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Items: 1 to 50 of 83

1.

The Effect of Psyllium Husk on Intestinal Microbiota in Constipated Patients and Healthy Controls.

Jalanka J, Major G, Murray K, Singh G, Nowak A, Kurtz C, Silos-Santiago I, Johnston JM, de Vos WM, Spiller R.

Int J Mol Sci. 2019 Jan 20;20(2). pii: E433. doi: 10.3390/ijms20020433.

2.

Chronic linaclotide treatment reduces colitis-induced neuroplasticity and reverses persistent bladder dysfunction.

Grundy L, Harrington AM, Castro J, Garcia-Caraballo S, Deiteren A, Maddern J, Rychkov GY, Ge P, Peters S, Feil R, Miller P, Ghetti A, Hannig G, Kurtz CB, Silos-Santiago I, Brierley SM.

JCI Insight. 2018 Oct 4;3(19). pii: 121841. doi: 10.1172/jci.insight.121841.

3.

A RNAscope whole mount approach that can be combined with immunofluorescence to quantify differential distribution of mRNA.

Kersigo J, Pan N, Lederman JD, Chatterjee S, Abel T, Pavlinkova G, Silos-Santiago I, Fritzsch B.

Cell Tissue Res. 2018 Nov;374(2):251-262. doi: 10.1007/s00441-018-2864-4. Epub 2018 Jul 5.

PMID:
29974252
4.

Guanylate cyclase 2C agonism corrects CFTR mutants.

Arora K, Huang Y, Mun K, Yarlagadda S, Sundaram N, Kessler MM, Hannig G, Kurtz CB, Silos-Santiago I, Helmrath M, Palermo JJ, Clancy JP, Steinbrecher KA, Naren AP.

JCI Insight. 2017 Oct 5;2(19). pii: 93686. doi: 10.1172/jci.insight.93686.

5.

Linaclotide activates guanylate cyclase-C/cGMP/protein kinase-II-dependent trafficking of CFTR in the intestine.

Ahsan MK, Tchernychev B, Kessler MM, Solinga RM, Arthur D, Linde CI, Silos-Santiago I, Hannig G, Ameen NA.

Physiol Rep. 2017 Jun;5(11). pii: e13299. doi: 10.14814/phy2.13299.

6.

MRP4 Modulation of the Guanylate Cyclase-C/cGMP Pathway: Effects on Linaclotide-Induced Electrolyte Secretion and cGMP Efflux.

Tchernychev B, Ge P, Kessler MM, Solinga RM, Wachtel D, Tobin JV, Thomas SR, Lunte CE, Fretzen A, Hannig G, Bryant AP, Kurtz CB, Currie MG, Silos-Santiago I.

J Pharmacol Exp Ther. 2015 Oct;355(1):48-56. doi: 10.1124/jpet.115.224329. Epub 2015 Jul 27.

PMID:
26216942
7.

Guanylate cyclase-C/cGMP: an emerging pathway in the regulation of visceral pain.

Hannig G, Tchernychev B, Kurtz CB, Bryant AP, Currie MG, Silos-Santiago I.

Front Mol Neurosci. 2014 Apr 16;7:31. doi: 10.3389/fnmol.2014.00031. eCollection 2014. Review.

8.

Linaclotide inhibits colonic nociceptors and relieves abdominal pain via guanylate cyclase-C and extracellular cyclic guanosine 3',5'-monophosphate.

Castro J, Harrington AM, Hughes PA, Martin CM, Ge P, Shea CM, Jin H, Jacobson S, Hannig G, Mann E, Cohen MB, MacDougall JE, Lavins BJ, Kurtz CB, Silos-Santiago I, Johnston JM, Currie MG, Blackshaw LA, Brierley SM.

Gastroenterology. 2013 Dec;145(6):1334-46.e1-11. doi: 10.1053/j.gastro.2013.08.017. Epub 2013 Aug 16.

9.

Gastrointestinal pain: unraveling a novel endogenous pathway through uroguanylin/guanylate cyclase-C/cGMP activation.

Silos-Santiago I, Hannig G, Eutamene H, Ustinova EE, Bernier SG, Ge P, Graul C, Jacobson S, Jin H, Liong E, Kessler MM, Reza T, Rivers S, Shea C, Tchernychev B, Bryant AP, Kurtz CB, Bueno L, Pezzone MA, Currie MG.

Pain. 2013 Sep;154(9):1820-30. doi: 10.1016/j.pain.2013.05.044. Epub 2013 Jun 5.

10.

Activation of guanylate cyclase-C attenuates stretch responses and sensitization of mouse colorectal afferents.

Feng B, Kiyatkin ME, La JH, Ge P, Solinga R, Silos-Santiago I, Gebhart GF.

J Neurosci. 2013 Jun 5;33(23):9831-9. doi: 10.1523/JNEUROSCI.5114-12.2013.

11.

TrkB is necessary for the normal development of the lung.

García-Suárez O, Pérez-Pinera P, Laurà R, Germana A, Esteban I, Cabo R, Silos-Santiago I, Cobo JL, Vega JA.

Respir Physiol Neurobiol. 2009 Jul 31;167(3):281-91. doi: 10.1016/j.resp.2009.06.001. Epub 2009 Jun 10.

PMID:
19523540
12.

Enteric glial cells express full-length TrkB and depend on TrkB expression for normal development.

Levanti MB, Esteban I, Ciriaco E, Pérez-Piñera P, Cabo R, García-Suarez O, Pardo B, Silos-Santiago I, Cobo J, Vega JA.

Neurosci Lett. 2009 Apr 17;454(1):16-21. doi: 10.1016/j.neulet.2009.02.051. Epub 2009 Feb 27.

PMID:
19429046
13.

Noradrenergic and opioidergic alterations in neuropathy in different rat strains.

Herradon G, Ezquerra L, Nguyen T, Wang C, Siso A, Franklin B, Dilorenzo L, Rossenfeld J, Silos-Santiago I, Alguacil LF.

Neurosci Lett. 2008 Jun 20;438(2):186-9. doi: 10.1016/j.neulet.2008.03.095.

PMID:
18472331
14.

Different pattern of pleiotrophin and midkine expression in neuropathic pain: correlation between changes in pleiotrophin gene expression and rat strain differences in neuropathic pain.

Ezquerra L, Alguacil LF, Nguyen T, Deuel TF, Silos-Santiago I, Herradon G.

Growth Factors. 2008 Feb;26(1):44-8. doi: 10.1080/08977190801987711.

PMID:
18365878
15.

Characterization of sensory deficits in TrkB knockout mice.

Perez-Pinera P, García-Suarez O, Germanà A, Díaz-Esnal B, de Carlos F, Silos-Santiago I, del Valle ME, Cobo J, Vega JA.

Neurosci Lett. 2008 Mar 5;433(1):43-7. doi: 10.1016/j.neulet.2007.12.035. Epub 2008 Jan 14.

PMID:
18248898
16.

The role of tetrodotoxin-resistant sodium channels in pain states: are they the next target for analgesic drugs?

Silos-Santiago I.

Curr Opin Investig Drugs. 2008 Jan;9(1):83-9. Review.

PMID:
18183535
17.

Changes in BDNF gene expression correlate with rat strain differences in neuropathic pain.

Herradon G, Ezquerra L, Nguyen T, Wang C, Siso A, Franklin B, Dilorenzo L, Rossenfeld J, Alguacil LF, Silos-Santiago I.

Neurosci Lett. 2007 Jun 15;420(3):273-6. Epub 2007 May 10.

PMID:
17556103
18.

Abnormal development of pacinian corpuscles in double trkB;trkC knockout mice.

de Carlos F, Cobo J, Germanà G, Silos-Santiago I, Laurà R, Haro JJ, Fariñas I, Vega JA.

Neurosci Lett. 2006 Dec 27;410(3):157-61. Epub 2006 Nov 13.

PMID:
17101216
19.

Expression of TrkB in the murine kidney.

García-Suárez O, González-Martínez T, Germana A, Monjil DF, Torrecilla JR, Laurà R, Silos-Santiago I, Guate JL, Vega JA.

Microsc Res Tech. 2006 Dec;69(12):1014-20.

PMID:
17013912
20.

Expression of the neurotrophin receptor TrkB in the mouse liver.

García-Suárez O, González-Martínez T, Perez-Perez M, Germana A, Blanco-Gélaz MA, Monjil DF, Ciriaco E, Silos-Santiago I, Vega JA.

Anat Embryol (Berl). 2006 Oct;211(5):465-73. Epub 2006 Jun 9.

PMID:
16763809
21.

Midkine is a potent regulator of the catecholamine biosynthesis pathway in mouse aorta.

Ezquerra L, Herradon G, Nguyen T, Silos-Santiago I, Deuel TF.

Life Sci. 2006 Aug 8;79(11):1049-55. Epub 2006 Mar 21.

PMID:
16643958
22.

Lewis and Fischer 344 strain differences in alpha2-adrenoceptors and tyrosine hydroxylase expression.

Herradón G, Ezquerra L, Morales L, Franklin B, Silos-Santiago I, Alguacil LF.

Life Sci. 2006 Jan 18;78(8):862-8. Epub 2005 Sep 1.

PMID:
16139312
23.
24.
25.

Selective glial cell line-derived neurotrophic factor production in adult dopaminergic carotid body cells in situ and after intrastriatal transplantation.

Villadiego J, Méndez-Ferrer S, Valdés-Sánchez T, Silos-Santiago I, Fariñas I, López-Barneo J, Toledo-Aral JJ.

J Neurosci. 2005 Apr 20;25(16):4091-8.

26.

The development of myelinated nociceptors is dependent upon trks in the trigeminal ganglion.

Ichikawa H, Matsuo S, Silos-Santiago I, Jacquin MF, Sugimoto T.

Acta Histochem. 2004;106(5):337-43.

PMID:
15530548
27.

Pleiotrophin is an important regulator of the renin-angiotensin system in mouse aorta.

Herradon G, Ezquerra L, Nguyen T, Vogt TF, Bronson R, Silos-Santiago I, Deuel TF.

Biochem Biophys Res Commun. 2004 Nov 19;324(3):1041-7.

PMID:
15485659
28.

Pleiotrophin is a major regulator of the catecholamine biosynthesis pathway in mouse aorta.

Ezquerra L, Herradón G, Nguyen T, Vogt TF, Bronson R, Silos-Santiago I, Deuel TF.

Biochem Biophys Res Commun. 2004 Oct 15;323(2):512-7.

PMID:
15369781
29.

TrkB mRNA and protein in mouse spleen: structure of the spleen of functionally deficient TrkB mice.

Pérez-Pérez M, García-Suárez O, Blanco-Gelaz MA, Esteban I, Ciriaco E, Laurà R, Germanà A, Silos-Santiago I, Vega JA.

Cell Tissue Res. 2004 May;316(2):179-87. Epub 2004 Mar 25.

PMID:
15045579
30.

Absence of Meissner corpuscles in the digital pads of mice lacking functional TrkB.

González-Martínez T, Germanà GP, Monjil DF, Silos-Santiago I, de Carlos F, Germanà G, Cobo J, Vega JA.

Brain Res. 2004 Mar 26;1002(1-2):120-8.

PMID:
14988041
31.

Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2.

Yu FH, Westenbroek RE, Silos-Santiago I, McCormick KA, Lawson D, Ge P, Ferriera H, Lilly J, DiStefano PS, Catterall WA, Scheuer T, Curtis R.

J Neurosci. 2003 Aug 20;23(20):7577-85.

32.

Crucial role of TrkB ligands in the survival and phenotypic differentiation of developing locus coeruleus noradrenergic neurons.

Holm PC, Rodríguez FJ, Kresse A, Canals JM, Silos-Santiago I, Arenas E.

Development. 2003 Aug;130(15):3535-45.

33.

Activation of spinal histamine H3 receptors inhibits mechanical nociception.

Cannon KE, Nalwalk JW, Stadel R, Ge P, Lawson D, Silos-Santiago I, Hough LB.

Eur J Pharmacol. 2003 Jun 6;470(3):139-47.

PMID:
12798951
34.

Improgan antinociception does not require neuronal histamine or histamine receptors.

Izadi Mobarakeh J, Nalwalk JW, Watanabe T, Sakurada S, Hoffman M, Leurs R, Timmerman H, Silos-Santiago I, Yanai K, Hough LB.

Brain Res. 2003 Jun 6;974(1-2):146-52.

PMID:
12742632
35.

Ruffini endings are absent from the periodontal ligament of trkB knockout mice.

Matsuo S, Ichikawa H, Silos-Santiago I, Kiyomiya K, Kurebe M, Arends JJ, Jacquin MF.

Somatosens Mot Res. 2002;19(3):213-7.

PMID:
12396578
36.

Massive lymphocyte apoptosis in the thymus of functionally deficient TrkB mice.

Garcia-Suarez O, Blanco-Gelaz MA, Lopez ML, Germana A, Cabo R, Díaz-Esnal B, Silos-Santiago I, Ciriaco E, Vega JA.

J Neuroimmunol. 2002 Aug;129(1-2):25-34.

PMID:
12161017
37.

Diverse dependencies of developing Merkel innervation on the trkA and both full-length and truncated isoforms of trkC.

Cronk KM, Wilkinson GA, Grimes R, Wheeler EF, Jhaveri S, Fundin BT, Silos-Santiago I, Tessarollo L, Reichardt LF, Rice FL.

Development. 2002 Aug;129(15):3739-50.

38.

TRPV3 is a calcium-permeable temperature-sensitive cation channel.

Xu H, Ramsey IS, Kotecha SA, Moran MM, Chong JA, Lawson D, Ge P, Lilly J, Silos-Santiago I, Xie Y, DiStefano PS, Curtis R, Clapham DE.

Nature. 2002 Jul 11;418(6894):181-6. Epub 2002 Jun 23.

PMID:
12077604
39.

Differential modulation of sodium channel gating and persistent sodium currents by the beta1, beta2, and beta3 subunits.

Qu Y, Curtis R, Lawson D, Gilbride K, Ge P, DiStefano PS, Silos-Santiago I, Catterall WA, Scheuer T.

Mol Cell Neurosci. 2001 Nov;18(5):570-80.

PMID:
11922146
40.

Impaired dental cytodifferentiation in glial cell-line derived growth factor (GDNF) deficient mice.

de Vicente JC, Cabo R, Ciriaco E, Laurà R, Naves FJ, Silos-Santiago I, Vega JA.

Ann Anat. 2002 Jan;184(1):85-92.

PMID:
11878293
41.

Pleiotrophin: a cytokine with diverse functions and a novel signaling pathway.

Deuel TF, Zhang N, Yeh HJ, Silos-Santiago I, Wang ZY.

Arch Biochem Biophys. 2002 Jan 15;397(2):162-71. Review.

PMID:
11795867
42.

Elimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domain.

Holmqvist MH, Cao J, Hernandez-Pineda R, Jacobson MD, Carroll KI, Sung MA, Betty M, Ge P, Gilbride KJ, Brown ME, Jurman ME, Lawson D, Silos-Santiago I, Xie Y, Covarrubias M, Rhodes KJ, Distefano PS, An WF.

Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):1035-40.

43.

Involvement of the NGF receptors (Trka and p75lngfr) in the development and maintenance of the thymus.

Garcia-Suárez O, Germanà A, Hannestad J, Ciriaco E, Silos-Santiago I, Germanà G, Vega JA.

Ital J Anat Embryol. 2001;106(2 Suppl 1):279-85.

PMID:
11729966
44.

trkA modulation of developing somatosensory neurons in oro-facial tissues: tooth pulp fibers are absent in trkA knockout mice.

Matsuo S, Ichikawa H, Henderson TA, Silos-Santiago I, Barbacid M, Arends JJ, Jacquin MF.

Neuroscience. 2001;105(3):747-60.

PMID:
11516838
45.

Developmental dependency of Merkel endings on trks in the palate.

Ichikawa H, Matsuo S, Silos-Santiago I, Jacquin MF, Sugimoto T.

Brain Res Mol Brain Res. 2001 Mar 31;88(1-2):171-5.

PMID:
11295244
46.

TrkA is necessary for the normal development of the murine thymus.

García-Suárez O, Germanà A, Hannestad J, Ciriaco E, Laurà R, Naves J, Esteban I, Silos-Santiago I, Vega JA.

J Neuroimmunol. 2000 Aug 1;108(1-2):11-21.

PMID:
10900332
47.

A novel nervous system beta subunit that downregulates human large conductance calcium-dependent potassium channels.

Weiger TM, Holmqvist MH, Levitan IB, Clark FT, Sprague S, Huang WJ, Ge P, Wang C, Lawson D, Jurman ME, Glucksmann MA, Silos-Santiago I, DiStefano PS, Curtis R.

J Neurosci. 2000 May 15;20(10):3563-70.

48.

Development of Meissner-like and Pacinian sensory corpuscles in the mouse demonstrated with specific markers for corpuscular constituents.

Albuerne M, De Lavallina J, Esteban I, Naves FJ, Silos-Santiago I, Vega JA.

Anat Rec. 2000 Mar 1;258(3):235-42.

49.

Developmental dependency of Meissner corpuscles on trkB but not trkA or trkC.

Ichikawa H, Matsuo S, Silos-Santiago I, Sugimoto T.

Neuroreport. 2000 Feb 7;11(2):259-62.

PMID:
10674466
50.

Proprioceptive afferents survive in the masseter muscle of trkC knockout mice.

Matsuo S, Ichikawa H, Silos-Santiago I, Arends JJ, Henderson TA, Kiyomiya K, Kurebe M, Jacquin MF.

Neuroscience. 2000;95(1):209-16.

PMID:
10619477

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