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Items: 41


Common genes associated with antidepressant response in mouse and man identify key role of glucocorticoid receptor sensitivity.

Carrillo-Roa T, Labermaier C, Weber P, Herzog DP, Lareau C, Santarelli S, Wagner KV, Rex-Haffner M, Harbich D, Scharf SH, Nemeroff CB, Dunlop BW, Craighead WE, Mayberg HS, Schmidt MV, Uhr M, Holsboer F, Sillaber I, Binder EB, Müller MB.

PLoS Biol. 2017 Dec 28;15(12):e2002690. doi: 10.1371/journal.pbio.2002690. eCollection 2017 Dec.


EV-3, an endogenous human erythropoietin isoform with distinct functional relevance.

Bonnas C, Wüstefeld L, Winkler D, Kronstein-Wiedemann R, Dere E, Specht K, Boxberg M, Tonn T, Ehrenreich H, Stadler H, Sillaber I.

Sci Rep. 2017 Jun 16;7(1):3684. doi: 10.1038/s41598-017-03167-0.


Delineation of molecular pathway activities of the chronic antidepressant treatment response suggests important roles for glutamatergic and ubiquitin-proteasome systems.

Park DI, Dournes C, Sillaber I, Ising M, Asara JM, Webhofer C, Filiou MD, Müller MB, Turck CW.

Transl Psychiatry. 2017 Apr 4;7(4):e1078. doi: 10.1038/tp.2017.39.


Neuroprotection and endocytosis: erythropoietin receptors in insect nervous systems.

Miljus N, Massih B, Weis MA, Rison JV, Bonnas CB, Sillaber I, Ehrenreich H, Geurten BR, Heinrich R.

J Neurochem. 2017 Apr;141(1):63-74. doi: 10.1111/jnc.13967. Epub 2017 Feb 28.


Purine and pyrimidine metabolism: Convergent evidence on chronic antidepressant treatment response in mice and humans.

Park DI, Dournes C, Sillaber I, Uhr M, Asara JM, Gassen NC, Rein T, Ising M, Webhofer C, Filiou MD, Müller MB, Turck CW.

Sci Rep. 2016 Oct 12;6:35317. doi: 10.1038/srep35317.


Exaggerated Increases in Microglia Proliferation, Brain Inflammatory Response and Sickness Behaviour upon Lipopolysaccharide Stimulation in Non-Obese Diabetic Mice.

McGuiness B, Gibney SM, Beumer W, Versnel MA, Sillaber I, Harkin A, Drexhage HA.

Neuroimmunomodulation. 2016;23(3):137-150. Epub 2016 Aug 17.


Proteomic and metabolomic profiling reveals time-dependent changes in hippocampal metabolism upon paroxetine treatment and biomarker candidates.

Webhofer C, Gormanns P, Reckow S, Lebar M, Maccarrone G, Ludwig T, Pütz B, Asara JM, Holsboer F, Sillaber I, Zieglgänsberger W, Turck CW.

J Psychiatr Res. 2013 Mar;47(3):289-98. doi: 10.1016/j.jpsychires.2012.11.003. Epub 2012 Dec 1.


Convergent animal and human evidence suggests the activin/inhibin pathway to be involved in antidepressant response.

Ganea K, Menke A, Schmidt MV, Lucae S, Rammes G, Liebl C, Harbich D, Sterlemann V, Storch C, Uhr M, Holsboer F, Binder EB, Sillaber I, Müller MB.

Transl Psychiatry. 2012 Oct 23;2:e177. doi: 10.1038/tp.2012.104.


Glutamatergic and dopaminergic neurons mediate anxiogenic and anxiolytic effects of CRHR1.

Refojo D, Schweizer M, Kuehne C, Ehrenberg S, Thoeringer C, Vogl AM, Dedic N, Schumacher M, von Wolff G, Avrabos C, Touma C, Engblom D, Schütz G, Nave KA, Eder M, Wotjak CT, Sillaber I, Holsboer F, Wurst W, Deussing JM.

Science. 2011 Sep 30;333(6051):1903-7. doi: 10.1126/science.1202107. Epub 2011 Sep 1.


Prediction of the risk of comorbid alcoholism in schizophrenia by interaction of common genetic variants in the corticotropin-releasing factor system.

Ribbe K, Ackermann V, Schwitulla J, Begemann M, Papiol S, Grube S, Sperling S, Friedrichs H, Jahn O, Sillaber I, Gefeller O, Krampe H, Ehrenreich H.

Arch Gen Psychiatry. 2011 Dec;68(12):1247-56. doi: 10.1001/archgenpsychiatry.2011.100. Epub 2011 Aug 1.


Metabolite profiling of antidepressant drug action reveals novel drug targets beyond monoamine elevation.

Webhofer C, Gormanns P, Tolstikov V, Zieglgänsberger W, Sillaber I, Holsboer F, Turck CW.

Transl Psychiatry. 2011 Dec 13;1:e58. doi: 10.1038/tp.2011.56.


Gene expression profiling in the stress control brain region hypothalamic paraventricular nucleus reveals a novel gene network including amyloid beta precursor protein.

Tsolakidou A, Czibere L, Pütz B, Trümbach D, Panhuysen M, Deussing JM, Wurst W, Sillaber I, Landgraf R, Holsboer F, Rein T.

BMC Genomics. 2010 Oct 8;11:546. doi: 10.1186/1471-2164-11-546.


Critical role of the embryonic mid-hindbrain organizer in the behavioral response to amphetamine and methylphenidate.

Tilleman H, Kofman O, Nashelsky L, Livneh U, Roz N, Sillaber I, Biegon A, Rehavi M, Brodski C.

Neuroscience. 2009 Nov 10;163(4):1012-23. doi: 10.1016/j.neuroscience.2009.07.040. Epub 2009 Jul 24.


Long-term anxiolytic and antidepressant-like behavioural effects of tiagabine, a selective GABA transporter-1 (GAT-1) inhibitor, coincide with a decrease in HPA system activity in C57BL/6 mice.

Thoeringer CK, Erhardt A, Sillaber I, Mueller MB, Ohl F, Holsboer F, Keck ME.

J Psychopharmacol. 2010 May;24(5):733-43. doi: 10.1177/0269881109103091. Epub 2009 Apr 3.


Chronic mild stress (CMS) in mice: of anhedonia, 'anomalous anxiolysis' and activity.

Schweizer MC, Henniger MS, Sillaber I.

PLoS One. 2009;4(1):e4326. doi: 10.1371/journal.pone.0004326. Epub 2009 Jan 29.


Profiling of behavioral changes and hippocampal gene expression in mice chronically treated with the SSRI paroxetine.

Sillaber I, Panhuysen M, Henniger MS, Ohl F, Kühne C, Pütz B, Pohl T, Deussing JM, Paez-Pereda M, Holsboer F.

Psychopharmacology (Berl). 2008 Nov;200(4):557-72. doi: 10.1007/s00213-008-1232-6. Epub 2008 Jul 16.


Acute stress regulation of neuroplasticity genes in mouse hippocampus CA3 area--possible novel signalling pathways.

Tsolakidou A, Trümbach D, Panhuysen M, Pütz B, Deussing J, Wurst W, Sillaber I, Holsboer F, Rein T.

Mol Cell Neurosci. 2008 Jul;38(3):444-52. doi: 10.1016/j.mcn.2008.04.005. Epub 2008 Apr 23.


The temporal dynamics of intrahippocampal corticosterone in response to stress-related stimuli with different emotional and physical load: an in vivo microdialysis study in C57BL/6 and DBA/2 inbred mice.

Thoeringer CK, Sillaber I, Roedel A, Erhardt A, Mueller MB, Ohl F, Holsboer F, Keck ME.

Psychoneuroendocrinology. 2007 Jul;32(6):746-57. Epub 2007 Jun 20.


P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder.

Lucae S, Salyakina D, Barden N, Harvey M, Gagné B, Labbé M, Binder EB, Uhr M, Paez-Pereda M, Sillaber I, Ising M, Brückl T, Lieb R, Holsboer F, Müller-Myhsok B.

Hum Mol Genet. 2006 Aug 15;15(16):2438-45. Epub 2006 Jul 5.


Genetic identification of AChE as a positive modulator of addiction to the psychostimulant D-amphetamine in zebrafish.

Ninkovic J, Folchert A, Makhankov YV, Neuhauss SC, Sillaber I, Straehle U, Bally-Cuif L.

J Neurobiol. 2006 Apr;66(5):463-75.


Gene expression regulation following behavioral sensitization to cocaine in transgenic mice lacking the glucocorticoid receptor in the brain.

Izawa R, Jaber M, Deroche-Gamonet V, Sillaber I, Kellendonk C, Le Moal M, Tronche F, Piazza PV.

Neuroscience. 2006 Feb;137(3):915-24. Epub 2005 Dec 2.


Corticotropin-releasing hormone activates ERK1/2 MAPK in specific brain areas.

Refojo D, Echenique C, Müller MB, Reul JM, Deussing JM, Wurst W, Sillaber I, Paez-Pereda M, Holsboer F, Arzt E.

Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6183-8. Epub 2005 Apr 15.


Stress and alcohol drinking.

Sillaber I, Henniger MS.

Ann Med. 2004;36(8):596-605. Review.


Identification of molecules potentially involved in mediating the in vivo actions of the corticotropin-releasing hormone receptor 1 antagonist, NBI30775 (R121919).

Post A, Ohl F, Almeida OF, Binder EB, Rücker M, Welt S, Binder E, Holsboer F, Sillaber I.

Psychopharmacology (Berl). 2005 Jun;180(1):150-8. Epub 2005 Jan 29.


Importance of NO/cGMP signalling via cGMP-dependent protein kinase II for controlling emotionality and neurobehavioural effects of alcohol.

Werner C, Raivich G, Cowen M, Strekalova T, Sillaber I, Buters JT, Spanagel R, Hofmann F.

Eur J Neurosci. 2004 Dec;20(12):3498-506.


Repetitive transcranial magnetic stimulation increases the release of dopamine in the nucleus accumbens shell of morphine-sensitized rats during abstinence.

Erhardt A, Sillaber I, Welt T, Müller MB, Singewald N, Keck ME.

Neuropsychopharmacology. 2004 Nov;29(11):2074-80.


Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress.

Müller MB, Zimmermann S, Sillaber I, Hagemeyer TP, Deussing JM, Timpl P, Kormann MS, Droste SK, Kühn R, Reul JM, Holsboer F, Wurst W.

Nat Neurosci. 2003 Oct;6(10):1100-7. Epub 2003 Sep 14.


The glucocorticoid receptor as a potential target to reduce cocaine abuse.

Deroche-Gamonet V, Sillaber I, Aouizerate B, Izawa R, Jaber M, Ghozland S, Kellendonk C, Le Moal M, Spanagel R, Schütz G, Tronche F, Piazza PV.

J Neurosci. 2003 Jun 1;23(11):4785-90.


Location and size of dopaminergic and serotonergic cell populations are controlled by the position of the midbrain-hindbrain organizer.

Brodski C, Weisenhorn DM, Signore M, Sillaber I, Oesterheld M, Broccoli V, Acampora D, Simeone A, Wurst W.

J Neurosci. 2003 May 15;23(10):4199-207.


The neuronal nitric oxide synthase gene is critically involved in neurobehavioral effects of alcohol.

Spanagel R, Siegmund S, Cowen M, Schroff KC, Schumann G, Fiserova M, Sillaber I, Wellek S, Singer M, Putzke J.

J Neurosci. 2002 Oct 1;22(19):8676-83.


Repetitive transcranial magnetic stimulation increases the release of dopamine in the mesolimbic and mesostriatal system.

Keck ME, Welt T, Müller MB, Erhardt A, Ohl F, Toschi N, Holsboer F, Sillaber I.

Neuropharmacology. 2002 Jul;43(1):101-9.


Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors.

Sillaber I, Rammes G, Zimmermann S, Mahal B, Zieglgänsberger W, Wurst W, Holsboer F, Spanagel R.

Science. 2002 May 3;296(5569):931-3.


Regulation of the hypothalamic-pituitary-adrenocortical system in mice deficient for CRH receptors 1 and 2.

Preil J, Müller MB, Gesing A, Reul JM, Sillaber I, van Gaalen MM, Landgrebe J, Holsboer F, Stenzel-Poore M, Wurst W.

Endocrinology. 2001 Nov;142(11):4946-55.


Differential analysis of behavior and diazepam-induced alterations in C57BL/6N and BALB/c mice using the modified hole board test.

Ohl F, Sillaber I, Binder E, Keck ME, Holsboer F.

J Psychiatr Res. 2001 May-Jun;35(3):147-54.


Selective activation of the hypothalamic vasopressinergic system in mice deficient for the corticotropin-releasing hormone receptor 1 is dependent on glucocorticoids.

Müller MB, Landgraf R, Preil J, Sillaber I, Kresse AE, Keck ME, Zimmermann S, Holsboer F, Wurst W.

Endocrinology. 2000 Nov;141(11):4262-9.


Acute transcranial magnetic stimulation of frontal brain regions selectively modulates the release of vasopressin, biogenic amines and amino acids in the rat brain.

Keck ME, Sillaber I, Ebner K, Welt T, Toschi N, Kaehler ST, Singewald N, Philippu A, Elbel GK, Wotjak CT, Holsboer F, Landgraf R, Engelmann M.

Eur J Neurosci. 2000 Oct;12(10):3713-20.


Acamprosate suppresses the expression of morphine-induced sensitization in rats but does not affect heroin self-administration or relapse induced by heroin or stress.

Spanagel R, Sillaber I, Zieglgänsberger W, Corrigall WA, Stewart J, Shaham Y.

Psychopharmacology (Berl). 1998 Oct;139(4):391-401.


Repeated administration of the neurotensin receptor antagonist SR 48692 differentially regulates mesocortical and mesolimbic dopaminergic systems.

Azzi M, Betancur C, Sillaber I, Spanagel R, Rostène W, Bérod A.

J Neurochem. 1998 Sep;71(3):1158-67.


Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1.

Timpl P, Spanagel R, Sillaber I, Kresse A, Reul JM, Stalla GK, Blanquet V, Steckler T, Holsboer F, Wurst W.

Nat Genet. 1998 Jun;19(2):162-6.


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