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Increased Levels of cAMP by the Calcium-Dependent Activation of Soluble Adenylyl Cyclase in Parkin-Mutant Fibroblasts.

Tanzarella P, Ferretta A, Barile SN, Ancona M, De Rasmo D, Signorile A, Papa S, Capitanio N, Pacelli C, Cocco T.

Cells. 2019 Mar 15;8(3). pii: E250. doi: 10.3390/cells8030250.


Prohibitins: A Critical Role in Mitochondrial Functions and Implication in Diseases.

Signorile A, Sgaramella G, Bellomo F, De Rasmo D.

Cells. 2019 Jan 18;8(1). pii: E71. doi: 10.3390/cells8010071. Review.


Impact of atypical mitochondrial cyclic-AMP level in nephropathic cystinosis.

Bellomo F, Signorile A, Tamma G, Ranieri M, Emma F, De Rasmo D.

Cell Mol Life Sci. 2018 Sep;75(18):3411-3422. doi: 10.1007/s00018-018-2800-5. Epub 2018 Mar 16.


Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy.

Celestini V, Tezil T, Russo L, Fasano C, Sanese P, Forte G, Peserico A, Lepore Signorile M, Longo G, De Rasmo D, Signorile A, Gadaleta RM, Scialpi N, Terao M, Garattini E, Cocco T, Villani G, Moschetta A, Grossi V, Simone C.

Cell Death Dis. 2018 Feb 14;9(2):231. doi: 10.1038/s41419-018-0336-0.


Genetic dissection of the relationships between grain yield components by genome-wide association mapping in a collection of tetraploid wheats.

Mangini G, Gadaleta A, Colasuonno P, Marcotuli I, Signorile AM, Simeone R, De Vita P, Mastrangelo AM, Laidò G, Pecchioni N, Blanco A.

PLoS One. 2018 Jan 11;13(1):e0190162. doi: 10.1371/journal.pone.0190162. eCollection 2018.


Resveratrol Modulation of Protein Expression in parkin-Mutant Human Skin Fibroblasts: A Proteomic Approach.

Vergara D, Gaballo A, Signorile A, Ferretta A, Tanzarella P, Pacelli C, Di Paola M, Cocco T, Maffia M.

Oxid Med Cell Longev. 2017;2017:2198243. doi: 10.1155/2017/2198243. Epub 2017 Sep 12.


Inhibition of Drp1-mediated mitochondrial fission improves mitochondrial dynamics and bioenergetics stimulating neurogenesis in hippocampal progenitor cells from a Down syndrome mouse model.

Valenti D, Rossi L, Marzulli D, Bellomo F, De Rasmo D, Signorile A, Vacca RA.

Biochim Biophys Acta Mol Basis Dis. 2017 Dec;1863(12):3117-3127. doi: 10.1016/j.bbadis.2017.09.014. Epub 2017 Sep 20.


Mitochondria as pharmacological targets in Down syndrome.

Valenti D, Braidy N, De Rasmo D, Signorile A, Rossi L, Atanasov AG, Volpicella M, Henrion-Caude A, Nabavi SM, Vacca RA.

Free Radic Biol Med. 2018 Jan;114:69-83. doi: 10.1016/j.freeradbiomed.2017.08.014. Epub 2017 Aug 31. Review.


Development of a High-Density SNP-Based Linkage Map and Detection of QTL for β-Glucans, Protein Content, Grain Yield per Spike and Heading Time in Durum Wheat.

Marcotuli I, Gadaleta A, Mangini G, Signorile AM, Zacheo SA, Blanco A, Simeone R, Colasuonno P.

Int J Mol Sci. 2017 Jun 21;18(6). pii: E1329. doi: 10.3390/ijms18061329.


Mitochondrial cAMP prevents apoptosis modulating Sirt3 protein level and OPA1 processing in cardiac myoblast cells.

Signorile A, Santeramo A, Tamma G, Pellegrino T, D'Oria S, Lattanzio P, De Rasmo D.

Biochim Biophys Acta Mol Cell Res. 2017 Feb;1864(2):355-366. doi: 10.1016/j.bbamcr.2016.11.022. Epub 2016 Nov 24.


Pharmacological Activation of Protein Phosphatase 2 A (PP2A): A Novel Strategy to Fight Against Human Malignancies?

Carratù MR, Signorile A, De Rasmo D, Reale A, Vacca A.

Curr Med Chem. 2016;23(38):4286-4296. Review.


Major pathogenic mechanisms in vascular dementia: Roles of cellular stress response and hormesis in neuroprotection.

Calabrese V, Giordano J, Signorile A, Laura Ontario M, Castorina S, De Pasquale C, Eckert G, Calabrese EJ.

J Neurosci Res. 2016 Dec;94(12):1588-1603. doi: 10.1002/jnr.23925. Epub 2016 Sep 23. Review.


The polyphenols resveratrol and epigallocatechin-3-gallate restore the severe impairment of mitochondria in hippocampal progenitor cells from a Down syndrome mouse model.

Valenti D, de Bari L, de Rasmo D, Signorile A, Henrion-Caude A, Contestabile A, Vacca RA.

Biochim Biophys Acta. 2016 Jun;1862(6):1093-104. doi: 10.1016/j.bbadis.2016.03.003. Epub 2016 Mar 7.


cAMP regulates the functional activity, coupling efficiency and structural organization of mammalian FOF1 ATP synthase.

De Rasmo D, Micelli L, Santeramo A, Signorile A, Lattanzio P, Papa S.

Biochim Biophys Acta. 2016 Apr;1857(4):350-8. doi: 10.1016/j.bbabio.2016.01.006. Epub 2016 Jan 13.


Impaired enzymatic defensive activity, mitochondrial dysfunction and proteasome activation are involved in RTT cell oxidative damage.

Cervellati C, Sticozzi C, Romani A, Belmonte G, De Rasmo D, Signorile A, Cervellati F, Milanese C, Mastroberardino PG, Pecorelli A, Savelli V, Forman HJ, Hayek J, Valacchi G.

Biochim Biophys Acta. 2015 Oct;1852(10 Pt A):2066-74. doi: 10.1016/j.bbadis.2015.07.014. Epub 2015 Jul 17.


Intramitochondrial adenylyl cyclase controls the turnover of nuclear-encoded subunits and activity of mammalian complex I of the respiratory chain.

De Rasmo D, Signorile A, Santeramo A, Larizza M, Lattanzio P, Capitanio G, Papa S.

Biochim Biophys Acta. 2015 Jan;1853(1):183-91. doi: 10.1016/j.bbamcr.2014.10.016. Epub 2014 Oct 28.


Regulation of the biogenesis of OXPHOS complexes in cell transition from replicating to quiescent state: involvement of PKA and effect of hydroxytyrosol.

Signorile A, Micelli L, De Rasmo D, Santeramo A, Papa F, Ficarella R, Gattoni G, Scacco S, Papa S.

Biochim Biophys Acta. 2014 Apr;1843(4):675-84. doi: 10.1016/j.bbamcr.2013.12.017. Epub 2014 Jan 3.


Epigallocatechin-3-gallate prevents oxidative phosphorylation deficit and promotes mitochondrial biogenesis in human cells from subjects with Down's syndrome.

Valenti D, De Rasmo D, Signorile A, Rossi L, de Bari L, Scala I, Granese B, Papa S, Vacca RA.

Biochim Biophys Acta. 2013 Apr;1832(4):542-52. doi: 10.1016/j.bbadis.2012.12.011. Epub 2013 Jan 2.


Are retinoids a promise for Alzheimer's disease management?

Carratù MR, Marasco C, Signorile A, Scuderi C, Steardo L.

Curr Med Chem. 2012;19(36):6119-25.


Oncogenic K-ras expression is associated with derangement of the cAMP/PKA pathway and forskolin-reversible alterations of mitochondrial dynamics and respiration.

Palorini R, De Rasmo D, Gaviraghi M, Sala Danna L, Signorile A, Cirulli C, Chiaradonna F, Alberghina L, Papa S.

Oncogene. 2013 Jan 17;32(3):352-62. doi: 10.1038/onc.2012.50. Epub 2012 Mar 12.


The oxidative phosphorylation system in mammalian mitochondria.

Papa S, Martino PL, Capitanio G, Gaballo A, De Rasmo D, Signorile A, Petruzzella V.

Adv Exp Med Biol. 2012;942:3-37. doi: 10.1007/978-94-007-2869-1_1. Review.


Activation of the cAMP cascade in human fibroblast cultures rescues the activity of oxidatively damaged complex I.

De Rasmo D, Signorile A, Larizza M, Pacelli C, Cocco T, Papa S.

Free Radic Biol Med. 2012 Feb 15;52(4):757-64. doi: 10.1016/j.freeradbiomed.2011.11.030. Epub 2011 Dec 16.


Respiratory chain complex I, a main regulatory target of the cAMP/PKA pathway is defective in different human diseases.

Papa S, Rasmo DD, Technikova-Dobrova Z, Panelli D, Signorile A, Scacco S, Petruzzella V, Papa F, Palmisano G, Gnoni A, Micelli L, Sardanelli AM.

FEBS Lett. 2012 Mar 9;586(5):568-77. doi: 10.1016/j.febslet.2011.09.019. Epub 2011 Sep 19. Review.


Rat embryo exposure to all-trans retinoic acid results in postnatal oxidative damage of respiratory complex I in the cerebellum.

Signorile A, Sardaro N, De Rasmo D, Scacco S, Papa F, Borracci P, Carratù MR, Papa S.

Mol Pharmacol. 2011 Oct;80(4):704-13. doi: 10.1124/mol.111.073353. Epub 2011 Jul 13.


Mitochondrial defect and PGC-1α dysfunction in parkin-associated familial Parkinson's disease.

Pacelli C, De Rasmo D, Signorile A, Grattagliano I, di Tullio G, D'Orazio A, Nico B, Comi GP, Ronchi D, Ferranini E, Pirolo D, Seibel P, Schubert S, Gaballo A, Villani G, Cocco T.

Biochim Biophys Acta. 2011 Aug;1812(8):1041-53. doi: 10.1016/j.bbadis.2010.12.022. Epub 2011 Jan 5.


T16189C mitochondrial DNA variant is associated with metabolic syndrome in Caucasian subjects.

Palmieri VO, De Rasmo D, Signorile A, Sardanelli AM, Grattagliano I, Minerva F, Cardinale G, Portincasa P, Papa S, Palasciano G.

Nutrition. 2011 Jul-Aug;27(7-8):773-7. doi: 10.1016/j.nut.2010.08.016. Epub 2010 Dec 10.


The β-adrenoceptor agonist isoproterenol promotes the activity of respiratory chain complex I and lowers cellular reactive oxygen species in fibroblasts and heart myoblasts.

De Rasmo D, Gattoni G, Papa F, Santeramo A, Pacelli C, Cocco T, Micelli L, Sardaro N, Larizza M, Scivetti M, Milano S, Signorile A.

Eur J Pharmacol. 2011 Feb 10;652(1-3):15-22. doi: 10.1016/j.ejphar.2010.11.016. Epub 2010 Nov 29.


cAMP/Ca2+ response element-binding protein plays a central role in the biogenesis of respiratory chain proteins in mammalian cells.

De Rasmo D, Signorile A, Papa F, Roca E, Papa S.

IUBMB Life. 2010 Jun;62(6):447-52. doi: 10.1002/iub.342. Review.


cAMP-dependent protein kinase regulates post-translational processing and expression of complex I subunits in mammalian cells.

Papa S, Scacco S, De Rasmo D, Signorile A, Papa F, Panelli D, Nicastro A, Scaringi R, Santeramo A, Roca E, Trentadue R, Larizza M.

Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):649-58. doi: 10.1016/j.bbabio.2010.03.013. Epub 2010 Mar 19.


cAMP response element-binding protein (CREB) is imported into mitochondria and promotes protein synthesis.

De Rasmo D, Signorile A, Roca E, Papa S.

FEBS J. 2009 Aug;276(16):4325-33. doi: 10.1111/j.1742-4658.2009.07133.x. Epub 2009 Jul 15.


Genetic and physical mapping of new EST-derived SSRs on the A and B genome chromosomes of wheat.

Gadaleta A, Giancaspro A, Giove SL, Zacheo S, Mangini G, Simeone R, Signorile A, Blanco A.

Theor Appl Genet. 2009 Mar;118(5):1015-25. doi: 10.1007/s00122-008-0958-1. Epub 2009 Jan 29.


Practical approaches to investigate redox regulation of heat shock protein expression and intracellular glutathione redox state.

Calabrese V, Signorile A, Cornelius C, Mancuso C, Scapagnini G, Ventimiglia B, Ragusa N, Dinkova-Kostova A.

Methods Enzymol. 2008;441:83-110. doi: 10.1016/S0076-6879(08)01206-8.


Mammalian complex I: a regulable and vulnerable pacemaker in mitochondrial respiratory function.

Papa S, De Rasmo D, Scacco S, Signorile A, Technikova-Dobrova Z, Palmisano G, Sardanelli AM, Papa F, Panelli D, Scaringi R, Santeramo A.

Biochim Biophys Acta. 2008 Jul-Aug;1777(7-8):719-28. doi: 10.1016/j.bbabio.2008.04.005. Epub 2008 Apr 11.


Mild gestational hyperglycemia and the metabolic syndrome in later life.

Bo S, Menato G, Botto C, Cotrino I, Bardelli C, Gambino R, Cassader M, Durazzo M, Signorile A, Massobrio M, Pagano G.

Metab Syndr Relat Disord. 2006 Summer;4(2):113-21. doi: 10.1089/met.2006.4.113.


The phosphorylation pattern of bovine heart complex I subunits.

Palmisano G, Sardanelli AM, Signorile A, Papa S, Larsen MR.

Proteomics. 2007 May;7(10):1575-83.


Mutations in structural genes of complex I associated with neurological diseases.

Scacco S, Petruzzella V, Bertini E, Luso A, Papa F, Bellomo F, Signorile A, Torraco A, Papa S.

Ital J Biochem. 2006 Sep-Dec;55(3-4):254-62. Review.


Occurrence of A-kinase anchor protein and associated cAMP-dependent protein kinase in the inner compartment of mammalian mitochondria.

Sardanelli AM, Signorile A, Nuzzi R, Rasmo DD, Technikova-Dobrova Z, Drahota Z, Occhiello A, Pica A, Papa S.

FEBS Lett. 2006 Oct 16;580(24):5690-6. Epub 2006 Sep 18.


cAMP controls oxygen metabolism in mammalian cells.

Piccoli C, Scacco S, Bellomo F, Signorile A, Iuso A, Boffoli D, Scrima R, Capitanio N, Papa S.

FEBS Lett. 2006 Aug 7;580(18):4539-43. Epub 2006 Jul 7.


Regulation by the cAMP cascade of oxygen free radical balance in mammalian cells.

Bellomo F, Piccoli C, Cocco T, Scacco S, Papa F, Gaballo A, Boffoli D, Signorile A, D'Aprile A, Scrima R, Sardanelli AM, Capitanio N, Papa S.

Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):495-502.


C-reactive protein and tumor necrosis factor-alpha in gestational hyperglycemia.

Bo S, Signorile A, Menato G, Gambino R, Bardelli C, Gallo ML, Cassader M, Massobrio M, Pagano GF.

J Endocrinol Invest. 2005 Oct;28(9):779-86.


Comparison of two enzyme immunometric assays to measure tumor necrosis factor-alpha in human serum.

Gambino R, Bo S, Signorile A, Menato G, Pagano G, Cassader M.

Clin Chim Acta. 2006 Feb;364(1-2):349-53. Epub 2005 Sep 8.


Gestational hyperglycemia, zinc, selenium, and antioxidant vitamins.

Bo S, Lezo A, Menato G, Gallo ML, Bardelli C, Signorile A, Berutti C, Massobrio M, Pagano GF.

Nutrition. 2005 Feb;21(2):186-91.


Mild gestational hyperglycemia, the metabolic syndrome and adverse neonatal outcomes.

Bo S, Menato G, Gallo ML, Bardelli C, Lezo A, Signorile A, Gambino R, Cassader M, Massobrio M, Pagano G.

Acta Obstet Gynecol Scand. 2004 Apr;83(4):335-40.


Obesity or diabetes: what is worse for the mother and for the baby?

Bo S, Menato G, Signorile A, Bardelli C, Lezo A, Gallo ML, Gambino R, Cassader M, Massobrio M, Pagano G.

Diabetes Metab. 2003 Apr;29(2 Pt 1):175-8.


Clinical characteristics and outcome of pregnancy in women with gestational hyperglycaemia with and without antibodies to beta-cell antigens.

Bo S, Menato G, Pinach S, Signorile A, Bardelli C, Lezo A, Marchisio B, Gentile L, Cassader M, Massobrio M, Pagano G.

Diabet Med. 2003 Jan;20(1):64-8.


Complex I and the cAMP cascade in human physiopathology.

Papa S, Scacco S, Sardanelli AM, Petruzzella V, Vergari R, Signorile A, Technikova-Dobrova Z.

Biosci Rep. 2002 Feb;22(1):3-16. Review.


Antioxidants, reactive oxygen and nitrogen species, gene induction and mitochondrial function.

Jackson MJ, Papa S, Bolaños J, Bruckdorfer R, Carlsen H, Elliott RM, Flier J, Griffiths HR, Heales S, Holst B, Lorusso M, Lund E, Øivind Moskaug J, Moser U, Di Paola M, Polidori MC, Signorile A, Stahl W, Viña-Ribes J, Astley SB.

Mol Aspects Med. 2002 Feb-Jun;23(1-3):209-85. Review. No abstract available.


Low socioeconomic status as a risk factor for gestational diabetes.

Bo S, Menato G, Bardelli C, Lezo A, Signorile A, Repetti E, Massobrio M, Pagano G.

Diabetes Metab. 2002 Apr;28(2):139-40. No abstract available.


The NADH: ubiquinone oxidoreductase (complex I) of the mammalian respiratory chain and the cAMP cascade.

Papa S, Sardanelli AM, Scacco S, Petruzzella V, Technikova-Dobrova Z, Vergari R, Signorile A.

J Bioenerg Biomembr. 2002 Feb;34(1):1-10. Review.


Serine (threonine) phosphatase(s) acting on cAMP-dependent phosphoproteins in mammalian mitochondria.

Signorile A, Sardanelli AM, Nuzzi R, Papa S.

FEBS Lett. 2002 Feb 13;512(1-3):91-4.

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