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Items: 13


Hyperactivation of MAPK Signaling Is Deleterious to RAS/RAF-mutant Melanoma.

Leung GP, Feng T, Sigoillot FD, Geyer FC, Shirley MD, Ruddy DA, Rakiec DP, Freeman AK, Engelman JA, Jaskelioff M, Stuart DD.

Mol Cancer Res. 2019 Jan;17(1):199-211. doi: 10.1158/1541-7786.MCR-18-0327. Epub 2018 Sep 10.


The G2/M regulator histone demethylase PHF8 is targeted for degradation by the anaphase-promoting complex containing CDC20.

Lim HJ, Dimova NV, Tan MK, Sigoillot FD, King RW, Shi Y.

Mol Cell Biol. 2013 Nov;33(21):4166-80. doi: 10.1128/MCB.00689-13. Epub 2013 Aug 26.


A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response.

Adamson B, Smogorzewska A, Sigoillot FD, King RW, Elledge SJ.

Nat Cell Biol. 2012 Feb 19;14(3):318-28. doi: 10.1038/ncb2426.


A bioinformatics method identifies prominent off-targeted transcripts in RNAi screens.

Sigoillot FD, Lyman S, Huckins JF, Adamson B, Chung E, Quattrochi B, King RW.

Nat Methods. 2012 Feb 19;9(4):363-6. doi: 10.1038/nmeth.1898.


A time-series method for automated measurement of changes in mitotic and interphase duration from time-lapse movies.

Sigoillot FD, Huckins JF, Li F, Zhou X, Wong ST, King RW.

PLoS One. 2011;6(9):e25511. doi: 10.1371/journal.pone.0025511. Epub 2011 Sep 26.


Vigilance and validation: Keys to success in RNAi screening.

Sigoillot FD, King RW.

ACS Chem Biol. 2011 Jan 21;6(1):47-60. doi: 10.1021/cb100358f. Epub 2010 Dec 28. Review.


Protein kinase C modulates the up-regulation of the pyrimidine biosynthetic complex, CAD, by MAP kinase.

Sigoillot FD, Kotsis DH, Masko EM, Bame M, Evans DR, Evans HI.

Front Biosci. 2007 May 1;12:3892-8.


Protein kinase A phosphorylation of the multifunctional protein CAD antagonizes activation by the MAP kinase cascade.

Kotsis DH, Masko EM, Sigoillot FD, Di Gregorio R, Guy-Evans HI, Evans DR.

Mol Cell Biochem. 2007 Jul;301(1-2):69-81. Epub 2007 Jan 6.


Nuclear localization and mitogen-activated protein kinase phosphorylation of the multifunctional protein CAD.

Sigoillot FD, Kotsis DH, Serre V, Sigoillot SM, Evans DR, Guy HI.

J Biol Chem. 2005 Jul 8;280(27):25611-20. Epub 2005 May 12.


Breakdown of the regulatory control of pyrimidine biosynthesis in human breast cancer cells.

Sigoillot FD, Sigoillot SM, Guy HI.

Int J Cancer. 2004 Apr 20;109(4):491-8.


Cell cycle-dependent regulation of pyrimidine biosynthesis.

Sigoillot FD, Berkowski JA, Sigoillot SM, Kotsis DH, Guy HI.

J Biol Chem. 2003 Jan 31;278(5):3403-9. Epub 2002 Nov 15.


Autophosphorylation of the mammalian multifunctional protein that initiates de novo pyrimidine biosynthesis.

Sigoillot FD, Evans DR, Guy HI.

J Biol Chem. 2002 Jul 5;277(27):24809-17. Epub 2002 May 1.


Growth-dependent regulation of mammalian pyrimidine biosynthesis by the protein kinase A and MAPK signaling cascades.

Sigoillot FD, Evans DR, Guy HI.

J Biol Chem. 2002 May 3;277(18):15745-51. Epub 2002 Feb 28.

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