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Items: 1 to 50 of 108

1.

A pre-existing population of ZEB2+ quiescent cells with stemness and mesenchymal features dictate chemoresistance in colorectal cancer.

Francescangeli F, Contavalli P, De Angelis ML, Careccia S, Signore M, Haas TL, Salaris F, Baiocchi M, Boe A, Giuliani A, Tcheremenskaia O, Pagliuca A, Guardiola O, Minchiotti G, Colace L, Ciardi A, D'Andrea V, La Torre F, Medema J, De Maria R, Zeuner A.

J Exp Clin Cancer Res. 2020 Jan 8;39(1):2. doi: 10.1186/s13046-019-1505-4.

2.

Fabrication and characterization of AlN-based flexible piezoelectric pressure sensor integrated into an implantable artificial pancreas.

Signore MA, Rescio G, De Pascali C, Iacovacci V, Dario P, Leone A, Quaranta F, Taurino A, Siciliano P, Francioso L.

Sci Rep. 2019 Nov 20;9(1):17130. doi: 10.1038/s41598-019-53713-1.

3.

Multiwalled Carbon Nanotubes and the Electrocatalytic Activity of Gluconobacter oxydans as the Basis of a Biosensor.

Plekhanova Y, Tarasov S, Bykov A, Prisyazhnaya N, Kolesov V, Sigaev V, Signore MA, Reshetilov A.

Biosensors (Basel). 2019 Nov 14;9(4). pii: E137. doi: 10.3390/bios9040137.

4.

A new bioavailable fenretinide formulation with antiproliferative, antimetabolic, and cytotoxic effects on solid tumors.

Orienti I, Francescangeli F, De Angelis ML, Fecchi K, Bongiorno-Borbone L, Signore M, Peschiaroli A, Boe A, Bruselles A, Costantino A, Eramo A, Salvati V, Sette G, Contavalli P, Zolla L, Oki T, Kitamura T, Spada M, Giuliani A, Baiocchi M, La Torre F, Melino G, Tartaglia M, De Maria R, Zeuner A.

Cell Death Dis. 2019 Jul 23;10(7):529. doi: 10.1038/s41419-019-1775-y.

5.

The kinase inhibitor SI113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells.

Matteoni S, Abbruzzese C, Matarrese P, De Luca G, Mileo AM, Miccadei S, Schenone S, Musumeci F, Haas TL, Sette G, Carapella CM, Amato R, Perrotti N, Signore M, Paggi MG.

J Exp Clin Cancer Res. 2019 May 17;38(1):202. doi: 10.1186/s13046-019-1212-1.

6.

Organoids as a new model for improving regenerative medicine and cancer personalized therapy in renal diseases.

Grassi L, Alfonsi R, Francescangeli F, Signore M, De Angelis ML, Addario A, Costantini M, Flex E, Ciolfi A, Pizzi S, Bruselles A, Pallocca M, Simone G, Haoui M, Falchi M, Milella M, Sentinelli S, Di Matteo P, Stellacci E, Gallucci M, Muto G, Tartaglia M, De Maria R, Bonci D.

Cell Death Dis. 2019 Feb 27;10(3):201. doi: 10.1038/s41419-019-1453-0.

7.

Effects of Polymer Matrices and Carbon Nanotubes on the Generation of Electric Energy in a Microbial Fuel Cell.

Plekhanova Y, Tarasov S, Kolesov V, Kuznetsova I, Signore M, Quaranta F, Reshetilov A.

Membranes (Basel). 2018 Oct 25;8(4). pii: E99. doi: 10.3390/membranes8040099.

8.

Renal cancer: new models and approach for personalizing therapy.

di Martino S, De Luca G, Grassi L, Federici G, Alfonsi R, Signore M, Addario A, De Salvo L, Francescangeli F, Sanchez M, Tirelli V, Muto G, Sperduti I, Sentinelli S, Costantini M, Pasquini L, Milella M, Haoui M, Simone G, Gallucci M, De Maria R, Bonci D.

J Exp Clin Cancer Res. 2018 Sep 5;37(1):217. doi: 10.1186/s13046-018-0874-4.

9.

Author Correction: P53 and mTOR signalling determine fitness selection through cell competition during early mouse embryonic development.

Bowling S, Di Gregorio A, Sancho M, Pozzi S, Aarts M, Signore M, Schneider MD, Martinez-Barbera JP, Gil J, Rodríguez TA.

Nat Commun. 2018 Aug 2;9(1):3123. doi: 10.1038/s41467-018-05718-z.

10.

P53 and mTOR signalling determine fitness selection through cell competition during early mouse embryonic development.

Bowling S, Di Gregorio A, Sancho M, Pozzi S, Aarts M, Signore M, D Schneider M, Martinez-Barbera JP, Gil J, Rodríguez TA.

Nat Commun. 2018 May 2;9(1):1763. doi: 10.1038/s41467-018-04167-y. Erratum in: Nat Commun. 2018 Aug 2;9(1):3123.

11.

Mice lacking Kcns1 in peripheral neurons show increased basal and neuropathic pain sensitivity.

Tsantoulas C, Denk F, Signore M, Nassar MA, Futai K, McMahon SB.

Pain. 2018 Aug;159(8):1641-1651. doi: 10.1097/j.pain.0000000000001255.

12.

The Double Face of Exosome-Carried MicroRNAs in Cancer Immunomodulation.

Alfonsi R, Grassi L, Signore M, Bonci D.

Int J Mol Sci. 2018 Apr 13;19(4). pii: E1183. doi: 10.3390/ijms19041183. Review.

13.

Effect of miR-204&211 and RUNX2 control on the fate of human mesenchymal stromal cells.

Sacchetti B, Fatica A, Sorci M, Sorrentino A, Signore M, Cerio A, Felicetti F, Feo A, Pelosi E, Caré A, Pescarmona E, Gordeladze JO, Valtieri M.

Regen Med Res. 2017;5:2. doi: 10.1051/rmr/170004. Epub 2017 Dec 5.

14.

Drug repurposing for the treatment of glioblastoma multiforme.

Abbruzzese C, Matteoni S, Signore M, Cardone L, Nath K, Glickson JD, Paggi MG.

J Exp Clin Cancer Res. 2017 Nov 28;36(1):169. doi: 10.1186/s13046-017-0642-x. Review.

15.

Integrin α7 Is a Functional Marker and Potential Therapeutic Target in Glioblastoma.

Haas TL, Sciuto MR, Brunetto L, Valvo C, Signore M, Fiori ME, di Martino S, Giannetti S, Morgante L, Boe A, Patrizii M, Warnken U, Schnölzer M, Ciolfi A, Di Stefano C, Biffoni M, Ricci-Vitiani L, Pallini R, De Maria R.

Cell Stem Cell. 2017 Jul 6;21(1):35-50.e9. doi: 10.1016/j.stem.2017.04.009. Epub 2017 Jun 9.

16.

Proteomic analysis of cerebrospinal fluid from children with central nervous system tumors identifies candidate proteins relating to tumor metastatic spread.

Spreafico F, Bongarzone I, Pizzamiglio S, Magni R, Taverna E, De Bortoli M, Ciniselli CM, Barzanò E, Biassoni V, Luchini A, Liotta LA, Zhou W, Signore M, Verderio P, Massimino M.

Oncotarget. 2017 Jul 11;8(28):46177-46190. doi: 10.18632/oncotarget.17579.

17.

Antibody Validation by Western Blotting.

Signore M, Manganelli V, Hodge A.

Methods Mol Biol. 2017;1606:51-70. doi: 10.1007/978-1-4939-6990-6_4.

PMID:
28501993
18.

CHK1-targeted therapy to deplete DNA replication-stressed, p53-deficient, hyperdiploid colorectal cancer stem cells.

Manic G, Signore M, Sistigu A, Russo G, Corradi F, Siteni S, Musella M, Vitale S, De Angelis ML, Pallocca M, Amoreo CA, Sperati F, Di Franco S, Barresi S, Policicchio E, De Luca G, De Nicola F, Mottolese M, Zeuner A, Fanciulli M, Stassi G, Maugeri-Saccà M, Baiocchi M, Tartaglia M, Vitale I, De Maria R.

Gut. 2018 May;67(5):903-917. doi: 10.1136/gutjnl-2016-312623. Epub 2017 Apr 7.

19.

Gut Mesenchymal Stromal Cells in Immunity.

Messina V, Buccione C, Marotta G, Ziccheddu G, Signore M, Mattia G, Puglisi R, Sacchetti B, Biancone L, Valtieri M.

Stem Cells Int. 2017;2017:8482326. doi: 10.1155/2017/8482326. Epub 2017 Feb 28. Review.

20.

Expression of Iron-Related Proteins Differentiate Non-Cancerous and Cancerous Breast Tumors.

Pizzamiglio S, De Bortoli M, Taverna E, Signore M, Veneroni S, Cho WC, Orlandi R, Verderio P, Bongarzone I.

Int J Mol Sci. 2017 Feb 14;18(2). pii: E410. doi: 10.3390/ijms18020410.

21.

The clinical value of patient-derived glioblastoma tumorspheres in predicting treatment response.

D'Alessandris QG, Biffoni M, Martini M, Runci D, Buccarelli M, Cenci T, Signore M, Stancato L, Olivi A, De Maria R, Larocca LM, Ricci-Vitiani L, Pallini R.

Neuro Oncol. 2017 Aug 1;19(8):1097-1108. doi: 10.1093/neuonc/now304.

22.

C-Met/miR-130b axis as novel mechanism and biomarker for castration resistance state acquisition.

Cannistraci A, Federici G, Addario A, Di Pace AL, Grassi L, Muto G, Collura D, Signore M, De Salvo L, Sentinelli S, Simone G, Costantini M, Nanni S, Farsetti A, Coppola V, De Maria R, Bonci D.

Oncogene. 2017 Jun 29;36(26):3718-3728. doi: 10.1038/onc.2016.505. Epub 2017 Feb 13.

PMID:
28192399
23.

Prospective, Randomized Clinical Trial of Povidone-Iodine 1.25% Solution Versus Topical Antibiotics for Treatment of Bacterial Keratitis.

Isenberg SJ, Apt L, Valenton M, Sharma S, Garg P, Thomas PA, Parmar P, Kaliamurthy J, Reyes JM, Ong D, Christenson PD, Del Signore M, Holland GN.

Am J Ophthalmol. 2017 Apr;176:244-253. doi: 10.1016/j.ajo.2016.10.004. Epub 2016 Oct 27.

PMID:
27984024
24.

Exosomes from human colorectal cancer induce a tumor-like behavior in colonic mesenchymal stromal cells.

Lugini L, Valtieri M, Federici C, Cecchetti S, Meschini S, Condello M, Signore M, Fais S.

Oncotarget. 2016 Aug 2;7(31):50086-50098. doi: 10.18632/oncotarget.10574.

25.

UCN-01 enhances cytotoxicity of irinotecan in colorectal cancer stem-like cells by impairing DNA damage response.

Signore M, Buccarelli M, Pilozzi E, De Luca G, Cappellari M, Fanciulli M, Goeman F, Melucci E, Biffoni M, Ricci-Vitiani L.

Oncotarget. 2016 Jul 12;7(28):44113-44128. doi: 10.18632/oncotarget.9859.

26.

Cancer Stem Cell-Based Models of Colorectal Cancer Reveal Molecular Determinants of Therapy Resistance.

De Angelis ML, Zeuner A, Policicchio E, Russo G, Bruselles A, Signore M, Vitale S, De Luca G, Pilozzi E, Boe A, Stassi G, Ricci-Vitiani L, Amoreo CA, Pagliuca A, Francescangeli F, Tartaglia M, De Maria R, Baiocchi M.

Stem Cells Transl Med. 2016 Apr;5(4):511-23. doi: 10.5966/sctm.2015-0214. Epub 2016 Mar 8.

27.

Metabolic/Proteomic Signature Defines Two Glioblastoma Subtypes With Different Clinical Outcome.

Marziali G, Signore M, Buccarelli M, Grande S, Palma A, Biffoni M, Rosi A, D'Alessandris QG, Martini M, Larocca LM, De Maria R, Pallini R, Ricci-Vitiani L.

Sci Rep. 2016 Feb 9;6:21557. doi: 10.1038/srep21557.

28.

Transcription factor 7-like 1 is involved in hypothalamo-pituitary axis development in mice and humans.

Gaston-Massuet C, McCabe MJ, Scagliotti V, Young RM, Carreno G, Gregory LC, Jayakody SA, Pozzi S, Gualtieri A, Basu B, Koniordou M, Wu CI, Bancalari RE, Rahikkala E, Veijola R, Lopponen T, Graziola F, Turton J, Signore M, Mousavy Gharavy SN, Charolidi N, Sokol SY, Andoniadou CL, Wilson SW, Merrill BJ, Dattani MT, Martinez-Barbera JP.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):E548-57. doi: 10.1073/pnas.1503346113. Epub 2016 Jan 13.

29.

Tamoxifen induces cellular stress in the nervous system by inhibiting cholesterol synthesis.

Denk F, Ramer LM, Erskine EL, Nassar MA, Bogdanov Y, Signore M, Wood JN, McMahon SB, Ramer MS.

Acta Neuropathol Commun. 2015 Nov 26;3:74. doi: 10.1186/s40478-015-0255-6.

30.

A simple and predictive phenotypic High Content Imaging assay for Plasmodium falciparum mature gametocytes to identify malaria transmission blocking compounds.

Lucantoni L, Silvestrini F, Signore M, Siciliano G, Eldering M, Dechering KJ, Avery VM, Alano P.

Sci Rep. 2015 Nov 10;5:16414. doi: 10.1038/srep16414.

31.

Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1.

Vacchelli E, Ma Y, Baracco EE, Sistigu A, Enot DP, Pietrocola F, Yang H, Adjemian S, Chaba K, Semeraro M, Signore M, De Ninno A, Lucarini V, Peschiaroli F, Businaro L, Gerardino A, Manic G, Ulas T, Günther P, Schultze JL, Kepp O, Stoll G, Lefebvre C, Mulot C, Castoldi F, Rusakiewicz S, Ladoire S, Apetoh L, Bravo-San Pedro JM, Lucattelli M, Delarasse C, Boige V, Ducreux M, Delaloge S, Borg C, André F, Schiavoni G, Vitale I, Laurent-Puig P, Mattei F, Zitvogel L, Kroemer G.

Science. 2015 Nov 20;350(6263):972-8. doi: 10.1126/science.aad0779. Epub 2015 Oct 29.

32.

Altered Traffic of Cardiolipin during Apoptosis: Exposure on the Cell Surface as a Trigger for "Antiphospholipid Antibodies".

Manganelli V, Capozzi A, Recalchi S, Signore M, Mattei V, Garofalo T, Misasi R, Degli Esposti M, Sorice M.

J Immunol Res. 2015;2015:847985. doi: 10.1155/2015/847985. Epub 2015 Sep 29. Review.

33.

miR-135b suppresses tumorigenesis in glioblastoma stem-like cells impairing proliferation, migration and self-renewal.

Lulli V, Buccarelli M, Martini M, Signore M, Biffoni M, Giannetti S, Morgante L, Marziali G, Ilari R, Pagliuca A, Larocca LM, De Maria R, Pallini R, Ricci-Vitiani L.

Oncotarget. 2015 Nov 10;6(35):37241-56. doi: 10.18632/oncotarget.5925.

34.

Combined PDK1 and CHK1 inhibition is required to kill glioblastoma stem-like cells in vitro and in vivo.

Signore M, Pelacchi F, di Martino S, Runci D, Biffoni M, Giannetti S, Morgante L, De Majo M, Petricoin EF, Stancato L, Larocca LM, De Maria R, Pallini R, Ricci-Vitiani L.

Cell Death Dis. 2014 May 8;5:e1223. doi: 10.1038/cddis.2014.188.

35.

Gene expression analysis of PTEN positive glioblastoma stem cells identifies DUB3 and Wee1 modulation in a cell differentiation model.

Forte S, Pagliuca A, Maniscalchi ET, Gulino R, Calabrese G, Ricci-Vitiani L, Pallini R, Signore M, Parenti R, De Maria R, Gulisano M.

PLoS One. 2013 Dec 12;8(12):e81432. doi: 10.1371/journal.pone.0081432. eCollection 2013.

36.

Pharmacological enhancement of mGlu1 metabotropic glutamate receptors causes a prolonged symptomatic benefit in a mouse model of spinocerebellar ataxia type 1.

Notartomaso S, Zappulla C, Biagioni F, Cannella M, Bucci D, Mascio G, Scarselli P, Fazio F, Weisz F, Lionetto L, Simmaco M, Gradini R, Battaglia G, Signore M, Puliti A, Nicoletti F.

Mol Brain. 2013 Nov 19;6:48. doi: 10.1186/1756-6606-6-48.

37.

Approaching the increasing complexity of non-small cell lung cancer taxonomy.

Maugeri-Sacca M, Bartucci M, Pagliuca A, Patrizii M, Signore M, De Maria R.

Curr Pharm Des. 2014;20(24):3973-81. Review.

PMID:
24138717
38.

Sox2(+) stem/progenitor cells in the adult mouse pituitary support organ homeostasis and have tumor-inducing potential.

Andoniadou CL, Matsushima D, Mousavy Gharavy SN, Signore M, Mackintosh AI, Schaeffer M, Gaston-Massuet C, Mollard P, Jacques TS, Le Tissier P, Dattani MT, Pevny LH, Martinez-Barbera JP.

Cell Stem Cell. 2013 Oct 3;13(4):433-45. doi: 10.1016/j.stem.2013.07.004.

39.

Cancer quasispecies and stem-like adaptive aneuploidy.

Napoletani D, Signore M, Struppa DC.

F1000Res. 2013 Dec 6;2:268. doi: 10.12688/f1000research.2-268.v1. eCollection 2013.

40.

EGFR inhibition abrogates leiomyosarcoma cell chemoresistance through inactivation of survival pathways and impairment of CSC potential.

Sette G, Salvati V, Memeo L, Fecchi K, Colarossi C, Di Matteo P, Signore M, Biffoni M, D'Andrea V, De Antoni E, Canzonieri V, De Maria R, Eramo A.

PLoS One. 2012;7(10):e46891. doi: 10.1371/journal.pone.0046891. Epub 2012 Oct 8.

41.

SOX2 regulates the hypothalamic-pituitary axis at multiple levels.

Jayakody SA, Andoniadou CL, Gaston-Massuet C, Signore M, Cariboni A, Bouloux PM, Le Tissier P, Pevny LH, Dattani MT, Martinez-Barbera JP.

J Clin Invest. 2012 Oct;122(10):3635-46. doi: 10.1172/JCI64311. Epub 2012 Sep 4.

42.

Proliferation state and polo-like kinase1 dependence of tumorigenic colon cancer cells.

Francescangeli F, Patrizii M, Signore M, Federici G, Di Franco S, Pagliuca A, Baiocchi M, Biffoni M, Ricci Vitiani L, Todaro M, De Maria R, Zeuner A.

Stem Cells. 2012 Sep;30(9):1819-30. doi: 10.1002/stem.1163.

43.

Platinum-gold nanoclusters as catalyst for direct methanol fuel cells.

Giorgi L, Giorgi R, Gagliardi S, Serra E, Alvisi M, Signore MA, Piscopiello E.

J Nanosci Nanotechnol. 2011 Oct;11(10):8804-11.

PMID:
22400263
44.

Identity and ranking of colonic mesenchymal stromal cells.

Signore M, Cerio AM, Boe A, Pagliuca A, Zaottini V, Schiavoni I, Fedele G, Petti S, Navarra S, Ausiello CM, Pelosi E, Fatica A, Sorrentino A, Valtieri M.

J Cell Physiol. 2012 Sep;227(9):3291-300. doi: 10.1002/jcp.24027.

PMID:
22170005
45.

Therapeutic targeting of Chk1 in NSCLC stem cells during chemotherapy.

Bartucci M, Svensson S, Romania P, Dattilo R, Patrizii M, Signore M, Navarra S, Lotti F, Biffoni M, Pilozzi E, Duranti E, Martinelli S, Rinaldo C, Zeuner A, Maugeri-Saccà M, Eramo A, De Maria R.

Cell Death Differ. 2012 May;19(5):768-78. doi: 10.1038/cdd.2011.170. Epub 2011 Nov 25.

46.

Antibody validation by Western blotting.

Signore M, Reeder KA.

Methods Mol Biol. 2012;823:139-55. doi: 10.1007/978-1-60327-216-2_10.

PMID:
22081344
47.

HESX1- and TCF3-mediated repression of Wnt/β-catenin targets is required for normal development of the anterior forebrain.

Andoniadou CL, Signore M, Young RM, Gaston-Massuet C, Wilson SW, Fuchs E, Martinez-Barbera JP.

Development. 2011 Nov;138(22):4931-42. doi: 10.1242/dev.066597. Epub 2011 Oct 17.

48.

Novel FGF8 mutations associated with recessive holoprosencephaly, craniofacial defects, and hypothalamo-pituitary dysfunction.

McCabe MJ, Gaston-Massuet C, Tziaferi V, Gregory LC, Alatzoglou KS, Signore M, Puelles E, Gerrelli D, Farooqi IS, Raza J, Walker J, Kavanaugh SI, Tsai PS, Pitteloud N, Martinez-Barbera JP, Dattani MT.

J Clin Endocrinol Metab. 2011 Oct;96(10):E1709-18. doi: 10.1210/jc.2011-0454. Epub 2011 Aug 10.

49.

Increased Wingless (Wnt) signaling in pituitary progenitor/stem cells gives rise to pituitary tumors in mice and humans.

Gaston-Massuet C, Andoniadou CL, Signore M, Jayakody SA, Charolidi N, Kyeyune R, Vernay B, Jacques TS, Taketo MM, Le Tissier P, Dattani MT, Martinez-Barbera JP.

Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11482-7. doi: 10.1073/pnas.1101553108. Epub 2011 Jun 2.

50.

Propranolol enhances cell cycle-related gene expression in pressure overloaded hearts.

Musumeci M, Maccari S, Sestili P, Signore M, Molinari P, Ambrosio C, Stati T, Colledge WH, Grace AA, Catalano L, Marano G.

Br J Pharmacol. 2011 Dec;164(8):1917-28. doi: 10.1111/j.1476-5381.2011.01504.x.

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