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Items: 1 to 50 of 116

1.

Current carried by the Slc26 family member prestin does not flow through the transporter pathway.

Bai JP, Moeini-Naghani I, Zhong S, Li FY, Bian S, Sigworth FJ, Santos-Sacchi J, Navaratnam D.

Sci Rep. 2017 Apr 19;7:46619. doi: 10.1038/srep46619.

2.

Statistical modeling and removal of lipid membrane projections for cryo-EM structure determination of reconstituted membrane proteins.

Jensen KH, Brandt SS, Shigematsu H, Sigworth FJ.

J Struct Biol. 2016 Apr;194(1):49-60. doi: 10.1016/j.jsb.2016.01.012. Epub 2016 Feb 1.

3.

Principles of cryo-EM single-particle image processing.

Sigworth FJ.

Microscopy (Oxf). 2016 Feb;65(1):57-67. doi: 10.1093/jmicro/dfv370. Epub 2015 Dec 24. Review.

4.

Removal of Vesicle Structures From Transmission Electron Microscope Images.

Jensen KH, Sigworth FJ, Brandt SS.

IEEE Trans Image Process. 2016 Feb;25(2):540-52. doi: 10.1109/TIP.2015.2504901. Epub 2015 Dec 3.

5.

Cryo-EM: Spinning the Micelles Away.

Singh SK, Sigworth FJ.

Structure. 2015 Sep 1;23(9):1561. doi: 10.1016/j.str.2015.08.001.

6.

Directly reconstructing principal components of heterogeneous particles from cryo-EM images.

Tagare HD, Kucukelbir A, Sigworth FJ, Wang H, Rao M.

J Struct Biol. 2015 Aug;191(2):245-62. doi: 10.1016/j.jsb.2015.05.007. Epub 2015 Jun 4.

7.

SubspaceEM: A fast maximum-a-posteriori algorithm for cryo-EM single particle reconstruction.

Dvornek NC, Sigworth FJ, Tagare HD.

J Struct Biol. 2015 May;190(2):200-14. doi: 10.1016/j.jsb.2015.03.009. Epub 2015 Mar 31.

8.

Automatic cryo-EM particle selection for membrane proteins in spherical liposomes.

Liu Y, Sigworth FJ.

J Struct Biol. 2014 Mar;185(3):295-302. doi: 10.1016/j.jsb.2014.01.004. Epub 2014 Jan 24.

9.

Quantifying the local resolution of cryo-EM density maps.

Kucukelbir A, Sigworth FJ, Tagare HD.

Nat Methods. 2014 Jan;11(1):63-5. doi: 10.1038/nmeth.2727. Epub 2013 Nov 10.

10.

Noise analysis and performance comparison of low current measurement systems for biomedical applications.

Dongsoo Kim, Goldstein B, Wei Tang, Sigworth FJ, Culurciello E.

IEEE Trans Biomed Circuits Syst. 2013 Feb;7(1):52-62. doi: 10.1109/TBCAS.2012.2192273.

PMID:
23853279
11.

Noise models and cryo-EM drift correction with a direct-electron camera.

Shigematsu H, Sigworth FJ.

Ultramicroscopy. 2013 Aug;131:61-9. doi: 10.1016/j.ultramic.2013.04.001. Epub 2013 Apr 18.

12.

State-dependent FRET reports calcium- and voltage-dependent gating-ring motions in BK channels.

Miranda P, Contreras JE, Plested AJ, Sigworth FJ, Holmgren M, Giraldez T.

Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5217-22. doi: 10.1073/pnas.1219611110. Epub 2013 Mar 11.

13.

Expression, purification and functional reconstitution of slack sodium-activated potassium channels.

Yan Y, Yang Y, Bian S, Sigworth FJ.

J Membr Biol. 2012 Nov;245(11):667-74. doi: 10.1007/s00232-012-9425-7. Epub 2012 Jun 23.

14.

Hydration-layer models for cryo-EM image simulation.

Shang Z, Sigworth FJ.

J Struct Biol. 2012 Oct;180(1):10-6. doi: 10.1016/j.jsb.2012.04.021. Epub 2012 May 17.

15.

A Bayesian adaptive basis algorithm for single particle reconstruction.

Kucukelbir A, Sigworth FJ, Tagare HD.

J Struct Biol. 2012 Jul;179(1):56-67. doi: 10.1016/j.jsb.2012.04.012. Epub 2012 May 1.

16.

Interactions between β-catenin and the HSlo potassium channel regulates HSlo surface expression.

Bian S, Bai JP, Chapin H, Le Moellic C, Dong H, Caplan M, Sigworth FJ, Navaratnam DS.

PLoS One. 2011;6(12):e28264. doi: 10.1371/journal.pone.0028264. Epub 2011 Dec 14.

17.

A novel conotoxin, qc16a, with a unique cysteine framework and folding.

Ye M, Hong J, Zhou M, Huang L, Shao X, Yang Y, Sigworth FJ, Chi C, Lin D, Wang C.

Peptides. 2011 Jun;32(6):1159-65. doi: 10.1016/j.peptides.2011.04.008. Epub 2011 Apr 15.

18.

Surface-Constrained 3D Reconstruction in Cryo-EM.

Barthel AC, Tagare H, Sigworth FJ.

Conf Rec Asilomar Conf Signals Syst Comput. 2011:1026-1030.

19.

Improved hidden Markov models for molecular motors, part 2: extensions and application to experimental data.

Syed S, Müllner FE, Selvin PR, Sigworth FJ.

Biophys J. 2010 Dec 1;99(11):3696-703. doi: 10.1016/j.bpj.2010.09.066.

20.

Improved hidden Markov models for molecular motors, part 1: basic theory.

Müllner FE, Syed S, Selvin PR, Sigworth FJ.

Biophys J. 2010 Dec 1;99(11):3684-95. doi: 10.1016/j.bpj.2010.09.067.

21.

An introduction to maximum-likelihood methods in cryo-EM.

Sigworth FJ, Doerschuk PC, Carazo JM, Scheres SH.

Methods Enzymol. 2010;482:263-94. doi: 10.1016/S0076-6879(10)82011-7.

22.

Liposomes on a streptavidin crystal: a system to study membrane proteins by cryo-EM.

Wang L, Sigworth FJ.

Methods Enzymol. 2010;481:147-64. doi: 10.1016/S0076-6879(10)81007-9.

23.

Patch-clamp amplifiers on a chip.

Weerakoon P, Culurciello E, Yang Y, Santos-Sacchi J, Kindlmann PJ, Sigworth FJ.

J Neurosci Methods. 2010 Oct 15;192(2):187-92. doi: 10.1016/j.jneumeth.2010.06.030. Epub 2010 Jul 15.

24.

An adaptive Expectation-Maximization algorithm with GPU implementation for electron cryomicroscopy.

Tagare HD, Barthel A, Sigworth FJ.

J Struct Biol. 2010 Sep;171(3):256-65. doi: 10.1016/j.jsb.2010.06.004. Epub 2010 Jun 9.

25.

Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack.

Brown MR, Kronengold J, Gazula VR, Chen Y, Strumbos JG, Sigworth FJ, Navaratnam D, Kaczmarek LK.

Nat Neurosci. 2010 Jul;13(7):819-21. doi: 10.1038/nn.2563. Epub 2010 May 30.

26.

Cloning and identification of tissue-specific expression of KCNN4 splice variants in rat colon.

Barmeyer C, Rahner C, Yang Y, Sigworth FJ, Binder HJ, Rajendran VM.

Am J Physiol Cell Physiol. 2010 Aug;299(2):C251-63. doi: 10.1152/ajpcell.00091.2009. Epub 2010 May 5.

27.

Reference Free Structure Determination through Eigenvectors of Center of Mass Operators.

Coifman RR, Shkolnisky Y, Sigworth FJ, Singer A.

Appl Comput Harmon Anal. 2010 May;28(3):296-312.

28.

Synthetic protocells to mimic and test cell function.

Xu J, Sigworth FJ, LaVan DA.

Adv Mater. 2010 Jan 5;22(1):120-7. doi: 10.1002/adma.200901945.

29.

Detecting consistent common lines in cryo-EM by voting.

Singer A, Coifman RR, Sigworth FJ, Chester DW, Shkolnisky Y.

J Struct Biol. 2010 Mar;169(3):312-22. doi: 10.1016/j.jsb.2009.11.003. Epub 2009 Nov 17.

30.

Structure of the BK potassium channel in a lipid membrane from electron cryomicroscopy.

Wang L, Sigworth FJ.

Nature. 2009 Sep 10;461(7261):292-5. doi: 10.1038/nature08291. Epub 2009 Aug 30.

31.

The N-terminal domain of Slack determines the formation and trafficking of Slick/Slack heteromeric sodium-activated potassium channels.

Chen H, Kronengold J, Yan Y, Gazula VR, Brown MR, Ma L, Ferreira G, Yang Y, Bhattacharjee A, Sigworth FJ, Salkoff L, Kaczmarek LK.

J Neurosci. 2009 Apr 29;29(17):5654-65. doi: 10.1523/JNEUROSCI.5978-08.2009.

32.

An integrated patch-clamp potentiostat with electrode compensation.

Weerakoon P, Culurciello E, Klemic KG, Sigworth FJ.

IEEE Trans Biomed Circuits Syst. 2009 Apr;3(2):117-25. doi: 10.1109/TBCAS.2008.2005419.

PMID:
23853203
33.

Graph Laplacian tomography from unknown random projections.

Coifman RR, Shkolnisky Y, Sigworth FJ, Singer A.

IEEE Trans Image Process. 2008 Oct;17(10):1891-9. doi: 10.1109/TIP.2008.2002305.

PMID:
18784036
34.

Streptavidin crystals as nanostructured supports and image-calibration references for cryo-EM data collection.

Wang L, Ounjai P, Sigworth FJ.

J Struct Biol. 2008 Nov;164(2):190-8. doi: 10.1016/j.jsb.2008.07.008. Epub 2008 Aug 5.

35.

Importance of the Debye screening length on nanowire field effect transistor sensors.

Stern E, Wagner R, Sigworth FJ, Breaker R, Fahmy TM, Reed MA.

Nano Lett. 2007 Nov;7(11):3405-9. Epub 2007 Oct 3.

36.

The last few frames of the voltage-gating movie.

Sigworth FJ.

Biophys J. 2007 Nov 1;93(9):2981-3. Epub 2007 Aug 17. Review. No abstract available.

37.
38.

Holey carbon micro-arrays for transmission electron microscopy: a microcontact printing approach.

Chester DW, Klemic JF, Stern E, Sigworth FJ, Klemic KG.

Ultramicroscopy. 2007 Aug;107(8):685-91. Epub 2007 Jan 30.

PMID:
17331648
39.

From cryo-EM, multiple protein structures in one shot.

Sigworth FJ.

Nat Methods. 2007 Jan;4(1):20-1. No abstract available.

PMID:
17195021
40.

Software tools for macromolecular microscopy.

Carragher B, Potter CS, Sigworth FJ.

J Struct Biol. 2007 Jan;157(1):1-2. Epub 2006 Nov 7. No abstract available.

PMID:
17169744
41.

Using cryo-EM to measure the dipole potential of a lipid membrane.

Wang L, Bose PS, Sigworth FJ.

Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18528-33. Epub 2006 Nov 20.

42.

Pharmacological activation and inhibition of Slack (Slo2.2) channels.

Yang B, Gribkoff VK, Pan J, Damagnez V, Dworetzky SI, Boissard CG, Bhattacharjee A, Yan Y, Sigworth FJ, Kaczmarek LK.

Neuropharmacology. 2006 Sep;51(4):896-906. Epub 2006 Jul 28.

PMID:
16876206
43.

Microfluidic system for planar patch clamp electrode arrays.

Li X, Klemic KG, Reed MA, Sigworth FJ.

Nano Lett. 2006 Apr;6(4):815-9.

PMID:
16608289
44.

Cryo-EM and single particles.

Wang L, Sigworth FJ.

Physiology (Bethesda). 2006 Feb;21:13-8. Review.

45.

Gating of acid-sensitive ion channel-1: release of Ca2+ block vs. allosteric mechanism.

Zhang P, Sigworth FJ, Canessa CM.

J Gen Physiol. 2006 Feb;127(2):109-17. Epub 2006 Jan 17.

46.

Generation of functional fluorescent BK channels by random insertion of GFP variants.

Giraldez T, Hughes TE, Sigworth FJ.

J Gen Physiol. 2005 Nov;126(5):429-38.

47.

Microchip technology in ion-channel research.

Sigworth FJ, Klemic KG.

IEEE Trans Nanobioscience. 2005 Mar;4(1):121-7. Review.

PMID:
15816178
48.

An air-molding technique for fabricating PDMS planar patch-clamp electrodes.

Klemic KG, Klemic JF, Sigworth FJ.

Pflugers Arch. 2005 Mar;449(6):564-72. Epub 2004 Dec 1.

PMID:
15578213
49.

Can Shaker potassium channels be locked in the deactivated state?

Yang Y, Yan Y, Sigworth FJ.

J Gen Physiol. 2004 Aug;124(2):163-71.

50.

Classical detection theory and the cryo-EM particle selection problem.

Sigworth FJ.

J Struct Biol. 2004 Jan-Feb;145(1-2):111-22.

PMID:
15065679

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