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Items: 1 to 50 of 173

1.

Fern genomes elucidate land plant evolution and cyanobacterial symbioses.

Li FW, Brouwer P, Carretero-Paulet L, Cheng S, de Vries J, Delaux PM, Eily A, Koppers N, Kuo LY, Li Z, Simenc M, Small I, Wafula E, Angarita S, Barker MS, Bräutigam A, dePamphilis C, Gould S, Hosmani PS, Huang YM, Huettel B, Kato Y, Liu X, Maere S, McDowell R, Mueller LA, Nierop KGJ, Rensing SA, Robison T, Rothfels CJ, Sigel EM, Song Y, Timilsena PR, Van de Peer Y, Wang H, Wilhelmsson PKI, Wolf PG, Xu X, Der JP, Schluepmann H, Wong GK, Pryer KM.

Nat Plants. 2018 Jul;4(7):460-472. doi: 10.1038/s41477-018-0188-8. Epub 2018 Jul 2.

PMID:
29967517
2.

Key receptor involved in neuronal signalling visualized.

Sigel E.

Nature. 2018 Jul;559(7712):37-38. doi: 10.1038/d41586-018-05538-7. No abstract available.

PMID:
29967383
3.

The Benzodiazepine Binding Sites of GABAA Receptors.

Sigel E, Ernst M.

Trends Pharmacol Sci. 2018 Jul;39(7):659-671. doi: 10.1016/j.tips.2018.03.006. Epub 2018 Apr 30. Review.

PMID:
29716746
4.

Agonists and Antagonists of Protease-Activated Receptor 2 Discovered within a DNA-Encoded Chemical Library Using Mutational Stabilization of the Target.

Brown DG, Brown GA, Centrella P, Certel K, Cooke RM, Cuozzo JW, Dekker N, Dumelin CE, Ferguson A, Fiez-Vandal C, Geschwindner S, Guié MA, Habeshian S, Keefe AD, Schlenker O, Sigel EA, Snijder A, Soutter HT, Sundström L, Troast DM, Wiggin G, Zhang J, Zhang Y, Clark MA.

SLAS Discov. 2018 Jun;23(5):429-436. doi: 10.1177/2472555217749847. Epub 2018 Jan 9.

PMID:
29316408
5.

Identification and characterization of the three members of the CLC family of anion transport proteins in Trypanosoma brucei.

Steinmann ME, Schmidt RS, Macêdo JP, Kunz Renggli C, Bütikofer P, Rentsch D, Mäser P, Sigel E.

PLoS One. 2017 Dec 15;12(12):e0188219. doi: 10.1371/journal.pone.0188219. eCollection 2017.

6.

Corrigendum: Discovery of a Potent BTK Inhibitor with a Novel Binding Mode by Using Parallel Selections with a DNAEncoded Chemical Library.

Cuozzo JW, Centrella PA, Gikunju D, Habeshian S, Hupp CD, Keefe AD, Sigel EA, Soutter HH, Thomson HA, Zhang Y, Clark MA.

Chembiochem. 2017 Dec 14;18(24):2441. doi: 10.1002/cbic.201700610. Epub 2017 Nov 22. No abstract available.

PMID:
29239533
7.

Correction to "Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors".

Johannes JW, Bates S, Beigie C, Belmonte MA, Breen J, Cao S, Centrella PA, Clark MA, Cuozzo JW, Dumelin CE, Ferguson AD, Habeshian S, Hargreaves D, Joubran C, Kazmirski S, Keefe AD, Lamb ML, Lan H, Li Y, Ma H, Mlynarski S, Packer MJ, Rawlins PB, Robbins DW, Shen H, Sigel EA, Soutter HH, Su N, Troast DM, Wang H, Wickson KF, Wu C, Zhang Y, Zhao Q, Zheng X, Hird AW.

ACS Med Chem Lett. 2017 Oct 18;8(11):1204. doi: 10.1021/acsmedchemlett.7b00397. eCollection 2017 Nov 9.

8.

α subunits in GABAA receptors are dispensable for GABA and diazepam action.

Wongsamitkul N, Maldifassi MC, Simeone X, Baur R, Ernst M, Sigel E.

Sci Rep. 2017 Nov 14;7(1):15498. doi: 10.1038/s41598-017-15628-7.

9.

Transporters of Trypanosoma brucei-phylogeny, physiology, pharmacology.

Schmidt RS, Macêdo JP, Steinmann ME, Salgado AG, Bütikofer P, Sigel E, Rentsch D, Mäser P.

FEBS J. 2018 Mar;285(6):1012-1023. doi: 10.1111/febs.14302. Epub 2017 Nov 13. Review.

PMID:
29063677
10.

Isoform-Selective ATAD2 Chemical Probe with Novel Chemical Structure and Unusual Mode of Action.

Fernández-Montalván AE, Berger M, Kuropka B, Koo SJ, Badock V, Weiske J, Puetter V, Holton SJ, Stöckigt D, Ter Laak A, Centrella PA, Clark MA, Dumelin CE, Sigel EA, Soutter HH, Troast DM, Zhang Y, Cuozzo JW, Keefe AD, Roche D, Rodeschini V, Chaikuad A, Díaz-Sáez L, Bennett JM, Fedorov O, Huber KVM, Hübner J, Weinmann H, Hartung IV, Gorjánácz M.

ACS Chem Biol. 2017 Nov 17;12(11):2730-2736. doi: 10.1021/acschembio.7b00708. Epub 2017 Oct 24.

PMID:
29043777
11.

Homoeologous chromosome pairing across the eukaryote phylogeny.

Grusz AL, Sigel EM, Witherup C.

Mol Phylogenet Evol. 2017 Dec;117:83-94. doi: 10.1016/j.ympev.2017.05.025. Epub 2017 Jun 8. Review.

PMID:
28602622
12.

TbIRK is a signature sequence free potassium channel from Trypanosoma brucei locating to acidocalcisomes.

Steinmann ME, Schmidt RS, Bütikofer P, Mäser P, Sigel E.

Sci Rep. 2017 Apr 6;7(1):656. doi: 10.1038/s41598-017-00752-1.

13.

Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors.

Johannes JW, Bates S, Beigie C, Belmonte MA, Breen J, Cao S, Centrella PA, Clark MA, Cuozzo JW, Dumelin CE, Ferguson AD, Habeshian S, Hargreaves D, Joubran C, Kazmirski S, Keefe AD, Lamb ML, Lan H, Li Y, Ma H, Mlynarski S, Packer MJ, Rawlins PB, Robbins DW, Shen H, Sigel EA, Soutter HH, Su N, Troast DM, Wang H, Wickson KF, Wu C, Zhang Y, Zhao Q, Zheng X, Hird AW.

ACS Med Chem Lett. 2016 Dec 27;8(2):239-244. doi: 10.1021/acsmedchemlett.6b00464. eCollection 2017 Feb 9. Erratum in: ACS Med Chem Lett. 2017 Oct 18;8(11):1204.

14.

H+-dependent inorganic phosphate uptake in Trypanosoma brucei is influenced by myo-inositol transporter.

Russo-Abrahão T, Koeller CM, Steinmann ME, Silva-Rito S, Marins-Lucena T, Alves-Bezerra M, Lima-Giarola NL, de-Paula IF, Gonzalez-Salgado A, Sigel E, Bütikofer P, Gondim KC, Heise N, Meyer-Fernandes JR.

J Bioenerg Biomembr. 2017 Apr;49(2):183-194. doi: 10.1007/s10863-017-9695-y. Epub 2017 Feb 9.

PMID:
28185085
15.

Xenopus Oocytes: Optimized Methods for Microinjection, Removal of Follicular Cell Layers, and Fast Solution Changes in Electrophysiological Experiments.

Maldifassi MC, Wongsamitkul N, Baur R, Sigel E.

J Vis Exp. 2016 Dec 31;(118). doi: 10.3791/55034.

PMID:
28117773
16.

Low Expression in Xenopus Oocytes and Unusual Functional Properties of α1β2γ2 GABAA Receptors with Non-Conventional Subunit Arrangement.

Baur R, Sigel E.

PLoS One. 2017 Jan 23;12(1):e0170572. doi: 10.1371/journal.pone.0170572. eCollection 2017.

17.

Functional sites for anesthetics in GABAA receptors.

Maldifassi MC, Sigel E.

Oncotarget. 2017 Feb 14;8(7):10779-10780. doi: 10.18632/oncotarget.14616. No abstract available.

18.

Discovery of a Potent BTK Inhibitor with a Novel Binding Mode by Using Parallel Selections with a DNA-Encoded Chemical Library.

Cuozzo JW, Centrella PA, Gikunju D, Habeshian S, Hupp CD, Keefe AD, Sigel EA, Soutter HH, Thomson HA, Zhang Y, Clark MA.

Chembiochem. 2017 May 4;18(9):864-871. doi: 10.1002/cbic.201600573. Epub 2017 Feb 8. Erratum in: Chembiochem. 2017 Dec 14;18(24):2441.

PMID:
28056160
19.

Discovery of cofactor-specific, bactericidal Mycobacterium tuberculosis InhA inhibitors using DNA-encoded library technology.

Soutter HH, Centrella P, Clark MA, Cuozzo JW, Dumelin CE, Guie MA, Habeshian S, Keefe AD, Kennedy KM, Sigel EA, Troast DM, Zhang Y, Ferguson AD, Davies G, Stead ER, Breed J, Madhavapeddi P, Read JA.

Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):E7880-E7889. Epub 2016 Nov 18.

20.

Addressing Firearm Violence in the Primary Health Care Setting.

Sigel E.

Adolesc Med State Art Rev. 2016 Fall;27(2):323-340. Review. No abstract available.

PMID:
29462523
21.

Toward Understanding Functional Properties and Subunit Arrangement of α4β2δ γ-Aminobutyric Acid, Type A (GABAA) Receptors.

Wongsamitkul N, Baur R, Sigel E.

J Biol Chem. 2016 Aug 26;291(35):18474-83. doi: 10.1074/jbc.M116.738906. Epub 2016 Jul 5.

22.

Molecular mode of action of CGS 9895 at α1 β2 γ2 GABAA receptors.

Maldifassi MC, Baur R, Sigel E.

J Neurochem. 2016 Sep;138(5):722-30. doi: 10.1111/jnc.13711. Epub 2016 Jul 18.

23.

Novel positive allosteric modulators of GABAA receptors with anesthetic activity.

Maldifassi MC, Baur R, Pierce D, Nourmahnad A, Forman SA, Sigel E.

Sci Rep. 2016 May 20;6:25943. doi: 10.1038/srep25943.

24.

Outcomes, Data, and Indicators of Violence at the Community Level.

Masho SW, Schoeny ME, Webster D, Sigel E.

J Prim Prev. 2016 Apr;37(2):121-39. doi: 10.1007/s10935-016-0429-4.

25.

Building an evidence-based multitiered system of supports for high-risk youth and communities.

Kingston BE, Mihalic SF, Sigel EJ.

Am J Orthopsychiatry. 2016 Mar;86(2):132-43. doi: 10.1037/ort0000110.

PMID:
26963183
26.

A new chromanone derivative isolated from Hypericum lissophloeus (Hypericaceae) potentiates GABAA receptor currents in a subunit specific fashion.

Crockett S, Baur R, Kunert O, Belaj F, Sigel E.

Bioorg Med Chem. 2016 Feb 15;24(4):681-5. doi: 10.1016/j.bmc.2015.12.037. Epub 2015 Dec 23.

PMID:
26791864
27.

Functional sites involved in modulation of the GABAA receptor channel by the intravenous anesthetics propofol, etomidate and pentobarbital.

Maldifassi MC, Baur R, Sigel E.

Neuropharmacology. 2016 Jun;105:207-214. doi: 10.1016/j.neuropharm.2016.01.003. Epub 2016 Jan 6.

PMID:
26767954
28.

Modulatory Effects of Eschscholzia californica Alkaloids on Recombinant GABAA Receptors.

Fedurco M, Gregorová J, Šebrlová K, Kantorová J, Peš O, Baur R, Sigel E, Táborská E.

Biochem Res Int. 2015;2015:617620. doi: 10.1155/2015/617620. Epub 2015 Oct 5.

29.

An Exploration into Fern Genome Space.

Wolf PG, Sessa EB, Marchant DB, Li FW, Rothfels CJ, Sigel EM, Gitzendanner MA, Visger CJ, Banks JA, Soltis DE, Soltis PS, Pryer KM, Der JP.

Genome Biol Evol. 2015 Aug 26;7(9):2533-44. doi: 10.1093/gbe/evv163.

30.

Flagellar membranes are rich in raft-forming phospholipids.

Serricchio M, Schmid AW, Steinmann ME, Sigel E, Rauch M, Julkowska D, Bonnefoy S, Fort C, Bastin P, Bütikofer P.

Biol Open. 2015 Aug 14;4(9):1143-53. doi: 10.1242/bio.011957.

31.

The evolutionary history of ferns inferred from 25 low-copy nuclear genes.

Rothfels CJ, Li FW, Sigel EM, Huiet L, Larsson A, Burge DO, Ruhsam M, Deyholos M, Soltis DE, Stewart CN Jr, Shaw SW, Pokorny L, Chen T, dePamphilis C, DeGironimo L, Chen L, Wei X, Sun X, Korall P, Stevenson DW, Graham SW, Wong GK, Pryer KM.

Am J Bot. 2015 Jul;102(7):1089-107. doi: 10.3732/ajb.1500089. Epub 2015 Jul 16.

32.

Use of Psychopharmacologic Medications in Adolescents With Restrictive Eating Disorders: Analysis of Data From the National Eating Disorder Quality Improvement Collaborative.

Monge MC, Forman SF, McKenzie NM, Rosen DS, Mammel KA, Callahan ST, Hehn R, Rome ES, Kapphahn CJ, Carlson JL, Romano ME, Malizio JB, Bravender TD, Sigel EJ, Rouse MR, Graham DA, Jay MS, Hergenroeder AC, Fisher MM, Golden NH, Woods ER.

J Adolesc Health. 2015 Jul;57(1):66-72. doi: 10.1016/j.jadohealth.2015.03.021.

PMID:
26095410
33.

Encoded Library Synthesis Using Chemical Ligation and the Discovery of sEH Inhibitors from a 334-Million Member Library.

Litovchick A, Dumelin CE, Habeshian S, Gikunju D, Guié MA, Centrella P, Zhang Y, Sigel EA, Cuozzo JW, Keefe AD, Clark MA.

Sci Rep. 2015 Jun 10;5:10916. doi: 10.1038/srep10916.

34.

Positive modulation of synaptic and extrasynaptic GABAA receptors by an antagonist of the high affinity benzodiazepine binding site.

Middendorp SJ, Maldifassi MC, Baur R, Sigel E.

Neuropharmacology. 2015 Aug;95:459-67. doi: 10.1016/j.neuropharm.2015.04.027. Epub 2015 May 9.

PMID:
25963418
35.

Trypanosoma brucei Bloodstream Forms Depend upon Uptake of myo-Inositol for Golgi Complex Phosphatidylinositol Synthesis and Normal Cell Growth.

González-Salgado A, Steinmann M, Major LL, Sigel E, Reymond JL, Smith TK, Bütikofer P.

Eukaryot Cell. 2015 Jun;14(6):616-24. doi: 10.1128/EC.00038-15. Epub 2015 Apr 17.

36.

A heteromeric potassium channel involved in the modulation of the plasma membrane potential is essential for the survival of African trypanosomes.

Steinmann ME, González-Salgado A, Bütikofer P, Mäser P, Sigel E.

FASEB J. 2015 Aug;29(8):3228-37. doi: 10.1096/fj.15-271353. Epub 2015 Apr 13.

PMID:
25868728
37.

Structural analogues of the natural products magnolol and honokiol as potent allosteric potentiators of GABA(A) receptors.

Fuchs A, Baur R, Schoeder C, Sigel E, Müller CE.

Bioorg Med Chem. 2014 Dec 15;22(24):6908-17. doi: 10.1016/j.bmc.2014.10.027. Epub 2014 Oct 22.

PMID:
25456080
38.

Monepantel irreversibly binds to and opens Haemonchus contortus MPTL-1 and Caenorhabditis elegans ACR-20 receptors.

Baur R, Beech R, Sigel E, Rufener L.

Mol Pharmacol. 2015 Jan;87(1):96-102. doi: 10.1124/mol.114.095653. Epub 2014 Oct 28.

39.

Between two fern genomes.

Sessa EB, Banks JA, Barker MS, Der JP, Duffy AM, Graham SW, Hasebe M, Langdale J, Li FW, Marchant DB, Pryer KM, Rothfels CJ, Roux SJ, Salmi ML, Sigel EM, Soltis DE, Soltis PS, Stevenson DW, Wolf PG.

Gigascience. 2014 Sep 25;3:15. doi: 10.1186/2047-217X-3-15. eCollection 2014. Review.

40.

Increasing documentation and referral for youth at risk for violence through the primary health care setting.

Sigel E, Harpin SB, Tung G.

Clin Pediatr (Phila). 2015 May;54(5):451-7. doi: 10.1177/0009922814553431. Epub 2014 Oct 9.

PMID:
25305258
41.

Origin of a novel regulatory module by duplication and degeneration of an ancient plant transcription factor.

Floyd SK, Ryan JG, Conway SJ, Brenner E, Burris KP, Burris JN, Chen T, Edger PP, Graham SW, Leebens-Mack JH, Pires JC, Rothfels CJ, Sigel EM, Stevenson DW, Neal Stewart C Jr, Wong GK, Bowman JL.

Mol Phylogenet Evol. 2014 Dec;81:159-73. doi: 10.1016/j.ympev.2014.06.017. Epub 2014 Sep 27.

42.
43.

Predictors of outcome at 1 year in adolescents with DSM-5 restrictive eating disorders: report of the national eating disorders quality improvement collaborative.

Forman SF, McKenzie N, Hehn R, Monge MC, Kapphahn CJ, Mammel KA, Callahan ST, Sigel EJ, Bravender T, Romano M, Rome ES, Robinson KA, Fisher M, Malizio JB, Rosen DS, Hergenroeder AC, Buckelew SM, Jay MS, Lindenbaum J, Rickert VI, Garber A, Golden NH, Woods ER.

J Adolesc Health. 2014 Dec;55(6):750-6. doi: 10.1016/j.jadohealth.2014.06.014. Epub 2014 Sep 4.

PMID:
25200345
44.

A pentasymmetric open channel blocker for Cys-loop receptor channels.

Carta V, Pangerl M, Baur R, Puthenkalam R, Ernst M, Trauner D, Sigel E.

PLoS One. 2014 Sep 3;9(9):e106688. doi: 10.1371/journal.pone.0106688. eCollection 2014.

45.

Trypanosoma brucei eflornithine transporter AAT6 is a low-affinity low-selective transporter for neutral amino acids.

Mathieu C, González Salgado A, Wirdnam C, Meier S, Grotemeyer MS, Inbar E, Mäser P, Zilberstein D, Sigel E, Bütikofer P, Rentsch D.

Biochem J. 2014 Oct 1;463(1):9-18. doi: 10.1042/BJ20140719.

PMID:
24988048
46.

Moderate concentrations of 4-O-methylhonokiol potentiate GABAA receptor currents stronger than honokiol.

Baur R, Schuehly W, Sigel E.

Biochim Biophys Acta. 2014 Oct;1840(10):3017-21. doi: 10.1016/j.bbagen.2014.06.016. Epub 2014 Jun 25.

PMID:
24973566
47.

Accelerated discovery of novel benzodiazepine ligands by experiment-guided virtual screening.

Middendorp SJ, Puthenkalam R, Baur R, Ernst M, Sigel E.

ACS Chem Biol. 2014 Aug 15;9(8):1854-9. doi: 10.1021/cb5001873. Epub 2014 Jun 27.

PMID:
24960548
48.

Relative positioning of classical benzodiazepines to the γ2-subunit of GABAA receptors.

Middendorp SJ, Hurni E, Schönberger M, Stein M, Pangerl M, Trauner D, Sigel E.

ACS Chem Biol. 2014 Aug 15;9(8):1846-53. doi: 10.1021/cb500186a. Epub 2014 Jul 1.

PMID:
24918742
49.

Horizontal transfer of an adaptive chimeric photoreceptor from bryophytes to ferns.

Li FW, Villarreal JC, Kelly S, Rothfels CJ, Melkonian M, Frangedakis E, Ruhsam M, Sigel EM, Der JP, Pittermann J, Burge DO, Pokorny L, Larsson A, Chen T, Weststrand S, Thomas P, Carpenter E, Zhang Y, Tian Z, Chen L, Yan Z, Zhu Y, Sun X, Wang J, Stevenson DW, Crandall-Stotler BJ, Shaw AJ, Deyholos MK, Soltis DE, Graham SW, Windham MD, Langdale JA, Wong GK, Mathews S, Pryer KM.

Proc Natl Acad Sci U S A. 2014 May 6;111(18):6672-7. doi: 10.1073/pnas.1319929111. Epub 2014 Apr 14.

50.

Transcriptome-mining for single-copy nuclear markers in ferns.

Rothfels CJ, Larsson A, Li FW, Sigel EM, Huiet L, Burge DO, Ruhsam M, Graham SW, Stevenson DW, Wong GK, Korall P, Pryer KM.

PLoS One. 2013 Oct 8;8(10):e76957. doi: 10.1371/journal.pone.0076957. eCollection 2013.

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