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Items: 1 to 50 of 155

1.

Intrahepatic Administration of Human Liver Stem Cells in Infants with Inherited Neonatal-Onset Hyperammonemia: A Phase I Study.

Spada M, Porta F, Righi D, Gazzera C, Tandoi F, Ferrero I, Fagioli F, Sanchez MBH, Calvo PL, Biamino E, Bruno S, Gunetti M, Contursi C, Lauritano C, Conio A, Amoroso A, Salizzoni M, Silengo L, Camussi G, Romagnoli R.

Stem Cell Rev Rep. 2019 Dec 2. doi: 10.1007/s12015-019-09925-z. [Epub ahead of print]

PMID:
31792768
2.

Characterization of Human Mesenchymal Stem Cells Isolated from the Testis.

De Chiara L, Famulari ES, Fagoonee S, van Daalen SKM, Buttiglieri S, Revelli A, Tolosano E, Silengo L, van Pelt AMM, Altruda F.

Stem Cells Int. 2018 Sep 3;2018:4910304. doi: 10.1155/2018/4910304. eCollection 2018.

3.

Heme accumulation in endothelial cells impairs angiogenesis by triggering paraptosis.

Petrillo S, Chiabrando D, Genova T, Fiorito V, Ingoglia G, Vinchi F, Mussano F, Carossa S, Silengo L, Altruda F, Merlo GR, Munaron L, Tolosano E.

Cell Death Differ. 2018 Mar;25(3):573-588. doi: 10.1038/s41418-017-0001-7. Epub 2017 Dec 11.

4.

The IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasis.

Fusella F, Seclì L, Busso E, Krepelova A, Moiso E, Rocca S, Conti L, Annaratone L, Rubinetto C, Mello-Grand M, Singh V, Chiorino G, Silengo L, Altruda F, Turco E, Morotti A, Oliviero S, Castellano I, Cavallo F, Provero P, Tarone G, Brancaccio M.

Nat Commun. 2017 Nov 21;8(1):1636. doi: 10.1038/s41467-017-01829-1.

5.

Data demonstrating the anti-oxidant role of hemopexin in the heart.

Ingoglia G, Sag CM, Rex N, De Franceschi L, Vinchi F, Cimino J, Petrillo S, Wagner S, Kreitmeier K, Silengo L, Altruda F, Maier LS, Hirsch E, Ghigo A, Tolosano E.

Data Brief. 2017 May 13;13:69-76. doi: 10.1016/j.dib.2017.05.026. eCollection 2017 Aug.

6.

Hemopexin counteracts systolic dysfunction induced by heme-driven oxidative stress.

Ingoglia G, Sag CM, Rex N, De Franceschi L, Vinchi F, Cimino J, Petrillo S, Wagner S, Kreitmeier K, Silengo L, Altruda F, Maier LS, Hirsch E, Ghigo A, Tolosano E.

Free Radic Biol Med. 2017 Jul;108:452-464. doi: 10.1016/j.freeradbiomed.2017.04.003. Epub 2017 Apr 8.

7.

The RNA-binding protein ESRP1 promotes human colorectal cancer progression.

Fagoonee S, Picco G, Orso F, Arrigoni A, Longo DL, Forni M, Scarfò I, Cassenti A, Piva R, Cassoni P, Silengo L, Tolosano E, Aime S, Taverna D, Pandolfi PP, Brancaccio M, Medico E, Altruda F.

Oncotarget. 2017 Feb 7;8(6):10007-10024. doi: 10.18632/oncotarget.14318.

8.

Mutations in the Heme Exporter FLVCR1 Cause Sensory Neurodegeneration with Loss of Pain Perception.

Chiabrando D, Castori M, di Rocco M, Ungelenk M, Gießelmann S, Di Capua M, Madeo A, Grammatico P, Bartsch S, Hübner CA, Altruda F, Silengo L, Tolosano E, Kurth I.

PLoS Genet. 2016 Dec 6;12(12):e1006461. doi: 10.1371/journal.pgen.1006461. eCollection 2016 Dec.

9.

Prospects for Adult Stem Cells in the Treatment of Liver Diseases.

Fagoonee S, Famulari ES, Silengo L, Camussi G, Altruda F.

Stem Cells Dev. 2016 Oct;25(20):1471-1482. Epub 2016 Sep 7.

10.

APL-1, an altered peptide ligand derived from heat-shock protein, alone or combined with methotrexate attenuates murine collagen-induced arthritis.

Lorenzo N, Altruda F, Silengo L, Del Carmen Dominguez M.

Clin Exp Med. 2017 May;17(2):209-216. doi: 10.1007/s10238-016-0412-7. Epub 2016 May 9.

PMID:
27160252
11.

Long Term Liver Engraftment of Functional Hepatocytes Obtained from Germline Cell-Derived Pluripotent Stem Cells.

Fagoonee S, Famulari ES, Silengo L, Tolosano E, Altruda F.

PLoS One. 2015 Aug 31;10(8):e0136762. doi: 10.1371/journal.pone.0136762. eCollection 2015.

12.

Crucial Role of FLVCR1a in the Maintenance of Intestinal Heme Homeostasis.

Fiorito V, Forni M, Silengo L, Altruda F, Tolosano E.

Antioxid Redox Signal. 2015 Dec 20;23(18):1410-23. doi: 10.1089/ars.2014.6216. Epub 2015 Jul 20.

13.

Alteration of heme metabolism in a cellular model of Diamond-Blackfan anemia.

Mercurio S, Aspesi A, Silengo L, Altruda F, Dianzani I, Chiabrando D.

Eur J Haematol. 2016 Apr;96(4):367-74. doi: 10.1111/ejh.12599. Epub 2015 Jun 25.

PMID:
26058344
14.

The heme exporter Flvcr1 regulates expansion and differentiation of committed erythroid progenitors by controlling intracellular heme accumulation.

Mercurio S, Petrillo S, Chiabrando D, Bassi ZI, Gays D, Camporeale A, Vacaru A, Miniscalco B, Valperga G, Silengo L, Altruda F, Baron MH, Santoro MM, Tolosano E.

Haematologica. 2015 Jun;100(6):720-9. doi: 10.3324/haematol.2014.114488. Epub 2015 Mar 20.

15.

Morgana acts as an oncosuppressor in chronic myeloid leukemia.

Di Savino A, Panuzzo C, Rocca S, Familiari U, Piazza R, Crivellaro S, Carrà G, Ferretti R, Fusella F, Giugliano E, Camporeale A, Franco I, Miniscalco B, Cutrin JC, Turco E, Silengo L, Hirsch E, Rege-Cambrin G, Gambacorti-Passerini C, Pandolfi PP, Papotti M, Saglio G, Tarone G, Morotti A, Brancaccio M.

Blood. 2015 Apr 2;125(14):2245-53. doi: 10.1182/blood-2014-05-575001. Epub 2015 Feb 12.

16.

Morgana acts as a proto-oncogene through inhibition of a ROCK-PTEN pathway.

Fusella F, Ferretti R, Recupero D, Rocca S, Di Savino A, Tornillo G, Silengo L, Turco E, Cabodi S, Provero P, Pandolfi PP, Sapino A, Tarone G, Brancaccio M.

J Pathol. 2014 Oct;234(2):152-63. doi: 10.1002/path.4341. Epub 2014 Aug 6.

PMID:
24615293
17.

Hypoxia controls Flvcr1 gene expression in Caco2 cells through HIF2α and ETS1.

Fiorito V, Neri F, Pala V, Silengo L, Oliviero S, Altruda F, Tolosano E.

Biochim Biophys Acta. 2014;1839(4):259-64. doi: 10.1016/j.bbagrm.2014.02.010. Epub 2014 Feb 24.

18.

Heme exporter FLVCR1a regulates heme synthesis and degradation and controls activity of cytochromes P450.

Vinchi F, Ingoglia G, Chiabrando D, Mercurio S, Turco E, Silengo L, Altruda F, Tolosano E.

Gastroenterology. 2014 May;146(5):1325-38. doi: 10.1053/j.gastro.2014.01.053. Epub 2014 Jan 31.

19.

APL-2, an altered peptide ligand derived from heat-shock protein 60, induces interleukin-10 in peripheral blood mononuclear cell derived from juvenile idiopathic arthritis patients and downregulates the inflammatory response in collagen-induced arthritis model.

Lorenzo N, Cantera D, Barberá A, Alonso A, Chall E, Franco L, Ancizar J, Nuñez Y, Altruda F, Silengo L, Padrón G, Del Carmen Dominguez M.

Clin Exp Med. 2015 Feb;15(1):31-9. doi: 10.1007/s10238-014-0273-x. Epub 2014 Jan 29.

20.

Acute-phase protein hemopexin is a negative regulator of Th17 response and experimental autoimmune encephalomyelitis development.

Rolla S, Ingoglia G, Bardina V, Silengo L, Altruda F, Novelli F, Tolosano E.

J Immunol. 2013 Dec 1;191(11):5451-9. doi: 10.4049/jimmunol.1203076. Epub 2013 Oct 23.

21.

Renal cells from spermatogonial germline stem cells protect against kidney injury.

De Chiara L, Fagoonee S, Ranghino A, Bruno S, Camussi G, Tolosano E, Silengo L, Altruda F.

J Am Soc Nephrol. 2014 Feb;25(2):316-28. doi: 10.1681/ASN.2013040367. Epub 2013 Oct 17.

22.

The RNA binding protein ESRP1 fine-tunes the expression of pluripotency-related factors in mouse embryonic stem cells.

Fagoonee S, Bearzi C, Di Cunto F, Clohessy JG, Rizzi R, Reschke M, Tolosano E, Provero P, Pandolfi PP, Silengo L, Altruda F.

PLoS One. 2013 Aug 27;8(8):e72300. doi: 10.1371/journal.pone.0072300. eCollection 2013.

23.

Lack of Plasma Protein Hemopexin Results in Increased Duodenal Iron Uptake.

Fiorito V, Geninatti Crich S, Silengo L, Aime S, Altruda F, Tolosano E.

PLoS One. 2013 Jun 27;8(6):e68146. doi: 10.1371/journal.pone.0068146. Print 2013.

24.

Hemopexin therapy improves cardiovascular function by preventing heme-induced endothelial toxicity in mouse models of hemolytic diseases.

Vinchi F, De Franceschi L, Ghigo A, Townes T, Cimino J, Silengo L, Hirsch E, Altruda F, Tolosano E.

Circulation. 2013 Mar 26;127(12):1317-29. doi: 10.1161/CIRCULATIONAHA.112.130179. Epub 2013 Feb 27.

25.

Ubiad1 is an antioxidant enzyme that regulates eNOS activity by CoQ10 synthesis.

Mugoni V, Postel R, Catanzaro V, De Luca E, Turco E, Digilio G, Silengo L, Murphy MP, Medana C, Stainier DY, Bakkers J, Santoro MM.

Cell. 2013 Jan 31;152(3):504-18. doi: 10.1016/j.cell.2013.01.013.

26.

Extracellular vesicles as an emerging mechanism of cell-to-cell communication.

Tetta C, Ghigo E, Silengo L, Deregibus MC, Camussi G.

Endocrine. 2013 Aug;44(1):11-9. doi: 10.1007/s12020-012-9839-0. Epub 2012 Dec 1. Review.

27.

The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation.

Chiabrando D, Marro S, Mercurio S, Giorgi C, Petrillo S, Vinchi F, Fiorito V, Fagoonee S, Camporeale A, Turco E, Merlo GR, Silengo L, Altruda F, Pinton P, Tolosano E.

J Clin Invest. 2012 Dec;122(12):4569-79. doi: 10.1172/JCI62422. Epub 2012 Nov 26.

28.

Cell-specific regulation of Ferroportin transcription following experimentally-induced acute anemia in mice.

Chiabrando D, Fiorito V, Marro S, Silengo L, Altruda F, Tolosano E.

Blood Cells Mol Dis. 2013 Jan;50(1):25-30. doi: 10.1016/j.bcmd.2012.08.002. Epub 2012 Aug 24.

29.

Therapeutic effect of an altered peptide ligand derived from heat-shock protein 60 by suppressing of inflammatory cytokines secretion in two animal models of rheumatoid arthritis.

Lorenzo N, Barberá A, Domínguez MC, Torres AM, Hernandez MV, Hernandez I, Gil R, Ancizar J, Garay H, Reyes O, Altruda F, Silengo L, Padrón G.

Autoimmunity. 2012 Sep;45(6):449-59. doi: 10.3109/08916934.2012.697592. Epub 2012 Jul 20.

PMID:
22686732
30.

ERK1/2 activation in heart is controlled by melusin, focal adhesion kinase and the scaffold protein IQGAP1.

Sbroggiò M, Bertero A, Velasco S, Fusella F, De Blasio E, Bahou WF, Silengo L, Turco E, Brancaccio M, Tarone G.

J Cell Sci. 2011 Oct 15;124(Pt 20):3515-24. doi: 10.1242/jcs.091140.

31.

Assessment of iron absorption in mice by ICP-MS measurements of (57)Fe levels.

Fiorito V, Geninatti Crich S, Silengo L, Altruda F, Aime S, Tolosano E.

Eur J Nutr. 2012 Oct;51(7):783-9. Epub 2011 Oct 19.

32.

The aging effect of chemotherapy on cultured human mesenchymal stem cells.

Buttiglieri S, Ruella M, Risso A, Spatola T, Silengo L, Avvedimento EV, Tarella C.

Exp Hematol. 2011 Dec;39(12):1171-81. doi: 10.1016/j.exphem.2011.08.009. Epub 2011 Aug 22.

PMID:
21864489
33.

A role for hemopexin in oligodendrocyte differentiation and myelin formation.

Morello N, Bianchi FT, Marmiroli P, Tonoli E, Rodriguez Menendez V, Silengo L, Cavaletti G, Vercelli A, Altruda F, Tolosano E.

PLoS One. 2011;6(5):e20173. doi: 10.1371/journal.pone.0020173. Epub 2011 May 25.

34.

Potential applications of germline cell-derived pluripotent stem cells in organ regeneration.

Fagoonee S, Pellicano R, Silengo L, Altruda F.

Organogenesis. 2011 Apr-Jun;7(2):116-22. doi: 10.4161/org.7.2.16284. Epub 2011 Apr 1. Review.

35.

IQGAP1 regulates ERK1/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload.

Sbroggiò M, Carnevale D, Bertero A, Cifelli G, De Blasio E, Mascio G, Hirsch E, Bahou WF, Turco E, Silengo L, Brancaccio M, Lembo G, Tarone G.

Cardiovasc Res. 2011 Aug 1;91(3):456-64. doi: 10.1093/cvr/cvr103. Epub 2011 Apr 14.

36.

Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ.

Perino A, Ghigo A, Ferrero E, Morello F, Santulli G, Baillie GS, Damilano F, Dunlop AJ, Pawson C, Walser R, Levi R, Altruda F, Silengo L, Langeberg LK, Neubauer G, Heymans S, Lembo G, Wymann MP, Wetzker R, Houslay MD, Iaccarino G, Scott JD, Hirsch E.

Mol Cell. 2011 Apr 8;42(1):84-95. doi: 10.1016/j.molcel.2011.01.030.

37.

Clinical, pathological and immunological features of psoriatic-like lesions affecting keratin 14-vascular endothelial growth factor transgenic mice.

Canavese M, Altruda F, Silengo L, Castiglioni V, Scanziani E, Radaelli E.

Histol Histopathol. 2011 Mar;26(3):285-96. doi: 10.14670/HH-26.285.

PMID:
21210341
38.

Generation of functional hepatocytes from mouse germ line cell-derived pluripotent stem cells in vitro.

Fagoonee S, Hobbs RM, De Chiara L, Cantarella D, Piro RM, Tolosano E, Medico E, Provero P, Pandolfi PP, Silengo L, Altruda F.

Stem Cells Dev. 2010 Aug;19(8):1183-94. doi: 10.1089/scd.2009.0496.

PMID:
20331356
39.

Morgana/chp-1, a ROCK inhibitor involved in centrosome duplication and tumorigenesis.

Ferretti R, Palumbo V, Di Savino A, Velasco S, Sbroggiò M, Sportoletti P, Micale L, Turco E, Silengo L, Palumbo G, Hirsch E, Teruya-Feldstein J, Bonaccorsi S, Pandolfi PP, Gatti M, Tarone G, Brancaccio M.

Dev Cell. 2010 Mar 16;18(3):486-95. doi: 10.1016/j.devcel.2009.12.020.

40.

Comparison of 3 Tfr2-deficient murine models suggests distinct functions for Tfr2-alpha and Tfr2-beta isoforms in different tissues.

Roetto A, Di Cunto F, Pellegrino RM, Hirsch E, Azzolino O, Bondi A, Defilippi I, Carturan S, Miniscalco B, Riondato F, Cilloni D, Silengo L, Altruda F, Camaschella C, Saglio G.

Blood. 2010 Apr 22;115(16):3382-9. doi: 10.1182/blood-2009-09-240960. Epub 2010 Feb 23.

41.

Therapeutic efficacy and immunological response of CCL5 antagonists in models of contact skin reaction.

Canavese M, Altruda F, Silengo L.

PLoS One. 2010 Jan 15;5(1):e8725. doi: 10.1371/journal.pone.0008725.

42.

Haemopexin affects iron distribution and ferritin expression in mouse brain.

Morello N, Tonoli E, Logrand F, Fiorito V, Fagoonee S, Turco E, Silengo L, Vercelli A, Altruda F, Tolosano E.

J Cell Mol Med. 2009 Oct;13(10):4192-204. doi: 10.1111/j.1582-4934.2008.00611.x.

43.

Convergence of integrins and EGF receptor signaling via PI3K/Akt/FoxO pathway in early gene Egr-1 expression.

Cabodi S, Morello V, Masi A, Cicchi R, Broggio C, Distefano P, Brunelli E, Silengo L, Pavone F, Arcangeli A, Turco E, Tarone G, Moro L, Defilippi P.

J Cell Physiol. 2009 Feb;218(2):294-303. doi: 10.1002/jcp.21603.

PMID:
18844239
44.

Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development.

Ciraolo E, Iezzi M, Marone R, Marengo S, Curcio C, Costa C, Azzolino O, Gonella C, Rubinetto C, Wu H, Dastrù W, Martin EL, Silengo L, Altruda F, Turco E, Lanzetti L, Musiani P, Rückle T, Rommel C, Backer JM, Forni G, Wymann MP, Hirsch E.

Sci Signal. 2008 Sep 9;1(36):ra3. doi: 10.1126/scisignal.1161577.

45.

Lack of plasma protein hemopexin dampens mercury-induced autoimmune response in mice.

Fagoonee S, Caorsi C, Giovarelli M, Stoltenberg M, Silengo L, Altruda F, Camussi G, Tolosano E, Bussolati B.

J Immunol. 2008 Aug 1;181(3):1937-47.

46.

Functional annotation and identification of candidate disease genes by computational analysis of normal tissue gene expression data.

Miozzi L, Piro RM, Rosa F, Ala U, Silengo L, Di Cunto F, Provero P.

PLoS One. 2008 Jun 18;3(6):e2439. doi: 10.1371/journal.pone.0002439.

47.

Hemopexin prevents endothelial damage and liver congestion in a mouse model of heme overload.

Vinchi F, Gastaldi S, Silengo L, Altruda F, Tolosano E.

Am J Pathol. 2008 Jul;173(1):289-99. doi: 10.2353/ajpath.2008.071130. Epub 2008 Jun 13.

48.

The mammalian CHORD-containing protein melusin is a stress response protein interacting with Hsp90 and Sgt1.

Sbroggiò M, Ferretti R, Percivalle E, Gutkowska M, Zylicz A, Michowski W, Kuznicki J, Accornero F, Pacchioni B, Lanfranchi G, Hamm J, Turco E, Silengo L, Tarone G, Brancaccio M.

FEBS Lett. 2008 Jun 11;582(13):1788-94. doi: 10.1016/j.febslet.2008.04.058. Epub 2008 May 12.

49.

The dream to re-build the human body.

Pellicano R, Silengo L, Gasbarrini A.

Panminerva Med. 2008 Mar;50(1):1-2. No abstract available.

PMID:
18427383
50.

Prediction of human disease genes by human-mouse conserved coexpression analysis.

Ala U, Piro RM, Grassi E, Damasco C, Silengo L, Oti M, Provero P, Di Cunto F.

PLoS Comput Biol. 2008 Mar 28;4(3):e1000043. doi: 10.1371/journal.pcbi.1000043.

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