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Prospective isolation of radiation induced erythroid stress progenitors reveals unique transcriptomic and epigenetic signatures enabling increased erythroid output.

Singbrant S, Mattebo A, Sigvardsson M, Strid T, Flygare J.

Haematologica. 2020 Jan 9. pii: haematol.2019.234542. doi: 10.3324/haematol.2019.234542. [Epub ahead of print]


Lin28b controls a neonatal to adult switch in B cell positive selection.

Vanhee S, Åkerstrand H, Kristiansen TA, Datta S, Montano G, Vergani S, Lang S, Ungerbäck J, Doyle A, Olsson K, Beneventi G, Jensen CT, Bellodi C, Soneji S, Sigvardsson M, Gyllenbäck EJ, Yuan J.

Sci Immunol. 2019 Sep 27;4(39). pii: eaax4453. doi: 10.1126/sciimmunol.aax4453.


PAX5 is part of a functional transcription factor network targeted in lymphoid leukemia.

Okuyama K, Strid T, Kuruvilla J, Somasundaram R, Cristobal S, Smith E, Prasad M, Fioretos T, Lilljebjörn H, Soneji S, Lang S, Ungerbäck J, Sigvardsson M.

PLoS Genet. 2019 Aug 5;15(8):e1008280. doi: 10.1371/journal.pgen.1008280. eCollection 2019 Aug.


Progression of progenitor B cell leukemia is associated with alterations of the bone marrow micro-environment.

Ahsberg J, Xiao P, Okuyama K, Somasundaram R, Strid T, Qian H, Sigvardsson M.

Haematologica. 2019 Jul 11. pii: haematol.2018.214031. doi: 10.3324/haematol.2018.214031. [Epub ahead of print]


Cutting Edge: Lymphomyeloid-Primed Progenitor Cell Fates Are Controlled by the Transcription Factor Tal1.

de Pooter RF, Dias S, Chowdhury M, Bartom ET, Okoreeh MK, Sigvardsson M, Kee BL.

J Immunol. 2019 May 15;202(10):2837-2842. doi: 10.4049/jimmunol.1801220. Epub 2019 Apr 8.


Pioneering, chromatin remodeling, and epigenetic constraint in early T-cell gene regulation by SPI1 (PU.1).

Ungerbäck J, Hosokawa H, Wang X, Strid T, Williams BA, Sigvardsson M, Rothenberg EV.

Genome Res. 2018 Oct;28(10):1508-1519. doi: 10.1101/gr.231423.117. Epub 2018 Aug 31.


Molecular Regulation of Differentiation in Early B-Lymphocyte Development.

Sigvardsson M.

Int J Mol Sci. 2018 Jun 30;19(7). pii: E1928. doi: 10.3390/ijms19071928. Review.


Distinct roles of mesenchymal stem and progenitor cells during the development of acute myeloid leukemia in mice.

Xiao P, Sandhow L, Heshmati Y, Kondo M, Bouderlique T, Dolinska M, Johansson AS, Sigvardsson M, Ekblom M, Walfridsson J, Qian H.

Blood Adv. 2018 Jun 26;2(12):1480-1494. doi: 10.1182/bloodadvances.2017013870.


Zinc Finger Protein 521 Regulates Early Hematopoiesis through Cell-Extrinsic Mechanisms in the Bone Marrow Microenvironment.

Fleenor CJ, Arends T, Lei H, Åhsberg J, Okuyama K, Kuruvilla J, Cristobal S, Rabe JL, Pandey A, Danhorn T, Straign D, Espinosa JM, Warming S, Pietras EM, Sigvardsson M, Hagman JR.

Mol Cell Biol. 2018 Aug 15;38(17). pii: e00603-17. doi: 10.1128/MCB.00603-17. Print 2018 Sep 1.


Dissection of progenitor compartments resolves developmental trajectories in B-lymphopoiesis.

Jensen CT, Åhsberg J, Sommarin MNE, Strid T, Somasundaram R, Okuyama K, Ungerbäck J, Kupari J, Airaksinen MS, Lang S, Bryder D, Soneji S, Karlsson G, Sigvardsson M.

J Exp Med. 2018 Jul 2;215(7):1947-1963. doi: 10.1084/jem.20171384. Epub 2018 Jun 13.


Transcription factor ID2 prevents E proteins from enforcing a naïve T lymphocyte gene program during NK cell development.

Zook EC, Li ZY, Xu Y, de Pooter RF, Verykokakis M, Beaulieu A, Lasorella A, Maienschein-Cline M, Sun JC, Sigvardsson M, Kee BL.

Sci Immunol. 2018 Apr 27;3(22). pii: eaao2139. doi: 10.1126/sciimmunol.aao2139.


Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells.

Guzzi N, Cieśla M, Ngoc PCT, Lang S, Arora S, Dimitriou M, Pimková K, Sommarin MNE, Munita R, Lubas M, Lim Y, Okuyama K, Soneji S, Karlsson G, Hansson J, Jönsson G, Lund AH, Sigvardsson M, Hellström-Lindberg E, Hsieh AC, Bellodi C.

Cell. 2018 May 17;173(5):1204-1216.e26. doi: 10.1016/j.cell.2018.03.008. Epub 2018 Apr 5.


Sipa1 deficiency-induced bone marrow niche alterations lead to the initiation of myeloproliferative neoplasm.

Xiao P, Dolinska M, Sandhow L, Kondo M, Johansson AS, Bouderlique T, Zhao Y, Li X, Dimitriou M, Rassidakis GZ, Hellström-Lindberg E, Minato N, Walfridsson J, Scadden DT, Sigvardsson M, Qian H.

Blood Adv. 2018 Mar 13;2(5):534-548. doi: 10.1182/bloodadvances.2017013599.


Regulatory T cells characterized by low Id3 expression are highly suppressive and accumulate during chronic infection.

Rauch KS, Hils M, Menner AJ, Sigvardsson M, Minguet S, Aichele P, Schachtrup C, Schachtrup K.

Oncotarget. 2017 Oct 27;8(61):102835-102851. doi: 10.18632/oncotarget.22159. eCollection 2017 Nov 28.


Don't judge a cell by its cover: heterogeneity within early lymphoid progenitors.

Karlsson G, Sigvardsson M, Böiers C.

EMBO J. 2017 Dec 15;36(24):3552-3554. doi: 10.15252/embj.201798443. Epub 2017 Nov 30. No abstract available.


Correction: Early onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT.

Keller B, Zaidman I, Yousefi OS, Hershkovitz D, Stein J, Unger S, Schachtrup K, Sigvardsson M, Kuperman AA, Shaag A, Schamel WW, Elpeleg O, Warnatz K, Stepensky P.

J Exp Med. 2017 Jul 3;214(7):2165. doi: 10.1084/jem.2015111005242017c. Epub 2017 Jun 1. No abstract available.


EZH2 Regulates the Developmental Timing of Effectors of the Pre-Antigen Receptor Checkpoints.

Jacobsen JA, Woodard J, Mandal M, Clark MR, Bartom ET, Sigvardsson M, Kee BL.

J Immunol. 2017 Jun 15;198(12):4682-4691. doi: 10.4049/jimmunol.1700319. Epub 2017 May 10.


Cellular plasticity in B-cell leukemia.

Somasundaram R, Strid T, Sigvardsson M.

Cell Cycle. 2017 Mar 19;16(6):495-496. doi: 10.1080/15384101.2017.1285635. Epub 2017 Jan 24. No abstract available.


Id3 Maintains Foxp3 Expression in Regulatory T Cells by Controlling a Transcriptional Network of E47, Spi-B, and SOCS3.

Rauch KS, Hils M, Lupar E, Minguet S, Sigvardsson M, Rottenberg ME, Izcue A, Schachtrup C, Schachtrup K.

Cell Rep. 2016 Dec 13;17(11):2827-2836. doi: 10.1016/j.celrep.2016.11.045.


Clonal conversion of B lymphoid leukemia reveals cross-lineage transfer of malignant states.

Somasundaram R, Åhsberg J, Okuyama K, Ungerbäck J, Lilljebjörn H, Fioretos T, Strid T, Sigvardsson M.

Genes Dev. 2016 Nov 15;30(22):2486-2499. Epub 2016 Dec 2.


Superenhancer reprogramming drives a B-cell-epithelial transition and high-risk leukemia.

Hu Y, Zhang Z, Kashiwagi M, Yoshida T, Joshi I, Jena N, Somasundaram R, Emmanuel AO, Sigvardsson M, Fitamant J, El-Bardeesy N, Gounari F, Van Etten RA, Georgopoulos K.

Genes Dev. 2016 Sep 1;30(17):1971-90. doi: 10.1101/gad.283762.116.


Identification of Stage-Specific Surface Markers in Early B Cell Development Provides Novel Tools for Identification of Progenitor Populations.

Jensen CT, Lang S, Somasundaram R, Soneji S, Sigvardsson M.

J Immunol. 2016 Sep 1;197(5):1937-44. doi: 10.4049/jimmunol.1600297. Epub 2016 Jul 25.


Type 1 Diabetes Mellitus Donor Mesenchymal Stromal Cells Exhibit Comparable Potency to Healthy Controls In Vitro.

Davies LC, Alm JJ, Heldring N, Moll G, Gavin C, Batsis I, Qian H, Sigvardsson M, Nilsson B, Kyllonen LE, Salmela KT, Carlsson PO, Korsgren O, Le Blanc K.

Stem Cells Transl Med. 2016 Nov;5(11):1485-1495. doi: 10.5966/sctm.2015-0272. Epub 2016 Jul 13.


Early onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT.

Keller B, Zaidman I, Yousefi OS, Hershkovitz D, Stein J, Unger S, Schachtrup K, Sigvardsson M, Kuperman AA, Shaag A, Schamel WW, Elpeleg O, Warnatz K, Stepensky P.

J Exp Med. 2016 Jun 27;213(7):1185-99. doi: 10.1084/jem.20151110. Epub 2016 May 30. Erratum in: J Exp Med. 2017 Jun 1;:.


The ETS1 transcription factor is required for the development and cytokine-induced expansion of ILC2.

Zook EC, Ramirez K, Guo X, van der Voort G, Sigvardsson M, Svensson EC, Fu YX, Kee BL.

J Exp Med. 2016 May 2;213(5):687-96. doi: 10.1084/jem.20150851. Epub 2016 Apr 11.


Exploring the multifaceted nature of the common lymphoid progenitor compartment.

Jensen CT, Strid T, Sigvardsson M.

Curr Opin Immunol. 2016 Apr;39:121-6. doi: 10.1016/j.coi.2016.01.009. Epub 2016 Feb 9. Review.


A novel Lin-CD34+CD38- integrin α2- bipotential megakaryocyte-erythrocyte progenitor population in the human bone marrow.

Wong WM, Dolinska M, Sigvardsson M, Ekblom M, Qian H.

Leukemia. 2016 Jun;30(6):1399-402. doi: 10.1038/leu.2015.300. Epub 2015 Oct 26. No abstract available.


Wipping p53 into subservience in B-cell development.

Sigvardsson M.

Blood. 2015 Jul 30;126(5):566-7. doi: 10.1182/blood-2015-06-649475. No abstract available.


Combined heterozygous loss of Ebf1 and Pax5 allows for T-lineage conversion of B cell progenitors.

Ungerbäck J, Åhsberg J, Strid T, Somasundaram R, Sigvardsson M.

J Exp Med. 2015 Jun 29;212(7):1109-23. doi: 10.1084/jem.20132100. Epub 2015 Jun 8.


Transcription factor networks in B-cell differentiation link development to acute lymphoid leukemia.

Somasundaram R, Prasad MA, Ungerbäck J, Sigvardsson M.

Blood. 2015 Jul 9;126(2):144-52. doi: 10.1182/blood-2014-12-575688. Epub 2015 May 19. Review.


Ebf1 heterozygosity results in increased DNA damage in pro-B cells and their synergistic transformation by Pax5 haploinsufficiency.

Prasad MA, Ungerbäck J, Åhsberg J, Somasundaram R, Strid T, Larsson M, Månsson R, De Paepe A, Lilljebjörn H, Fioretos T, Hagman J, Sigvardsson M.

Blood. 2015 Jun 25;125(26):4052-9. doi: 10.1182/blood-2014-12-617282. Epub 2015 Apr 2.


Splenic B cells from Hymenolepis diminuta-infected mice ameliorate colitis independent of T cells and via cooperation with macrophages.

Reyes JL, Wang A, Fernando MR, Graepel R, Leung G, van Rooijen N, Sigvardsson M, McKay DM.

J Immunol. 2015 Jan 1;194(1):364-78. doi: 10.4049/jimmunol.1400738. Epub 2014 Dec 1.


Essential functions for ID proteins at multiple checkpoints in invariant NKT cell development.

Verykokakis M, Krishnamoorthy V, Iavarone A, Lasorella A, Sigvardsson M, Kee BL.

J Immunol. 2013 Dec 15;191(12):5973-83. doi: 10.4049/jimmunol.1301521. Epub 2013 Nov 15.


Early B-cell factor 1 regulates the expansion of B-cell progenitors in a dose-dependent manner.

Åhsberg J, Ungerbäck J, Strid T, Welinder E, Stjernberg J, Larsson M, Qian H, Sigvardsson M.

J Biol Chem. 2013 Nov 15;288(46):33449-61. doi: 10.1074/jbc.M113.506261. Epub 2013 Sep 27.


An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state.

Wahlestedt M, Norddahl GL, Sten G, Ugale A, Frisk MA, Mattsson R, Deierborg T, Sigvardsson M, Bryder D.

Blood. 2013 May 23;121(21):4257-64. doi: 10.1182/blood-2012-11-469080. Epub 2013 Mar 8.


E2A transcription factors limit expression of Gata3 to facilitate T lymphocyte lineage commitment.

Xu W, Carr T, Ramirez K, McGregor S, Sigvardsson M, Kee BL.

Blood. 2013 Feb 28;121(9):1534-42. doi: 10.1182/blood-2012-08-449447. Epub 2013 Jan 7.


Positive intergenic feedback circuitry, involving EBF1 and FOXO1, orchestrates B-cell fate.

Mansson R, Welinder E, Åhsberg J, Lin YC, Benner C, Glass CK, Lucas JS, Sigvardsson M, Murre C.

Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):21028-33. doi: 10.1073/pnas.1211427109. Epub 2012 Dec 4.


Molecular characterization of prospectively isolated multipotent mesenchymal progenitors provides new insight into the cellular identity of mesenchymal stem cells in mouse bone marrow.

Qian H, Badaloni A, Chiara F, Stjernberg J, Polisetti N, Nihlberg K, Consalez GG, Sigvardsson M.

Mol Cell Biol. 2013 Feb;33(4):661-77. doi: 10.1128/MCB.01287-12. Epub 2012 Nov 26.


Expression of integrin α2 receptor in human cord blood CD34+CD38-CD90+ stem cells engrafting long-term in NOD/SCID-IL2Rγ(c) null mice.

Wong WM, Sigvardsson M, Åstrand-Grundström I, Hogge D, Larsson J, Qian H, Ekblom M.

Stem Cells. 2013 Feb;31(2):360-71. doi: 10.1002/stem.1282.


Transcription factor dose links development to disease.

Sigvardsson M.

Blood. 2012 Nov 1;120(18):3630-1. doi: 10.1182/blood-2012-09-455113. No abstract available.


Single-cell analysis of early B-lymphocyte development suggests independent regulation of lineage specification and commitment in vivo.

Zandi S, Ahsberg J, Tsapogas P, Stjernberg J, Qian H, Sigvardsson M.

Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15871-6. Epub 2012 Sep 10.


Lipopolysaccharide-induced fever depends on prostaglandin E2 production specifically in brain endothelial cells.

Engström L, Ruud J, Eskilsson A, Larsson A, Mackerlova L, Kugelberg U, Qian H, Vasilache AM, Larsson P, Engblom D, Sigvardsson M, Jönsson JI, Blomqvist A.

Endocrinology. 2012 Oct;153(10):4849-61. Epub 2012 Aug 7.


Reduced repression of cytokine signaling ameliorates age-induced decline in hematopoietic stem cell function.

Norddahl GL, Wahlestedt M, Gisler S, Sigvardsson M, Bryder D.

Aging Cell. 2012 Dec;11(6):1128-31. doi: 10.1111/j.1474-9726.2012.00863.x. Epub 2012 Aug 27.


p38 Mitogen-activated protein kinase/signal transducer and activator of transcription-3 pathway signaling regulates expression of inhibitory molecules in T cells activated by HIV-1-exposed dendritic cells.

Che KF, Shankar EM, Muthu S, Zandi S, Sigvardsson M, Hinkula J, Messmer D, Larsson M.

Mol Med. 2012 Oct 24;18:1169-82. doi: 10.2119/molmed.2012.00103.


Primary mesenchymal stem and progenitor cells from bone marrow lack expression of CD44 protein.

Qian H, Le Blanc K, Sigvardsson M.

J Biol Chem. 2012 Jul 27;287(31):25795-807. doi: 10.1074/jbc.M112.339622. Epub 2012 May 31.


Gene deregulation and chronic activation in natural killer cells deficient in the transcription factor ETS1.

Ramirez K, Chandler KJ, Spaulding C, Zandi S, Sigvardsson M, Graves BJ, Kee BL.

Immunity. 2012 Jun 29;36(6):921-32. doi: 10.1016/j.immuni.2012.04.006. Epub 2012 May 17.


The transcription factors E2A and HEB act in concert to induce the expression of FOXO1 in the common lymphoid progenitor.

Welinder E, Mansson R, Mercer EM, Bryder D, Sigvardsson M, Murre C.

Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17402-7. doi: 10.1073/pnas.1111766108. Epub 2011 Oct 4.


B-lymphocyte commitment: identifying the point of no return.

Welinder E, Ahsberg J, Sigvardsson M.

Semin Immunol. 2011 Oct;23(5):335-40. doi: 10.1016/j.smim.2011.08.005. Epub 2011 Sep 23. Review.


Multilineage priming of enhancer repertoires precedes commitment to the B and myeloid cell lineages in hematopoietic progenitors.

Mercer EM, Lin YC, Benner C, Jhunjhunwala S, Dutkowski J, Flores M, Sigvardsson M, Ideker T, Glass CK, Murre C.

Immunity. 2011 Sep 23;35(3):413-25. doi: 10.1016/j.immuni.2011.06.013. Epub 2011 Sep 8.


IL-7 mediates Ebf-1-dependent lineage restriction in early lymphoid progenitors.

Tsapogas P, Zandi S, Åhsberg J, Zetterblad J, Welinder E, Jönsson JI, Månsson R, Qian H, Sigvardsson M.

Blood. 2011 Aug 4;118(5):1283-90. doi: 10.1182/blood-2011-01-332189. Epub 2011 Jun 7.


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