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Clin Chem. 2019 Jan;65(1):67-73. doi: 10.1373/clinchem.2018.294538. Epub 2018 Nov 20.

Identifying and Eliminating Laboratory Contamination by Topical Testosterone Therapeutics.

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ARUP Laboratories, Salt Lake City, UT;
Department of Pathology, University of Utah, Salt Lake City, UT.
ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT.
ARUP Laboratories, Salt Lake City, UT.


Many prescription and over-the-counter drugs are available as topical formulations. Contamination of clinical laboratory workspaces by topical drugs may increase the risk of potential interference with diagnostic testing. An example of localized workspace contamination attributed to a topical hormonal drug (testosterone, T) is presented to highlight significant challenges in identifying and resolving this potential problem. Investigation included precision studies, instrument service and parts replacement, instrument replacement, airflow analysis, environmental dust sampling, and the development of customized methods for workspace monitoring and cleaning. Laboratory policies and procedures were also revised to minimize future risk.

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