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Items: 1 to 50 of 57

1.

Drug sensitivity screening and genomic characterization of 45 HPV-negative head and neck carcinoma cell lines for novel biomarkers of drug efficacy.

Lepikhova T, Karhemo PR, Louhimo R, Yadav B, Murumägi A, Kulesskiy E, Kivento M, Sihto H, Grénman R, Syrjänen SM, Kallioniemi O, Aittokallio T, Wennerberg K, Joensuu H, Monni O.

Mol Cancer Ther. 2018 Jul 3. pii: molcanther.0733.2017. doi: 10.1158/1535-7163.MCT-17-0733. [Epub ahead of print]

PMID:
29970484
2.

Expression of cell cycle regulators and frequency of TP53 mutations in high risk gastrointestinal stromal tumors prior to adjuvant imatinib treatment.

Ihle MA, Huss S, Jeske W, Hartmann W, Merkelbach-Bruse S, Schildhaus HU, Büttner R, Sihto H, Sundby Hall K, Eriksson M, Reichardt P, Joensuu H, Wardelmann E.

PLoS One. 2018 Feb 16;13(2):e0193048. doi: 10.1371/journal.pone.0193048. eCollection 2018.

3.

Clinical relevance of integrin alpha 4 in gastrointestinal stromal tumours.

Pulkka OP, Mpindi JP, Tynninen O, Nilsson B, Kallioniemi O, Sihto H, Joensuu H.

J Cell Mol Med. 2018 Apr;22(4):2220-2230. doi: 10.1111/jcmm.13502. Epub 2018 Jan 29.

4.

Reduced Enterotoxin D Formation on Boiled Ham in Staphylococcus Aureus Δagr Mutant.

Susilo YB, Sihto HM, Rådström P, Stephan R, Johler S, Schelin J.

Toxins (Basel). 2017 Aug 25;9(9). pii: E263. doi: 10.3390/toxins9090263.

5.

Effect of food-related stress conditions and loss of agr and sigB on seb promoter activity in S. aureus.

Sihto HM, Stephan R, Engl C, Chen J, Johler S.

Food Microbiol. 2017 Aug;65:205-212. doi: 10.1016/j.fm.2017.03.006. Epub 2017 Mar 7.

6.

SLUG transcription factor: a pro-survival and prognostic factor in gastrointestinal stromal tumour.

Pulkka OP, Nilsson B, Sarlomo-Rikala M, Reichardt P, Eriksson M, Hall KS, Wardelmann E, Vehtari A, Joensuu H, Sihto H.

Br J Cancer. 2017 Apr 25;116(9):1195-1202. doi: 10.1038/bjc.2017.82. Epub 2017 Mar 23.

7.

Effect of KIT and PDGFRA Mutations on Survival in Patients With Gastrointestinal Stromal Tumors Treated With Adjuvant Imatinib: An Exploratory Analysis of a Randomized Clinical Trial.

Joensuu H, Wardelmann E, Sihto H, Eriksson M, Sundby Hall K, Reichardt A, Hartmann JT, Pink D, Cameron S, Hohenberger P, Al-Batran SE, Schlemmer M, Bauer S, Nilsson B, Kallio R, Junnila J, Vehtari A, Reichardt P.

JAMA Oncol. 2017 May 1;3(5):602-609. doi: 10.1001/jamaoncol.2016.5751.

8.

Motility of glioblastoma cells is driven by netrin-1 induced gain of stemness.

Ylivinkka I, Sihto H, Tynninen O, Hu Y, Laakso A, Kivisaari R, Laakkonen P, Keski-Oja J, Hyytiäinen M.

J Exp Clin Cancer Res. 2017 Jan 9;36(1):9. doi: 10.1186/s13046-016-0482-0.

9.

History of chronic inflammatory disorders increases the risk of Merkel cell carcinoma, but does not correlate with Merkel cell polyomavirus infection.

Sahi H, Sihto H, Artama M, Koljonen V, Böhling T, Pukkala E.

Br J Cancer. 2017 Jan 17;116(2):260-264. doi: 10.1038/bjc.2016.391. Epub 2016 Dec 15.

10.

L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling.

Jacquemet G, Baghirov H, Georgiadou M, Sihto H, Peuhu E, Cettour-Janet P, He T, Perälä M, Kronqvist P, Joensuu H, Ivaska J.

Nat Commun. 2016 Dec 2;7:13297. doi: 10.1038/ncomms13297.

11.

Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription.

Kaukonen R, Mai A, Georgiadou M, Saari M, De Franceschi N, Betz T, Sihto H, Ventelä S, Elo L, Jokitalo E, Westermarck J, Kellokumpu-Lehtinen PL, Joensuu H, Grenman R, Ivaska J.

Nat Commun. 2016 Aug 4;7:12237. doi: 10.1038/ncomms12237.

12.

Sequence Variability in Staphylococcal Enterotoxin Genes seb, sec, and sed.

Johler S, Sihto HM, Macori G, Stephan R.

Toxins (Basel). 2016 Jun 1;8(6). pii: E169. doi: 10.3390/toxins8060169.

13.

Biological subtyping of early breast cancer: a study comparing RT-qPCR with immunohistochemistry.

Wirtz RM, Sihto H, Isola J, Heikkilä P, Kellokumpu-Lehtinen PL, Auvinen P, Turpeenniemi-Hujanen T, Jyrkkiö S, Lakis S, Schlombs K, Laible M, Weber S, Eidt S, Sahin U, Joensuu H.

Breast Cancer Res Treat. 2016 Jun;157(3):437-46. doi: 10.1007/s10549-016-3835-7. Epub 2016 May 24.

14.

Adjuvant Imatinib for High-Risk GI Stromal Tumor: Analysis of a Randomized Trial.

Joensuu H, Eriksson M, Sundby Hall K, Reichardt A, Hartmann JT, Pink D, Ramadori G, Hohenberger P, Al-Batran SE, Schlemmer M, Bauer S, Wardelmann E, Nilsson B, Sihto H, Bono P, Kallio R, Junnila J, Alvegård T, Reichardt P.

J Clin Oncol. 2016 Jan 20;34(3):244-50. doi: 10.1200/JCO.2015.62.9170. Epub 2015 Nov 2.

PMID:
26527782
15.

Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion.

Tervonen TA, Belitškin D, Pant SM, Englund JI, Marques E, Ala-Hongisto H, Nevalaita L, Sihto H, Heikkilä P, Leidenius M, Hewitson K, Ramachandra M, Moilanen A, Joensuu H, Kovanen PE, Poso A, Klefström J.

Oncogene. 2016 Apr 7;35(14):1832-46. doi: 10.1038/onc.2015.248. Epub 2015 Jul 13.

PMID:
26165838
16.

Temporal expression of the staphylococcal enterotoxin D gene under NaCl stress conditions.

Sihto HM, Tasara T, Stephan R, Johler S.

FEMS Microbiol Lett. 2015 Mar;362(6). pii: fnv024. doi: 10.1093/femsle/fnv024. Epub 2015 Feb 16.

17.

Elevated levels of StAR-related lipid transfer protein 3 alter cholesterol balance and adhesiveness of breast cancer cells: potential mechanisms contributing to progression of HER2-positive breast cancers.

Vassilev B, Sihto H, Li S, Hölttä-Vuori M, Ilola J, Lundin J, Isola J, Kellokumpu-Lehtinen PL, Joensuu H, Ikonen E.

Am J Pathol. 2015 Apr;185(4):987-1000. doi: 10.1016/j.ajpath.2014.12.018. Epub 2015 Feb 12.

PMID:
25681734
18.
19.

Risk factors for gastrointestinal stromal tumor recurrence in patients treated with adjuvant imatinib.

Joensuu H, Eriksson M, Hall KS, Hartmann JT, Pink D, Schütte J, Ramadori G, Hohenberger P, Duyster J, Al-Batran SE, Schlemmer M, Bauer S, Wardelmann E, Sarlomo-Rikala M, Nilsson B, Sihto H, Ballman KV, Leinonen M, DeMatteo RP, Reichardt P.

Cancer. 2014 Aug 1;120(15):2325-33. doi: 10.1002/cncr.28669. Epub 2014 Apr 15.

20.

RB1 gene in Merkel cell carcinoma: hypermethylation in all tumors and concurrent heterozygous deletions in the polyomavirus-negative subgroup.

Sahi H, Savola S, Sihto H, Koljonen V, Bohling T, Knuutila S.

APMIS. 2014 Dec;122(12):1157-66. doi: 10.1111/apm.12274. Epub 2014 Apr 16.

PMID:
24735260
21.

Prokineticins and Merkel cell polyomavirus infection in Merkel cell carcinoma.

Lauttia S, Sihto H, Kavola H, Koljonen V, Böhling T, Joensuu H.

Br J Cancer. 2014 Mar 18;110(6):1446-55. doi: 10.1038/bjc.2014.20. Epub 2014 Feb 4.

22.

Novel target for peptide-based imaging and treatment of brain tumors.

Hyvönen M, Enbäck J, Huhtala T, Lammi J, Sihto H, Weisell J, Joensuu H, Rosenthal-Aizman K, El-Andaloussi S, Langel U, Närvänen A, Bergers G, Laakkonen P.

Mol Cancer Ther. 2014 Apr;13(4):996-1007. doi: 10.1158/1535-7163.MCT-13-0684. Epub 2014 Feb 3.

23.

Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis.

Arjonen A, Kaukonen R, Mattila E, Rouhi P, Högnäs G, Sihto H, Miller BW, Morton JP, Bucher E, Taimen P, Virtakoivu R, Cao Y, Sansom OJ, Joensuu H, Ivaska J.

J Clin Invest. 2014 Mar;124(3):1069-82.

24.

Microarray-based characterization of Staphylococcus aureus isolates obtained from chicken carcasses.

Ebner R, Johler S, Sihto HM, Stephan R, Zweifel C.

J Food Prot. 2013 Aug;76(8):1471-4. doi: 10.4315/0362-028X.JFP-13-009.

PMID:
23905809
25.

Outbreak of Staphylococcal food poisoning due to SEA-producing Staphylococcus aureus.

Johler S, Tichaczek-Dischinger PS, Rau J, Sihto HM, Lehner A, Adam M, Stephan R.

Foodborne Pathog Dis. 2013 Sep;10(9):777-81. doi: 10.1089/fpd.2013.1503. Epub 2013 Jun 15.

26.

Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1.

Laine A, Sihto H, Come C, Rosenfeldt MT, Zwolinska A, Niemelä M, Khanna A, Chan EK, Kähäri VM, Kellokumpu-Lehtinen PL, Sansom OJ, Evan GI, Junttila MR, Ryan KM, Marine JC, Joensuu H, Westermarck J.

Cancer Discov. 2013 Feb;3(2):182-97. doi: 10.1158/2159-8290.CD-12-0292. Epub 2013 Jan 10.

27.
28.

Bcl-2 expression indicates better prognosis of Merkel cell carcinoma regardless of the presence of Merkel cell polyomavirus.

Sahi H, Koljonen V, Kavola H, Haglund C, Tukiainen E, Sihto H, Böhling T.

Virchows Arch. 2012 Nov;461(5):553-9. doi: 10.1007/s00428-012-1310-3. Epub 2012 Sep 14.

PMID:
22976527
29.

Lateral distribution of Merkel cell carcinoma in a nationwide cohort.

Koljonen V, Kluger N, Sihto H, Böhling T.

J Eur Acad Dermatol Venereol. 2013 Jul;27(7):884-8. doi: 10.1111/j.1468-3083.2012.04600.x. Epub 2012 Jun 14.

PMID:
22741742
30.

Tumor infiltrating immune cells and outcome of Merkel cell carcinoma: a population-based study.

Sihto H, Böhling T, Kavola H, Koljonen V, Salmi M, Jalkanen S, Joensuu H.

Clin Cancer Res. 2012 May 15;18(10):2872-81. doi: 10.1158/1078-0432.CCR-11-3020. Epub 2012 Mar 30.

31.

One vs three years of adjuvant imatinib for operable gastrointestinal stromal tumor: a randomized trial.

Joensuu H, Eriksson M, Sundby Hall K, Hartmann JT, Pink D, Schütte J, Ramadori G, Hohenberger P, Duyster J, Al-Batran SE, Schlemmer M, Bauer S, Wardelmann E, Sarlomo-Rikala M, Nilsson B, Sihto H, Monge OR, Bono P, Kallio R, Vehtari A, Leinonen M, Alvegård T, Reichardt P.

JAMA. 2012 Mar 28;307(12):1265-72. doi: 10.1001/jama.2012.347.

PMID:
22453568
32.

CIP2A signature reveals the MYC dependency of CIP2A-regulated phenotypes and its clinical association with breast cancer subtypes.

Niemelä M, Kauko O, Sihto H, Mpindi JP, Nicorici D, Pernilä P, Kallioniemi OP, Joensuu H, Hautaniemi S, Westermarck J.

Oncogene. 2012 Sep 27;31(39):4266-78. doi: 10.1038/onc.2011.599. Epub 2012 Jan 16.

PMID:
22249265
33.

Long-term prognosis of breast cancer detected by mammography screening or other methods.

Lehtimäki T, Lundin M, Linder N, Sihto H, Holli K, Turpeenniemi-Hujanen T, Kataja V, Isola J, Joensuu H, Lundin J.

Breast Cancer Res. 2011;13(6):R134. doi: 10.1186/bcr3080. Epub 2011 Dec 28.

34.

Breast cancer biological subtypes and protein expression predict for the preferential distant metastasis sites: a nationwide cohort study.

Sihto H, Lundin J, Lundin M, Lehtimäki T, Ristimäki A, Holli K, Sailas L, Kataja V, Turpeenniemi-Hujanen T, Isola J, Heikkilä P, Joensuu H.

Breast Cancer Res. 2011 Sep 13;13(5):R87. doi: 10.1186/bcr2944.

35.

An extensive tumor array analysis supports tumor suppressive role for nucleophosmin in breast cancer.

Karhemo PR, Rivinoja A, Lundin J, Hyvönen M, Chernenko A, Lammi J, Sihto H, Lundin M, Heikkilä P, Joensuu H, Bono P, Laakkonen P.

Am J Pathol. 2011 Aug;179(2):1004-14. doi: 10.1016/j.ajpath.2011.04.009. Epub 2011 Jun 2.

36.

Merkel cell polyomavirus infection, large T antigen, retinoblastoma protein and outcome in Merkel cell carcinoma.

Sihto H, Kukko H, Koljonen V, Sankila R, Böhling T, Joensuu H.

Clin Cancer Res. 2011 Jul 15;17(14):4806-13. doi: 10.1158/1078-0432.CCR-10-3363. Epub 2011 Jun 3.

37.

Development and evaluation of a virtual microscopy application for automated assessment of Ki-67 expression in breast cancer.

Konsti J, Lundin M, Joensuu H, Lehtimäki T, Sihto H, Holli K, Turpeenniemi-Hujanen T, Kataja V, Sailas L, Isola J, Lundin J.

BMC Clin Pathol. 2011 Jan 25;11:3. doi: 10.1186/1472-6890-11-3.

38.

Association of Merkel cell polyomavirus infection with tumor p53, KIT, stem cell factor, PDGFR-alpha and survival in Merkel cell carcinoma.

Waltari M, Sihto H, Kukko H, Koljonen V, Sankila R, Böhling T, Joensuu H.

Int J Cancer. 2011 Aug 1;129(3):619-28. doi: 10.1002/ijc.25720. Epub 2011 Jan 18.

39.

Expression of KIT receptor tyrosine kinase in endothelial cells of juvenile brain tumors.

Puputti M, Tynninen O, Pernilä P, Salmi M, Jalkanen S, Paetau A, Sihto H, Joensuu H.

Brain Pathol. 2010 Jul;20(4):763-70. doi: 10.1111/j.1750-3639.2009.00357.x. Epub 2009 Nov 30.

40.

Tumour microvessel endothelial cell KIT and stem cell factor expression in human solid tumours.

Sihto H, Tynninen O, Halonen M, Puputti M, Karjalainen-Lindsberg ML, Kukko H, Joensuu H.

Histopathology. 2009 Nov;55(5):544-53. doi: 10.1111/j.1365-2559.2009.03418.x.

PMID:
19912360
41.

Chronic lymphocytic leukaemia patients have a high risk of Merkel-cell polyomavirus DNA-positive Merkel-cell carcinoma.

Koljonen V, Kukko H, Pukkala E, Sankila R, Böhling T, Tukiainen E, Sihto H, Joensuu H.

Br J Cancer. 2009 Oct 20;101(8):1444-7. doi: 10.1038/sj.bjc.6605306. Epub 2009 Sep 15.

42.

Incidence of Merkel cell carcinoma in renal transplant recipients.

Koljonen V, Kukko H, Tukiainen E, Böhling T, Sankila R, Pukkala E, Sihto H, Joensuu H, Kyllönen L, Mäkisalo H.

Nephrol Dial Transplant. 2009 Oct;24(10):3231-5. doi: 10.1093/ndt/gfp334. Epub 2009 Jul 8.

PMID:
19586970
43.

Clinical factors associated with Merkel cell polyomavirus infection in Merkel cell carcinoma.

Sihto H, Kukko H, Koljonen V, Sankila R, Böhling T, Joensuu H.

J Natl Cancer Inst. 2009 Jul 1;101(13):938-45. doi: 10.1093/jnci/djp139. Epub 2009 Jun 17.

PMID:
19535775
44.

Molecular subtypes of breast cancers detected in mammography screening and outside of screening.

Sihto H, Lundin J, Lehtimäki T, Sarlomo-Rikala M, Bützow R, Holli K, Sailas L, Kataja V, Lundin M, Turpeenniemi-Hujanen T, Isola J, Heikkilä P, Joensuu H.

Clin Cancer Res. 2008 Jul 1;14(13):4103-10. doi: 10.1158/1078-0432.CCR-07-5003.

45.

VEGFR-3 expression is restricted to blood and lymphatic vessels in solid tumors.

Petrova TV, Bono P, Holnthoner W, Chesnes J, Pytowski B, Sihto H, Laakkonen P, Heikkilä P, Joensuu H, Alitalo K.

Cancer Cell. 2008 Jun;13(6):554-6. doi: 10.1016/j.ccr.2008.04.022. No abstract available.

46.

Endothelial cell KIT expression in human tumours.

Sihto H, Tynninen O, Bützow R, Saarialho-Kere U, Joensuu H.

J Pathol. 2007 Mar;211(4):481-8.

PMID:
17294421
47.

Amplification of KIT, PDGFRA, VEGFR2, and EGFR in gliomas.

Puputti M, Tynninen O, Sihto H, Blom T, Mäenpää H, Isola J, Paetau A, Joensuu H, Nupponen NN.

Mol Cancer Res. 2006 Dec;4(12):927-34.

48.

Platelet-derived growth factor receptor family mutations in gastrointestinal stromal tumours.

Sihto H, Franssila K, Tanner M, Vasama-Nolvi C, Sarlomo-Rikala M, Nupponen NN, Joensuu H, Isola J.

Scand J Gastroenterol. 2006 Jul;41(7):805-11.

PMID:
16785193
49.

Gastrointestinal stromal tumors with KIT exon 11 deletions are associated with poor prognosis.

Andersson J, Bümming P, Meis-Kindblom JM, Sihto H, Nupponen N, Joensuu H, Odén A, Gustavsson B, Kindblom LG, Nilsson B.

Gastroenterology. 2006 May;130(6):1573-81.

PMID:
16697720
50.

Allelic imbalance of HER2 variant in sporadic breast and ovarian cancer.

Puputti M, Sihto H, Isola J, Butzow R, Joensuu H, Nupponen NN.

Cancer Genet Cytogenet. 2006 May;167(1):32-8.

PMID:
16682283

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