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Items: 1 to 50 of 271

1.

PPARγ and RhoBTB1 in hypertension.

Fang S, Sigmund CD.

Curr Opin Nephrol Hypertens. 2019 Nov 27. doi: 10.1097/MNH.0000000000000579. [Epub ahead of print]

PMID:
31789920
2.

Cul3 regulates cyclin E1 protein abundance via a degron located within the N-terminal region of cyclin E.

Davidge B, Rebola KGO, Agbor LN, Sigmund CD, Singer JD.

J Cell Sci. 2019 Nov 6;132(21). pii: jcs233049. doi: 10.1242/jcs.233049.

PMID:
31636116
3.

Conditional deletion of smooth muscle Cullin-3 causes severe progressive hypertension.

Agbor LN, Nair AR, Wu J, Lu KT, Davis DR, Keen HL, Quelle FW, McCormick JA, Singer JD, Sigmund CD.

JCI Insight. 2019 Jun 11;5. pii: 129793. doi: 10.1172/jci.insight.129793.

4.

Endothelial PPARγ (Peroxisome Proliferator-Activated Receptor-γ) Protects From Angiotensin II-Induced Endothelial Dysfunction in Adult Offspring Born From Pregnancies Complicated by Hypertension.

Nair AR, Silva SD Jr, Agbor LN, Wu J, Nakagawa P, Mukohda M, Lu KT, Sandgren JA, Pierce GL, Santillan MK, Grobe JL, Sigmund CD.

Hypertension. 2019 Jul;74(1):173-183. doi: 10.1161/HYPERTENSIONAHA.119.13101. Epub 2019 May 20.

PMID:
31104564
5.

RhoBTB1 protects against hypertension and arterial stiffness by restraining phosphodiesterase 5 activity.

Mukohda M, Fang S, Wu J, Agbor LN, Nair AR, Ibeawuchi SC, Hu C, Liu X, Lu KT, Guo DF, Davis DR, Keen HL, Quelle FW, Sigmund CD.

J Clin Invest. 2019 Mar 21;129(6):2318-2332. doi: 10.1172/JCI123462.

6.

Interference With Endothelial PPAR (Peroxisome Proliferator-Activated Receptor)-γ Causes Accelerated Cerebral Vascular Dysfunction in Response to Endogenous Renin-Angiotensin System Activation.

Nair AR, Agbor LN, Mukohda M, Liu X, Hu C, Wu J, Sigmund CD.

Hypertension. 2018 Nov;72(5):1227-1235. doi: 10.1161/HYPERTENSIONAHA.118.11857.

7.

Revised guidelines to enhance the rigor and reproducibility of research published in American Physiological Society journals.

Yosten GLC, Adams JC, Bennett CN, Bunnett NW, Scheman R, Sigmund CD, Yates BJ, Zucker IH, Samson WK.

Am J Physiol Regul Integr Comp Physiol. 2018 Dec 1;315(6):R1251-R1253. doi: 10.1152/ajpregu.00274.2018. Epub 2018 Oct 17. No abstract available.

8.

Arginine vasopressin infusion is sufficient to model clinical features of preeclampsia in mice.

Sandgren JA, Deng G, Linggonegoro DW, Scroggins SM, Perschbacher KJ, Nair AR, Nishimura TE, Zhang SY, Agbor LN, Wu J, Keen HL, Naber MC, Pearson NA, Zimmerman KA, Weiss RM, Bowdler NC, Usachev YM, Santillan DA, Potthoff MJ, Pierce GL, Gibson-Corley KN, Sigmund CD, Santillan MK, Grobe JL.

JCI Insight. 2018 Oct 4;3(19). pii: 99403. doi: 10.1172/jci.insight.99403.

9.

Dual gain and loss of cullin 3 function mediates familial hyperkalemic hypertension.

Cornelius RJ, Zhang C, Erspamer KJ, Agbor LN, Sigmund CD, Singer JD, Yang CL, Ellison DH.

Am J Physiol Renal Physiol. 2018 Oct 1;315(4):F1006-F1018. doi: 10.1152/ajprenal.00602.2017. Epub 2018 Jun 13.

10.

Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology.

Forrester SJ, Booz GW, Sigmund CD, Coffman TM, Kawai T, Rizzo V, Scalia R, Eguchi S.

Physiol Rev. 2018 Jul 1;98(3):1627-1738. doi: 10.1152/physrev.00038.2017. Review.

11.

Endothelial PPARγ (Peroxisome Proliferator-Activated Receptor-γ) Is Essential for Preventing Endothelial Dysfunction With Aging.

De Silva TM, Li Y, Kinzenbaw DA, Sigmund CD, Faraci FM.

Hypertension. 2018 Jul;72(1):227-234. doi: 10.1161/HYPERTENSIONAHA.117.10799. Epub 2018 May 7.

12.

Elevated vasopressin in pregnant mice induces T-helper subset alterations consistent with human preeclampsia.

Scroggins SM, Santillan DA, Lund JM, Sandgren JA, Krotz LK, Hamilton WS, Devor EJ, Davis HA, Pierce GL, Gibson-Corley KN, Sigmund CD, Grobe JL, Santillan MK.

Clin Sci (Lond). 2018 Feb 14;132(3):419-436. doi: 10.1042/CS20171059. Print 2018 Feb 14.

13.

Angiotensin AT1A receptors expressed in vasopressin-producing cells of the supraoptic nucleus contribute to osmotic control of vasopressin.

Sandgren JA, Linggonegoro DW, Zhang SY, Sapouckey SA, Claflin KE, Pearson NA, Leidinger MR, Pierce GL, Santillan MK, Gibson-Corley KN, Sigmund CD, Grobe JL.

Am J Physiol Regul Integr Comp Physiol. 2018 Jun 1;314(6):R770-R780. doi: 10.1152/ajpregu.00435.2017. Epub 2018 Jan 24.

14.

Overexpression of the neuronal human (pro)renin receptor mediates angiotensin II-independent blood pressure regulation in the central nervous system.

Peng H, Jensen DD, Li W, Sullivan MN, Buller SA, Worker CJ, Cooper SG, Zheng S, Earley S, Sigmund CD, Feng Y.

Am J Physiol Heart Circ Physiol. 2018 Mar 1;314(3):H580-H592. doi: 10.1152/ajpheart.00310.2017. Epub 2017 Dec 15.

15.

Mutant Cullin 3 causes familial hyperkalemic hypertension via dominant effects.

Ferdaus MZ, Miller LN, Agbor LN, Saritas T, Singer JD, Sigmund CD, McCormick JA.

JCI Insight. 2017 Dec 21;2(24). pii: 96700. doi: 10.1172/jci.insight.96700.

16.

Potential mechanisms of hypothalamic renin-angiotensin system activation by leptin and DOCA-salt for the control of resting metabolism.

Sapouckey SA, Deng G, Sigmund CD, Grobe JL.

Physiol Genomics. 2017 Dec 1;49(12):722-732. doi: 10.1152/physiolgenomics.00087.2017. Epub 2017 Oct 6. Review.

17.

PPARγ and retinol binding protein 7 form a regulatory hub promoting antioxidant properties of the endothelium.

Woll AW, Quelle FW, Sigmund CD.

Physiol Genomics. 2017 Nov 1;49(11):653-658. doi: 10.1152/physiolgenomics.00055.2017. Epub 2017 Sep 15. Review.

18.

Selective Deletion of Renin-b in the Brain Alters Drinking and Metabolism.

Shinohara K, Nakagawa P, Gomez J, Morgan DA, Littlejohn NK, Folchert MD, Weidemann BJ, Liu X, Walsh SA, Ponto LL, Rahmouni K, Grobe JL, Sigmund CD.

Hypertension. 2017 Nov;70(5):990-997. doi: 10.1161/HYPERTENSIONAHA.117.09923. Epub 2017 Sep 5.

19.

Genetic Interference With Endothelial PPAR-γ (Peroxisome Proliferator-Activated Receptor-γ) Augments Effects of Angiotensin II While Impairing Responses to Angiotensin 1-7.

De Silva TM, Hu C, Kinzenbaw DA, Modrick ML, Sigmund CD, Faraci FM.

Hypertension. 2017 Sep;70(3):559-565. doi: 10.1161/HYPERTENSIONAHA.117.09358. Epub 2017 Jul 3.

20.

How Is the Brain Renin-Angiotensin System Regulated?

Nakagawa P, Sigmund CD.

Hypertension. 2017 Jul;70(1):10-18. doi: 10.1161/HYPERTENSIONAHA.117.08550. Epub 2017 May 30. Review. No abstract available.

21.

Hypertension-Causing Mutation in Peroxisome Proliferator-Activated Receptor γ Impairs Nuclear Export of Nuclear Factor-κB p65 in Vascular Smooth Muscle.

Mukohda M, Lu KT, Guo DF, Wu J, Keen HL, Liu X, Ketsawatsomkron P, Stump M, Rahmouni K, Quelle FW, Sigmund CD.

Hypertension. 2017 Jul;70(1):174-182. doi: 10.1161/HYPERTENSIONAHA.117.09276. Epub 2017 May 15.

22.

Evidence for intraventricular secretion of angiotensinogen and angiotensin by the subfornical organ using transgenic mice.

Agassandian K, Grobe JL, Liu X, Agassandian M, Thompson AP, Sigmund CD, Cassell MD.

Am J Physiol Regul Integr Comp Physiol. 2017 Jun 1;312(6):R973-R981. doi: 10.1152/ajpregu.00511.2016. Epub 2017 May 10.

23.

No Brain Renin-Angiotensin System: Déjà vu All Over Again?

Sigmund CD, Diz DI, Chappell MC.

Hypertension. 2017 Jun;69(6):1007-1010. doi: 10.1161/HYPERTENSIONAHA.117.09167. Epub 2017 Apr 10. No abstract available.

24.

Retinol-binding protein 7 is an endothelium-specific PPARγ cofactor mediating an antioxidant response through adiponectin.

Hu C, Keen HL, Lu KT, Liu X, Wu J, Davis DR, Ibeawuchi SC, Vogel S, Quelle FW, Sigmund CD.

JCI Insight. 2017 Mar 23;2(6):e91738. doi: 10.1172/jci.insight.91738.

25.

Microarray Analysis of Hypertension.

Keen HL, Sigmund CD.

Methods Mol Biol. 2017;1527:41-52. doi: 10.1007/978-1-4939-6625-7_3. Review.

PMID:
28116705
26.

Cullin-3 mutation causes arterial stiffness and hypertension through a vascular smooth muscle mechanism.

Agbor LN, Ibeawuchi SC, Hu C, Wu J, Davis DR, Keen HL, Quelle FW, Sigmund CD.

JCI Insight. 2016 Nov 17;1(19):e91015. doi: 10.1172/jci.insight.91015.

27.

Nervous System Expression of PPARγ and Mutant PPARγ Has Profound Effects on Metabolic Regulation and Brain Development.

Stump M, Guo DF, Lu KT, Mukohda M, Cassell MD, Norris AW, Rahmouni K, Sigmund CD.

Endocrinology. 2016 Nov;157(11):4266-4275. Epub 2016 Aug 30.

28.

Selective Deletion of the Brain-Specific Isoform of Renin Causes Neurogenic Hypertension.

Shinohara K, Liu X, Morgan DA, Davis DR, Sequeira-Lopez ML, Cassell MD, Grobe JL, Rahmouni K, Sigmund CD.

Hypertension. 2016 Dec;68(6):1385-1392. Epub 2016 Oct 17.

29.

Role of CaMKII in Ang-II-dependent small artery remodeling.

Prasad AM, Ketsawatsomkron P, Nuno DW, Koval OM, Dibbern ME, Venema AN, Sigmund CD, Lamping KG, Grumbach IM.

Vascul Pharmacol. 2016 Dec;87:172-179. doi: 10.1016/j.vph.2016.09.007. Epub 2016 Sep 20.

30.

Suppression of Resting Metabolism by the Angiotensin AT2 Receptor.

Littlejohn NK, Keen HL, Weidemann BJ, Claflin KE, Tobin KV, Markan KR, Park S, Naber MC, Gourronc FA, Pearson NA, Liu X, Morgan DA, Klingelhutz AJ, Potthoff MJ, Rahmouni K, Sigmund CD, Grobe JL.

Cell Rep. 2016 Aug 9;16(6):1548-1560. doi: 10.1016/j.celrep.2016.07.003. Epub 2016 Jul 28.

31.

Collecting Duct Renin Does Not Mediate DOCA-Salt Hypertension or Renal Injury.

Song K, Stuart D, Abraham N, Wang F, Wang S, Yang T, Sigmund CD, Kohan DE, Ramkumar N.

PLoS One. 2016 Jul 28;11(7):e0159872. doi: 10.1371/journal.pone.0159872. eCollection 2016.

32.

mTORC1 Signaling Contributes to Drinking But Not Blood Pressure Responses to Brain Angiotensin II.

Muta K, Morgan DA, Grobe JL, Sigmund CD, Rahmouni K.

Endocrinology. 2016 Aug;157(8):3140-8. doi: 10.1210/en.2016-1243. Epub 2016 Jun 2.

33.

Effect of selective expression of dominant-negative PPARγ in pro-opiomelanocortin neurons on the control of energy balance.

Stump M, Guo DF, Lu KT, Mukohda M, Liu X, Rahmouni K, Sigmund CD.

Physiol Genomics. 2016 Jul 1;48(7):491-501. doi: 10.1152/physiolgenomics.00032.2016. Epub 2016 May 13.

34.

Estrogen Receptor α Is Required for Maintaining Baseline Renin Expression.

Lu KT, Keen HL, Weatherford ET, Sequeira-Lopez ML, Gomez RA, Sigmund CD.

Hypertension. 2016 May;67(5):992-9. doi: 10.1161/HYPERTENSIONAHA.115.07082. Epub 2016 Feb 29.

35.

Introduction to the American Heart Association's Hypertension Strategically Focused Research Network.

Muntner P, Becker RC, Calhoun D, Chen D, Cowley AW Jr, Flynn JT, Grobe JL, Kidambi S, Kotchen TA, Lackland DT, Leslie KK, Li Y, Liang M, Lloyd A, Mattson DL, Mendizabal B, Mitsnefes M, Nair A, Pierce GL, Pollock JS, Safford MM, Santillan MK, Sigmund CD, Thomas SJ, Urbina EM.

Hypertension. 2016 Apr;67(4):674-80. doi: 10.1161/HYPERTENSIONAHA.115.06433. Epub 2016 Feb 22. Review. No abstract available.

36.

Hypertension: A Disease That Strikes Around the Clock.

Wu J, Sigmund CD.

Hypertension. 2016 Mar;67(3):493-5. doi: 10.1161/HYPERTENSIONAHA.115.06331. Epub 2016 Jan 18. No abstract available.

37.

Fibrotic Aortic Valve Stenosis in Hypercholesterolemic/Hypertensive Mice.

Chu Y, Lund DD, Doshi H, Keen HL, Knudtson KL, Funk ND, Shao JQ, Cheng J, Hajj GP, Zimmerman KA, Davis MK, Brooks RM, Chapleau MW, Sigmund CD, Weiss RM, Heistad DD.

Arterioscler Thromb Vasc Biol. 2016 Mar;36(3):466-74. doi: 10.1161/ATVBAHA.115.306912. Epub 2016 Jan 14.

38.

Protective Role for Tissue Inhibitor of Metalloproteinase-4, a Novel Peroxisome Proliferator-Activated Receptor-γ Target Gene, in Smooth Muscle in Deoxycorticosterone Acetate-Salt Hypertension.

Ketsawatsomkron P, Keen HL, Davis DR, Lu KT, Stump M, De Silva TM, Hilzendeger AM, Grobe JL, Faraci FM, Sigmund CD.

Hypertension. 2016 Jan;67(1):214-22. doi: 10.1161/HYPERTENSIONAHA.115.06391. Epub 2015 Nov 23.

39.

Endothelial PPAR-γ provides vascular protection from IL-1β-induced oxidative stress.

Mukohda M, Stump M, Ketsawatsomkron P, Hu C, Quelle FW, Sigmund CD.

Am J Physiol Heart Circ Physiol. 2016 Jan 1;310(1):H39-48. doi: 10.1152/ajpheart.00490.2015. Epub 2015 Nov 13.

40.

Interference with PPARγ in endothelium accelerates angiotensin II-induced endothelial dysfunction.

Hu C, Lu KT, Mukohda M, Davis DR, Faraci FM, Sigmund CD.

Physiol Genomics. 2016 Feb;48(2):124-34. doi: 10.1152/physiolgenomics.00087.2015. Epub 2015 Nov 3.

41.

PPARγ Regulation in Hypertension and Metabolic Syndrome.

Stump M, Mukohda M, Hu C, Sigmund CD.

Curr Hypertens Rep. 2015 Dec;17(12):89. doi: 10.1007/s11906-015-0601-x. Review.

42.

Vascular versus tubular renin: role in kidney development.

Sequeira-Lopez ML, Nagalakshmi VK, Li M, Sigmund CD, Gomez RA.

Am J Physiol Regul Integr Comp Physiol. 2015 Sep 15;309(6):R650-7. doi: 10.1152/ajpregu.00313.2015. Epub 2015 Aug 5.

43.

Hypertension-causing Mutations in Cullin3 Protein Impair RhoA Protein Ubiquitination and Augment the Association with Substrate Adaptors.

Ibeawuchi SR, Agbor LN, Quelle FW, Sigmund CD.

J Biol Chem. 2015 Jul 31;290(31):19208-17. doi: 10.1074/jbc.M115.645358. Epub 2015 Jun 22.

44.

Calcium/calmodulin-dependent kinase II inhibition in smooth muscle reduces angiotensin II-induced hypertension by controlling aortic remodeling and baroreceptor function.

Prasad AM, Morgan DA, Nuno DW, Ketsawatsomkron P, Bair TB, Venema AN, Dibbern ME, Kutschke WJ, Weiss RM, Lamping KG, Chapleau MW, Sigmund CD, Rahmouni K, Grumbach IM.

J Am Heart Assoc. 2015 Jun 15;4(6):e001949. doi: 10.1161/JAHA.115.001949.

45.

Smooth Muscle Peroxisome Proliferator-Activated Receptor γ Plays a Critical Role in Formation and Rupture of Cerebral Aneurysms in Mice In Vivo.

Hasan DM, Starke RM, Gu H, Wilson K, Chu Y, Chalouhi N, Heistad DD, Faraci FM, Sigmund CD.

Hypertension. 2015 Jul;66(1):211-20. doi: 10.1161/HYPERTENSIONAHA.115.05332. Epub 2015 Apr 27.

46.

Brain endoplasmic reticulum stress mechanistically distinguishes the saline-intake and hypertensive response to deoxycorticosterone acetate-salt.

Jo F, Jo H, Hilzendeger AM, Thompson AP, Cassell MD, Rutkowski DT, Davisson RL, Grobe JL, Sigmund CD.

Hypertension. 2015 Jun;65(6):1341-8. doi: 10.1161/HYPERTENSIONAHA.115.05377. Epub 2015 Apr 20.

47.

Vasopressin: the missing link for preeclampsia?

Sandgren JA, Scroggins SM, Santillan DA, Devor EJ, Gibson-Corley KN, Pierce GL, Sigmund CD, Santillan MK, Grobe JL.

Am J Physiol Regul Integr Comp Physiol. 2015 Nov 1;309(9):R1062-4. doi: 10.1152/ajpregu.00073.2015. Epub 2015 Mar 25. Review.

48.

Endothelial PPAR-γ protects against vascular thrombosis by downregulating P-selectin expression.

Jin H, Gebska MA, Blokhin IO, Wilson KM, Ketsawatsomkron P, Chauhan AK, Keen HL, Sigmund CD, Lentz SR.

Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):838-44. doi: 10.1161/ATVBAHA.115.305378. Epub 2015 Feb 12.

49.

Pregnant mice lacking indoleamine 2,3-dioxygenase exhibit preeclampsia phenotypes.

Santillan MK, Pelham CJ, Ketsawatsomkron P, Santillan DA, Davis DR, Devor EJ, Gibson-Corley KN, Scroggins SM, Grobe JL, Yang B, Hunter SK, Sigmund CD.

Physiol Rep. 2015 Jan 19;3(1). pii: e12257. doi: 10.14814/phy2.12257. Print 2015 Jan 1.

50.

Molecular mechanisms regulating vascular tone by peroxisome proliferator activated receptor gamma.

Ketsawatsomkron P, Sigmund CD.

Curr Opin Nephrol Hypertens. 2015 Mar;24(2):123-30. doi: 10.1097/MNH.0000000000000103. Review.

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