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Items: 1 to 50 of 198

1.

Addendum: A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs.

Murai S, Yamaguchi Y, Shirasaki Y, Yamagishi M, Shindo R, Hildebrand JM, Miura R, Nakabayashi O, Totsuka M, Tomida T, Adachi-Akahane S, Uemura S, Silke J, Yagita H, Miura M, Nakano H.

Nat Commun. 2019 Apr 25;10(1):1923. doi: 10.1038/s41467-019-09536-9.

2.
3.

Targeting XIAP and PPARγ in Granulosa Cell Tumors Alters Metabolic Signaling.

Leung DTH, Rainczuk A, Nguyen T, Stephens A, Silke J, Fuller PJ, Chu S.

J Proteome Res. 2019 Apr 5;18(4):1691-1702. doi: 10.1021/acs.jproteome.8b00917. Epub 2019 Mar 4.

PMID:
30706710
4.

Antagonism of IAPs Enhances CAR T-cell Efficacy.

Michie J, Beavis PA, Freeman AJ, Vervoort SJ, Ramsbottom KM, Narasimhan V, Lelliott EJ, Lalaoui N, Ramsay RG, Johnstone RW, Silke J, Darcy PK, Voskoboinik I, Kearney CJ, Oliaro J.

Cancer Immunol Res. 2019 Feb;7(2):183-192. doi: 10.1158/2326-6066.CIR-18-0428. Epub 2019 Jan 16.

PMID:
30651288
5.

RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation.

Liccardi G, Ramos Garcia L, Tenev T, Annibaldi A, Legrand AJ, Robertson D, Feltham R, Anderton H, Darding M, Peltzer N, Dannappel M, Schünke H, Fava LL, Haschka MD, Glatter T, Nesvizhskii A, Schmidt A, Harris PA, Bertin J, Gough PJ, Villunger A, Silke J, Pasparakis M, Bianchi K, Meier P.

Mol Cell. 2019 Feb 7;73(3):413-428.e7. doi: 10.1016/j.molcel.2018.11.010. Epub 2018 Dec 28.

6.

Combined PPARγ Activation and XIAP Inhibition as a Potential Therapeutic Strategy for Ovarian Granulosa Cell Tumors.

Leung DTH, Nguyen T, Oliver EM, Matti J, Alexiadis M, Silke J, Jobling TW, Fuller PJ, Chu S.

Mol Cancer Ther. 2019 Feb;18(2):364-375. doi: 10.1158/1535-7163.MCT-18-0078. Epub 2018 Dec 7.

PMID:
30530769
7.

The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation.

Vince JE, De Nardo D, Gao W, Vince AJ, Hall C, McArthur K, Simpson D, Vijayaraj S, Lindqvist LM, Bouillet P, Rizzacasa MA, Man SM, Silke J, Masters SL, Lessene G, Huang DCS, Gray DHD, Kile BT, Shao F, Lawlor KE.

Cell Rep. 2018 Nov 27;25(9):2339-2353.e4. doi: 10.1016/j.celrep.2018.10.103.

8.

A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs.

Murai S, Yamaguchi Y, Shirasaki Y, Yamagishi M, Shindo R, Hildebrand JM, Miura R, Nakabayashi O, Totsuka M, Tomida T, Adachi-Akahane S, Uemura S, Silke J, Yagita H, Miura M, Nakano H.

Nat Commun. 2018 Oct 26;9(1):4457. doi: 10.1038/s41467-018-06985-6.

9.
10.

LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L.

Taraborrelli L, Peltzer N, Montinaro A, Kupka S, Rieser E, Hartwig T, Sarr A, Darding M, Draber P, Haas TL, Akarca A, Marafioti T, Pasparakis M, Bertin J, Gough PJ, Bouillet P, Strasser A, Leverkus M, Silke J, Walczak H.

Nat Commun. 2018 Sep 25;9(1):3910. doi: 10.1038/s41467-018-06155-8.

11.

RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development.

Anderton H, Bandala-Sanchez E, Simpson DS, Rickard JA, Ng AP, Di Rago L, Hall C, Vince JE, Silke J, Liccardi G, Feltham R.

Cell Death Differ. 2019 May;26(5):877-889. doi: 10.1038/s41418-018-0166-8. Epub 2018 Sep 5.

PMID:
30185824
12.

Methods for Studying TNF-Mediated Necroptosis in Cultured Cells.

Liu Z, Silke J, Hildebrand JM.

Methods Mol Biol. 2018;1857:53-61. doi: 10.1007/978-1-4939-8754-2_5.

PMID:
30136229
13.

The Walrus and the Carpenter: Complex Regulation of Tumor Immunity in Colorectal Cancer.

Dewson G, Silke J.

Cell. 2018 Jun 28;174(1):14-16. doi: 10.1016/j.cell.2018.06.009.

14.

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis.

Petrie EJ, Sandow JJ, Jacobsen AV, Smith BJ, Griffin MDW, Lucet IS, Dai W, Young SN, Tanzer MC, Wardak A, Liang LY, Cowan AD, Hildebrand JM, Kersten WJA, Lessene G, Silke J, Czabotar PE, Webb AI, Murphy JM.

Nat Commun. 2018 Jun 21;9(1):2422. doi: 10.1038/s41467-018-04714-7.

15.

Tumor immune evasion arises through loss of TNF sensitivity.

Kearney CJ, Vervoort SJ, Hogg SJ, Ramsbottom KM, Freeman AJ, Lalaoui N, Pijpers L, Michie J, Brown KK, Knight DA, Sutton V, Beavis PA, Voskoboinik I, Darcy PK, Silke J, Trapani JA, Johnstone RW, Oliaro J.

Sci Immunol. 2018 May 18;3(23). pii: eaar3451. doi: 10.1126/sciimmunol.aar3451.

PMID:
29776993
16.

LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis.

Peltzer N, Darding M, Montinaro A, Draber P, Draberova H, Kupka S, Rieser E, Fisher A, Hutchinson C, Taraborrelli L, Hartwig T, Lafont E, Haas TL, Shimizu Y, Böiers C, Sarr A, Rickard J, Alvarez-Diaz S, Ashworth MT, Beal A, Enver T, Bertin J, Kaiser W, Strasser A, Silke J, Bouillet P, Walczak H.

Nature. 2018 May;557(7703):112-117. doi: 10.1038/s41586-018-0064-8. Epub 2018 Apr 25.

17.

Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2.

Annibaldi A, Wicky John S, Vanden Berghe T, Swatek KN, Ruan J, Liccardi G, Bianchi K, Elliott PR, Choi SM, Van Coillie S, Bertin J, Wu H, Komander D, Vandenabeele P, Silke J, Meier P.

Mol Cell. 2018 Feb 15;69(4):566-580.e5. doi: 10.1016/j.molcel.2018.01.027.

18.

The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis.

Davies KA, Tanzer MC, Griffin MDW, Mok YF, Young SN, Qin R, Petrie EJ, Czabotar PE, Silke J, Murphy JM.

Cell Death Differ. 2018 Sep;25(9):1567-1580. doi: 10.1038/s41418-018-0061-3. Epub 2018 Feb 14.

19.

IAPs Regulate Distinct Innate Immune Pathways to Co-ordinate the Response to Bacterial Peptidoglycans.

Stafford CA, Lawlor KE, Heim VJ, Bankovacki A, Bernardini JP, Silke J, Nachbur U.

Cell Rep. 2018 Feb 6;22(6):1496-1508. doi: 10.1016/j.celrep.2018.01.024.

20.

NOD1 is required for Helicobacter pylori induction of IL-33 responses in gastric epithelial cells.

Tran LS, Tran D, De Paoli A, D'Costa K, Creed SJ, Ng GZ, Le L, Sutton P, Silke J, Nachbur U, Ferrero RL.

Cell Microbiol. 2018 May;20(5):e12826. doi: 10.1111/cmi.12826. Epub 2018 Feb 15.

PMID:
29392836
21.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G.

Cell Death Differ. 2018 Mar;25(3):486-541. doi: 10.1038/s41418-017-0012-4. Epub 2018 Jan 23. Review.

22.
23.

Necroptotic signaling is primed in Mycobacterium tuberculosis-infected macrophages, but its pathophysiological consequence in disease is restricted.

Stutz MD, Ojaimi S, Allison C, Preston S, Arandjelovic P, Hildebrand JM, Sandow JJ, Webb AI, Silke J, Alexander WS, Pellegrini M.

Cell Death Differ. 2018 May;25(5):951-965. doi: 10.1038/s41418-017-0031-1. Epub 2017 Dec 11.

24.

The TNF Receptor Superfamily-NF-κB Axis Is Critical to Maintain Effector Regulatory T Cells in Lymphoid and Non-lymphoid Tissues.

Vasanthakumar A, Liao Y, Teh P, Pascutti MF, Oja AE, Garnham AL, Gloury R, Tempany JC, Sidwell T, Cuadrado E, Tuijnenburg P, Kuijpers TW, Lalaoui N, Mielke LA, Bryant VL, Hodgkin PD, Silke J, Smyth GK, Nolte MA, Shi W, Kallies A.

Cell Rep. 2017 Sep 19;20(12):2906-2920. doi: 10.1016/j.celrep.2017.08.068. Epub 2017 Sep 7.

25.

Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding.

Feltham RL, Moulin M, Vince JE, Mace PD, Wong WW, Anderton H, Day CL, Vaux DL, Silke J.

J Biol Chem. 2017 Aug 25;292(34):14310. doi: 10.1074/jbc.A109.087635. No abstract available.

26.

XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1β Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation.

Lawlor KE, Feltham R, Yabal M, Conos SA, Chen KW, Ziehe S, Graß C, Zhan Y, Nguyen TA, Hall C, Vince AJ, Chatfield SM, D'Silva DB, Pang KC, Schroder K, Silke J, Vaux DL, Jost PJ, Vince JE.

Cell Rep. 2017 Jul 18;20(3):668-682. doi: 10.1016/j.celrep.2017.06.073.

27.

PD-L1 and IAPs co-operate to protect tumors from cytotoxic lymphocyte-derived TNF.

Kearney CJ, Lalaoui N, Freeman AJ, Ramsbottom KM, Silke J, Oliaro J.

Cell Death Differ. 2017 Oct;24(10):1705-1716. doi: 10.1038/cdd.2017.94. Epub 2017 Jun 30.

28.

Correction: TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1.

Etemadi N, Chopin M, Anderton H, Tanzer MC, Rickard JA, Abeysekera W, Hall C, Spall SK, Wang B, Xiong Y, Hla T, Pitson SM, Bonder CS, Wong WW, Ernst M, Smyth GK, Vaux DL, Nutt SL, Nachbur U, Silke J.

Elife. 2017 Jun 27;6. pii: e29849. doi: 10.7554/eLife.29849. No abstract available.

29.

Inhibitor of Apoptosis Proteins (IAPs) Limit RIPK1-Mediated Skin Inflammation.

Anderton H, Rickard JA, Varigos GA, Lalaoui N, Silke J.

J Invest Dermatol. 2017 Nov;137(11):2371-2379. doi: 10.1016/j.jid.2017.05.031. Epub 2017 Jun 22. Erratum in: J Invest Dermatol. 2018 Sep;138(9):2084.

30.

The small molecule that packs a punch: ubiquitin-mediated regulation of RIPK1/FADD/caspase-8 complexes.

Feltham R, Silke J.

Cell Death Differ. 2017 Jul;24(7):1196-1204. doi: 10.1038/cdd.2017.67. Epub 2017 Jun 2. Review.

31.

MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death.

Jaco I, Annibaldi A, Lalaoui N, Wilson R, Tenev T, Laurien L, Kim C, Jamal K, Wicky John S, Liccardi G, Chau D, Murphy JM, Brumatti G, Feltham R, Pasparakis M, Silke J, Meier P.

Mol Cell. 2017 Jun 1;66(5):698-710.e5. doi: 10.1016/j.molcel.2017.05.003. Epub 2017 May 11.

32.

Biosensors for the monitoring of harmful algal blooms.

McPartlin DA, Loftus JH, Crawley AS, Silke J, Murphy CS, O'Kennedy RJ.

Curr Opin Biotechnol. 2017 Jun;45:164-169. doi: 10.1016/j.copbio.2017.02.018. Review.

PMID:
28427011
33.

Engineered Exosomes as Vehicles for Biologically Active Proteins.

Sterzenbach U, Putz U, Low LH, Silke J, Tan SS, Howitt J.

Mol Ther. 2017 Jun 7;25(6):1269-1278. doi: 10.1016/j.ymthe.2017.03.030. Epub 2017 Apr 13.

34.

How Changes in Anti-SD Sequences Would Affect SD Sequences in Escherichia coli and Bacillus subtilis.

Abolbaghaei A, Silke JR, Xia X.

G3 (Bethesda). 2017 May 5;7(5):1607-1615. doi: 10.1534/g3.117.039305.

35.

Jekyll & Hyde: The Other Life of the Death Ligand TRAIL.

Lalaoui N, Silke J.

Mol Cell. 2017 Feb 16;65(4):585-587. doi: 10.1016/j.molcel.2017.02.004.

36.

IAPs and Cell Death.

Silke J, Vince J.

Curr Top Microbiol Immunol. 2017;403:95-117. doi: 10.1007/82_2016_507. Review.

PMID:
28204973
37.

'Did He Who Made the Lamb Make Thee?' New Developments in Treating the 'Fearful Symmetry' of Acute Myeloid Leukemia.

Brumatti G, Lalaoui N, Wei AH, Silke J.

Trends Mol Med. 2017 Mar;23(3):264-281. doi: 10.1016/j.molmed.2017.01.005. Epub 2017 Feb 11. Review.

PMID:
28196625
38.

Erratum: EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation.

Pearson JS, Giogha C, Mühlen S, Nachbur U, Pham CL, Zhang Y, Hildebrand JM, Oates CV, Lung TW, Ingle D, Dagley LF, Bankovacki A, Petrie EJ, Schroeder GN, Crepin VF, Frankel G, Masters SL, Vince J, Murphy JM, Sunde M, Webb AI, Silke J, Hartland EL.

Nat Microbiol. 2017 Feb 13;2:17024. doi: 10.1038/nmicrobiol.2017.24. No abstract available.

39.

Combination of IAP antagonist and IFNγ activates novel caspase-10- and RIPK1-dependent cell death pathways.

Tanzer MC, Khan N, Rickard JA, Etemadi N, Lalaoui N, Spall SK, Hildebrand JM, Segal D, Miasari M, Chau D, Wong WL, McKinlay M, Chunduru SK, Benetatos CA, Condon SM, Vince JE, Herold MJ, Silke J.

Cell Death Differ. 2017 Mar;24(3):481-491. doi: 10.1038/cdd.2016.147. Epub 2017 Jan 20.

40.

EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation.

Pearson JS, Giogha C, Mühlen S, Nachbur U, Pham CL, Zhang Y, Hildebrand JM, Oates CV, Lung TW, Ingle D, Dagley LF, Bankovacki A, Petrie EJ, Schroeder GN, Crepin VF, Frankel G, Masters SL, Vince J, Murphy JM, Sunde M, Webb AI, Silke J, Hartland EL.

Nat Microbiol. 2017 Jan 13;2:16258. doi: 10.1038/nmicrobiol.2016.258. Erratum in: Nat Microbiol. 2017 Feb 13;2:17024.

41.

Harmful algal bloom forecast system for SW Ireland. Part II: Are operational oceanographic models useful in a HAB warning system.

Cusack C, Dabrowski T, Lyons K, Berry A, Westbrook G, Salas R, Duffy C, Nolan G, Silke J.

Harmful Algae. 2016 Mar;53:86-101. doi: 10.1016/j.hal.2015.11.013. Epub 2016 May 3.

PMID:
28073449
42.

Potential impact of an exceptional bloom of Karenia mikimotoi on dissolved oxygen levels in waters off western Ireland.

O'Boyle S, McDermott G, Silke J, Cusack C.

Harmful Algae. 2016 Mar;53:77-85. doi: 10.1016/j.hal.2015.11.014. Epub 2016 May 3.

PMID:
28073447
43.

Harmful algal bloom forecast system for SW Ireland. Part I: Description and validation of an operational forecasting model.

Dabrowski T, Lyons K, Nolan G, Berry A, Cusack C, Silke J.

Harmful Algae. 2016 Mar;53:64-76. doi: 10.1016/j.hal.2015.11.015. Epub 2016 May 3.

PMID:
28073446
44.

Applied simulations and integrated modelling for the understanding of toxic and harmful algal blooms (ASIMUTH): Integrated HAB forecast systems for Europe's Atlantic Arc.

Maguire J, Cusack C, Ruiz-Villarreal M, Silke J, McElligott D, Davidson K.

Harmful Algae. 2016 Mar;53:160-166. doi: 10.1016/j.hal.2015.11.006. Epub 2016 May 3.

PMID:
28073441
45.

Forecasting the risk of harmful algal blooms.

Davidson K, Anderson DM, Mateus M, Reguera B, Silke J, Sourisseau M, Maguire J.

Harmful Algae. 2016 Mar;53:1-7. doi: 10.1016/j.hal.2015.11.005. Epub 2016 May 3.

46.

In the Midst of Life-Cell Death: What Is It, What Is It Good for, and How to Study It.

Silke J, Johnstone RW.

Cold Spring Harb Protoc. 2016 Dec 1;2016(12). doi: 10.1101/pdb.top070508.

PMID:
27934692
47.

Inhibitor of Apoptosis Protein-1 Regulates Tumor Necrosis Factor-Mediated Destruction of Intestinal Epithelial Cells.

Grabinger T, Bode KJ, Demgenski J, Seitz C, Delgado ME, Kostadinova F, Reinhold C, Etemadi N, Wilhelm S, Schweinlin M, Hänggi K, Knop J, Hauck C, Walles H, Silke J, Wajant H, Nachbur U, W Wei-Lynn W, Brunner T.

Gastroenterology. 2017 Mar;152(4):867-879. doi: 10.1053/j.gastro.2016.11.019. Epub 2016 Nov 24.

48.

Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis.

Teh CE, Lalaoui N, Jain R, Policheni AN, Heinlein M, Alvarez-Diaz S, Sheridan JM, Rieser E, Deuser S, Darding M, Koay HF, Hu Y, Kupresanin F, O'Reilly LA, Godfrey DI, Smyth GK, Bouillet P, Strasser A, Walczak H, Silke J, Gray DH.

Nat Commun. 2016 Nov 18;7:13353. doi: 10.1038/ncomms13353.

49.

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics.

Lalaoui N, Hänggi K, Brumatti G, Chau D, Nguyen NN, Vasilikos L, Spilgies LM, Heckmann DA, Ma C, Ghisi M, Salmon JM, Matthews GM, de Valle E, Moujalled DM, Menon MB, Spall SK, Glaser SP, Richmond J, Lock RB, Condon SM, Gugasyan R, Gaestel M, Guthridge M, Johnstone RW, Munoz L, Wei A, Ekert PG, Vaux DL, Wong WW, Silke J.

Cancer Cell. 2016 Sep 12;30(3):499-500. doi: 10.1016/j.ccell.2016.08.009. Epub 2016 Sep 12. No abstract available.

50.

The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis.

Alvarez-Diaz S, Dillon CP, Lalaoui N, Tanzer MC, Rodriguez DA, Lin A, Lebois M, Hakem R, Josefsson EC, O'Reilly LA, Silke J, Alexander WS, Green DR, Strasser A.

Immunity. 2016 Sep 20;45(3):513-526. doi: 10.1016/j.immuni.2016.07.016. Epub 2016 Aug 11.

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