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Items: 24


Engineering tyrosine residues into hemoglobin enhances heme reduction, decreases oxidative stress and increases vascular retention of a hemoglobin based blood substitute.

Cooper CE, Silkstone GGA, Simons M, Rajagopal B, Syrett N, Shaik T, Gretton S, Welbourn E, Bülow L, Eriksson NL, Ronda L, Mozzarelli A, Eke A, Mathe D, Reeder BJ.

Free Radic Biol Med. 2019 Apr;134:106-118. doi: 10.1016/j.freeradbiomed.2018.12.030. Epub 2018 Dec 27.


Novel Redox Active Tyrosine Mutations Enhance the Regeneration of Functional Oxyhemoglobin from Methemoglobin: Implications for Design of Blood Substitutes.

Silkstone GGA, Simons M, Rajagopal BS, Shaik T, Reeder BJ, Cooper CE.

Adv Exp Med Biol. 2018;1072:221-225. doi: 10.1007/978-3-319-91287-5_35.


Comparison of the oxidative reactivity of recombinant fetal and adult human hemoglobin: implications for the design of hemoglobin-based oxygen carriers.

Simons M, Gretton S, Silkstone GGA, Rajagopal BS, Allen-Baume V, Syrett N, Shaik T, Leiva-Eriksson N, Ronda L, Mozzarelli A, Strader MB, Alayash AI, Reeder BJ, Cooper CE.

Biosci Rep. 2018 Jul 2;38(4). pii: BSR20180370. doi: 10.1042/BSR20180370. Print 2018 Aug 31.


Engineering tyrosine electron transfer pathways decreases oxidative toxicity in hemoglobin: implications for blood substitute design.

Silkstone GG, Silkstone RS, Wilson MT, Simons M, Bülow L, Kallberg K, Ratanasopa K, Ronda L, Mozzarelli A, Reeder BJ, Cooper CE.

Biochem J. 2016 Oct 1;473(19):3371-83. doi: 10.1042/BCJ20160243. Epub 2016 Jul 28.


A Further Investigation of the Effects of Extremely Low Frequency Magnetic Fields on Alkaline Phosphatase and Acetylcholinesterase.

Silkstone G, Wilson MT.

PLoS One. 2016 Mar 10;11(3):e0148369. doi: 10.1371/journal.pone.0148369. eCollection 2016.


The βLys66Tyr Variant of Human Hemoglobin as a Component of a Blood Substitute.

Silkstone RS, Silkstone G, Baath JA, Rajagopal B, Nicholls P, Reeder BJ, Ronda L, Bulow L, Cooper CE.

Adv Exp Med Biol. 2016;876:455-460. doi: 10.1007/978-1-4939-3023-4_57.


Kinetic studies on the oxidation of semiquinone and hydroquinone forms of Arabidopsis cryptochrome by molecular oxygen.

van Wilderen LJ, Silkstone G, Mason M, van Thor JJ, Wilson MT.

FEBS Open Bio. 2015 Oct 27;5:885-92. doi: 10.1016/j.fob.2015.10.007. eCollection 2015.


NO binding to the proapoptotic cytochrome c-cardiolipin complex.

Hough MA, Silkstone G, Worrall JA, Wilson MT.

Vitam Horm. 2014;96:193-209. doi: 10.1016/B978-0-12-800254-4.00008-8. Review.


The hydrogen-peroxide-induced radical behaviour in human cytochrome c-phospholipid complexes: implications for the enhanced pro-apoptotic activity of the G41S mutant.

Rajagopal BS, Edzuma AN, Hough MA, Blundell KL, Kagan VE, Kapralov AA, Fraser LA, Butt JN, Silkstone GG, Wilson MT, Svistunenko DA, Worrall JA.

Biochem J. 2013 Dec 15;456(3):441-52. doi: 10.1042/BJ20130758.


Nitric oxide binding to the cardiolipin complex of ferric cytochrome C.

Silkstone G, Kapetanaki SM, Husu I, Vos MH, Wilson MT.

Biochemistry. 2012 Aug 28;51(34):6760-6. Epub 2012 Aug 14.


Haptoglobin binding stabilizes hemoglobin ferryl iron and the globin radical on tyrosine β145.

Cooper CE, Schaer DJ, Buehler PW, Wilson MT, Reeder BJ, Silkstone G, Svistunenko DA, Bulow L, Alayash AI.

Antioxid Redox Signal. 2013 Jun 10;18(17):2264-73. doi: 10.1089/ars.2012.4547. Epub 2012 Aug 6.


An investigation into a cardiolipin acyl chain insertion site in cytochrome c.

Rajagopal BS, Silkstone GG, Nicholls P, Wilson MT, Worrall JA.

Biochim Biophys Acta. 2012 May;1817(5):780-91. doi: 10.1016/j.bbabio.2012.02.010. Epub 2012 Feb 16.


Reexamination of magnetic isotope and field effects on adenosine triphosphate production by creatine kinase.

Crotty D, Silkstone G, Poddar S, Ranson R, Prina-Mello A, Wilson MT, Coey JM.

Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1437-42. doi: 10.1073/pnas.1117840108. Epub 2011 Dec 23.


Probing a complex of cytochrome c and cardiolipin by magnetic circular dichroism spectroscopy: implications for the initial events in apoptosis.

Bradley JM, Silkstone G, Wilson MT, Cheesman MR, Butt JN.

J Am Chem Soc. 2011 Dec 14;133(49):19676-9. doi: 10.1021/ja209144h. Epub 2011 Nov 18.


Nitric oxide binds to the proximal heme coordination site of the ferrocytochrome c/cardiolipin complex: formation mechanism and dynamics.

Silkstone G, Kapetanaki SM, Husu I, Vos MH, Wilson MT.

J Biol Chem. 2010 Jun 25;285(26):19785-92. doi: 10.1074/jbc.M109.067736. Epub 2010 Apr 15.


Disruption of the M80-Fe ligation stimulates the translocation of cytochrome c to the cytoplasm and nucleus in nonapoptotic cells.

Godoy LC, Muñoz-Pinedo C, Castro L, Cardaci S, Schonhoff CM, King M, Tórtora V, Marín M, Miao Q, Jiang JF, Kapralov A, Jemmerson R, Silkstone GG, Patel JN, Evans JE, Wilson MT, Green DR, Kagan VE, Radi R, Mannick JB.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2653-8. doi: 10.1073/pnas.0809279106. Epub 2009 Feb 5.


Interaction of carbon monoxide with the apoptosis-inducing cytochrome c-cardiolipin complex.

Kapetanaki SM, Silkstone G, Husu I, Liebl U, Wilson MT, Vos MH.

Biochemistry. 2009 Feb 24;48(7):1613-9. doi: 10.1021/bi801817v.


Ligand dynamics in an electron transfer protein. Picosecond geminate recombination of carbon monoxide to heme in mutant forms of cytochrome c.

Silkstone G, Jasaitis A, Wilson MT, Vos MH.

J Biol Chem. 2007 Jan 19;282(3):1638-49. Epub 2006 Nov 17.


Geminate carbon monoxide rebinding to a c-type haem.

Silkstone G, Jasaitis A, Vos MH, Wilson MT.

Dalton Trans. 2005 Nov 7;(21):3489-94. Epub 2005 Sep 26.


EPR and optical spectroscopic studies of Met80X mutants of yeast ferricytochrome c. Models for intermediates in the alkaline transition.

Silkstone GG, Cooper CE, Svistunenko D, Wilson MT.

J Am Chem Soc. 2005 Jan 12;127(1):92-9.


Measurements of associations of cell-surface receptors by single-particle fluorescence imaging.

Cherry RJ, Morrison IE, Karakikes I, Barber RE, Silkstone G, Fernández N.

Biochem Soc Trans. 2003 Oct;31(Pt 5):1028-31. Review.


Extracellular heme peroxidases in actinomycetes: a case of mistaken identity.

Mason MG, Ball AS, Reeder BJ, Silkstone G, Nicholls P, Wilson MT.

Appl Environ Microbiol. 2001 Oct;67(10):4512-9.


Yeast iso-1-cytochrome c met80X mutants: the pKa of the spin state transition as a probe for haem pocket flexibility.

Silkstone G, Stanway G, Wilson MT.

Biochem Soc Trans. 1998 Nov;26(4):S348. No abstract available.


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