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Items: 7


Synthesis and biological evaluation of (-)-dictyostatin and stereoisomers.

Shin Y, Fournier JH, Br├╝ckner A, Madiraju C, Balachandran R, Raccor BS, Edler MC, Hamel E, Sikorski RP, Vogt A, Day BW, Curran DP.

Tetrahedron. 2007 Aug 27;63(35):8537-8562.


A phase I study of 17-allylamino-17-demethoxygeldanamycin combined with paclitaxel in patients with advanced solid malignancies.

Ramalingam SS, Egorin MJ, Ramanathan RK, Remick SC, Sikorski RP, Lagattuta TF, Chatta GS, Friedland DM, Stoller RG, Potter DM, Ivy SP, Belani CP.

Clin Cancer Res. 2008 Jun 1;14(11):3456-61. doi: 10.1158/1078-0432.CCR-07-5088.


A cell-active inhibitor of mitogen-activated protein kinase phosphatases restores paclitaxel-induced apoptosis in dexamethasone-protected cancer cells.

Vogt A, McDonald PR, Tamewitz A, Sikorski RP, Wipf P, Skoko JJ 3rd, Lazo JS.

Mol Cancer Ther. 2008 Feb;7(2):330-40. doi: 10.1158/1535-7163.MCT-07-2165. Epub 2008 Feb 1.


Cell-based and biochemical structure-activity analyses of analogs of the microtubule stabilizer dictyostatin.

Raccor BS, Vogt A, Sikorski RP, Madiraju C, Balachandran R, Montgomery K, Shin Y, Fukui Y, Jung WH, Curran DP, Day BW.

Mol Pharmacol. 2008 Mar;73(3):718-26. Epub 2007 Dec 11.


Total synthesis and biological evaluation of C16 analogs of (-)-dictyostatin.

Jung WH, Harrison C, Shin Y, Fournier JH, Balachandran R, Raccor BS, Sikorski RP, Vogt A, Curran DP, Day BW.

J Med Chem. 2007 Jun 28;50(13):2951-66. Epub 2007 Jun 2.


Cellular analysis of disorazole C and structure-activity relationship of analogs of the natural product.

Wipf P, Graham TH, Vogt A, Sikorski RP, Ducruet AP, Lazo JS.

Chem Biol Drug Des. 2006 Jan;67(1):66-73.


The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor of mitogen-activated protein kinase phosphatase-1.

Vogt A, Tamewitz A, Skoko J, Sikorski RP, Giuliano KA, Lazo JS.

J Biol Chem. 2005 May 13;280(19):19078-86. Epub 2005 Mar 7.

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