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Items: 1 to 50 of 106

1.

Conserved regulation of neurodevelopmental processes and behavior by FoxP in Drosophila.

Castells-Nobau A, Eidhof I, Fenckova M, Brenman-Suttner DB, Scheffer-de Gooyert JM, Christine S, Schellevis RL, van der Laan K, Quentin C, van Ninhuijs L, Hofmann F, Ejsmont R, Fisher SE, Kramer JM, Sigrist SJ, Simon AF, Schenck A.

PLoS One. 2019 Feb 12;14(2):e0211652. doi: 10.1371/journal.pone.0211652. eCollection 2019.

2.

Phosphorylation of the Bruchpilot N-terminus unlocks axonal transport of active zone building blocks.

Driller JH, Lützkendorf J, Depner H, Siebert M, Kuropka B, Weise C, Piao C, Petzoldt AG, Lehmann M, Stelzl U, Zahedi R, Sickmann A, Freund C, Sigrist SJ, Wahl MC.

J Cell Sci. 2019 Feb 11. pii: jcs.225151. doi: 10.1242/jcs.225151. [Epub ahead of print]

PMID:
30745339
3.

The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial.

Wirth M, Benson G, Schwarz C, Köbe T, Grittner U, Schmitz D, Sigrist SJ, Bohlken J, Stekovic S, Madeo F, Flöel A.

Cortex. 2018 Dec;109:181-188. doi: 10.1016/j.cortex.2018.09.014. Epub 2018 Oct 4.

PMID:
30388439
4.

Coupling the Structural and Functional Assembly of Synaptic Release Sites.

Ghelani T, Sigrist SJ.

Front Neuroanat. 2018 Oct 16;12:81. doi: 10.3389/fnana.2018.00081. eCollection 2018. Review.

5.

The Long and Short of It: A Dwarf Neurexin Suffices for Synapse Assembly.

Ramesh N, Sigrist SJ.

Neuron. 2018 Oct 10;100(1):6-8. doi: 10.1016/j.neuron.2018.09.035.

PMID:
30308172
6.

Presynaptic Biogenesis Requires Axonal Transport of Lysosome-Related Vesicles.

Vukoja A, Rey U, Petzoldt AG, Ott C, Vollweiter D, Quentin C, Puchkov D, Reynolds E, Lehmann M, Hohensee S, Rosa S, Lipowsky R, Sigrist SJ, Haucke V.

Neuron. 2018 Sep 19;99(6):1216-1232.e7. doi: 10.1016/j.neuron.2018.08.004. Epub 2018 Aug 30.

PMID:
30174114
7.

Active Zone Scaffold Protein Ratios Tune Functional Diversity across Brain Synapses.

Fulterer A, Andlauer TFM, Ender A, Maglione M, Eyring K, Woitkuhn J, Lehmann M, Matkovic-Rachid T, Geiger JRP, Walter AM, Nagel KI, Sigrist SJ.

Cell Rep. 2018 May 1;23(5):1259-1274. doi: 10.1016/j.celrep.2018.03.126.

8.

Guidelines and recommendations on yeast cell death nomenclature.

Carmona-Gutierrez D, Bauer MA, Zimmermann A, Aguilera A, Austriaco N, Ayscough K, Balzan R, Bar-Nun S, Barrientos A, Belenky P, Blondel M, Braun RJ, Breitenbach M, Burhans WC, Büttner S, Cavalieri D, Chang M, Cooper KF, Côrte-Real M, Costa V, Cullin C, Dawes I, Dengjel J, Dickman MB, Eisenberg T, Fahrenkrog B, Fasel N, Fröhlich KU, Gargouri A, Giannattasio S, Goffrini P, Gourlay CW, Grant CM, Greenwood MT, Guaragnella N, Heger T, Heinisch J, Herker E, Herrmann JM, Hofer S, Jiménez-Ruiz A, Jungwirth H, Kainz K, Kontoyiannis DP, Ludovico P, Manon S, Martegani E, Mazzoni C, Megeney LA, Meisinger C, Nielsen J, Nyström T, Osiewacz HD, Outeiro TF, Park HO, Pendl T, Petranovic D, Picot S, Polčic P, Powers T, Ramsdale M, Rinnerthaler M, Rockenfeller P, Ruckenstuhl C, Schaffrath R, Segovia M, Severin FF, Sharon A, Sigrist SJ, Sommer-Ruck C, Sousa MJ, Thevelein JM, Thevissen K, Titorenko V, Toledano MB, Tuite M, Vögtle FN, Westermann B, Winderickx J, Wissing S, Wölfl S, Zhang ZJ, Zhao RY, Zhou B, Galluzzi L, Kroemer G, Madeo F.

Microb Cell. 2018 Jan 1;5(1):4-31. doi: 10.15698/mic2018.01.607. Review.

9.

Inhibition of oxidative stress in cholinergic projection neurons fully rescues aging-associated olfactory circuit degeneration in Drosophila.

Hussain A, Pooryasin A, Zhang M, Loschek LF, La Fortezza M, Friedrich AB, Blais CM, Üçpunar HK, Yépez VA, Lehmann M, Gompel N, Gagneur J, Sigrist SJ, Grunwald Kadow IC.

Elife. 2018 Jan 18;7. pii: e32018. doi: 10.7554/eLife.32018.

10.

Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline.

Schwarz C, Stekovic S, Wirth M, Benson G, Royer P, Sigrist SJ, Pieber T, Dammbrueck C, Magnes C, Eisenberg T, Pendl T, Bohlken J, Köbe T, Madeo F, Flöel A.

Aging (Albany NY). 2018 Jan 8;10(1):19-33. doi: 10.18632/aging.101354.

11.

Vesicle release site organization at synaptic active zones.

Walter AM, Böhme MA, Sigrist SJ.

Neurosci Res. 2018 Feb;127:3-13. doi: 10.1016/j.neures.2017.12.006. Epub 2017 Dec 21. Review.

PMID:
29275162
12.

Mitochondrial energy metabolism is required for lifespan extension by the spastic paraplegia-associated protein spartin.

Ring J, Rockenfeller P, Abraham C, Tadic J, Poglitsch M, Schimmel K, Westermayer J, Schauer S, Achleitner B, Schimpel C, Moitzi B, Rechberger GN, Sigrist SJ, Carmona-Gutierrez D, Kroemer G, Büttner S, Eisenberg T, Madeo F.

Microb Cell. 2017 Nov 30;4(12):411-422. doi: 10.15698/mic2017.12.603.

13.

Diacylglycerol triggers Rim101 pathway-dependent necrosis in yeast: a model for lipotoxicity.

Rockenfeller P, Smolnig M, Diessl J, Bashir M, Schmiedhofer V, Knittelfelder O, Ring J, Franz J, Foessl I, Khan MJ, Rost R, Graier WF, Kroemer G, Zimmermann A, Carmona-Gutierrez D, Eisenberg T, Büttner S, Sigrist SJ, Kühnlein RP, Kohlwein SD, Gourlay CW, Madeo F.

Cell Death Differ. 2018 Mar;25(4):765-781. doi: 10.1038/s41418-017-0014-2. Epub 2017 Dec 11.

14.

Stable Positioning of Unc13 Restricts Synaptic Vesicle Fusion to Defined Release Sites to Promote Synchronous Neurotransmission.

Reddy-Alla S, Böhme MA, Reynolds E, Beis C, Grasskamp AT, Mampell MM, Maglione M, Jusyte M, Rey U, Babikir H, McCarthy AW, Quentin C, Matkovic T, Bergeron DD, Mushtaq Z, Göttfert F, Owald D, Mielke T, Hell SW, Sigrist SJ, Walter AM.

Neuron. 2017 Sep 13;95(6):1350-1364.e12. doi: 10.1016/j.neuron.2017.08.016. Epub 2017 Aug 31.

15.

Age-associated increase of the active zone protein Bruchpilot within the honeybee mushroom body.

Gehring KB, Heufelder K, Depner H, Kersting I, Sigrist SJ, Eisenhardt D.

PLoS One. 2017 Apr 24;12(4):e0175894. doi: 10.1371/journal.pone.0175894. eCollection 2017.

16.

Presynaptic morphogenesis, active zone organization and structural plasticity in Drosophila.

Van Vactor D, Sigrist SJ.

Curr Opin Neurobiol. 2017 Apr;43:119-129. doi: 10.1016/j.conb.2017.03.003. Epub 2017 Apr 5. Review.

17.

Dietary spermidine for lowering high blood pressure.

Eisenberg T, Abdellatif M, Zimmermann A, Schroeder S, Pendl T, Harger A, Stekovic S, Schipke J, Magnes C, Schmidt A, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Carmona-Gutierrez D, Pietrocola F, Pieber TR, Sigrist SJ, Linke WA, Mühlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F.

Autophagy. 2017 Apr 3;13(4):767-769. doi: 10.1080/15548627.2017.1280225. Epub 2017 Jan 24.

18.

Spermidine boosts autophagy to protect from synapse aging.

Bhukel A, Madeo F, Sigrist SJ.

Autophagy. 2017 Feb;13(2):444-445. doi: 10.1080/15548627.2016.1265193. Epub 2016 Dec 27.

19.

Cardioprotection and lifespan extension by the natural polyamine spermidine.

Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, Harger A, Schipke J, Zimmermann A, Schmidt A, Tong M, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Magnes C, Trausinger G, Narath S, Meinitzer A, Hu Z, Kirsch A, Eller K, Carmona-Gutierrez D, Büttner S, Pietrocola F, Knittelfelder O, Schrepfer E, Rockenfeller P, Simonini C, Rahn A, Horsch M, Moreth K, Beckers J, Fuchs H, Gailus-Durner V, Neff F, Janik D, Rathkolb B, Rozman J, de Angelis MH, Moustafa T, Haemmerle G, Mayr M, Willeit P, von Frieling-Salewsky M, Pieske B, Scorrano L, Pieber T, Pechlaner R, Willeit J, Sigrist SJ, Linke WA, Mühlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F.

Nat Med. 2016 Dec;22(12):1428-1438. doi: 10.1038/nm.4222. Epub 2016 Nov 14.

20.

Spermidine Suppresses Age-Associated Memory Impairment by Preventing Adverse Increase of Presynaptic Active Zone Size and Release.

Gupta VK, Pech U, Bhukel A, Fulterer A, Ender A, Mauermann SF, Andlauer TF, Antwi-Adjei E, Beuschel C, Thriene K, Maglione M, Quentin C, Bushow R, Schwärzel M, Mielke T, Madeo F, Dengjel J, Fiala A, Sigrist SJ.

PLoS Biol. 2016 Sep 29;14(9):e1002563. doi: 10.1371/journal.pbio.1002563. eCollection 2016 Sep.

21.

RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses.

Grauel MK, Maglione M, Reddy-Alla S, Willmes CG, Brockmann MM, Trimbuch T, Rosenmund T, Pangalos M, Vardar G, Stumpf A, Walter AM, Rost BR, Eickholt BJ, Haucke V, Schmitz D, Sigrist SJ, Rosenmund C.

Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11615-11620. Epub 2016 Sep 26.

22.

Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca(2+) channel-vesicle coupling.

Böhme MA, Beis C, Reddy-Alla S, Reynolds E, Mampell MM, Grasskamp AT, Lützkendorf J, Bergeron DD, Driller JH, Babikir H, Göttfert F, Robinson IM, O'Kane CJ, Hell SW, Wahl MC, Stelzl U, Loll B, Walter AM, Sigrist SJ.

Nat Neurosci. 2016 Oct;19(10):1311-20. doi: 10.1038/nn.4364. Epub 2016 Aug 15.

PMID:
27526206
23.

Neuroscience: Nanocolumns at the heart of the synapse.

Sigrist SJ, Petzoldt AG.

Nature. 2016 Aug 11;536(7615):151-2. Epub 2016 Jul 27. No abstract available.

PMID:
27462816
24.

Mechanisms controlling assembly and plasticity of presynaptic active zone scaffolds.

Petzoldt AG, Lützkendorf J, Sigrist SJ.

Curr Opin Neurobiol. 2016 Aug;39:69-76. doi: 10.1016/j.conb.2016.04.009. Epub 2016 Apr 29. Review.

PMID:
27131423
25.

Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function.

Muhammad K, Reddy-Alla S, Driller JH, Schreiner D, Rey U, Böhme MA, Hollmann C, Ramesh N, Depner H, Lützkendorf J, Matkovic T, Götz T, Bergeron DD, Schmoranzer J, Goettfert F, Holt M, Wahl MC, Hell SW, Scheiffele P, Walter AM, Loll B, Sigrist SJ.

Nat Commun. 2015 Oct 16;6:8362. doi: 10.1038/ncomms9362.

26.

Conditional depletion of intellectual disability and Parkinsonism candidate gene ATP6AP2 in fly and mouse induces cognitive impairment and neurodegeneration.

Dubos A, Castells-Nobau A, Meziane H, Oortveld MA, Houbaert X, Iacono G, Martin C, Mittelhaeuser C, Lalanne V, Kramer JM, Bhukel A, Quentin C, Slabbert J, Verstreken P, Sigrist SJ, Messaddeq N, Birling MC, Selloum M, Stunnenberg HG, Humeau Y, Schenck A, Herault Y.

Hum Mol Genet. 2015 Dec 1;24(23):6736-55. doi: 10.1093/hmg/ddv380. Epub 2015 Sep 16.

27.

Dynamical Organization of Syntaxin-1A at the Presynaptic Active Zone.

Ullrich A, Böhme MA, Schöneberg J, Depner H, Sigrist SJ, Noé F.

PLoS Comput Biol. 2015 Sep 14;11(9):e1004407. doi: 10.1371/journal.pcbi.1004407. eCollection 2015 Sep.

28.

A high affinity RIM-binding protein/Aplip1 interaction prevents the formation of ectopic axonal active zones.

Siebert M, Böhme MA, Driller JH, Babikir H, Mampell MM, Rey U, Ramesh N, Matkovic T, Holton N, Reddy-Alla S, Göttfert F, Kamin D, Quentin C, Klinedinst S, Andlauer TF, Hell SW, Collins CA, Wahl MC, Loll B, Sigrist SJ.

Elife. 2015 Aug 14;4. doi: 10.7554/eLife.06935.

29.

Ultrafast, temporally stochastic STED nanoscopy of millisecond dynamics.

Schneider J, Zahn J, Maglione M, Sigrist SJ, Marquard J, Chojnacki J, Kräusslich HG, Sahl SJ, Engelhardt J, Hell SW.

Nat Methods. 2015 Sep;12(9):827-30. doi: 10.1038/nmeth.3481. Epub 2015 Jul 27.

PMID:
26214129
30.

Lights on for the molecular players of presynaptic plasticity.

Böhme MA, Sigrist SJ.

Neuron. 2015 May 6;86(3):603-4. doi: 10.1016/j.neuron.2015.04.021.

31.

Structures of Drosophila melanogaster Rab2 and Rab3 bound to GMPPNP.

Lardong JA, Driller JH, Depner H, Weise C, Petzoldt A, Wahl MC, Sigrist SJ, Loll B.

Acta Crystallogr F Struct Biol Commun. 2015 Jan 1;71(Pt 1):34-40. doi: 10.1107/S2053230X1402617X. Epub 2015 Jan 1.

32.

Spermidine protects against α-synuclein neurotoxicity.

Büttner S, Broeskamp F, Sommer C, Markaki M, Habernig L, Alavian-Ghavanini A, Carmona-Gutierrez D, Eisenberg T, Michael E, Kroemer G, Tavernarakis N, Sigrist SJ, Madeo F.

Cell Cycle. 2014;13(24):3903-8. doi: 10.4161/15384101.2014.973309.

33.

Synaptogenesis.

Petzoldt AG, Sigrist SJ.

Curr Biol. 2014 Nov 17;24(22):R1076-80. doi: 10.1016/j.cub.2014.10.024. Epub 2014 Nov 17.

34.

Differential centrifugation-based biochemical fractionation of the Drosophila adult CNS.

Depner H, Lützkendorf J, Babkir HA, Sigrist SJ, Holt MG.

Nat Protoc. 2014 Dec;9(12):2796-808. doi: 10.1038/nprot.2014.192. Epub 2014 Nov 13.

PMID:
25393777
35.

Drep-2 is a novel synaptic protein important for learning and memory.

Andlauer TF, Scholz-Kornehl S, Tian R, Kirchner M, Babikir HA, Depner H, Loll B, Quentin C, Gupta VK, Holt MG, Dipt S, Cressy M, Wahl MC, Fiala A, Selbach M, Schwärzel M, Sigrist SJ.

Elife. 2014 Nov 13;3. doi: 10.7554/eLife.03895.

36.

Gating characteristics control glutamate receptor distribution and trafficking in vivo.

Petzoldt AG, Lee YH, Khorramshahi O, Reynolds E, Plested AJ, Herzel H, Sigrist SJ.

Curr Biol. 2014 Sep 8;24(17):2059-65. doi: 10.1016/j.cub.2014.07.051. Epub 2014 Aug 14.

37.

Drosophila Syd-1, liprin-α, and protein phosphatase 2A B' subunit Wrd function in a linear pathway to prevent ectopic accumulation of synaptic materials in distal axons.

Li L, Tian X, Zhu M, Bulgari D, Böhme MA, Goettfert F, Wichmann C, Sigrist SJ, Levitan ES, Wu C.

J Neurosci. 2014 Jun 18;34(25):8474-87. doi: 10.1523/JNEUROSCI.0409-14.2014.

38.

Acetyl-coenzyme A: a metabolic master regulator of autophagy and longevity.

Schroeder S, Pendl T, Zimmermann A, Eisenberg T, Carmona-Gutierrez D, Ruckenstuhl C, Mariño G, Pietrocola F, Harger A, Magnes C, Sinner F, Pieber TR, Dengjel J, Sigrist SJ, Kroemer G, Madeo F.

Autophagy. 2014 Jul;10(7):1335-7. doi: 10.4161/auto.28919. Epub 2014 May 15.

39.

A presynaptic role for the cytomatrix protein GIT in synaptic vesicle recycling.

Podufall J, Tian R, Knoche E, Puchkov D, Walter AM, Rosa S, Quentin C, Vukoja A, Jung N, Lampe A, Wichmann C, Böhme M, Depner H, Zhang YQ, Schmoranzer J, Sigrist SJ, Haucke V.

Cell Rep. 2014 Jun 12;7(5):1417-1425. doi: 10.1016/j.celrep.2014.04.051. Epub 2014 May 29.

40.

Nucleocytosolic depletion of the energy metabolite acetyl-coenzyme a stimulates autophagy and prolongs lifespan.

Eisenberg T, Schroeder S, Andryushkova A, Pendl T, Küttner V, Bhukel A, Mariño G, Pietrocola F, Harger A, Zimmermann A, Moustafa T, Sprenger A, Jany E, Büttner S, Carmona-Gutierrez D, Ruckenstuhl C, Ring J, Reichelt W, Schimmel K, Leeb T, Moser C, Schatz S, Kamolz LP, Magnes C, Sinner F, Sedej S, Fröhlich KU, Juhasz G, Pieber TR, Dengjel J, Sigrist SJ, Kroemer G, Madeo F.

Cell Metab. 2014 Mar 4;19(3):431-44. doi: 10.1016/j.cmet.2014.02.010.

41.

Neurotransmission: spontaneous and evoked release filing for divorce.

Walter AM, Haucke V, Sigrist SJ.

Curr Biol. 2014 Mar 3;24(5):R192-4. doi: 10.1016/j.cub.2014.01.037.

42.

Spermidine-triggered autophagy ameliorates memory during aging.

Sigrist SJ, Carmona-Gutierrez D, Gupta VK, Bhukel A, Mertel S, Eisenberg T, Madeo F.

Autophagy. 2014 Jan;10(1):178-9. doi: 10.4161/auto.26918. Epub 2013 Nov 15.

43.

Endonuclease G mediates α-synuclein cytotoxicity during Parkinson's disease.

Büttner S, Habernig L, Broeskamp F, Ruli D, Vögtle FN, Vlachos M, Macchi F, Küttner V, Carmona-Gutierrez D, Eisenberg T, Ring J, Markaki M, Taskin AA, Benke S, Ruckenstuhl C, Braun R, Van den Haute C, Bammens T, van der Perren A, Fröhlich KU, Winderickx J, Kroemer G, Baekelandt V, Tavernarakis N, Kovacs GG, Dengjel J, Meisinger C, Sigrist SJ, Madeo F.

EMBO J. 2013 Nov 27;32(23):3041-54. doi: 10.1038/emboj.2013.228. Epub 2013 Oct 15.

44.

Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner.

Gupta VK, Scheunemann L, Eisenberg T, Mertel S, Bhukel A, Koemans TS, Kramer JM, Liu KS, Schroeder S, Stunnenberg HG, Sinner F, Magnes C, Pieber TR, Dipt S, Fiala A, Schenck A, Schwaerzel M, Madeo F, Sigrist SJ.

Nat Neurosci. 2013 Oct;16(10):1453-60. doi: 10.1038/nn.3512. Epub 2013 Sep 1.

PMID:
23995066
45.

The Bruchpilot cytomatrix determines the size of the readily releasable pool of synaptic vesicles.

Matkovic T, Siebert M, Knoche E, Depner H, Mertel S, Owald D, Schmidt M, Thomas U, Sickmann A, Kamin D, Hell SW, Bürger J, Hollmann C, Mielke T, Wichmann C, Sigrist SJ.

J Cell Biol. 2013 Aug 19;202(4):667-83. doi: 10.1083/jcb.201301072.

46.

Seeing the forest tree by tree: super-resolution light microscopy meets the neurosciences.

Maglione M, Sigrist SJ.

Nat Neurosci. 2013 Jul;16(7):790-7. doi: 10.1038/nn.3403. Epub 2013 Jun 25. Review.

PMID:
23799471
47.

Sperm(idine) answers the next generation.

Gupta VK, Sigrist SJ.

Cell Cycle. 2013 Feb 15;12(4):542-3. doi: 10.4161/cc.23676. Epub 2013 Jan 31. No abstract available.

48.

RIM controls homeostatic plasticity through modulation of the readily-releasable vesicle pool.

Müller M, Liu KS, Sigrist SJ, Davis GW.

J Neurosci. 2012 Nov 21;32(47):16574-85. doi: 10.1523/JNEUROSCI.0981-12.2012.

49.

The Ca2+/Mn2+ ion-pump PMR1 links elevation of cytosolic Ca(2+) levels to α-synuclein toxicity in Parkinson's disease models.

Büttner S, Faes L, Reichelt WN, Broeskamp F, Habernig L, Benke S, Kourtis N, Ruli D, Carmona-Gutierrez D, Eisenberg T, D'hooge P, Ghillebert R, Franssens V, Harger A, Pieber TR, Freudenberger P, Kroemer G, Sigrist SJ, Winderickx J, Callewaert G, Tavernarakis N, Madeo F.

Cell Death Differ. 2013 Mar;20(3):465-77. doi: 10.1038/cdd.2012.142. Epub 2012 Nov 16.

50.

Spermidine promotes stress resistance in Drosophila melanogaster through autophagy-dependent and -independent pathways.

Minois N, Carmona-Gutierrez D, Bauer MA, Rockenfeller P, Eisenberg T, Brandhorst S, Sigrist SJ, Kroemer G, Madeo F.

Cell Death Dis. 2012 Oct 11;3:e401. doi: 10.1038/cddis.2012.139.

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