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Items: 41

1.

Baquiloprim, a new antifolate antibacterial: in vitro activity and pharmacokinetic properties in cattle.

White G, Daluge SM, Sigel CW, Ferone R, Wilson HR.

Res Vet Sci. 1993 May;54(3):372-8.

PMID:
8337486
2.

Pharmacokinetics and disposition in the rat of a DNA intercalator 502U83.

Patel DK, Lewis RP, Hinton ML, Schroeder DH, Shockcor JP, Johnson RL, Sigel CW.

Drug Metab Dispos. 1993 Jan-Feb;21(1):62-70.

PMID:
8095228
3.

The disposition and metabolism of [14C]piritrexim in dogs after intravenous and oral administration.

Woolley JL, Deangelis DV, Grace ME, Liao SH, Crouch RC, Sigel CW.

Drug Metab Dispos. 1991 Nov-Dec;19(6):1139-46.

PMID:
1687022
4.

Metabolism of a novel antitumor agent, crisnatol, by a human hepatoma cell line, Hep G2, and hepatic microsomes. Characterization of metabolites.

Patel DK, Shockcor JP, Chang SY, Sigel CW, Huber BE.

Biochem Pharmacol. 1991 Jul 5;42(2):337-46.

PMID:
1650211
5.

The disposition and metabolism of [14C]piritrexim in rats after intravenous and oral administration.

Woolley JL, Deangelis DV, Crouch RC, Shockcor JP, Sigel CW.

Drug Metab Dispos. 1991 May-Jun;19(3):600-8.

PMID:
1680625
6.

Disposition, metabolism, and excretion of the anticancer agent crisnatol in the rat.

Patel DK, Woolley JL Jr, Shcokcor JP, Johnson RL, Taylor LC, Sigel CW.

Drug Metab Dispos. 1991 Mar-Apr;19(2):491-7.

PMID:
1676660
7.
8.

Competitive protein binding assay for piritrexim.

Woolley JL Jr, Ringstad JL, Sigel CW.

J Pharm Sci. 1989 Sep;78(9):749-52.

PMID:
2585269
9.

2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 13. Some alkenyl derivatives with high in vitro activity against anaerobic organisms.

Roth B, Tidwell MY, Ferone R, Baccanari DP, Sigel CW, DeAngelis D, Elwell LP.

J Med Chem. 1989 Aug;32(8):1949-58.

PMID:
2754716
10.

2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 9. Lipophilic trimethoprim analogues as antigonococcal agents.

Roth B, Baccanari DP, Sigel CW, Hubbell JP, Eaddy J, Kao JC, Grace ME, Rauckman BS.

J Med Chem. 1988 Jan;31(1):122-9.

PMID:
3121854
11.

Preclinical biochemical pharmacology and toxicology of piritrexim, a lipophilic inhibitor of dihydrofolate reductase.

Sigel CW, Macklin AW, Woolley JL Jr, Johnson NW, Collier MA, Blum MR, Clendeninn NJ, Everitt BJ, Grebe G, Mackars A, et al.

NCI Monogr. 1987;(5):111-20.

PMID:
3431588
13.
14.

Development of pharmacokinetic models for sulfonamides in food animals: metabolic depletion profile of sulfadiazine in the calf.

Woolley JL Jr, Sigel CW.

Am J Vet Res. 1982 May;43(5):768-74. No abstract available.

PMID:
7091837
15.

Evaluation of the lipid-soluble diaminopyrimidines, metoprine and etoprine, in the avian sarcoma virus rat glioma model.

Serano RD, Sigel CW, Nichol CA, Bigner DD.

Cancer Treat Rep. 1982 Jan;66(1):99-106.

PMID:
6272992
16.

Serum concentrations of trimethoprim and sulfadiazine following oral paste administration to the horse.

Sigel CW, Byars TD, Divers TJ, Murch O, DeAngelis D.

Am J Vet Res. 1981 Nov;42(11):2002-5.

PMID:
7337298
17.

2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 5. 3',5'-Dimethoxy-4'-substituted-benzyl analogues of trimethoprim.

Roth B, Aig E, Rauckman BS, Strelitz JZ, Phillips AP, Ferone R, Bushby SR, Sigel CW.

J Med Chem. 1981 Aug;24(8):933-41.

PMID:
7035668
18.
19.

Trimethoprim and sulfadiazine concentrations in aqueous and vitreous humors of the dog.

Sigel CW, Macklin AW, Grace ME, Tracy CH.

Vet Med Small Anim Clin. 1981 Jul;76(7):991-3. No abstract available.

PMID:
6975528
20.

Pharmacokinetics of trimethoprim and sulfadiazine in the dog: urine concentrations after oral administration.

Sigel CW, Ling GV, Bushby SR, Woolley JL Jr, DeAngelis D, Eure S.

Am J Vet Res. 1981 Jun;42(6):996-1001.

PMID:
7283250
21.

II. Novel deaminated sulfadiazine metabolites in neonatal calf tissue, plasma, and urine following oral treatment of 14C-sulfadiazine.

Woolley JL Jr, Sigel CW, Wels CM.

Life Sci. 1980 Nov 17;27(20):1819-26. No abstract available.

PMID:
7464453
22.

Synthesis and antitumor activity of 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine.

Grivsky EM, Lee S, Sigel CW, Duch DS, Nichol CA.

J Med Chem. 1980 Mar;23(3):327-9.

PMID:
6928967
23.

Metabolism and disposition by the rat of 35S-sulfadiazine alone and in the presence of trimethoprim.

Woolley JL Jr, Sigel CW.

Drug Metab Dispos. 1979 Mar-Apr;7(2):94-9.

PMID:
38079
24.

Lipid-soluble inhibitors of dihydrofolate reductase. I. Kinetics, tissue distribution, and extent of metabolism of pyrimethamine, metoprine, and etoprine in the rat, dog, and man.

Cavallito JC, Nichol CA, Brenckman WD Jr, Deangelis RL, Stickney DR, Simmons WS, Sigel CW.

Drug Metab Dispos. 1978 May-Jun;6(3):329-37.

PMID:
26555
25.

Lipid-soluble diaminopyrimidine inhibitors of dihydrofolate reductase.

Nichol CA, Cavallito JC, Woolley JL, Sigel CW.

Cancer Treat Rep. 1977 Jul;61(4):559-64.

PMID:
301777
26.

Structure and stereochemistry of jatrophone, a novel macrocyclic diterpenoid tumor inhibitor.

Kupchan SM, Sigel CW, Matz MJ, Gilmore CJ, Bryan RF.

J Am Chem Soc. 1976 Apr 14;98(8):2295-2300. No abstract available.

PMID:
1254866
27.

Diffusion of trimethoprim and sulfamethoxazole from susceptibility disks into agar medium.

Grace ME, Bushby SR, Sigel CW.

Antimicrob Agents Chemother. 1975 Jul;8(1):45-9.

28.

Use of 1-H nuclear magnetic resonance spectroscopy for sequence and configuration analysis of cyclic tetrapeptides. The structure of Tentoxin-1,2a--d.

Meyer WL, Templeton GE, Grable CI, Jones R, Kuyper LF, Lewis RB, Sigel CW, Woodhead SH.

J Am Chem Soc. 1975 Jun 25;97(13):3202-9. No abstract available.

PMID:
1141586
29.

Specific TLC tissue residue determination of sulfadiazine following fluorescamine derivatization.

Sigel CW, Woolley JL Jr, Nichol CA.

J Pharm Sci. 1975 Jun;64(6):973-6.

PMID:
1133754
30.

The isolation and structural elucidation of bruceantin and bruceantinol, new potent antileukemic quassinoids from Brucea antidysenterica.

Kupchan SM, Britton RW, Lacadie JA, Ziegler MF, Sigel CW.

J Org Chem. 1975 Mar 7;40(5):648-54. No abstract available.

PMID:
1133627
31.

Specific TLC determination of trimethoprim and sulfamethoxazole in plasma.

Sigel CW, Grace ME, Nichol CA, Hitchings GH.

J Pharm Sci. 1974 Aug;63(8):1212-5. No abstract available.

PMID:
4854354
32.

Reaction of biological thiols with the tumor inhibitor jatrophone. Inhibition of RNA polymerase.

Lillehaug JR, Kleppe K, Sigel CW, Kupchan SM.

Biochim Biophys Acta. 1973 Nov 15;327(1):92-100. No abstract available.

PMID:
4589016
33.

Metabolism of trimethoprim in man and measurement of a new metabolite: a new fluorescence assay.

Sigel CW, Grace ME, Nichol CA.

J Infect Dis. 1973 Nov;128:Suppl:580-3 p. No abstract available.

PMID:
4758049
34.

A new fluorescence assay of trimethoprim and metabolites using quantitative thin-layer chromatography.

Sigel CW, Grace ME.

J Chromatogr. 1973 May 30;80(1):111-6. No abstract available.

PMID:
4708398
35.

Datiscacin, a novel cytotoxic cucurbitacin 20-acetate from Datisca glomerata.

Kupchan SM, Tsou G, Sigel CW.

J Org Chem. 1973 Apr 6;38(7):1420-1. No abstract available.

PMID:
4694234
36.

Identification of trimethoprim 3-oxide as a new urinary metabolite of trimethoprim in man.

Sigel CW, Brent DA.

J Pharm Sci. 1973 Apr;62(4):694-5. No abstract available.

PMID:
4699000
37.

Bruceantin, a new potent antileukemic simaroubolide from Brucea antidysenterica.

Kupchan SM, Britton RW, Ziegler MF, Sigel CW.

J Org Chem. 1973 Jan 12;38(1):178-9. No abstract available.

PMID:
4682660
38.

Datiscoside, a novel antileukemic cucurbitacin glycoside from Datisca glomerata.

Kupchan SM, Sigel CW, Guttman LJ, Restivo RJ, Bryan RF.

J Am Chem Soc. 1972 Feb 23;94(4):1353-4. No abstract available.

PMID:
5060279
39.

Tumor inhibitors. LXV. Bersenogenin, berscillogenin, and 3-epiberscillogenin, three new cytotoxic bufadienolides from Bersama abyssinica.

Kupchan SM, Moniot JL, Sigel CW, Hemingway RJ.

J Org Chem. 1971 Sep 10;36(18):2611-6. No abstract available.

PMID:
5130582
40.

Tumor inhibitors. 33. Cytotoxic flavones from eupatorium species.

Kupchan SM, Sigel CW, Hemingway RJ, Knox JR, Udayamurthy MS.

Tetrahedron. 1969 Apr;25(8):1603-15. No abstract available.

PMID:
5816031
41.

A kinetic study of the ninhydrin reaction.

Friedman M, Sigel CW.

Biochemistry. 1966 Feb;5(2):478-85. No abstract available.

PMID:
5940932

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