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Increased T Cell Differentiation and Cytolytic Function in Bangladeshi Compared to American Children.

Wagar LE, Bolen CR, Sigal N, Lopez Angel CJ, Guan L, Kirkpatrick BD, Haque R, Tibshirani RJ, Parsonnet J, Petri WA Jr, Davis MM.

Front Immunol. 2019 Sep 20;10:2239. doi: 10.3389/fimmu.2019.02239. eCollection 2019.


Comprehensive Immune Monitoring of Clinical Trials to Advance Human Immunotherapy.

Hartmann FJ, Babdor J, Gherardini PF, Amir ED, Jones K, Sahaf B, Marquez DM, Krutzik P, O'Donnell E, Sigal N, Maecker HT, Meyer E, Spitzer MH, Bendall SC.

Cell Rep. 2019 Jul 16;28(3):819-831.e4. doi: 10.1016/j.celrep.2019.06.049.


Controlled branched-chain amino acids auxotrophy in Listeria monocytogenes allows isoleucine to serve as a host signal and virulence effector.

Brenner M, Lobel L, Borovok I, Sigal N, Herskovits AA.

PLoS Genet. 2018 Mar 12;14(3):e1007283. doi: 10.1371/journal.pgen.1007283. eCollection 2018 Mar.


Temperate bacteriophages as regulators of host behavior.

Argov T, Azulay G, Pasechnek A, Stadnyuk O, Ran-Sapir S, Borovok I, Sigal N, Herskovits AA.

Curr Opin Microbiol. 2017 Aug;38:81-87. doi: 10.1016/j.mib.2017.05.002. Epub 2017 May 23. Review.


Metabolic Genetic Screens Reveal Multidimensional Regulation of Virulence Gene Expression in Listeria monocytogenes and an Aminopeptidase That Is Critical for PrfA Protein Activation.

Friedman S, Linsky M, Lobel L, Rabinovich L, Sigal N, Herskovits AA.

Infect Immun. 2017 May 23;85(6). pii: e00027-17. doi: 10.1128/IAI.00027-17. Print 2017 Jun.


L-glutamine Induces Expression of Listeria monocytogenes Virulence Genes.

Haber A, Friedman S, Lobel L, Burg-Golani T, Sigal N, Rose J, Livnat-Levanon N, Lewinson O, Herskovits AA.

PLoS Pathog. 2017 Jan 23;13(1):e1006161. doi: 10.1371/journal.ppat.1006161. eCollection 2017 Jan.


An Effective Counterselection System for Listeria monocytogenes and Its Use To Characterize the Monocin Genomic Region of Strain 10403S.

Argov T, Rabinovich L, Sigal N, Herskovits AA.

Appl Environ Microbiol. 2017 Mar 2;83(6). pii: e02927-16. doi: 10.1128/AEM.02927-16. Print 2017 Mar 15.


RNA Purification from Intracellularly Grown Listeria monocytogenes in Macrophage Cells.

Sigal N, Pasechnek A, Herskovits AA.

J Vis Exp. 2016 Jun 4;(112). doi: 10.3791/54044.


Detection, phenotyping, and quantification of antigen-specific T cells using a peptide-MHC dodecamer.

Huang J, Zeng X, Sigal N, Lund PJ, Su LF, Huang H, Chien YH, Davis MM.

Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):E1890-7. doi: 10.1073/pnas.1602488113. Epub 2016 Mar 15.


A new perspective on lysogeny: prophages as active regulatory switches of bacteria.

Feiner R, Argov T, Rabinovich L, Sigal N, Borovok I, Herskovits AA.

Nat Rev Microbiol. 2015 Oct;13(10):641-50. doi: 10.1038/nrmicro3527. Review.


The human P-glycoprotein transporter enhances the type I interferon response to Listeria monocytogenes infection.

Sigal N, Kaplan Zeevi M, Weinstein S, Peer D, Herskovits AA.

Infect Immun. 2015 Jun;83(6):2358-68. doi: 10.1128/IAI.00380-15. Epub 2015 Mar 30.


The metabolic regulator CodY links Listeria monocytogenes metabolism to virulence by directly activating the virulence regulatory gene prfA.

Lobel L, Sigal N, Borovok I, Belitsky BR, Sonenshein AL, Herskovits AA.

Mol Microbiol. 2015 Feb;95(4):624-44. doi: 10.1111/mmi.12890. Epub 2014 Dec 30.


Listeria monocytogenes MDR transporters are involved in LTA synthesis and triggering of innate immunity during infection.

Tadmor K, Pozniak Y, Burg Golani T, Lobel L, Brenner M, Sigal N, Herskovits AA.

Front Cell Infect Microbiol. 2014 Feb 25;4:16. doi: 10.3389/fcimb.2014.00016. eCollection 2014.


Listeria monocytogenes multidrug resistance transporters and cyclic di-AMP, which contribute to type I interferon induction, play a role in cell wall stress.

Kaplan Zeevi M, Shafir NS, Shaham S, Friedman S, Sigal N, Nir Paz R, Boneca IG, Herskovits AA.

J Bacteriol. 2013 Dec;195(23):5250-61. doi: 10.1128/JB.00794-13. Epub 2013 Sep 20.


Membrane chaperone SecDF plays a role in the secretion of Listeria monocytogenes major virulence factors.

Burg-Golani T, Pozniak Y, Rabinovich L, Sigal N, Nir Paz R, Herskovits AA.

J Bacteriol. 2013 Dec;195(23):5262-72. doi: 10.1128/JB.00697-13. Epub 2013 Sep 20.


Combinatorial tetramer staining and mass cytometry analysis facilitate T-cell epitope mapping and characterization.

Newell EW, Sigal N, Nair N, Kidd BA, Greenberg HB, Davis MM.

Nat Biotechnol. 2013 Jul;31(7):623-9. doi: 10.1038/nbt.2593. Epub 2013 Jun 9.


Integrative genomic analysis identifies isoleucine and CodY as regulators of Listeria monocytogenes virulence.

Lobel L, Sigal N, Borovok I, Ruppin E, Herskovits AA.

PLoS Genet. 2012 Sep;8(9):e1002887. doi: 10.1371/journal.pgen.1002887. Epub 2012 Sep 6.


Prophage excision activates Listeria competence genes that promote phagosomal escape and virulence.

Rabinovich L, Sigal N, Borovok I, Nir-Paz R, Herskovits AA.

Cell. 2012 Aug 17;150(4):792-802. doi: 10.1016/j.cell.2012.06.036.


Manipulating the drug/proton antiport stoichiometry of the secondary multidrug transporter MdfA.

Tirosh O, Sigal N, Gelman A, Sahar N, Fluman N, Siemion S, Bibi E.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12473-8. doi: 10.1073/pnas.1203632109. Epub 2012 Jul 16.


Cytometry by time-of-flight shows combinatorial cytokine expression and virus-specific cell niches within a continuum of CD8+ T cell phenotypes.

Newell EW, Sigal N, Bendall SC, Nolan GP, Davis MM.

Immunity. 2012 Jan 27;36(1):142-52. doi: 10.1016/j.immuni.2012.01.002. Erratum in: Immunity. 2013 Jan 24;38(1):198-9.


Chromatin regulators as capacitors of interspecies variations in gene expression.

Tirosh I, Reikhav S, Sigal N, Assia Y, Barkai N.

Mol Syst Biol. 2010 Nov 30;6:435. doi: 10.1038/msb.2010.84.


Divergence of nucleosome positioning between two closely related yeast species: genetic basis and functional consequences.

Tirosh I, Sigal N, Barkai N.

Mol Syst Biol. 2010 May 11;6:365. doi: 10.1038/msb.2010.20.


Widespread remodeling of mid-coding sequence nucleosomes by Isw1.

Tirosh I, Sigal N, Barkai N.

Genome Biol. 2010;11(5):R49. doi: 10.1186/gb-2010-11-5-r49. Epub 2010 May 10.


Radical polymerization of the silene (Me3Si)2Si=CR2 by hydrogen transfer from a trimethylsilyl group.

Bravo-Zhivotovskii D, Melamed S, Molev V, Sigal N, Tumanskii B, Botoshansky M, Molev G, Apeloig Y.

Angew Chem Int Ed Engl. 2009;48(10):1834-7. doi: 10.1002/anie.200805840.


The secondary multidrug/proton antiporter MdfA tolerates displacements of an essential negatively charged side chain.

Sigal N, Fluman N, Siemion S, Bibi E.

J Biol Chem. 2009 Mar 13;284(11):6966-71. doi: 10.1074/jbc.M808877200. Epub 2009 Jan 7.


E. coli multidrug transporter MdfA is a monomer.

Sigal N, Lewinson O, Wolf SG, Bibi E.

Biochemistry. 2007 May 1;46(17):5200-8. Epub 2007 Apr 4.


MdfA from Escherichia coli, a model protein for studying secondary multidrug transport.

Sigal N, Cohen-Karni D, Siemion S, Bibi E.

J Mol Microbiol Biotechnol. 2006;11(6):308-17. Review.


Promiscuity in multidrug recognition and transport: the bacterial MFS Mdr transporters.

Lewinson O, Adler J, Sigal N, Bibi E.

Mol Microbiol. 2006 Jul;61(2):277-84. Review.


3D model of the Escherichia coli multidrug transporter MdfA reveals an essential membrane-embedded positive charge.

Sigal N, Vardy E, Molshanski-Mor S, Eitan A, Pilpel Y, Schuldiner S, Bibi E.

Biochemistry. 2005 Nov 15;44(45):14870-80.


Surfing the piperazine core of tricyclic farnesyltransferase inhibitors.

Rokosz LL, Huang CY, Reader JC, Stauffer TM, Chelsky D, Sigal NH, Ganguly AK, Baldwin JJ.

Bioorg Med Chem Lett. 2005 Dec 15;15(24):5537-43. Epub 2005 Oct 3.


The guanine nucleotide exchange factor trio activates the phagocyte NADPH oxidase in the absence of GDP to GTP exchange on Rac. "The emperor's nw clothes".

Sigal N, Gorzalczany Y, Sarfstein R, Weinbaum C, Zheng Y, Pick E.

J Biol Chem. 2003 Feb 14;278(7):4854-61. Epub 2002 Dec 9.


Mapping of functional domains in the p22(phox) subunit of flavocytochrome b(559) participating in the assembly of the NADPH oxidase complex by "peptide walking".

Dahan I, Issaeva I, Gorzalczany Y, Sigal N, Hirshberg M, Pick E.

J Biol Chem. 2002 Mar 8;277(10):8421-32. Epub 2001 Dec 3.


A Novel CSiP Ring from the Reaction of a Complexed Phosphinidene and a Silene This work was supported by the Council for Chemical Sciences of the Netherlands Organization for Scientific Research (NWO/CW).

Vlaar MJ, Ehlers AW, de Kanter FJ, Schakel M, Spek AL, Lutz M, Sigal N, Apeloig Y, Lammertsma K.

Angew Chem Int Ed Engl. 2000 Nov 17;39(22):4127-4130. No abstract available.


Targeting of Rac1 to the phagocyte membrane is sufficient for the induction of NADPH oxidase assembly.

Gorzalczany Y, Sigal N, Itan M, Lotan O, Pick E.

J Biol Chem. 2000 Dec 22;275(51):40073-81.


Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry.

McMillan K, Adler M, Auld DS, Baldwin JJ, Blasko E, Browne LJ, Chelsky D, Davey D, Dolle RE, Eagen KA, Erickson S, Feldman RI, Glaser CB, Mallari C, Morrissey MM, Ohlmeyer MH, Pan G, Parkinson JF, Phillips GB, Polokoff MA, Sigal NH, Vergona R, Whitlow M, Young TA, Devlin JJ.

Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1506-11.


Small molecule antagonists of the bradykinin B1 receptor.

Horlick RA, Ohlmeyer MH, Stroke IL, Strohl B, Pan G, Schilling AE, Paradkar V, Quintero JG, You M, Riviello C, Thorn MB, Damaj B, Fitzpatrick VD, Dolle RE, Webb ML, Baldwin JJ, Sigal NH.

Immunopharmacology. 1999 Sep;43(2-3):169-77.


A tacrolimus-related immunosuppressant with reduced toxicity.

Dumont FJ, Koprak S, Staruch MJ, Talento A, Koo G, DaSilva C, Sinclair PJ, Wong F, Woods J, Barker J, Pivnichny J, Singer I, Sigal NH, Williamson AR, Parsons WH, Wyvratt M.

Transplantation. 1998 Jan 15;65(1):18-26.


A tacrolimus-related immunosuppressant with biochemical properties distinct from those of tacrolimus.

Peterson LB, Cryan JG, Rosa R, Martin MM, Wilusz MB, Sinclair PJ, Wong F, Parsons JN, O'Keefe SJ, Parsons WH, Wyvratt M, Sigal NH, Williamson AR, Wiederrecht GJ.

Transplantation. 1998 Jan 15;65(1):10-8.


New technologies for high-throughput screening.

Burbaum JJ, Sigal NH.

Curr Opin Chem Biol. 1997 Jun;1(1):72-8. Review.


Blockade of the voltage-gated potassium channel Kv1.3 inhibits immune responses in vivo.

Koo GC, Blake JT, Talento A, Nguyen M, Lin S, Sirotina A, Shah K, Mulvany K, Hora D Jr, Cunningham P, Wunderler DL, McManus OB, Slaughter R, Bugianesi R, Felix J, Garcia M, Williamson J, Kaczorowski G, Sigal NH, Springer MS, Feeney W.

J Immunol. 1997 Jun 1;158(11):5120-8.


A paradigm for drug discovery employing encoded combinatorial libraries.

Burbaum JJ, Ohlmeyer MH, Reader JC, Henderson I, Dillard LW, Li G, Randle TL, Sigal NH, Chelsky D, Baldwin JJ.

Proc Natl Acad Sci U S A. 1995 Jun 20;92(13):6027-31.


The mechanism of action of FK-506 and cyclosporin A.

Wiederrecht G, Lam E, Hung S, Martin M, Sigal N.

Ann N Y Acad Sci. 1993 Nov 30;696:9-19. Review.


FK-506--a novel immunosuppressant.

Parsons WH, Sigal NH, Wyvratt MJ.

Ann N Y Acad Sci. 1993 Jun 23;685:22-36. Review. No abstract available.


Voltage-gated potassium channels regulate calcium-dependent pathways involved in human T lymphocyte activation.

Lin CS, Boltz RC, Blake JT, Nguyen M, Talento A, Fischer PA, Springer MS, Sigal NH, Slaughter RS, Garcia ML, et al.

J Exp Med. 1993 Mar 1;177(3):637-45.


A single administration of LFA-1 antibody confers prolonged allograft survival.

Talento A, Nguyen M, Blake T, Sirotina A, Fioravanti C, Burkholder D, Gibson R, Sigal NH, Springer MS, Koo GC.

Transplantation. 1993 Feb;55(2):418-22.


Recent advances in the mechanism of action of cyclosporine and FK506.

Tocci MJ, Sigal NH.

Curr Opin Nephrol Hypertens. 1992 Dec;1(2):236-42. Review.


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