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Items: 50


With some risk-taking and luck: A veterinarian's adventures in viral immunology.

Sigal LJ.

PLoS Pathog. 2018 Jul 5;14(7):e1007000. doi: 10.1371/journal.ppat.1007000. eCollection 2018 Jul. No abstract available.


Migratory Dendritic Cells, Group 1 Innate Lymphoid Cells, and Inflammatory Monocytes Collaborate to Recruit NK Cells to the Virus-Infected Lymph Node.

Wong E, Xu RH, Rubio D, Lev A, Stotesbury C, Fang M, Sigal LJ.

Cell Rep. 2018 Jul 3;24(1):142-154. doi: 10.1016/j.celrep.2018.06.004.


Cutting Edge: Protection by Antiviral Memory CD8 T Cells Requires Rapidly Produced Antigen in Large Amounts.

Remakus S, Ma X, Tang L, Xu RH, Knudson C, Melo-Silva CR, Rubio D, Kuo YM, Andrews A, Sigal LJ.

J Immunol. 2018 May 15;200(10):3347-3352. doi: 10.4049/jimmunol.1701568. Epub 2018 Apr 11.


DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death.

Thapa RJ, Ingram JP, Ragan KB, Nogusa S, Boyd DF, Benitez AA, Sridharan H, Kosoff R, Shubina M, Landsteiner VJ, Andrake M, Vogel P, Sigal LJ, tenOever BR, Thomas PG, Upton JW, Balachandran S.

Cell Host Microbe. 2016 Nov 9;20(5):674-681. doi: 10.1016/j.chom.2016.09.014. Epub 2016 Oct 13.


The Pathogenesis and Immunobiology of Mousepox.

Sigal LJ.

Adv Immunol. 2016;129:251-76. doi: 10.1016/ Epub 2015 Nov 21. Review.


Sequential Activation of Two Pathogen-Sensing Pathways Required for Type I Interferon Expression and Resistance to an Acute DNA Virus Infection.

Xu RH, Wong EB, Rubio D, Roscoe F, Ma X, Nair S, Remakus S, Schwendener R, John S, Shlomchik M, Sigal LJ.

Immunity. 2015 Dec 15;43(6):1148-59. doi: 10.1016/j.immuni.2015.11.015.


Protective CD8+ T cell memory without help.

Fang M, Sigal LJ.

Oncotarget. 2015 Oct 6;6(30):28529-30. doi: 10.18632/oncotarget.5449. No abstract available.


Targeted Blockade of JAK/STAT3 Signaling Inhibits Ovarian Carcinoma Growth.

Gritsina G, Xiao F, O'Brien SW, Gabbasov R, Maglaty MA, Xu RH, Thapa RJ, Zhou Y, Nicolas E, Litwin S, Balachandran S, Sigal LJ, Huszar D, Connolly DC.

Mol Cancer Ther. 2015 Apr;14(4):1035-47. doi: 10.1158/1535-7163.MCT-14-0800. Epub 2015 Feb 2.


The natural killer cell dysfunction of aged mice is due to the bone marrow stroma and is not restored by IL-15/IL-15Rα treatment.

Nair S, Fang M, Sigal LJ.

Aging Cell. 2015 Apr;14(2):180-90. doi: 10.1111/acel.12291. Epub 2014 Nov 16.


CD4+ T cell help is dispensable for protective CD8+ T cell memory against mousepox virus following vaccinia virus immunization.

Fang M, Remakus S, Roscoe F, Ma X, Sigal LJ.

J Virol. 2015 Jan;89(1):776-83. doi: 10.1128/JVI.02176-14. Epub 2014 Oct 29.


Impact of distinct poxvirus infections on the specificities and functionalities of CD4+ T cell responses.

Siciliano NA, Hersperger AR, Lacuanan AM, Xu RH, Sidney J, Sette A, Sigal LJ, Eisenlohr LC.

J Virol. 2014 Sep 1;88(17):10078-91. doi: 10.1128/JVI.01150-14. Epub 2014 Jun 25.


MyD88-dependent immunity to a natural model of vaccinia virus infection does not involve Toll-like receptor 2.

Davies ML, Sei JJ, Siciliano NA, Xu RH, Roscoe F, Sigal LJ, Eisenlohr LC, Norbury CC.

J Virol. 2014 Mar;88(6):3557-67. doi: 10.1128/JVI.02776-13. Epub 2014 Jan 8.


Crosstalk between the type 1 interferon and nuclear factor kappa B pathways confers resistance to a lethal virus infection.

Rubio D, Xu RH, Remakus S, Krouse TE, Truckenmiller ME, Thapa RJ, Balachandran S, Alcamí A, Norbury CC, Sigal LJ.

Cell Host Microbe. 2013 Jun 12;13(6):701-10. doi: 10.1016/j.chom.2013.04.015.


Memory CD8⁺ T cells can outsource IFN-γ production but not cytolytic killing for antiviral protection.

Remakus S, Rubio D, Lev A, Ma X, Fang M, Xu RH, Sigal LJ.

Cell Host Microbe. 2013 May 15;13(5):546-557. doi: 10.1016/j.chom.2013.04.004.


Immunology: Memory cells sound the alarm.

Smith-Garvin JE, Sigal LJ.

Nature. 2013 May 9;497(7448):194-6. doi: 10.1038/497194b. No abstract available.


The mature virion of ectromelia virus, a pathogenic poxvirus, is capable of intrahepatic spread and can serve as a target for delayed therapy.

Ma X, Xu RH, Roscoe F, Whitbeck JC, Eisenberg RJ, Cohen GH, Sigal LJ.

J Virol. 2013 Jun;87(12):7046-53. doi: 10.1128/JVI.03158-12. Epub 2013 Apr 17.


Memory CD8⁺ T cell protection.

Remakus S, Sigal LJ.

Adv Exp Med Biol. 2013;785:77-86. doi: 10.1007/978-1-4614-6217-0_9. Review.


Memory CD8+ T cells specific for a single immunodominant or subdominant determinant induced by peptide-dendritic cell immunization protect from an acute lethal viral disease.

Remakus S, Rubio D, Ma X, Sette A, Sigal LJ.

J Virol. 2012 Sep;86(18):9748-59. doi: 10.1128/JVI.00981-12. Epub 2012 Jun 27.


Perforin-dependent CD4+ T-cell cytotoxicity contributes to control a murine poxvirus infection.

Fang M, Siciliano NA, Hersperger AR, Roscoe F, Hu A, Ma X, Shamsedeen AR, Eisenlohr LC, Sigal LJ.

Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9983-8. doi: 10.1073/pnas.1202143109. Epub 2012 Jun 4.


Antibody inhibition of a viral type 1 interferon decoy receptor cures a viral disease by restoring interferon signaling in the liver.

Xu RH, Rubio D, Roscoe F, Krouse TE, Truckenmiller ME, Norbury CC, Hudson PN, Damon IK, Alcamí A, Sigal LJ.

PLoS Pathog. 2012 Jan;8(1):e1002475. doi: 10.1371/journal.ppat.1002475. Epub 2012 Jan 5.


Gamma interferon and perforin control the strength, but not the hierarchy, of immunodominance of an antiviral CD8+ T cell response.

Remakus S, Sigal LJ.

J Virol. 2011 Dec;85(23):12578-84. doi: 10.1128/JVI.05334-11. Epub 2011 Sep 14.


CD94 is essential for NK cell-mediated resistance to a lethal viral disease.

Fang M, Orr MT, Spee P, Egebjerg T, Lanier LL, Sigal LJ.

Immunity. 2011 Apr 22;34(4):579-89. doi: 10.1016/j.immuni.2011.02.015.


Development and function of CD94-deficient natural killer cells.

Orr MT, Wu J, Fang M, Sigal LJ, Spee P, Egebjerg T, Dissen E, Fossum S, Phillips JH, Lanier LL.

PLoS One. 2010 Dec 3;5(12):e15184. doi: 10.1371/journal.pone.0015184.


Age-dependent susceptibility to a viral disease due to decreased natural killer cell numbers and trafficking.

Fang M, Roscoe F, Sigal LJ.

J Exp Med. 2010 Oct 25;207(11):2369-81. doi: 10.1084/jem.20100282. Epub 2010 Sep 27.


Direct presentation is sufficient for an efficient anti-viral CD8+ T cell response.

Xu RH, Remakus S, Ma X, Roscoe F, Sigal LJ.

PLoS Pathog. 2010 Feb 12;6(2):e1000768. doi: 10.1371/journal.ppat.1000768.


The orthopoxvirus type I IFN binding protein is essential for virulence and an effective target for vaccination.

Xu RH, Cohen M, Tang Y, Lazear E, Whitbeck JC, Eisenberg RJ, Cohen GH, Sigal LJ.

J Exp Med. 2008 Apr 14;205(4):981-92. doi: 10.1084/jem.20071854. Epub 2008 Apr 7.


Enhanced NK-cell development and function in BCAP-deficient mice.

MacFarlane AW 4th, Yamazaki T, Fang M, Sigal LJ, Kurosaki T, Campbell KS.

Blood. 2008 Jul 1;112(1):131-40. doi: 10.1182/blood-2007-08-107847. Epub 2008 Mar 12.


A role for NKG2D in NK cell-mediated resistance to poxvirus disease.

Fang M, Lanier LL, Sigal LJ.

PLoS Pathog. 2008 Feb 8;4(2):e30. doi: 10.1371/journal.ppat.0040030.


Memory CD8+ T cells are gatekeepers of the lymph node draining the site of viral infection.

Xu RH, Fang M, Klein-Szanto A, Sigal LJ.

Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):10992-7. Epub 2007 Jun 19.


The multiple routes of MHC-I cross-presentation.

Ramirez MC, Sigal LJ.

Trends Microbiol. 2004 May;12(5):204-7. Review. No abstract available.


Cross priming or direct priming: is that really the question?

Norbury CC, Sigal LJ.

Curr Opin Immunol. 2003 Feb;15(1):82-8. Review. No abstract available.


Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen.

Sigal LJ, Crotty S, Andino R, Rock KL.

Nature. 1999 Mar 4;398(6722):77-80.


The role of B7-1 and B7-2 costimulation for the generation of CTL responses in vivo.

Sigal LJ, Reiser H, Rock KL.

J Immunol. 1998 Sep 15;161(6):2740-5.


Role of non-anchor residues of Db-restricted peptides in class I binding and TCR triggering.

Sigal LJ, Wylie DE.

Mol Immunol. 1996 Dec;33(17-18):1323-33.


Changes in mononuclear peripheral blood cells in cattle with foot-and-mouth disease.

Sigal LJ, Gomez G, Braun M.

Vet Immunol Immunopathol. 1992 Jan 31;30(4):431-8.


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