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Items: 1 to 50 of 207

1.

Deletion 6q drives T-cell leukemia progression by ribosome modulation.

Gachet S, El-Chaar T, Avran D, Genescà E, Catez F, Quentin S, Delord M, Thérizols G, Briot D, Meunier G, Hernandez L, Pla M, Smits WK, Buijs-Gladdines JGCAM, Van Loocke W, Menschaert G, André-Schmutz I, Taghon T, Van Vlierberghe P, Meijerink JP, Baruchel A, Dombret H, Clappier E, Diaz JJ, Gazin C, de The H, Sigaux F, Soulier J.

Cancer Discov. 2018 Sep 28. pii: CD-17-0831. doi: 10.1158/2159-8290.CD-17-0831. [Epub ahead of print]

PMID:
30266814
2.

Genetic polymorphisms associated with increased risk of developing chronic myelogenous leukemia.

Bruzzoni-Giovanelli H, González JR, Sigaux F, Villoutreix BO, Cayuela JM, Guilhot J, Preudhomme C, Guilhot F, Poyet JL, Rousselot P.

Oncotarget. 2015 Nov 3;6(34):36269-77. doi: 10.18632/oncotarget.5915.

3.

Defective NK Cells in Acute Myeloid Leukemia Patients at Diagnosis Are Associated with Blast Transcriptional Signatures of Immune Evasion.

Khaznadar Z, Boissel N, Agaugué S, Henry G, Cheok M, Vignon M, Geromin D, Cayuela JM, Castaigne S, Pautas C, Raffoux E, Lachuer J, Sigaux F, Preudhomme C, Dombret H, Dulphy N, Toubert A.

J Immunol. 2015 Sep 15;195(6):2580-90. doi: 10.4049/jimmunol.1500262. Epub 2015 Aug 5.

4.

SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage.

Clifford R, Louis T, Robbe P, Ackroyd S, Burns A, Timbs AT, Wright Colopy G, Dreau H, Sigaux F, Judde JG, Rotger M, Telenti A, Lin YL, Pasero P, Maelfait J, Titsias M, Cohen DR, Henderson SJ, Ross MT, Bentley D, Hillmen P, Pettitt A, Rehwinkel J, Knight SJ, Taylor JC, Crow YJ, Benkirane M, Schuh A.

Blood. 2014 Feb 13;123(7):1021-31. doi: 10.1182/blood-2013-04-490847. Epub 2013 Dec 12.

5.

High imatinib dose overcomes insufficient response associated with ABCG2 haplotype in chronic myelogenous leukemia patients.

Delord M, Rousselot P, Cayuela JM, Sigaux F, Guilhot J, Preudhomme C, Guilhot F, Loiseau P, Raffoux E, Geromin D, Génin E, Calvo F, Bruzzoni-Giovanelli H.

Oncotarget. 2013 Oct;4(10):1582-91.

6.

An intragenic ERG deletion is a marker of an oncogenic subtype of B-cell precursor acute lymphoblastic leukemia with a favorable outcome despite frequent IKZF1 deletions.

Clappier E, Auclerc MF, Rapion J, Bakkus M, Caye A, Khemiri A, Giroux C, Hernandez L, Kabongo E, Savola S, Leblanc T, Yakouben K, Plat G, Costa V, Ferster A, Girard S, Fenneteau O, Cayuela JM, Sigaux F, Dastugue N, Suciu S, Benoit Y, Bertrand Y, Soulier J, Cavé H.

Leukemia. 2014 Jan;28(1):70-7. doi: 10.1038/leu.2013.277. Epub 2013 Sep 25.

PMID:
24064621
7.

Human skin carcinoma arising from kidney transplant-derived tumor cells.

Verneuil L, Varna M, Ratajczak P, Leboeuf C, Plassa LF, Elbouchtaoui M, Schneider P, Sandid W, Lebbé C, Peraldi MN, Sigaux F, de Thé H, Janin A.

J Clin Invest. 2013 Sep;123(9):3797-801. doi: 10.1172/JCI66721. Epub 2013 Aug 27.

8.

Identification of TMEM131L as a novel regulator of thymocyte proliferation in humans.

Maharzi N, Parietti V, Nelson E, Denti S, Robledo-Sarmiento M, Setterblad N, Parcelier A, Pla M, Sigaux F, Gluckman JC, Canque B.

J Immunol. 2013 Jun 15;190(12):6187-97. doi: 10.4049/jimmunol.1300400. Epub 2013 May 20.

9.

The power of one.

Louvard D, Sigaux F, Robine S.

Sci Transl Med. 2012 Apr 18;4(130):130fs7. doi: 10.1126/scitranslmed.3004102.

PMID:
22517881
10.

α2β1 integrin promotes chemoresistance against doxorubicin in cancer cells through extracellular signal-regulated kinase (ERK).

Naci D, El Azreq MA, Chetoui N, Lauden L, Sigaux F, Charron D, Al-Daccak R, Aoudjit F.

J Biol Chem. 2012 May 18;287(21):17065-76. doi: 10.1074/jbc.M112.349365. Epub 2012 Mar 28.

11.

AF1q/MLLT11 regulates the emergence of human prothymocytes through cooperative interaction with the Notch signaling pathway.

Parcelier A, Maharzi N, Delord M, Robledo-Sarmiento M, Nelson E, Belakhdar-Mekid H, Pla M, Kuranda K, Parietti V, Goodhardt M, Legrand N, Bernstein ID, Gluckman JC, Sigaux F, Canque B.

Blood. 2011 Aug 18;118(7):1784-96. doi: 10.1182/blood-2011-01-333179. Epub 2011 Jun 28.

12.

PTPN2 negatively regulates oncogenic JAK1 in T-cell acute lymphoblastic leukemia.

Kleppe M, Soulier J, Asnafi V, Mentens N, Hornakova T, Knoops L, Constantinescu S, Sigaux F, Meijerink JP, Vandenberghe P, Tartaglia M, Foa R, Macintyre E, Haferlach T, Cools J.

Blood. 2011 Jun 30;117(26):7090-8. doi: 10.1182/blood-2010-10-314286. Epub 2011 May 6.

13.

Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia.

Homminga I, Pieters R, Langerak AW, de Rooi JJ, Stubbs A, Verstegen M, Vuerhard M, Buijs-Gladdines J, Kooi C, Klous P, van Vlierberghe P, Ferrando AA, Cayuela JM, Verhaaf B, Beverloo HB, Horstmann M, de Haas V, Wiekmeijer AS, Pike-Overzet K, Staal FJ, de Laat W, Soulier J, Sigaux F, Meijerink JP.

Cancer Cell. 2011 Apr 12;19(4):484-97. doi: 10.1016/j.ccr.2011.02.008.

14.

Clonal selection in xenografted human T cell acute lymphoblastic leukemia recapitulates gain of malignancy at relapse.

Clappier E, Gerby B, Sigaux F, Delord M, Touzri F, Hernandez L, Ballerini P, Baruchel A, Pflumio F, Soulier J.

J Exp Med. 2011 Apr 11;208(4):653-61. doi: 10.1084/jem.20110105. Epub 2011 Apr 4.

15.

Cartridge-based automated BCR-ABL1 mRNA quantification: solving the issues of standardization, at what cost?

Cayuela JM, Macintyre E, Darlington M, Abdelali RB, Fund X, Villarese P, Tulliez M, Raffoux E, Sigaux F, Réa D, Seror V.

Haematologica. 2011 May;96(5):664-71. doi: 10.3324/haematol.2010.034389. Epub 2011 Feb 17.

16.

Myelodysplasia and leukemia of Fanconi anemia are associated with a specific pattern of genomic abnormalities that includes cryptic RUNX1/AML1 lesions.

Quentin S, Cuccuini W, Ceccaldi R, Nibourel O, Pondarre C, Pagès MP, Vasquez N, Dubois d'Enghien C, Larghero J, Peffault de Latour R, Rocha V, Dalle JH, Schneider P, Michallet M, Michel G, Baruchel A, Sigaux F, Gluckman E, Leblanc T, Stoppa-Lyonnet D, Preudhomme C, Socié G, Soulier J.

Blood. 2011 Apr 14;117(15):e161-70. doi: 10.1182/blood-2010-09-308726. Epub 2011 Feb 16.

17.

Prognostic value of minimal residual disease by real-time quantitative PCR in acute myeloid leukemia with CBFB-MYH11 rearrangement: the French experience.

Guièze R, Renneville A, Cayuela JM, Abdelali RB, Boissel N, de Botton S, Rubio MT, Mazingue F, Macintyre EA, Cheok M, Sigaux F, Fenaux P, Dombret H, Preudhomme C.

Leukemia. 2010 Jul;24(7):1386-8. doi: 10.1038/leu.2010.112. Epub 2010 May 27. No abstract available.

PMID:
20508610
18.

Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia.

Kleppe M, Lahortiga I, El Chaar T, De Keersmaecker K, Mentens N, Graux C, Van Roosbroeck K, Ferrando AA, Langerak AW, Meijerink JP, Sigaux F, Haferlach T, Wlodarska I, Vandenberghe P, Soulier J, Cools J.

Nat Genet. 2010 Jun;42(6):530-5. doi: 10.1038/ng.587. Epub 2010 May 16.

19.

Haploinsufficiency of the IKZF1 (IKAROS) tumor suppressor gene cooperates with BCR-ABL in a transgenic model of acute lymphoblastic leukemia.

Virely C, Moulin S, Cobaleda C, Lasgi C, Alberdi A, Soulier J, Sigaux F, Chan S, Kastner P, Ghysdael J.

Leukemia. 2010 Jun;24(6):1200-4. doi: 10.1038/leu.2010.63. Epub 2010 Apr 15. No abstract available.

PMID:
20393504
20.

Genetic inactivation of Ikaros is a rare event in human T-ALL.

Marçais A, Jeannet R, Hernandez L, Soulier J, Sigaux F, Chan S, Kastner P.

Leuk Res. 2010 Apr;34(4):426-9. doi: 10.1016/j.leukres.2009.09.012. Epub 2009 Sep 30.

PMID:
19796813
21.

[Improve the interdisciplinarity of the research to decrease cancer in France].

Sigaux F.

Med Sci (Paris). 2009 May;25(5):435-6. doi: 10.1051/medsci/2009255435. French. No abstract available.

22.

Impact of genotype on survival of children with T-cell acute lymphoblastic leukemia treated according to the French protocol FRALLE-93: the effect of TLX3/HOX11L2 gene expression on outcome.

Ballerini P, Landman-Parker J, Cayuela JM, Asnafi V, Labopin M, Gandemer V, Perel Y, Michel G, Leblanc T, Schmitt C, Fasola S, Hagemejier A, Sigaux F, Auclerc MF, Douay L, Leverger G, Baruchel A.

Haematologica. 2008 Nov;93(11):1658-65. doi: 10.3324/haematol.13291. Epub 2008 Oct 2.

23.

Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1.

Hacein-Bey-Abina S, Garrigue A, Wang GP, Soulier J, Lim A, Morillon E, Clappier E, Caccavelli L, Delabesse E, Beldjord K, Asnafi V, MacIntyre E, Dal Cortivo L, Radford I, Brousse N, Sigaux F, Moshous D, Hauer J, Borkhardt A, Belohradsky BH, Wintergerst U, Velez MC, Leiva L, Sorensen R, Wulffraat N, Blanche S, Bushman FD, Fischer A, Cavazzana-Calvo M.

J Clin Invest. 2008 Sep;118(9):3132-42. doi: 10.1172/JCI35700.

24.

p16INK4A tumor suppressor gene expression and CD3epsilon deficiency but not pre-TCR deficiency inhibit TAL1-linked T-lineage leukemogenesis.

Fasseu M, Aplan PD, Chopin M, Boissel N, Bories JC, Soulier J, von Boehmer H, Sigaux F, Regnault A.

Blood. 2007 Oct 1;110(7):2610-9. Epub 2007 May 16.

25.

The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL), the translocation defining a new T-ALL subtype in very young children.

Clappier E, Cuccuini W, Kalota A, Crinquette A, Cayuela JM, Dik WA, Langerak AW, Montpellier B, Nadel B, Walrafen P, Delattre O, Aurias A, Leblanc T, Dombret H, Gewirtz AM, Baruchel A, Sigaux F, Soulier J.

Blood. 2007 Aug 15;110(4):1251-61. Epub 2007 Apr 23.

26.

NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth.

Palomero T, Lim WK, Odom DT, Sulis ML, Real PJ, Margolin A, Barnes KC, O'Neil J, Neuberg D, Weng AP, Aster JC, Sigaux F, Soulier J, Look AT, Young RA, Califano A, Ferrando AA.

Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18261-6. Epub 2006 Nov 17. Erratum in: Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4240.

27.

Clinical, cytogenetic and molecular characteristics of 14 T-ALL patients carrying the TCRbeta-HOXA rearrangement: a study of the Groupe Francophone de Cytogénétique Hématologique.

Cauwelier B, Cavé H, Gervais C, Lessard M, Barin C, Perot C, Van den Akker J, Mugneret F, Charrin C, Pagès MP, Grégoire MJ, Jonveaux P, Lafage-Pochitaloff M, Mozzicconacci MJ, Terré C, Luquet I, Cornillet-Lefebvre P, Laurence B, Plessis G, Lefebvre C, Leroux D, Antoine-Poirel H, Graux C, Mauvieux L, Heimann P, Chalas C, Clappier E, Verhasselt B, Benoit Y, Moerloose BD, Poppe B, Van Roy N, Keersmaecker KD, Cools J, Sigaux F, Soulier J, Hagemeijer A, Paepe AD, Dastugue N, Berger R, Speleman F.

Leukemia. 2007 Jan;21(1):121-8. Epub 2006 Oct 12.

PMID:
17039236
28.

Most immature T-ALLs express Ra-IL3 (CD123): possible target for DT-IL3 therapy.

Lhermitte L, de Labarthe A, Dupret C, Lapillonne H, Millien C, Landman-Parker J, Hermine O, Baruchel A, Sigaux F, Macintyre E, Asnafi V.

Leukemia. 2006 Oct;20(10):1908-10. Epub 2006 Aug 10. No abstract available.

PMID:
16900212
29.

Comparison of the latest commercial short and long oligonucleotide microarray technologies.

de Reyniès A, Geromin D, Cayuela JM, Petel F, Dessen P, Sigaux F, Rickman DS.

BMC Genomics. 2006 Mar 15;7:51.

30.

Disruption of T cell regulatory pathways is necessary for immunotherapeutic cure of T cell acute lymphoblastic leukemia in mice.

Fiorentino S, Chopin M, Dastot H, Boissel N, Reboul M, Legrès L, Janin A, Aplan P, Sigaux F, Regnault A.

Eur Cytokine Netw. 2005 Dec;16(4):300-8.

31.

Cyclin D2 dysregulation by chromosomal translocations to TCR loci in T-cell acute lymphoblastic leukemias.

Clappier E, Cuccuini W, Cayuela JM, Vecchione D, Baruchel A, Dombret H, Sigaux F, Soulier J.

Leukemia. 2006 Jan;20(1):82-6.

PMID:
16270038
32.

HOXA genes are included in genetic and biologic networks defining human acute T-cell leukemia (T-ALL).

Soulier J, Clappier E, Cayuela JM, Regnault A, García-Peydró M, Dombret H, Baruchel A, Toribio ML, Sigaux F.

Blood. 2005 Jul 1;106(1):274-86. Epub 2005 Mar 17.

33.

Evaluation of real-time quantitative PCR machines for the monitoring of fusion gene transcripts using the Europe against cancer protocol.

Silvy M, Mancini J, Thirion X, Sigaux F, Gabert J.

Leukemia. 2005 Feb;19(2):305-7. No abstract available.

PMID:
15618967
34.

Repression of transcription at the human T-cell receptor Vbeta2.2 segment is mediated by a MAX/MAD/mSin3 complex acting as a scaffold for HDAC activity.

Font MP, Cubizolles M, Dombret H, Cazes L, Brenac V, Sigaux F, Buckle M.

Biochem Biophys Res Commun. 2004 Dec 17;325(3):1021-9.

PMID:
15541391
35.

The development of early and mature B cells is impaired in mice deficient for the Ets-1 transcription factor.

Eyquem S, Chemin K, Fasseu M, Chopin M, Sigaux F, Cumano A, Bories JC.

Eur J Immunol. 2004 Nov;34(11):3187-96.

36.

Detection of somatic mosaicism and classification of Fanconi anemia patients by analysis of the FA/BRCA pathway.

Soulier J, Leblanc T, Larghero J, Dastot H, Shimamura A, Guardiola P, Esperou H, Ferry C, Jubert C, Feugeas JP, Henri A, Toubert A, Socié G, Baruchel A, Sigaux F, D'Andrea AD, Gluckman E.

Blood. 2005 Feb 1;105(3):1329-36. Epub 2004 Sep 21.

37.

[Development of a new strategy for minimal residual disease monitoring in children with B-precursor acute lymphoblastic leukemia].

Bonjean B, Grollet L, Visentin E, Sigaux F, Cayuela JM.

Ann Biol Clin (Paris). 2004 Jul-Aug;62(4):465-70. French.

38.

Glycoprotein 170 induces platelet-activating factor receptor membrane expression and confers tumor cell hypersensitivity to NK-dependent cell lysis.

Geromin D, Bourge JF, Soulié A, Pawliuk R, Fleet C, Michel E, Denizot Y, Berthou C, Leboulch P, Sigaux F, Sasportes M.

J Immunol. 2004 Mar 15;172(6):3604-11.

39.

Varicella-zoster viral meningitis mimicking lymphoma.

Park S, Leymarie V, Agbalika F, Galicier L, Oksenhendler E, Sigaux F, Noguera ME.

Leuk Lymphoma. 2003 Oct;44(10):1793-5.

PMID:
14692535
40.

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1.

Hacein-Bey-Abina S, Von Kalle C, Schmidt M, McCormack MP, Wulffraat N, Leboulch P, Lim A, Osborne CS, Pawliuk R, Morillon E, Sorensen R, Forster A, Fraser P, Cohen JI, de Saint Basile G, Alexander I, Wintergerst U, Frebourg T, Aurias A, Stoppa-Lyonnet D, Romana S, Radford-Weiss I, Gross F, Valensi F, Delabesse E, Macintyre E, Sigaux F, Soulier J, Leiva LE, Wissler M, Prinz C, Rabbitts TH, Le Deist F, Fischer A, Cavazzana-Calvo M.

Science. 2003 Oct 17;302(5644):415-9. Erratum in: Science. 2003 Oct 24;302(5645):568.

41.

Regression of CD8+ pseudolymphoma after HIV antiviral triple therapy.

Schartz NE, De La Blanchardiére A, Alaoui S, Morel P, Sigaux F, Vignon-Pennamen MD, Flageul B, Lebbé C.

J Am Acad Dermatol. 2003 Jul;49(1):139-41.

PMID:
12833028
42.

Peripheral T-cell lymphoma with eosinophilia presenting as monoarthritis: a case study.

Daneshpouy M, Bataille D, Rivet J, Riviere O, Morel P, Amouroux J, Briere J, Sigaux F, Janin A.

Leuk Lymphoma. 2002 Sep;43(9):1875-9.

PMID:
12685848
43.

Disruption of the lineage restriction of TCR beta gene rearrangements.

Eyquem S, Lagresle C, Fasseu M, Sigaux F, Bories JC.

Eur J Immunol. 2002 Nov;32(11):3256-66.

44.

Successful rituximab treatment of an EBV-related lymphoproliferative disease arising after autologous transplantation for angioimmunoblastic T-cell lymphoma.

Park S, Noguera ME, Brière J, Feuillard J, Cayuela JM, Sigaux F, Brice P.

Hematol J. 2002;3(6):317-20.

PMID:
12522456
45.

Prognostic significance of FLT3 internal tandem repeat in patients with de novo acute myeloid leukemia treated with reinforced courses of chemotherapy.

Boissel N, Cayuela JM, Preudhomme C, Thomas X, Grardel N, Fund X, Tigaud I, Raffoux E, Rousselot P, Sigaux F, Degos L, Castaigne S, Fenaux P, Dombret H.

Leukemia. 2002 Sep;16(9):1699-704.

46.

In vitro and in vivo effectiveness of arsenic trioxide against murine T-cell prolymphocytic leukaemia.

Récher C, Chopin M, Raffoux E, Pierron G, Poupon J, Sigaux F, Dombret H, Stern MH.

Br J Haematol. 2002 May;117(2):343-50.

PMID:
11972516
47.

A clinical, molecular and cytogenetic study of 12 cases of human herpesvirus 8 associated primary effusion lymphoma in HIV-infected patients.

Boulanger E, Agbalika F, Maarek O, Daniel MT, Grollet L, Molina JM, Sigaux F, Oksenhendler E.

Hematol J. 2001;2(3):172-9. Review.

PMID:
11920242
48.

Aplastic anemia and paroxysmal nocturnal hemoglobinuria: a follow-up study of the glycosylphosphatidylinositol-anchored proteins defect.

Noguera ME, Leymarie V, Bittencourt E, Gluckman E, Sigaux F, Socié G.

Hematol J. 2000;1(4):250-3.

PMID:
11920198
49.

Recurrent molecular deletion of the 12p13 region, centromeric to ETV6/TEL, in T-cell prolymphocytic leukemia.

Hetet G, Dastot H, Baens M, Brizard A, Sigaux F, Grandchamp B, Stern MH.

Hematol J. 2000;1(1):42-7.

PMID:
11920168
50.

Deregulated expression of promyelocytic leukemia zinc finger protein in B-cell chronic lymphocytic leukemias does not affect cyclin A expression.

Parrado A, Noguera ME, Delmer A, McKenna S, Davies J, Le Gall I, Bentley P, Whittaker JA, Sigaux F, Chomienne C, Padua RA.

Hematol J. 2000;1(1):15-27.

PMID:
11920165

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