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Items: 1 to 50 of 116

1.

Network-Specific Synchronization of Electrical Slow-Wave Oscillations Regulates Sleep Drive in Drosophila.

Raccuglia D, Huang S, Ender A, Heim MM, Laber D, Suárez-Grimalt R, Liotta A, Sigrist SJ, Geiger JRP, Owald D.

Curr Biol. 2019 Nov 4;29(21):3611-3621.e3. doi: 10.1016/j.cub.2019.08.070. Epub 2019 Oct 17.

2.

RIM-BP2 primes synaptic vesicles via recruitment of Munc13-1 at hippocampal mossy fiber synapses.

Brockmann MM, Maglione M, Willmes CG, Stumpf A, Bouazza BA, Velasquez LM, Grauel MK, Beed P, Lehmann M, Gimber N, Schmoranzer J, Sigrist SJ, Rosenmund C, Schmitz D.

Elife. 2019 Sep 19;8. pii: e43243. doi: 10.7554/eLife.43243.

3.

Maintenance of cell type-specific connectivity and circuit function requires Tao kinase.

Tenedini FM, Sáez González M, Hu C, Pedersen LH, Petruzzi MM, Spitzweck B, Wang D, Richter M, Petersen M, Szpotowicz E, Schweizer M, Sigrist SJ, Calderon de Anda F, Soba P.

Nat Commun. 2019 Aug 5;10(1):3506. doi: 10.1038/s41467-019-11408-1.

4.

4,4'Dimethoxychalcone: a natural flavonoid that promotes health through autophagy-dependent and -independent effects.

Zimmermann A, Kainz K, Hofer SJ, Bauer MA, Schroeder S, Dengjel J, Pietrocola F, Kepp O, Ruckenstuhl C, Eisenberg T, Sigrist SJ, Madeo F, Carmona-Gutierrez D, Kroemer G.

Autophagy. 2019 Sep;15(9):1662-1664. doi: 10.1080/15548627.2019.1632623. Epub 2019 Jun 28.

5.

Targeting GATA transcription factors - a novel strategy for anti-aging interventions?

Zimmermann A, Kainz K, Hofer SJ, Bauer MA, Schroeder S, Dengjel J, Pietrocola F, Kepp O, Ruckenstuhl C, Eisenberg T, Sigrist SJ, Madeo F, Kroemer G, Carmona-Gutierrez D.

Microb Cell. 2019 May 6;6(5):212-216. doi: 10.15698/mic2019.05.676.

6.

Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline (SmartAge)-study protocol for a randomized controlled trial.

Wirth M, Schwarz C, Benson G, Horn N, Buchert R, Lange C, Köbe T, Hetzer S, Maglione M, Michael E, Märschenz S, Mai K, Kopp U, Schmitz D, Grittner U, Sigrist SJ, Stekovic S, Madeo F, Flöel A.

Alzheimers Res Ther. 2019 May 1;11(1):36. doi: 10.1186/s13195-019-0484-1.

7.

Homeostatic scaling of active zone scaffolds maintains global synaptic strength.

Goel P, Dufour Bergeron D, Böhme MA, Nunnelly L, Lehmann M, Buser C, Walter AM, Sigrist SJ, Dickman D.

J Cell Biol. 2019 May 6;218(5):1706-1724. doi: 10.1083/jcb.201807165. Epub 2019 Mar 26.

8.

Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner.

Bhukel A, Beuschel CB, Maglione M, Lehmann M, Juhász G, Madeo F, Sigrist SJ.

Nat Commun. 2019 Mar 21;10(1):1318. doi: 10.1038/s41467-019-09262-2.

9.

Rapid active zone remodeling consolidates presynaptic potentiation.

Böhme MA, McCarthy AW, Grasskamp AT, Beuschel CB, Goel P, Jusyte M, Laber D, Huang S, Rey U, Petzoldt AG, Lehmann M, Göttfert F, Haghighi P, Hell SW, Owald D, Dickman D, Sigrist SJ, Walter AM.

Nat Commun. 2019 Mar 6;10(1):1085. doi: 10.1038/s41467-019-08977-6.

10.

The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species.

Carmona-Gutierrez D, Zimmermann A, Kainz K, Pietrocola F, Chen G, Maglioni S, Schiavi A, Nah J, Mertel S, Beuschel CB, Castoldi F, Sica V, Trausinger G, Raml R, Sommer C, Schroeder S, Hofer SJ, Bauer MA, Pendl T, Tadic J, Dammbrueck C, Hu Z, Ruckenstuhl C, Eisenberg T, Durand S, Bossut N, Aprahamian F, Abdellatif M, Sedej S, Enot DP, Wolinski H, Dengjel J, Kepp O, Magnes C, Sinner F, Pieber TR, Sadoshima J, Ventura N, Sigrist SJ, Kroemer G, Madeo F.

Nat Commun. 2019 Feb 19;10(1):651. doi: 10.1038/s41467-019-08555-w.

11.

Conserved regulation of neurodevelopmental processes and behavior by FoxP in Drosophila.

Castells-Nobau A, Eidhof I, Fenckova M, Brenman-Suttner DB, Scheffer-de Gooyert JM, Christine S, Schellevis RL, van der Laan K, Quentin C, van Ninhuijs L, Hofmann F, Ejsmont R, Fisher SE, Kramer JM, Sigrist SJ, Simon AF, Schenck A.

PLoS One. 2019 Feb 12;14(2):e0211652. doi: 10.1371/journal.pone.0211652. eCollection 2019.

12.

Phosphorylation of the Bruchpilot N-terminus in Drosophila unlocks axonal transport of active zone building blocks.

Driller JH, Lützkendorf J, Depner H, Siebert M, Kuropka B, Weise C, Piao C, Petzoldt AG, Lehmann M, Stelzl U, Zahedi R, Sickmann A, Freund C, Sigrist SJ, Wahl MC.

J Cell Sci. 2019 Mar 18;132(6). pii: jcs225151. doi: 10.1242/jcs.225151.

13.

The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial.

Wirth M, Benson G, Schwarz C, Köbe T, Grittner U, Schmitz D, Sigrist SJ, Bohlken J, Stekovic S, Madeo F, Flöel A.

Cortex. 2018 Dec;109:181-188. doi: 10.1016/j.cortex.2018.09.014. Epub 2018 Oct 4.

PMID:
30388439
14.

Coupling the Structural and Functional Assembly of Synaptic Release Sites.

Ghelani T, Sigrist SJ.

Front Neuroanat. 2018 Oct 16;12:81. doi: 10.3389/fnana.2018.00081. eCollection 2018. Review.

15.

The Long and Short of It: A Dwarf Neurexin Suffices for Synapse Assembly.

Ramesh N, Sigrist SJ.

Neuron. 2018 Oct 10;100(1):6-8. doi: 10.1016/j.neuron.2018.09.035.

16.

Presynaptic Biogenesis Requires Axonal Transport of Lysosome-Related Vesicles.

Vukoja A, Rey U, Petzoldt AG, Ott C, Vollweiter D, Quentin C, Puchkov D, Reynolds E, Lehmann M, Hohensee S, Rosa S, Lipowsky R, Sigrist SJ, Haucke V.

Neuron. 2018 Sep 19;99(6):1216-1232.e7. doi: 10.1016/j.neuron.2018.08.004. Epub 2018 Aug 30.

17.

Active Zone Scaffold Protein Ratios Tune Functional Diversity across Brain Synapses.

Fulterer A, Andlauer TFM, Ender A, Maglione M, Eyring K, Woitkuhn J, Lehmann M, Matkovic-Rachid T, Geiger JRP, Walter AM, Nagel KI, Sigrist SJ.

Cell Rep. 2018 May 1;23(5):1259-1274. doi: 10.1016/j.celrep.2018.03.126.

18.

Guidelines and recommendations on yeast cell death nomenclature.

Carmona-Gutierrez D, Bauer MA, Zimmermann A, Aguilera A, Austriaco N, Ayscough K, Balzan R, Bar-Nun S, Barrientos A, Belenky P, Blondel M, Braun RJ, Breitenbach M, Burhans WC, Büttner S, Cavalieri D, Chang M, Cooper KF, Côrte-Real M, Costa V, Cullin C, Dawes I, Dengjel J, Dickman MB, Eisenberg T, Fahrenkrog B, Fasel N, Fröhlich KU, Gargouri A, Giannattasio S, Goffrini P, Gourlay CW, Grant CM, Greenwood MT, Guaragnella N, Heger T, Heinisch J, Herker E, Herrmann JM, Hofer S, Jiménez-Ruiz A, Jungwirth H, Kainz K, Kontoyiannis DP, Ludovico P, Manon S, Martegani E, Mazzoni C, Megeney LA, Meisinger C, Nielsen J, Nyström T, Osiewacz HD, Outeiro TF, Park HO, Pendl T, Petranovic D, Picot S, Polčic P, Powers T, Ramsdale M, Rinnerthaler M, Rockenfeller P, Ruckenstuhl C, Schaffrath R, Segovia M, Severin FF, Sharon A, Sigrist SJ, Sommer-Ruck C, Sousa MJ, Thevelein JM, Thevissen K, Titorenko V, Toledano MB, Tuite M, Vögtle FN, Westermann B, Winderickx J, Wissing S, Wölfl S, Zhang ZJ, Zhao RY, Zhou B, Galluzzi L, Kroemer G, Madeo F.

Microb Cell. 2018 Jan 1;5(1):4-31. doi: 10.15698/mic2018.01.607. Review.

19.

Inhibition of oxidative stress in cholinergic projection neurons fully rescues aging-associated olfactory circuit degeneration in Drosophila.

Hussain A, Pooryasin A, Zhang M, Loschek LF, La Fortezza M, Friedrich AB, Blais CM, Üçpunar HK, Yépez VA, Lehmann M, Gompel N, Gagneur J, Sigrist SJ, Grunwald Kadow IC.

Elife. 2018 Jan 18;7. pii: e32018. doi: 10.7554/eLife.32018.

20.

Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline.

Schwarz C, Stekovic S, Wirth M, Benson G, Royer P, Sigrist SJ, Pieber T, Dammbrueck C, Magnes C, Eisenberg T, Pendl T, Bohlken J, Köbe T, Madeo F, Flöel A.

Aging (Albany NY). 2018 Jan 8;10(1):19-33. doi: 10.18632/aging.101354.

21.

Vesicle release site organization at synaptic active zones.

Walter AM, Böhme MA, Sigrist SJ.

Neurosci Res. 2018 Feb;127:3-13. doi: 10.1016/j.neures.2017.12.006. Epub 2017 Dec 21. Review.

PMID:
29275162
22.

Mitochondrial energy metabolism is required for lifespan extension by the spastic paraplegia-associated protein spartin.

Ring J, Rockenfeller P, Abraham C, Tadic J, Poglitsch M, Schimmel K, Westermayer J, Schauer S, Achleitner B, Schimpel C, Moitzi B, Rechberger GN, Sigrist SJ, Carmona-Gutierrez D, Kroemer G, Büttner S, Eisenberg T, Madeo F.

Microb Cell. 2017 Nov 30;4(12):411-422. doi: 10.15698/mic2017.12.603.

23.

Diacylglycerol triggers Rim101 pathway-dependent necrosis in yeast: a model for lipotoxicity.

Rockenfeller P, Smolnig M, Diessl J, Bashir M, Schmiedhofer V, Knittelfelder O, Ring J, Franz J, Foessl I, Khan MJ, Rost R, Graier WF, Kroemer G, Zimmermann A, Carmona-Gutierrez D, Eisenberg T, Büttner S, Sigrist SJ, Kühnlein RP, Kohlwein SD, Gourlay CW, Madeo F.

Cell Death Differ. 2018 Mar;25(4):767-783. doi: 10.1038/s41418-017-0014-2. Epub 2017 Dec 11.

24.

Stable Positioning of Unc13 Restricts Synaptic Vesicle Fusion to Defined Release Sites to Promote Synchronous Neurotransmission.

Reddy-Alla S, Böhme MA, Reynolds E, Beis C, Grasskamp AT, Mampell MM, Maglione M, Jusyte M, Rey U, Babikir H, McCarthy AW, Quentin C, Matkovic T, Bergeron DD, Mushtaq Z, Göttfert F, Owald D, Mielke T, Hell SW, Sigrist SJ, Walter AM.

Neuron. 2017 Sep 13;95(6):1350-1364.e12. doi: 10.1016/j.neuron.2017.08.016. Epub 2017 Aug 31.

25.

Age-associated increase of the active zone protein Bruchpilot within the honeybee mushroom body.

Gehring KB, Heufelder K, Depner H, Kersting I, Sigrist SJ, Eisenhardt D.

PLoS One. 2017 Apr 24;12(4):e0175894. doi: 10.1371/journal.pone.0175894. eCollection 2017.

26.

Presynaptic morphogenesis, active zone organization and structural plasticity in Drosophila.

Van Vactor D, Sigrist SJ.

Curr Opin Neurobiol. 2017 Apr;43:119-129. doi: 10.1016/j.conb.2017.03.003. Epub 2017 Apr 5. Review.

27.

Dietary spermidine for lowering high blood pressure.

Eisenberg T, Abdellatif M, Zimmermann A, Schroeder S, Pendl T, Harger A, Stekovic S, Schipke J, Magnes C, Schmidt A, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Carmona-Gutierrez D, Pietrocola F, Pieber TR, Sigrist SJ, Linke WA, Mühlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F.

Autophagy. 2017 Apr 3;13(4):767-769. doi: 10.1080/15548627.2017.1280225. Epub 2017 Jan 24.

28.

Spermidine boosts autophagy to protect from synapse aging.

Bhukel A, Madeo F, Sigrist SJ.

Autophagy. 2017 Feb;13(2):444-445. doi: 10.1080/15548627.2016.1265193. Epub 2016 Dec 27.

29.

Cardioprotection and lifespan extension by the natural polyamine spermidine.

Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, Harger A, Schipke J, Zimmermann A, Schmidt A, Tong M, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Magnes C, Trausinger G, Narath S, Meinitzer A, Hu Z, Kirsch A, Eller K, Carmona-Gutierrez D, Büttner S, Pietrocola F, Knittelfelder O, Schrepfer E, Rockenfeller P, Simonini C, Rahn A, Horsch M, Moreth K, Beckers J, Fuchs H, Gailus-Durner V, Neff F, Janik D, Rathkolb B, Rozman J, de Angelis MH, Moustafa T, Haemmerle G, Mayr M, Willeit P, von Frieling-Salewsky M, Pieske B, Scorrano L, Pieber T, Pechlaner R, Willeit J, Sigrist SJ, Linke WA, Mühlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F.

Nat Med. 2016 Dec;22(12):1428-1438. doi: 10.1038/nm.4222. Epub 2016 Nov 14.

30.

Spermidine Suppresses Age-Associated Memory Impairment by Preventing Adverse Increase of Presynaptic Active Zone Size and Release.

Gupta VK, Pech U, Bhukel A, Fulterer A, Ender A, Mauermann SF, Andlauer TF, Antwi-Adjei E, Beuschel C, Thriene K, Maglione M, Quentin C, Bushow R, Schwärzel M, Mielke T, Madeo F, Dengjel J, Fiala A, Sigrist SJ.

PLoS Biol. 2016 Sep 29;14(9):e1002563. doi: 10.1371/journal.pbio.1002563. eCollection 2016 Sep.

31.

RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses.

Grauel MK, Maglione M, Reddy-Alla S, Willmes CG, Brockmann MM, Trimbuch T, Rosenmund T, Pangalos M, Vardar G, Stumpf A, Walter AM, Rost BR, Eickholt BJ, Haucke V, Schmitz D, Sigrist SJ, Rosenmund C.

Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11615-11620. Epub 2016 Sep 26.

32.

Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca(2+) channel-vesicle coupling.

Böhme MA, Beis C, Reddy-Alla S, Reynolds E, Mampell MM, Grasskamp AT, Lützkendorf J, Bergeron DD, Driller JH, Babikir H, Göttfert F, Robinson IM, O'Kane CJ, Hell SW, Wahl MC, Stelzl U, Loll B, Walter AM, Sigrist SJ.

Nat Neurosci. 2016 Oct;19(10):1311-20. doi: 10.1038/nn.4364. Epub 2016 Aug 15.

PMID:
27526206
33.

Neuroscience: Nanocolumns at the heart of the synapse.

Sigrist SJ, Petzoldt AG.

Nature. 2016 Aug 11;536(7615):151-2. Epub 2016 Jul 27. No abstract available.

PMID:
27462816
34.

Mechanisms controlling assembly and plasticity of presynaptic active zone scaffolds.

Petzoldt AG, Lützkendorf J, Sigrist SJ.

Curr Opin Neurobiol. 2016 Aug;39:69-76. doi: 10.1016/j.conb.2016.04.009. Epub 2016 Apr 29. Review.

PMID:
27131423
35.

Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function.

Muhammad K, Reddy-Alla S, Driller JH, Schreiner D, Rey U, Böhme MA, Hollmann C, Ramesh N, Depner H, Lützkendorf J, Matkovic T, Götz T, Bergeron DD, Schmoranzer J, Goettfert F, Holt M, Wahl MC, Hell SW, Scheiffele P, Walter AM, Loll B, Sigrist SJ.

Nat Commun. 2015 Oct 16;6:8362. doi: 10.1038/ncomms9362.

36.

Conditional depletion of intellectual disability and Parkinsonism candidate gene ATP6AP2 in fly and mouse induces cognitive impairment and neurodegeneration.

Dubos A, Castells-Nobau A, Meziane H, Oortveld MA, Houbaert X, Iacono G, Martin C, Mittelhaeuser C, Lalanne V, Kramer JM, Bhukel A, Quentin C, Slabbert J, Verstreken P, Sigrist SJ, Messaddeq N, Birling MC, Selloum M, Stunnenberg HG, Humeau Y, Schenck A, Herault Y.

Hum Mol Genet. 2015 Dec 1;24(23):6736-55. doi: 10.1093/hmg/ddv380. Epub 2015 Sep 16.

37.

Dynamical Organization of Syntaxin-1A at the Presynaptic Active Zone.

Ullrich A, Böhme MA, Schöneberg J, Depner H, Sigrist SJ, Noé F.

PLoS Comput Biol. 2015 Sep 14;11(9):e1004407. doi: 10.1371/journal.pcbi.1004407. eCollection 2015 Sep.

38.

A high affinity RIM-binding protein/Aplip1 interaction prevents the formation of ectopic axonal active zones.

Siebert M, Böhme MA, Driller JH, Babikir H, Mampell MM, Rey U, Ramesh N, Matkovic T, Holton N, Reddy-Alla S, Göttfert F, Kamin D, Quentin C, Klinedinst S, Andlauer TF, Hell SW, Collins CA, Wahl MC, Loll B, Sigrist SJ.

Elife. 2015 Aug 14;4. doi: 10.7554/eLife.06935.

39.

Ultrafast, temporally stochastic STED nanoscopy of millisecond dynamics.

Schneider J, Zahn J, Maglione M, Sigrist SJ, Marquard J, Chojnacki J, Kräusslich HG, Sahl SJ, Engelhardt J, Hell SW.

Nat Methods. 2015 Sep;12(9):827-30. doi: 10.1038/nmeth.3481. Epub 2015 Jul 27.

PMID:
26214129
40.

Lights on for the molecular players of presynaptic plasticity.

Böhme MA, Sigrist SJ.

Neuron. 2015 May 6;86(3):603-4. doi: 10.1016/j.neuron.2015.04.021.

41.

Structures of Drosophila melanogaster Rab2 and Rab3 bound to GMPPNP.

Lardong JA, Driller JH, Depner H, Weise C, Petzoldt A, Wahl MC, Sigrist SJ, Loll B.

Acta Crystallogr F Struct Biol Commun. 2015 Jan 1;71(Pt 1):34-40. doi: 10.1107/S2053230X1402617X. Epub 2015 Jan 1.

42.

Spermidine protects against α-synuclein neurotoxicity.

Büttner S, Broeskamp F, Sommer C, Markaki M, Habernig L, Alavian-Ghavanini A, Carmona-Gutierrez D, Eisenberg T, Michael E, Kroemer G, Tavernarakis N, Sigrist SJ, Madeo F.

Cell Cycle. 2014;13(24):3903-8. doi: 10.4161/15384101.2014.973309.

43.

Synaptogenesis.

Petzoldt AG, Sigrist SJ.

Curr Biol. 2014 Nov 17;24(22):R1076-80. doi: 10.1016/j.cub.2014.10.024. Epub 2014 Nov 17.

44.

Differential centrifugation-based biochemical fractionation of the Drosophila adult CNS.

Depner H, Lützkendorf J, Babkir HA, Sigrist SJ, Holt MG.

Nat Protoc. 2014 Dec;9(12):2796-808. doi: 10.1038/nprot.2014.192. Epub 2014 Nov 13.

PMID:
25393777
45.

Drep-2 is a novel synaptic protein important for learning and memory.

Andlauer TF, Scholz-Kornehl S, Tian R, Kirchner M, Babikir HA, Depner H, Loll B, Quentin C, Gupta VK, Holt MG, Dipt S, Cressy M, Wahl MC, Fiala A, Selbach M, Schwärzel M, Sigrist SJ.

Elife. 2014 Nov 13;3. doi: 10.7554/eLife.03895.

46.

Gating characteristics control glutamate receptor distribution and trafficking in vivo.

Petzoldt AG, Lee YH, Khorramshahi O, Reynolds E, Plested AJ, Herzel H, Sigrist SJ.

Curr Biol. 2014 Sep 8;24(17):2059-65. doi: 10.1016/j.cub.2014.07.051. Epub 2014 Aug 14.

47.

Drosophila Syd-1, liprin-α, and protein phosphatase 2A B' subunit Wrd function in a linear pathway to prevent ectopic accumulation of synaptic materials in distal axons.

Li L, Tian X, Zhu M, Bulgari D, Böhme MA, Goettfert F, Wichmann C, Sigrist SJ, Levitan ES, Wu C.

J Neurosci. 2014 Jun 18;34(25):8474-87. doi: 10.1523/JNEUROSCI.0409-14.2014.

48.

Acetyl-coenzyme A: a metabolic master regulator of autophagy and longevity.

Schroeder S, Pendl T, Zimmermann A, Eisenberg T, Carmona-Gutierrez D, Ruckenstuhl C, Mariño G, Pietrocola F, Harger A, Magnes C, Sinner F, Pieber TR, Dengjel J, Sigrist SJ, Kroemer G, Madeo F.

Autophagy. 2014 Jul;10(7):1335-7. doi: 10.4161/auto.28919. Epub 2014 May 15.

49.

A presynaptic role for the cytomatrix protein GIT in synaptic vesicle recycling.

Podufall J, Tian R, Knoche E, Puchkov D, Walter AM, Rosa S, Quentin C, Vukoja A, Jung N, Lampe A, Wichmann C, Böhme M, Depner H, Zhang YQ, Schmoranzer J, Sigrist SJ, Haucke V.

Cell Rep. 2014 Jun 12;7(5):1417-1425. doi: 10.1016/j.celrep.2014.04.051. Epub 2014 May 29.

50.

Nucleocytosolic depletion of the energy metabolite acetyl-coenzyme a stimulates autophagy and prolongs lifespan.

Eisenberg T, Schroeder S, Andryushkova A, Pendl T, Küttner V, Bhukel A, Mariño G, Pietrocola F, Harger A, Zimmermann A, Moustafa T, Sprenger A, Jany E, Büttner S, Carmona-Gutierrez D, Ruckenstuhl C, Ring J, Reichelt W, Schimmel K, Leeb T, Moser C, Schatz S, Kamolz LP, Magnes C, Sinner F, Sedej S, Fröhlich KU, Juhasz G, Pieber TR, Dengjel J, Sigrist SJ, Kroemer G, Madeo F.

Cell Metab. 2014 Mar 4;19(3):431-44. doi: 10.1016/j.cmet.2014.02.010.

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