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National Toxicology Program Position Statement on Informed ("Nonblinded") Analysis in Toxicologic Pathology Evaluation.

Sills RC, Cesta MF, Willson CJ, Brix AE, Berridge BR.

Toxicol Pathol. 2019 Sep 15:192623319873974. doi: 10.1177/0192623319873974. [Epub ahead of print]


Genome-wide promoter DNA methylation profiling of hepatocellular carcinomas arising either spontaneously or due to chronic exposure to Ginkgo biloba extract (GBE) in B6C3F1/N mice.

Kovi RC, Bhusari S, Mav D, Shah RR, Ton TV, Hoenerhoff MJ, Sills RC, Pandiri AR.

Arch Toxicol. 2019 Aug;93(8):2219-2235. doi: 10.1007/s00204-019-02505-7. Epub 2019 Jul 5.


Do GISTs Occur in Rats and Mice? Immunohistochemical Characterization of Gastrointestinal Tumors Diagnosed as Smooth Muscle Tumors in The National Toxicology Program.

Janardhan KS, Venkannagari P, Jensen H, Hoenerhoff MJ, Herbert RA, Malarkey DE, Sills RC, Pandiri AR.

Toxicol Pathol. 2019 Jul;47(5):577-584. doi: 10.1177/0192623319845838. Epub 2019 May 7.


Mutational analysis of pentabrominated diphenyl-induced hepatocellular tumors in rats and mice, tissue levels of PBDE congeners in rats and mice, and AhR genotyping of Wistar Han rats.

Dunnick JK, Pandiri AR, Merrick BA, Kissling GE, Cunny H, Mutlu E, Waidyanatha S, Sills RC, Hong HL, Ton TV, Maynor T, Rescio L, Phillips SL, Devito MJ, Brix A.

Data Brief. 2018 Oct 28;21:2125-2128. doi: 10.1016/j.dib.2018.10.104. eCollection 2018 Dec.


An Fe-Ni-Cr embedded atom method potential for austenitic and ferritic systems.

Zhou XW, Foster ME, Sills RB.

J Comput Chem. 2018 Nov 5;39(29):2420-2431. doi: 10.1002/jcc.25573. Epub 2018 Oct 31.


Dislocation Networks and the Microstructural Origin of Strain Hardening.

Sills RB, Bertin N, Aghaei A, Cai W.

Phys Rev Lett. 2018 Aug 24;121(8):085501. doi: 10.1103/PhysRevLett.121.085501.


Exome Sequencing of Fresh-frozen or Formalin-fixed Paraffin-embedded B6C3F1/N Mouse Hepatocellular Carcinomas Arising Either Spontaneously or due to Chronic Chemical Exposure.

Auerbach SS, Xu M, Merrick BA, Hoenerhoff MJ, Phadke D, Taxman DJ, Shah R, Hong HL, Ton TV, Kovi RC, Sills RC, Pandiri AR.

Toxicol Pathol. 2018 Aug;46(6):706-718. doi: 10.1177/0192623318789398. Epub 2018 Jul 25.


Whole exome sequencing in the rat.

Foley JF, Phadke DP, Hardy O, Hardy S, Miller V, Madan A, Howard K, Kruse K, Lord C, Ramaiahgari S, Solomon GG, Shah RR, Pandiri AR, Herbert RA, Sills RC, Merrick BA.

BMC Genomics. 2018 Jun 20;19(1):487. doi: 10.1186/s12864-018-4858-8.


Carcinogenic activity of pentabrominated diphenyl ether mixture (DE-71) in rats and mice.

Dunnick JK, Pandiri AR, Merrick BA, Kissling GE, Cunny H, Mutlu E, Waidyanatha S, Sills R, Hong HL, Ton TV, Maynor T, Recio L, Phillips SL, Devito MJ, Brix A.

Toxicol Rep. 2018 May 25;5:615-624. doi: 10.1016/j.toxrep.2018.05.010. eCollection 2018.


Reduced Disc Shedding and Phagocytosis of Photoreceptor Outer Segment Contributes to Kava Kava Extract-induced Retinal Degeneration in F344/N Rats.

Yamashita H, Hoenerhoff MJ, Shockley KR, Peddada SD, Gerrish KE, Sutton D, Cummings CA, Wang Y, Julie FF, Behl M, Waidyanatha S, Sills RC, Pandiri AR.

Toxicol Pathol. 2018 Jul;46(5):564-573. doi: 10.1177/0192623318778796. Epub 2018 May 27.


NTP/NIEHS Global Contributions to Toxicologic Pathology.

Sills R, Brix A, Cesta M, Churchill SR, Cora MC, Dixon D, Dykstra M, Flake G, Herbert R, Kovi R, Janardhan K, King-Herbert A, Malarkey D, Pandiri A, Travlos G, Willson C, Elmore SA.

Toxicol Pathol. 2017 Dec;45(8):1035-1038. doi: 10.1177/0192623317740326. Epub 2017 Nov 16.


Chemical Exacerbation of Light-induced Retinal Degeneration in F344/N Rats in National Toxicology Program Rodent Bioassays.

Yamashita H, Hoenerhoff MJ, Peddada SD, Sills RC, Pandiri AR.

Toxicol Pathol. 2016 Aug;44(6):892-903. doi: 10.1177/0192623316650050. Epub 2016 May 26.


Renal Cell Carcinomas in Vinylidene Chloride-exposed Male B6C3F1 Mice Are Characterized by Oxidative Stress and TP53 Pathway Dysregulation.

Hayes SA, Pandiri AR, Ton TV, Hong HH, Clayton NP, Shockley KR, Peddada SD, Gerrish K, Wyde M, Sills RC, Hoenerhoff MJ.

Toxicol Pathol. 2016 Jan;44(1):71-87. doi: 10.1177/0192623315610820. Epub 2015 Dec 17.


Mass spectrometric analysis of rat cerebrospinal fluid proteins following exposure to the neurotoxicant carbonyl sulfide.

Lardinois O, Kirby PJ, Morgan DL, Sills RC, Tomer KB, Deterding LJ.

Rapid Commun Mass Spectrom. 2015 Apr 30;29(8):782. doi: 10.1002/rcm.7166. No abstract available.


Immunohistochemical Expression of Cyclin D1, Cytokeratin 20, and Uroplakin III in Proliferative Urinary Bladder Lesions Induced by o-Nitroanisole in Fischer 344/N Rats.

Willson CJ, Flake GP, Sills RC, Kissling GE, Cesta MF.

Vet Pathol. 2016 May;53(3):682-90. doi: 10.1177/0300985815603432. Epub 2015 Aug 28.


Genomic Profiling Reveals Unique Molecular Alterations in Hepatoblastomas and Adjacent Hepatocellular Carcinomas in B6C3F1 Mice.

Bhusari S, Pandiri AR, Nagai H, Wang Y, Foley J, Hong HH, Ton TV, DeVito M, Shockley KR, Peddada SD, Gerrish KE, Malarkey DE, Hooth MJ, Sills RC, Hoenerhoff MJ.

Toxicol Pathol. 2015 Dec;43(8):1114-26. doi: 10.1177/0192623315599853. Epub 2015 Aug 18.


Kras, Egfr, and Tp53 Mutations in B6C3F1/N Mouse and F344/NTac Rat Alveolar/Bronchiolar Carcinomas Resulting from Chronic Inhalation Exposure to Cobalt Metal.

Hong HH, Hoenerhoff MJ, Ton TV, Herbert RA, Kissling GE, Hooth MJ, Behl M, Witt KL, Smith-Roe SL, Sills RC, Pandiri AR.

Toxicol Pathol. 2015 Aug;43(6):872-82. doi: 10.1177/0192623315581192. Epub 2015 Jun 9.


A Bamboo-Inspired Nanostructure Design for Flexible, Foldable, and Twistable Energy Storage Devices.

Sun Y, Sills RB, Hu X, Seh ZW, Xiao X, Xu H, Luo W, Jin H, Xin Y, Li T, Zhang Z, Zhou J, Cai W, Huang Y, Cui Y.

Nano Lett. 2015 Jun 10;15(6):3899-906. doi: 10.1021/acs.nanolett.5b00738. Epub 2015 May 26.


Mass spectrometric analysis of rat cerebrospinal fluid proteins following exposure to the neurotoxicant carbonyl sulfide.

Lardinois O, Kirby PJ, Morgan DL, Sills RC, Tomer KB, Deterding LJ.

Rapid Commun Mass Spectrom. 2014 Dec 15;28(23):2531-8. doi: 10.1002/rcm.7046. Erratum in: Rapid Commun Mass Spectrom. 2015 Apr 30;29(8):782.


Gene expression of mesothelioma in vinylidene chloride-exposed F344/N rats reveal immune dysfunction, tissue damage, and inflammation pathways.

Blackshear PE, Pandiri AR, Nagai H, Bhusari S, Hong HH, Ton TV, Clayton NP, Wyde M, Shockley KR, Peddada SD, Gerrish KE, Sills RC, Hoenerhoff MJ.

Toxicol Pathol. 2015 Feb;43(2):171-85. doi: 10.1177/0192623314537885. Epub 2014 Jun 23.


FutureTox II: Contemporary Concepts in Toxicology: "Pathways to prediction: in vitro and in silico models for predictive toxicology".

Elmore SA, Ryan AM, Wood CE, Crabbs TA, Sills RC.

Toxicol Pathol. 2014 Jul;42(5):940-2. doi: 10.1177/0192623314537135. Epub 2014 May 22. No abstract available.


Animal models of peripheral neuropathy due to environmental toxicants.

Rao DB, Jortner BS, Sills RC.

ILAR J. 2014;54(3):315-23. doi: 10.1093/ilar/ilt058. Review.


The National Toxicology Program Web-based nonneoplastic lesion atlas: a global toxicology and pathology resource.

Cesta MF, Malarkey DE, Herbert RA, Brix A, Hamlin MH 2nd, Singletary E, Sills RC, Bucher JR, Birnbaum LS.

Toxicol Pathol. 2014;42(2):458-60. doi: 10.1177/0192623313517304.


Environmental pathobiology and global opportunities.

Schmidt SP, Jokinen MP, Law JM, Pandiri AR, Weddle DL, Wolf JC, Sills RC.

Vet Pathol. 2013 Sep;50(5):733-4. doi: 10.1177/0300985813485098. No abstract available.


Spontaneous mesotheliomas in F344/N rats are characterized by dysregulation of cellular growth and immune function pathways.

Blackshear PE, Pandiri AR, Ton TV, Clayton NP, Shockley KR, Peddada SD, Gerrish KE, Sills RC, Hoenerhoff MJ.

Toxicol Pathol. 2014 Jul;42(5):863-76. doi: 10.1177/0192623313501894. Epub 2013 Aug 26.


Mutation spectra of Kras and Tp53 in urethral and lung neoplasms in B6C3F1 mice treated with 3,3',4,4'-tetrachloroazobenzene.

Bhusari S, Malarkey DE, Hong HH, Wang Y, Masinde T, Nolan M, Hooth MJ, Lea IA, Vasconcelos D, Sills RC, Hoenerhoff MJ.

Toxicol Pathol. 2014;42(3):555-64. doi: 10.1177/0192623313491169. Epub 2013 May 23.


Complex histopathologic response in rat kidney to oral β-myrcene: an unusual dose-related nephrosis and low-dose alpha2u-globulin nephropathy.

Cesta MF, Hard GC, Boyce JT, Ryan MJ, Chan PC, Sills RC.

Toxicol Pathol. 2013;41(8):1068-77. doi: 10.1177/0192623313482057. Epub 2013 Mar 26.


STP position paper: Recommended practices for sampling and processing the nervous system (brain, spinal cord, nerve, and eye) during nonclinical general toxicity studies.

Bolon B, Garman RH, Pardo ID, Jensen K, Sills RC, Roulois A, Radovsky A, Bradley A, Andrews-Jones L, Butt M, Gumprecht L.

Toxicol Pathol. 2013;41(7):1028-48. doi: 10.1177/0192623312474865. Epub 2013 Mar 7.


Hepatocellular carcinomas in B6C3F1 mice treated with Ginkgo biloba extract for two years differ from spontaneous liver tumors in cancer gene mutations and genomic pathways.

Hoenerhoff MJ, Pandiri AR, Snyder SA, Hong HH, Ton TV, Peddada S, Shockley K, Witt K, Chan P, Rider C, Kooistra L, Nyska A, Sills RC.

Toxicol Pathol. 2013 Aug;41(6):826-41. doi: 10.1177/0192623312467520. Epub 2012 Dec 21.


Differential transcriptomic analysis of spontaneous lung tumors in B6C3F1 mice: comparison to human non-small cell lung cancer.

Pandiri AR, Sills RC, Ziglioli V, Ton TV, Hong HH, Lahousse SA, Gerrish KE, Auerbach SS, Shockley KR, Bushel PR, Peddada SD, Hoenerhoff MJ.

Toxicol Pathol. 2012 Dec;40(8):1141-59. doi: 10.1177/0192623312447543. Epub 2012 Jun 11.


Proliferative and nonproliferative lesions of the rat and mouse central and peripheral nervous systems.

Kaufmann W, Bolon B, Bradley A, Butt M, Czasch S, Garman RH, George C, Gröters S, Krinke G, Little P, McKay J, Narama I, Rao D, Shibutani M, Sills R.

Toxicol Pathol. 2012 Jun;40(4 Suppl):87S-157S. doi: 10.1177/0192623312439125.


Testing an aflatoxin B1 gene signature in rat archival tissues.

Merrick BA, Auerbach SS, Stockton PS, Foley JF, Malarkey DE, Sills RC, Irwin RD, Tice RR.

Chem Res Toxicol. 2012 May 21;25(5):1132-44. doi: 10.1021/tx3000945. Epub 2012 May 4.


Immunohistochemical investigation of F344/N rat islet cell tumors from national toxicology program studies.

Koivisto C, Flake GP, Kolenda-Roberts H, Masinde T, Kissling GE, Sills RC, Hoenerhoff MJ.

Toxicol Pathol. 2012 Jul;40(5):751-63. doi: 10.1177/0192623312441407. Epub 2012 Apr 3.


Aloe vera non-decolorized whole leaf extract-induced large intestinal tumors in F344 rats share similar molecular pathways with human sporadic colorectal tumors.

Pandiri AR, Sills RC, Hoenerhoff MJ, Peddada SD, Ton TV, Hong HH, Flake GP, Malarkey DE, Olson GR, Pogribny IP, Walker NJ, Boudreau MD.

Toxicol Pathol. 2011 Dec;39(7):1065-74. doi: 10.1177/0192623311422081. Epub 2011 Sep 21.


Global gene profiling of spontaneous hepatocellular carcinoma in B6C3F1 mice: similarities in the molecular landscape with human liver cancer.

Hoenerhoff MJ, Pandiri AR, Lahousse SA, Hong HH, Ton TV, Masinde T, Auerbach SS, Gerrish K, Bushel PR, Shockley KR, Peddada SD, Sills RC.

Toxicol Pathol. 2011 Jun;39(4):678-99. doi: 10.1177/0192623311407213. Epub 2011 May 13.


Histopathological evaluation of the nervous system in National Toxicology Program rodent studies: a modified approach.

Rao DB, Little PB, Malarkey DE, Herbert RA, Sills RC.

Toxicol Pathol. 2011 Apr;39(3):463-70. doi: 10.1177/0192623311401044. Epub 2011 Mar 23.


Should trauma patients with a Glasgow Coma Scale score of 3 be intubated prior to hospital arrival?

Irvin CB, Szpunar S, Cindrich LA, Walters J, Sills R.

Prehosp Disaster Med. 2010 Nov-Dec;25(6):541-6.


Gene expression, biomarkers, and glial cells in nervous system diseases.

Sills RC, Garman RH.

Toxicol Pathol. 2011 Jan;39(1):97-8. doi: 10.1177/0192623310390393. Epub 2010 Dec 8.


Gene expression and mutation assessment provide clues of genetic and epigenetic mechanisms in liver tumors of oxazepam-exposed mice.

Lahousse SA, Hoenerhoff M, Collins J, Ton TV, Masinde T, Olson D, Rebolloso Y, Koujitani T, Tomer KB, Hong HH, Bucher J, Sills RC.

Vet Pathol. 2011 Jul;48(4):875-84. doi: 10.1177/0300985810390019. Epub 2010 Dec 7.


H-ras consensus sequence and mutations in primary hepatocellular carcinomas of lemurs and lorises.

Cullen JM, Williams C, Zadrozny L, Otstot JT, Solomon GG, Sills RC, Hong HH.

Vet Pathol. 2011 Jul;48(4):868-74. doi: 10.1177/0300985810388526. Epub 2010 Dec 1.


Introduction and commentary: "toxicologic neuropathology"--and a whole lot more!: the 2010 joint STP/IFSTP international symposium on toxicologic pathology.

Bolon B, Funk KA, Sills RC.

Toxicol Pathol. 2011 Jan;39(1):11-4. doi: 10.1177/0192623310385144. Epub 2010 Nov 15. No abstract available.


Characterization of side population cells in human malignant mesothelioma cell lines.

Kai K, D'Costa S, Yoon BI, Brody AR, Sills RC, Kim Y.

Lung Cancer. 2010 Nov;70(2):146-51. doi: 10.1016/j.lungcan.2010.04.020. Epub 2010 May 20.


What do we need to know prior to thinking about incorporating an epigenetic evaluation into safety assessments?

Goodman JI, Augustine KA, Cunnningham ML, Dixon D, Dragan YP, Falls JG, Rasoulpour RJ, Sills RC, Storer RD, Wolf DC, Pettit SD.

Toxicol Sci. 2010 Aug;116(2):375-81. doi: 10.1093/toxsci/kfq133. Epub 2010 Apr 29.


Commentary: update on animal models for NTP studies.

King-Herbert AP, Sills RC, Bucher JR.

Toxicol Pathol. 2010 Jan;38(1):180-1. doi: 10.1177/0192623309356450. Epub 2009 Dec 17.


Amygdala volume in depressed patients with bipolar disorder assessed using high resolution 3T MRI: the impact of medication.

Savitz J, Nugent AC, Bogers W, Liu A, Sills R, Luckenbaugh DA, Bain EE, Price JL, Zarate C, Manji HK, Cannon DM, Marrett S, Charney DS, Drevets WC.

Neuroimage. 2010 Feb 15;49(4):2966-76. doi: 10.1016/j.neuroimage.2009.11.025. Epub 2009 Nov 17.


A review of the molecular mechanisms of chemically induced neoplasia in rat and mouse models in National Toxicology Program bioassays and their relevance to human cancer.

Hoenerhoff MJ, Hong HH, Ton TV, Lahousse SA, Sills RC.

Toxicol Pathol. 2009 Dec;37(7):835-48. doi: 10.1177/0192623309351726. Review.


Re-evaluation of kidney histopathology from 13-week toxicity and two-year carcinogenicity studies of melamine in the F344 rat: morphologic evidence of retrograde nephropathy.

Hard GC, Flake GP, Sills RC.

Vet Pathol. 2009 Nov;46(6):1248-57. doi: 10.1354/vp.08-VP-0317-F-FL. Epub 2009 Jul 15.


Gene expression studies reveal that DNA damage, vascular perturbation, and inflammation contribute to the pathogenesis of carbonyl sulfide neurotoxicity.

Morrison JP, Ton TV, Collins JB, Switzer RC, Little PB, Morgan DL, Sills RC.

Toxicol Pathol. 2009 Jun;37(4):502-11. doi: 10.1177/0192623309335631. Epub 2009 Apr 24.


Veterinary pathology and peer review.

Cantor GH, Caswell JL, Crissman JW, Gillette DM, Gunson DE, Hogenesch H, Kiupel M, Mense MG, Miller MA, Rush LJ, Leger JA, Schoeb TR, Sellers RS, Sills RC, Swayne DE, Thomas HC, Ward JM, Alden CL.

Vet Pathol. 2009 Mar;46(2):173-5. doi: 10.1354/vp.46-2-173. No abstract available.


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