Costa RP, Santos RHN, Berwanger O, Bosquetti R, Pagano R, Mota LGS, de Oliveira JD, Soares RM, Galante AP, da Silva SA, Zampieri FG, Kovacs C, Amparo FC, Moreira P, da Silva RA, Dos Santos KG, Monteiro AS, Paiva CCJ, Magnoni CD, Moreira ASB, Peçanha DO, Missias KCS, de Paula LS, Marotto D, Souza P, Martins PRT, Dos Santos EM, Santos MR, Silva LP, Torres RS, Barbosa SNAA, de Pinho PM, de Araujo SHA, Veríssimo AOL, Guterres AS, Cardoso AFR, Palmeira MM, de Ataíde BRB, Costa LPS, Marinho HA, de Araújo CBP, Carvalho HMS, Maquiné RO, Caiado AC, de Matos CH, Barretta C, Specht CM, Onofrei M, Bertacco RTA, Borges LR, Bertoldi EG, Longo A, Ribas BLP, Dobke F, Pretto ADB, Bachettini NP, Gastaud A, Necchi R, Souza GC, Zuchinali P, Fracasso BM, Bobadra S, Sangali TD, Salamoni J, Garlini LM, Shirmann GS, de Los Santos MLP, Bortonili VMS, Dos Santos CP, Bragança GCM, Ambrózio CL, E Lima SB, Schiavini J, Napparo AS, Boemo JL, Nagano FEZ, Modanese PVG, Cunha NM, Frehner C, da Silva LF, Formentini FS, Ramos MEM, Ramos SS, Lucas MCS, Machado BG, Ruschel KB, Beiersdorf JR, Nunes CE, Rech RL, Damiani M, Berbigier M, Poloni S, Vian I, Russo DS, Rodrigues JA, de Moraes MAP, da Costa LM, Boklis M, El Kik RM, Adorne EF, Teixeira JM, Trescastro EP, Chiesa FL, Telles CT, Pellegrini LA, Reis LF, Cardoso RGM, Closs VE, Feres NH, da Silva NF, Silva NE, Dutra ES, Ito MK, Lima MEP, Carvalho APPF, Taboada MIS, Machado MMA, David MM, Júnior DGS, Dourado C, Fagundes VCFO, Uehara RM, Sasso S, Vieira JSO, de Oliveira BAS, Pereira JL, Rodrigues IG, Pinho CPS, Sousa ACS, Almeida AS, de Jesus MT, da Silva GB, Alves LVS, Nascimento VOG, Vieira SA, Coura AGL, Dantas CF, Leda NMFS, Medeiros AL, Andrade ACL, Pinheiro JMF, de Lima LRM, Sabino LS, de Souza CVS, Vasconcelos SML, Costa FA, Ferreira RC, Cardoso IB, Navarro LNP, Ferreira RB, Júnior AES, Silva MBG, Almeida KMM, Penafort AM, de Queirós APO, Farias GMN, Carlos DMO, Cordeiro CGNC, Vasconcelos VB, de Araújo EMVMC, Sahade V, Ribeiro CSA, Araujo GA, Gonçalves LB, Teixeira CS, Silva LMAJ, da Costa LB, Souza TS, de Jesus SO, Luna AB, da Rocha BRS, Santos MA, Neto JAF, Dias LPP, Cantanhede RCA, Morais JM, Duarte RCL, Barbosa ECB, Barbosa JMA, de Sousa RML, Dos Santos AF, Teixeira AF, Moriguchi EH, Bruscato NM, Kesties J, Vivian L, de Carli W, Shumacher M, Izar MCO, Asoo MT, Kato JT, Martins CM, Machado VA, Bittencourt CRO, de Freitas TT, Sant'Anna VAR, Lopes JD, Fischer SCPM, Pinto SL, Silva KC, Gratão LHA, Holzbach LC, Backes LM, Rodrigues MP, Deucher KLAL, Cantarelli M, Bertoni VM, Rampazzo D, Bressan J, Hermsdorff HHM, Caldas APS, Felício MB, Honório CR, da Silva A, Souza SR, Rodrigues PA, de Meneses TMX, Kumbier MCC, Barreto AL, Cavalcanti AB.

Am Heart J. 2019 Sep;215:187-197. doi: 10.1016/j.ahj.2019.06.010. Epub 2019 Jun 21.

24.

Interactome of Glyceraldehyde-3-Phosphate Dehydrogenase Points to the Existence of Metabolons in Paracoccidioides lutzii.

E Silva KSF, Lima RM, Baeza LC, Lima PS, Cordeiro TM, Charneau S, da Silva RA, Soares CMA, Pereira M.

Front Microbiol. 2019 Jul 9;10:1537. doi: 10.3389/fmicb.2019.01537. eCollection 2019.

25.

Candida albicans-Cell Interactions Activate Innate Immune Defense in Human Palate Epithelial Primary Cells via Nitric Oxide (NO) and β-Defensin 2 (hBD-2).

Casaroto AR, da Silva RA, Salmeron S, Rezende MLR, Dionísio TJ, Santos CFD, Pinke KH, Klingbeil MFG, Salomão PA, Lopes MMR, Lara VS.

Cells. 2019 Jul 12;8(7). pii: E707. doi: 10.3390/cells8070707.

26.

Insights into the Metabolism of Oleaginous Rhodococcus spp.

Alvarez HM, Herrero OM, Silva RA, Hernández MA, Lanfranconi MP, Villalba MS.

Appl Environ Microbiol. 2019 Aug 29;85(18). pii: e00498-19. doi: 10.1128/AEM.00498-19. Print 2019 Sep 15. Review.

PMID:
31324625
27.

Insights into the full-length SRPK2 structure and its hydrodynamic behavior.

Barbosa ÉAA, Seraphim TV, Gandin CA, Teixeira LF, da Silva RAG, Righetto GL, Goncalves KA, Vasconcellos RS, Almeida MR, Silva Júnior A, Fietto JLR, Kobarg J, Gileadi C, Massirer KB, Borges JC, de Oliveira Neto M, Bressan GC.

Int J Biol Macromol. 2019 Sep 15;137:205-214. doi: 10.1016/j.ijbiomac.2019.06.135. Epub 2019 Jun 20.

PMID:
31229549
28.

Impact of Lifting of Two Types of Barrels on Postural Control, Trunk Muscle Recruitment, and Kinematic Measures in Manual Workers.

Cavaguchi AMS, Oliveira MR, Macedo CG, Souza PEA, Aguiar AF, Dallaire M, Ngomo S, Silva RAD.

Int J Environ Res Public Health. 2019 Jun 20;16(12). pii: E2183. doi: 10.3390/ijerph16122183.

29.

Cognitive performance and salivary cortisol levels in school children.

Teixeira SM, Reyes AN, da Silva RA, de Mattos Souza LD, Moreira FP, Wiener CD, Oses JP, de Figueiredo VLM, Jansen K.

Psychiatry Clin Neurosci. 2019 Sep;73(9):596-597. doi: 10.1111/pcn.12904. Epub 2019 Jul 20. No abstract available.

PMID:
31226231
30.

Interleukin-6 and Interleukin-10 in mood disorders: A population-based study.

Wiener CD, Moreira FP, Portela LV, Strogulski NR, Lara DR, da Silva RA, Souza LDM, Jansen K, Oses JP.

Psychiatry Res. 2019 Mar;273:685-689. doi: 10.1016/j.psychres.2019.01.100. Epub 2019 Jan 31.

PMID:
31207853
31.

Isolated involvement of external capsules and claustrum in status epilepticus.

Silva RAE, Sousa TAP.

Arq Neuropsiquiatr. 2019 May 1;77(5):369. doi: 10.1590/0004-282X20190040. No abstract available.

32.

Serum level of nerve growth factor is a potential biomarker of conversion to bipolar disorder in women with major depressive disorder.

Pedrotti Moreira F, Cardoso TC, Mondin TC, Wiener CD, de Mattos Souza LD, Oses JP, Jansen K, da Silva RA.

Psychiatry Clin Neurosci. 2019 Sep;73(9):590-593. doi: 10.1111/pcn.12896. Epub 2019 Jul 1.

PMID:
31170316
33.

Seroprevalence for dengue virus in a hyperendemic area and associated socioeconomic and demographic factors using a cross-sectional design and a geostatistical approach, state of São Paulo, Brazil.

Chiaravalloti-Neto F, da Silva RA, Zini N, da Silva GCD, da Silva NS, Parra MCP, Dibo MR, Estofolete CF, Fávaro EA, Dutra KR, Mota MTO, Guimarães GF, Terzian ACB, Blangiardo M, Nogueira ML.

BMC Infect Dis. 2019 May 20;19(1):441. doi: 10.1186/s12879-019-4074-4.

34.

HOXA9 mediates and marks premalignant compartment size expansion in colonic adenomas.

Janmaat VT, Liu H, da Silva RA, Wisse PHA, Spaander MCW, Ten Hagen TLM, Smits R, Bruno MJ, Fuhler GM, Peppelenbosch MP.

Carcinogenesis. 2019 Feb 20. pii: bgz038. doi: 10.1093/carcin/bgz038. [Epub ahead of print]

PMID:
31099823
35.

Histopathological, histoenzymological, immunohistochemical and immunofluorescence analysis of tissue response to sealing materials after furcation perforation.

Silva RAB, Borges ATN, Hernandéz-Gatón P, de Queiroz AM, Arzate H, Romualdo PC, Nelson-Filho P, Silva LAB.

Int Endod J. 2019 Oct;52(10):1489-1500. doi: 10.1111/iej.13145. Epub 2019 Jun 5.

PMID:
31099018
36.

HOXA cluster gene expression during osteoblast differentiation involves epigenetic control.

da Silva RA, Fuhler GM, Janmaat VT, da C Fernandes CJ, da Silva Feltran G, Oliveira FA, Matos AA, Oliveira RC, Ferreira MR, Zambuzzi WF, Peppelenbosch MP.

Bone. 2019 Aug;125:74-86. doi: 10.1016/j.bone.2019.04.026. Epub 2019 May 1.

PMID:
31054377
37.

Radiotherapy impairs adhesive bonding in permanent teeth.

Arid J, Palma-Dibb RG, de Oliveira HF, Nelson-Filho P, de Carvalho FK, da Silva LAB, de Siqueira Mellara T, da Silva RAB, Faraoni JJ, de Queiroz AM.

Support Care Cancer. 2019 Apr 24. doi: 10.1007/s00520-019-04782-5. [Epub ahead of print]

PMID:
31020438
38.

Balance and Gait of Frail, Pre-Frail, and Robust Older Hispanics.

Vieira ER, Da Silva RA, Severi MT, Barbosa AC, Amick Iii BC, Zevallos JC, Martinez IL, Chaves PHM.

Geriatrics (Basel). 2018 Jul 18;3(3). pii: E42. doi: 10.3390/geriatrics3030042.

39.

Displacement of Submacular Hemorrhage With Subretinal Injection of Recombinant Tissue Plasminogen Activator and Gas Tamponade in the Setting of Myopic Degeneration.

Shields RA, Tang PH, Regillo CD, Silva RA.

Ophthalmic Surg Lasers Imaging Retina. 2019 Apr 1;50(4):257-259. doi: 10.3928/23258160-20190401-11.

PMID:
30998250
40.

Microbial species associated with dental caries found in saliva and in situ after use of self-ligating and conventional brackets.

Bergamo AZN, Matsumoto MAN, Nascimento CD, Andrucioli MCD, Romano FL, Silva RAB, Silva LAB, Nelson-Filho P.

J Appl Oral Sci. 2019;27:e20180426. doi: 10.1590/1678-7757-2018-0426. Epub 2019 Apr 11.

41.

Clinical outcomes and childhood trauma in bipolar disorder: A community sample of young adults.

Farias CA, Cardoso TA, Mondin TC, Souza LDM, da Silva RA, Kapczinski F, Magalhães PVDS, Jansen K.

Psychiatry Res. 2019 May;275:228-232. doi: 10.1016/j.psychres.2018.12.114. Epub 2018 Dec 21.

PMID:
30928726
42.

Persistence of symptoms after cognitive therapies is associated with childhood trauma: A six months follow-up study.

Konradt CE, Vieira IS, Cardoso TA, Zeni CP, Souza LDM, da Silva RA, Jansen K.

Psychiatry Res. 2019 May;275:177-180. doi: 10.1016/j.psychres.2019.02.044. Epub 2019 Feb 20.

PMID:
30921748
43.

Undernutrition impairs the quality of growth plate and trabecular and cortical bones in growing rats1.

Guedes PMSG, Zamarioli A, Botega II, Silva RABD, Issa JPM, Butezloff MM, Sousa YTCS, Ximenez JPB, Volpon JB.

Acta Cir Bras. 2019 Mar 18;34(3):e201900301. doi: 10.1590/s0102-865020190030000001.

44.

Epigenetic modifications induced by exercise: Drug-free intervention to improve cognitive deficits associated with obesity.

Barros L, Eichwald T, Solano AF, Scheffer D, da Silva RA, Gaspar JM, Latini A.

Physiol Behav. 2019 May 15;204:309-323. doi: 10.1016/j.physbeh.2019.03.009. Epub 2019 Mar 12. Review.

PMID:
30876771
45.

Bone callus formation is highly disrupted by dietary restriction in growing rats sustaining a femoral fracture1.

Botega II, Zamarioli A, Guedes PMSG, Silva RABD, Issa JPM, Butezloff MM, Sousa YTCS, Ximenez JPB, Volpon JB.

Acta Cir Bras. 2019 Feb 14;34(1):e20190010000002. doi: 10.1590/s0102-865020190010000002.

46.

Variability in malaria cases and the association with rainfall and rivers water levels in Amazonas State, Brazil.

Wolfarth-Couto B, Silva RAD, Filizola N.

Cad Saude Publica. 2019 Feb 11;35(2):e00020218. doi: 10.1590/0102-311X00020218. English, Portuguese.

47.

Antiproliferative xylan from corn cobs induces apoptosis in tumor cells.

Melo-Silveira RF, Viana RLS, Sabry DA, da Silva RA, Machado D, Nascimento AKL, Scortecci KC, Ferreira-Halder CV, Sassaki GL, Rocha HAO.

Carbohydr Polym. 2019 Apr 15;210:245-253. doi: 10.1016/j.carbpol.2019.01.073. Epub 2019 Jan 23.

PMID:
30732760
48.

Biological Rhythm Disruption Associated with Obesity in School Children.

Pereira LR, Moreira FP, Reyes AN, Bach SL, Amaral PLD, Motta JDS, da Silva RA, Jansen K.

Child Obes. 2019 Apr;15(3):200-205. doi: 10.1089/chi.2018.0212. Epub 2019 Jan 29.

PMID:
30694701
49.

Mechanical, chemical and antimicrobial properties of a bisphenol A-free pit-and-fissure sealant.

Fiorati-Aguiar SM, Lucisano MP, Silva LABD, Silva RABD, Spadaro ACC, Borsatto MC, Nelson-Filho P.

Am J Dent. 2018 Dec;31(6):279-284.

PMID:
30658372
50.

Age- and low back pain-related differences in trunk muscle activation during one-legged stance balance task.

da Silva RA, Vieira ER, Léonard G, Beaulieu LD, Ngomo S, Nowotny AH, Amorim CF.

Gait Posture. 2019 Mar;69:25-30. doi: 10.1016/j.gaitpost.2019.01.016. Epub 2019 Jan 11.

PMID:
30658312

Supplemental Content

Loading ...
Support Center