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Items: 46

1.

Immunogenicity Testing of Lipidoids In Vitro and In Silico: Modulating Lipidoid-Mediated TLR4 Activation by Nanoparticle Design.

de Groot AM, Thanki K, Gangloff M, Falkenberg E, Zeng X, van Bijnen DCJ, van Eden W, Franzyk H, Nielsen HM, Broere F, Gay NJ, Foged C, Sijts AJAM.

Mol Ther Nucleic Acids. 2018 Jun 1;11:159-169. doi: 10.1016/j.omtn.2018.02.003. Epub 2018 Feb 13.

2.

Nanoporous Microneedle Arrays Effectively Induce Antibody Responses against Diphtheria and Tetanus Toxoid.

de Groot AM, Platteel ACM, Kuijt N, van Kooten PJS, Vos PJ, Sijts AJAM, van der Maaden K.

Front Immunol. 2017 Dec 13;8:1789. doi: 10.3389/fimmu.2017.01789. eCollection 2017.

3.

Efficacy Testing of H56 cDNA Tattoo Immunization against Tuberculosis in a Mouse Model.

Platteel ACM, Nieuwenhuizen NE, Domaszewska T, Schürer S, Zedler U, Brinkmann V, Sijts AJAM, Kaufmann SHE.

Front Immunol. 2017 Dec 11;8:1744. doi: 10.3389/fimmu.2017.01744. eCollection 2017.

4.

An Unexpected Major Role for Proteasome-Catalyzed Peptide Splicing in Generation of T Cell Epitopes: Is There Relevance for Vaccine Development?

Platteel ACM, Liepe J, van Eden W, Mishto M, Sijts AJAM.

Front Immunol. 2017 Nov 3;8:1441. doi: 10.3389/fimmu.2017.01441. eCollection 2017. Review.

5.

Dissecting antigen processing and presentation routes in dermal vaccination strategies.

Platteel ACM, Henri S, Zaiss DM, Sijts AJAM.

Vaccine. 2017 Dec 15;35(50):7057-7063. doi: 10.1016/j.vaccine.2017.10.044. Epub 2017 Nov 1.

6.

Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion.

Minutti CM, Drube S, Blair N, Schwartz C, McCrae JC, McKenzie AN, Kamradt T, Mokry M, Coffer PJ, Sibilia M, Sijts AJ, Fallon PG, Maizels RM, Zaiss DM.

Immunity. 2017 Oct 17;47(4):710-722.e6. doi: 10.1016/j.immuni.2017.09.013.

7.

Hollow microneedle-mediated intradermal delivery of model vaccine antigen-loaded PLGA nanoparticles elicits protective T cell-mediated immunity to an intracellular bacterium.

de Groot AM, Du G, Mönkäre J, Platteel ACM, Broere F, Bouwstra JA, Sijts AJAM.

J Control Release. 2017 Nov 28;266:27-35. doi: 10.1016/j.jconrel.2017.09.017. Epub 2017 Sep 14.

8.

Multi-level Strategy for Identifying Proteasome-Catalyzed Spliced Epitopes Targeted by CD8+ T Cells during Bacterial Infection.

Platteel ACM, Liepe J, Textoris-Taube K, Keller C, Henklein P, Schalkwijk HH, Cardoso R, Kloetzel PM, Mishto M, Sijts AJAM.

Cell Rep. 2017 Aug 1;20(5):1242-1253. doi: 10.1016/j.celrep.2017.07.026.

9.

Strategies to enhance immunogenicity of cDNA vaccine encoded antigens by modulation of antigen processing.

Platteel ACM, Marit de Groot A, Keller C, Andersen P, Ovaa H, Kloetzel PM, Mishto M, Sijts AJAM.

Vaccine. 2016 Sep 30;34(42):5132-5140. doi: 10.1016/j.vaccine.2016.08.039. Epub 2016 Sep 1.

PMID:
27593157
10.

CD8(+) T cells of Listeria monocytogenes-infected mice recognize both linear and spliced proteasome products.

Platteel AC, Mishto M, Textoris-Taube K, Keller C, Liepe J, Busch DH, Kloetzel PM, Sijts AJ.

Eur J Immunol. 2016 May;46(5):1109-18. doi: 10.1002/eji.201545989. Epub 2016 Mar 16.

11.

Surface coating of siRNA-peptidomimetic nano-self-assemblies with anionic lipid bilayers: enhanced gene silencing and reduced adverse effects in vitro.

Zeng X, de Groot AM, Sijts AJ, Broere F, Oude Blenke E, Colombo S, van Eden W, Franzyk H, Nielsen HM, Foged C.

Nanoscale. 2015 Dec 14;7(46):19687-98. doi: 10.1039/c5nr04807a.

PMID:
26553270
12.

Basophil-derived amphiregulin is essential for UVB irradiation-induced immune suppression.

Meulenbroeks C, van Weelden H, Schwartz C, Voehringer D, Redegeld FAM, Rutten VPMG, Willemse T, Sijts AJAM, Zaiss DMW.

J Invest Dermatol. 2015 Jan;135(1):222-228. doi: 10.1038/jid.2014.329. Epub 2014 Jul 4.

13.

Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity.

van Loosdregt J, Fleskens V, Fu J, Brenkman AB, Bekker CP, Pals CE, Meerding J, Berkers CR, Barbi J, Gröne A, Sijts AJ, Maurice MM, Kalkhoven E, Prakken BJ, Ovaa H, Pan F, Zaiss DM, Coffer PJ.

Immunity. 2013 Aug 22;39(2):259-71. doi: 10.1016/j.immuni.2013.05.018.

14.

Canonical Wnt signaling negatively modulates regulatory T cell function.

van Loosdregt J, Fleskens V, Tiemessen MM, Mokry M, van Boxtel R, Meerding J, Pals CE, Kurek D, Baert MR, Delemarre EM, Gröne A, Koerkamp MJ, Sijts AJ, Nieuwenhuis EE, Maurice MM, van Es JH, Ten Berge D, Holstege FC, Staal FJ, Zaiss DM, Prakken BJ, Coffer PJ.

Immunity. 2013 Aug 22;39(2):298-310. doi: 10.1016/j.immuni.2013.07.019. Epub 2013 Aug 15.

15.

Amphiregulin enhances regulatory T cell-suppressive function via the epidermal growth factor receptor.

Zaiss DM, van Loosdregt J, Gorlani A, Bekker CP, Gröne A, Sibilia M, van Bergen en Henegouwen PM, Roovers RC, Coffer PJ, Sijts AJ.

Immunity. 2013 Feb 21;38(2):275-84. doi: 10.1016/j.immuni.2012.09.023. Epub 2013 Jan 17.

16.

CCR2 defines a distinct population of NK cells and mediates their migration during influenza virus infection in mice.

van Helden MJ, Zaiss DM, Sijts AJ.

PLoS One. 2012;7(12):e52027. doi: 10.1371/journal.pone.0052027. Epub 2012 Dec 13.

17.

Pre-existing virus-specific CD8(+) T-cells provide protection against pneumovirus-induced disease in mice.

van Helden MJ, van Kooten PJ, Bekker CP, Gröne A, Topham DJ, Easton AJ, Boog CJ, Busch DH, Zaiss DM, Sijts AJ.

Vaccine. 2012 Oct 5;30(45):6382-8. doi: 10.1016/j.vaccine.2012.08.027. Epub 2012 Aug 29.

18.

Induction of humoral and cellular immune responses by antigen-expressing immunostimulatory liposomes.

Amidi M, van Helden MJ, Tabataei NR, de Goede AL, Schouten M, de Bot V, Lanzi A, Gruters RA, Rimmelzwaan GF, Sijts AJ, Mastrobattista E.

J Control Release. 2012 Dec 28;164(3):323-30. doi: 10.1016/j.jconrel.2012.08.016. Epub 2012 Aug 21.

PMID:
22940204
19.

The bone marrow functions as the central site of proliferation for long-lived NK cells.

van Helden MJ, de Graaf N, Boog CJ, Topham DJ, Zaiss DM, Sijts AJ.

J Immunol. 2012 Sep 1;189(5):2333-7. doi: 10.4049/jimmunol.1200008. Epub 2012 Jul 20.

20.

The Tricky Balancing Act of using Heat Shock Proteins for Cross-Presentation.

Sijts AJ, van Eden W.

Front Immunol. 2012 May 10;3:114. doi: 10.3389/fimmu.2012.00114. eCollection 2012. No abstract available.

21.

Identification of novel avian influenza virus derived CD8+ T-cell epitopes.

Reemers SS, van Haarlem DA, Sijts AJ, Vervelde L, Jansen CA.

PLoS One. 2012;7(2):e31953. doi: 10.1371/journal.pone.0031953. Epub 2012 Feb 23.

22.

Immunoproteasome-deficiency has no effects on NK cell education, but confers lymphocytes into targets for NK cells in infected wild-type mice.

van Helden MJ, de Graaf N, Bekker CP, Boog CJ, Zaiss DM, Sijts AJ.

PLoS One. 2011;6(8):e23769. doi: 10.1371/journal.pone.0023769. Epub 2011 Aug 24.

23.

Proteasome immunosubunits protect against the development of CD8 T cell-mediated autoimmune diseases.

Zaiss DM, Bekker CP, Gröne A, Lie BA, Sijts AJ.

J Immunol. 2011 Sep 1;187(5):2302-9. doi: 10.4049/jimmunol.1101003. Epub 2011 Jul 29.

24.

PA28 and the proteasome immunosubunits play a central and independent role in the production of MHC class I-binding peptides in vivo.

de Graaf N, van Helden MJ, Textoris-Taube K, Chiba T, Topham DJ, Kloetzel PM, Zaiss DM, Sijts AJ.

Eur J Immunol. 2011 Apr;41(4):926-35. doi: 10.1002/eji.201041040. Epub 2011 Mar 1.

25.

Considerations in the design of vaccines that induce CD8 T cell mediated immunity.

Zaiss DM, Boog CJ, van Eden W, Sijts AJ.

Vaccine. 2010 Nov 16;28(49):7716-22. doi: 10.1016/j.vaccine.2010.08.101. Epub 2010 Sep 17. Review.

PMID:
20851090
26.

Enumeration of cytotoxic CD8 T cells ex vivo during the response to Listeria monocytogenes infection.

Zaiss DM, Sijts AJ, Mosmann TR.

Infect Immun. 2008 Oct;76(10):4609-14. doi: 10.1128/IAI.00563-08. Epub 2008 Aug 4.

27.
28.

Rates of processing determine the immunogenicity of immunoproteasome-generated epitopes.

Deol P, Zaiss DM, Monaco JJ, Sijts AJ.

J Immunol. 2007 Jun 15;178(12):7557-62.

29.

Protein vaccines induce uncommitted IL-2-secreting human and mouse CD4 T cells, whereas infections induce more IFN-gamma-secreting cells.

Divekar AA, Zaiss DM, Lee FE, Liu D, Topham DJ, Sijts AJ, Mosmann TR.

J Immunol. 2006 Feb 1;176(3):1465-73.

30.

The RTP site shared by the HIV-1 Tat protein and the 11S regulator subunit alpha is crucial for their effects on proteasome function including antigen processing.

Huang X, Seifert U, Salzmann U, Henklein P, Preissner R, Henke W, Sijts AJ, Kloetzel PM, Dubiel W.

J Mol Biol. 2002 Nov 1;323(4):771-82.

PMID:
12419264
31.

PI31 is a modulator of proteasome formation and antigen processing.

Zaiss DM, Standera S, Kloetzel PM, Sijts AJ.

Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14344-9. Epub 2002 Oct 8.

32.

Expression of the proteasome activator PA28 rescues the presentation of a cytotoxic T lymphocyte epitope on melanoma cells.

Sun Y, Sijts AJ, Song M, Janek K, Nussbaum AK, Kral S, Schirle M, Stevanovic S, Paschen A, Schild H, Kloetzel PM, Schadendorf D.

Cancer Res. 2002 May 15;62(10):2875-82.

33.

MHC class I antigen processing of an adenovirus CTL epitope is linked to the levels of immunoproteasomes in infected cells.

Sijts AJ, Standera S, Toes RE, Ruppert T, Beekman NJ, van Veelen PA, Ossendorp FA, Melief CJ, Kloetzel PM.

J Immunol. 2000 May 1;164(9):4500-6.

34.

Efficient generation of a hepatitis B virus cytotoxic T lymphocyte epitope requires the structural features of immunoproteasomes.

Sijts AJ, Ruppert T, Rehermann B, Schmidt M, Koszinowski U, Kloetzel PM.

J Exp Med. 2000 Feb 7;191(3):503-14.

35.

The proteasome inhibitor PI31 competes with PA28 for binding to 20S proteasomes.

Zaiss DM, Standera S, Holzhütter H, Kloetzel P, Sijts AJ.

FEBS Lett. 1999 Sep 3;457(3):333-8.

36.

MHC class I antigen processing of Listeria monocytogenes proteins: implications for dominant and subdominant CTL responses.

Pamer EG, Sijts AJ, Villanueva MS, Busch DH, Vijh S.

Immunol Rev. 1997 Aug;158:129-36. Review.

PMID:
9314081
39.

CTL epitope generation is tightly linked to cellular proteolysis of a Listeria monocytogenes antigen.

Sijts AJ, Villanueva MS, Pamer EG.

J Immunol. 1996 Feb 15;156(4):1497-503.

PMID:
8568253
40.

Two Listeria monocytogenes CTL epitopes are processed from the same antigen with different efficiencies.

Sijts AJ, Neisig A, Neefjes J, Pamer EG.

J Immunol. 1996 Jan 15;156(2):683-92.

PMID:
8543821
41.
42.

Major differences in transporter associated with antigen presentation (TAP)-dependent translocation of MHC class I-presentable peptides and the effect of flanking sequences.

Neisig A, Roelse J, Sijts AJ, Ossendorp F, Feltkamp MC, Kast WM, Melief CJ, Neefjes JJ.

J Immunol. 1995 Feb 1;154(3):1273-9.

PMID:
7822796
43.

Identification of an H-2 Kb-presented Moloney murine leukemia virus cytotoxic T-lymphocyte epitope that displays enhanced recognition in H-2 Db mutant bm13 mice.

Sijts AJ, De Bruijn ML, Ressing ME, Nieland JD, Mengedé EA, Boog CJ, Ossendorp F, Kast WM, Melief CJ.

J Virol. 1994 Sep;68(9):6038-46.

45.

Differential effect of transporter Tap 2 gene introduction into RMA-S cells on viral antigen processing.

Ossevoort MA, Sijts AJ, van Veen KJ, Momburg F, Hämmerling GJ, Seelig A, Butcher GW, Howard JC, Kast WM, Melief CJ.

Eur J Immunol. 1993 Dec;23(12):3082-8.

PMID:
8258321
46.

Cytotoxic T lymphocytes against the antigen-processing-defective RMA-S tumor cell line.

Sijts AJ, De Bruijn ML, Nieland JD, Kast WM, Melief CJ.

Eur J Immunol. 1992 Jun;22(6):1639-42.

PMID:
1601045

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