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Items: 1 to 50 of 52

1.

Telemedicine for Interfacility Nurse Handoffs.

Lieng MK, Siefkes HM, Rosenthal JL, Sauers-Ford HS, Mouzoon JL, Sigal IS, Dayal P, Chen ST, McBeth CL, Dial S, Dizon G, Dannewitz HE, Kozycz K, Jennings-Hill TL, Martinson JM, Huerta JK, Pons EA, Vance N, Warnock BN, Marcin JP.

Pediatr Crit Care Med. 2019 Sep;20(9):832-840. doi: 10.1097/PCC.0000000000002011.

PMID:
31232857
2.

Association of Insurance With Use of Emergency Medical Services Among Children.

Dayal P, Ruttan TK, Kissee JL, Sigal IS, Marcin JP.

Pediatr Emerg Care. 2017 Nov 20. doi: 10.1097/PEC.0000000000001352. [Epub ahead of print]

PMID:
29189593
3.

Association Between Insurance and Transfer of Injured Children From Emergency Departments.

Huang Y, Kissee JL, Dayal P, Wang NE, Sigal IS, Marcin JP.

Pediatrics. 2017 Oct;140(4). pii: e20163640. doi: 10.1542/peds.2016-3640. Epub 2017 Sep 19.

4.

Design and synthesis of HIV protease inhibitors. Variations of the carboxy terminus of the HIV protease inhibitor L-682,679.

deSolms SJ, Giuliani EA, Guare JP, Vacca JP, Sanders WM, Graham SL, Wiggins JM, Darke PL, Sigal IS, Zugay JA, et al.

J Med Chem. 1991 Sep;34(9):2852-7.

PMID:
1910089
5.

L-687,908, a potent hydroxyethylene-containing HIV protease inhibitor.

Vacca JP, Guare JP, deSolms SJ, Sanders WM, Giuliani EA, Young SD, Darke PL, Zugay J, Sigal IS, Schleif WA, et al.

J Med Chem. 1991 Mar;34(3):1225-8. No abstract available.

PMID:
2002465
6.

Separation of the structural requirements for agonist-promoted activation and sequestration of the beta-adrenergic receptor.

Cheung AH, Dixon RA, Hill WS, Sigal IS, Strader CD.

Mol Pharmacol. 1990 Jun;37(6):775-9.

PMID:
2163011
7.

Genetic approaches to the determination of structure-function relationships of G protein-coupled receptors.

Strader CD, Sigal IS, Dixon RA.

Trends Pharmacol Sci. 1989 Dec;Suppl:26-30. Review.

PMID:
2559516
8.

Affinity purification of the HIV-1 protease.

Heimbach JC, Garsky VM, Michelson SR, Dixon RA, Sigal IS, Darke PL.

Biochem Biophys Res Commun. 1989 Nov 15;164(3):955-60.

PMID:
2686642
9.

A single amino acid substitution in the beta-adrenergic receptor promotes partial agonist activity from antagonists.

Strader CD, Candelore MR, Hill WS, Dixon RA, Sigal IS.

J Biol Chem. 1989 Oct 5;264(28):16470-7.

10.

Xenopus oocyte germinal-vesicle breakdown induced by [Val12]Ras is inhibited by a cytosol-localized Ras mutant.

Gibbs JB, Schaber MD, Schofield TL, Scolnick EM, Sigal IS.

Proc Natl Acad Sci U S A. 1989 Sep;86(17):6630-4.

11.

Identification of two serine residues involved in agonist activation of the beta-adrenergic receptor.

Strader CD, Candelore MR, Hill WS, Sigal IS, Dixon RA.

J Biol Chem. 1989 Aug 15;264(23):13572-8.

12.

Mapping the functional domains of the beta-adrenergic receptor.

Strader CD, Sigal IS, Dixon RA.

Am J Respir Cell Mol Biol. 1989 Aug;1(2):81-6. Review.

PMID:
2559762
13.

Structural basis of beta-adrenergic receptor function.

Strader CD, Sigal IS, Dixon RA.

FASEB J. 1989 May;3(7):1825-32.

PMID:
2541037
14.

Oncogenes.

Sigal IS, Gibbs JB.

Curr Opin Cell Biol. 1989 Apr;1(2):286-90. Review. No abstract available.

PMID:
2698681
15.

A C-terminal domain of GAP is sufficient to stimulate ras p21 GTPase activity.

Marshall MS, Hill WS, Ng AS, Vogel US, Schaber MD, Scolnick EM, Dixon RA, Sigal IS, Gibbs JB.

EMBO J. 1989 Apr;8(4):1105-10.

16.

Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1.

Navia MA, Fitzgerald PM, McKeever BM, Leu CT, Heimbach JC, Herber WK, Sigal IS, Darke PL, Springer JP.

Nature. 1989 Feb 16;337(6208):615-20.

PMID:
2645523
17.

Human immunodeficiency virus protease. Bacterial expression and characterization of the purified aspartic protease.

Darke PL, Leu CT, Davis LJ, Heimbach JC, Diehl RE, Hill WS, Dixon RA, Sigal IS.

J Biol Chem. 1989 Feb 5;264(4):2307-12.

18.

Crystallization of the aspartylprotease from the human immunodeficiency virus, HIV-1.

McKeever BM, Navia MA, Fitzgerald PM, Springer JP, Leu CT, Heimbach JC, Herbert WK, Sigal IS, Darke PL.

J Biol Chem. 1989 Feb 5;264(4):1919-21.

19.

Agonist-promoted sequestration of the beta 2-adrenergic receptor requires regions involved in functional coupling with Gs.

Cheung AH, Sigal IS, Dixon RA, Strader CD.

Mol Pharmacol. 1989 Jan;35(1):132-8.

PMID:
2563305
20.

Genetic analysis of the molecular basis for beta-adrenergic receptor subtype specificity.

Dixon RA, Hill WS, Candelore MR, Rands E, Diehl RE, Marshall MS, Sigal IS, Strader CD.

Proteins. 1989;6(3):267-74.

PMID:
2560192
21.

Ras interaction with the GTPase-activating protein (GAP).

Schaber MD, Garsky VM, Boylan D, Hill WS, Scolnick EM, Marshall MS, Sigal IS, Gibbs JB.

Proteins. 1989;6(3):306-15.

PMID:
2516318
22.

HIV-1 protease specificity of peptide cleavage is sufficient for processing of gag and pol polyproteins.

Darke PL, Nutt RF, Brady SF, Garsky VM, Ciccarone TM, Leu CT, Lumma PK, Freidinger RM, Veber DF, Sigal IS.

Biochem Biophys Res Commun. 1988 Oct 14;156(1):297-303.

PMID:
3052448
23.

Chemical synthesis and enzymatic activity of a 99-residue peptide with a sequence proposed for the human immunodeficiency virus protease.

Nutt RF, Brady SF, Darke PL, Ciccarone TM, Colton CD, Nutt EM, Rodkey JA, Bennett CD, Waxman LH, Sigal IS, et al.

Proc Natl Acad Sci U S A. 1988 Oct;85(19):7129-33.

24.

Cloning of bovine GAP and its interaction with oncogenic ras p21.

Vogel US, Dixon RA, Schaber MD, Diehl RE, Marshall MS, Scolnick EM, Sigal IS, Gibbs JB.

Nature. 1988 Sep 1;335(6185):90-3.

PMID:
2842690
25.

Conserved aspartic acid residues 79 and 113 of the beta-adrenergic receptor have different roles in receptor function.

Strader CD, Sigal IS, Candelore MR, Rands E, Hill WS, Dixon RA.

J Biol Chem. 1988 Jul 25;263(21):10267-71.

26.

Purification of ras GTPase activating protein from bovine brain.

Gibbs JB, Schaber MD, Allard WJ, Sigal IS, Scolnick EM.

Proc Natl Acad Sci U S A. 1988 Jul;85(14):5026-30.

27.

Active human immunodeficiency virus protease is required for viral infectivity.

Kohl NE, Emini EA, Schleif WA, Davis LJ, Heimbach JC, Dixon RA, Scolnick EM, Sigal IS.

Proc Natl Acad Sci U S A. 1988 Jul;85(13):4686-90.

28.

Inhibition of yeast adenylate cyclase by antibodies to ras p21.

Gibbs JB, Marsico-Ahern JD, Scolnick EM, Sigal IS.

Biochem J. 1988 May 15;252(1):289-92.

29.

The ras oncogene. A structure and some function.

Sigal IS.

Nature. 1988 Apr 7;332(6164):485-6. No abstract available.

PMID:
2833701
30.

An adenylate cyclase from Saccharomyces cerevisiae that is stimulated by RAS proteins with effector mutations.

Marshall MS, Gibbs JB, Scolnick EM, Sigal IS.

Mol Cell Biol. 1988 Jan;8(1):52-61.

31.

Structure/function studies of the ras protein.

Sigal IS, Marshall MS, Schaber MD, Vogel US, Scolnick EM, Gibbs JB.

Cold Spring Harb Symp Quant Biol. 1988;53 Pt 2:863-9. No abstract available.

PMID:
3151189
32.

The ras oncogene protein as a G-protein.

Sigal IS, D'Alonzo JS, Ahern JD, Marshall MS, Smith GM, Scolnick EM, Gibbs JB.

Adv Second Messenger Phosphoprotein Res. 1988;21:193-200. Review. No abstract available.

PMID:
3137958
33.

Structure-function analysis of the beta-adrenergic receptor.

Dixon RA, Sigal IS, Strader CD.

Cold Spring Harb Symp Quant Biol. 1988;53 Pt 1:487-97. No abstract available.

PMID:
2855488
34.

Sequence of the gene encoding the human M1 muscarinic acetylcholine receptor.

Allard WJ, Sigal IS, Dixon RA.

Nucleic Acids Res. 1987 Dec 23;15(24):10604. No abstract available.

35.

Mutations that uncouple the beta-adrenergic receptor from Gs and increase agonist affinity.

Strader CD, Dixon RA, Cheung AH, Candelore MR, Blake AD, Sigal IS.

J Biol Chem. 1987 Dec 5;262(34):16439-43. Erratum in: J Biol Chem 1988 Feb 25;263(6):3050.

36.

Structural features required for ligand binding to the beta-adrenergic receptor.

Dixon RA, Sigal IS, Candelore MR, Register RB, Scattergood W, Rands E, Strader CD.

EMBO J. 1987 Nov;6(11):3269-75.

37.

Molecular approaches towards an anti-ras drug.

Sigal IS, Smith GM, Jurnak F, Marsico-Ahern JD, D'Alonzo JS, Scolnick EM, Gibbs JB.

Anticancer Drug Des. 1987 Oct;2(2):107-15. Review.

PMID:
3130069
38.

Identification of guanine nucleotides bound to ras-encoded proteins in growing yeast cells.

Gibbs JB, Schaber MD, Marshall MS, Scolnick EM, Sigal IS.

J Biol Chem. 1987 Aug 5;262(22):10426-9.

39.

Regulatory function of the Saccharomyces cerevisiae RAS C-terminus.

Marshall MS, Gibbs JB, Scolnick EM, Sigal IS.

Mol Cell Biol. 1987 Jul;7(7):2309-15.

40.

Identification of residues required for ligand binding to the beta-adrenergic receptor.

Strader CD, Sigal IS, Register RB, Candelore MR, Rands E, Dixon RA.

Proc Natl Acad Sci U S A. 1987 Jul;84(13):4384-8.

41.

The carboxyl terminus of the hamster beta-adrenergic receptor expressed in mouse L cells is not required for receptor sequestration.

Strader CD, Sigal IS, Blake AD, Cheung AH, Register RB, Rands E, Zemcik BA, Candelore MR, Dixon RA.

Cell. 1987 Jun 19;49(6):855-63.

PMID:
3034435
42.

CDC25: a component of the RAS-adenylate cyclase pathway in Saccharomyces cerevisiae.

Robinson LC, Gibbs JB, Marshall MS, Sigal IS, Tatchell K.

Science. 1987 Mar 6;235(4793):1218-21.

PMID:
3547648
43.

Ligand binding to the beta-adrenergic receptor involves its rhodopsin-like core.

Dixon RA, Sigal IS, Rands E, Register RB, Candelore MR, Blake AD, Strader CD.

Nature. 1987 Mar 5-11;326(6108):73-7.

PMID:
2881211
44.

cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.

Kobilka BK, Dixon RA, Frielle T, Dohlman HG, Bolanowski MA, Sigal IS, Yang-Feng TL, Francke U, Caron MG, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 1987 Jan;84(1):46-50.

45.

Identification of effector residues and a neutralizing epitope of Ha-ras-encoded p21.

Sigal IS, Gibbs JB, D'Alonzo JS, Scolnick EM.

Proc Natl Acad Sci U S A. 1986 Jul;83(13):4725-9.

46.

Cloning of the gene and cDNA for mammalian beta-adrenergic receptor and homology with rhodopsin.

Dixon RA, Kobilka BK, Strader DJ, Benovic JL, Dohlman HG, Frielle T, Bolanowski MA, Bennett CD, Rands E, Diehl RE, Mumford RA, Slater EE, Sigal IS, Caron MG, Lefkowitz RJ, Strader CD.

Nature. 1986 May 1-7;321(6065):75-9.

PMID:
3010132
47.

Mutant ras-encoded proteins with altered nucleotide binding exert dominant biological effects.

Sigal IS, Gibbs JB, D'Alonzo JS, Temeles GL, Wolanski BS, Socher SH, Scolnick EM.

Proc Natl Acad Sci U S A. 1986 Feb;83(4):952-6.

48.

Mammalian and yeast ras gene products: biological function in their heterologous systems.

DeFeo-Jones D, Tatchell K, Robinson LC, Sigal IS, Vass WC, Lowy DR, Scolnick EM.

Science. 1985 Apr 12;228(4696):179-84.

PMID:
3883495
49.

Yeast and mammalian ras proteins have conserved biochemical properties.

Temeles GL, Gibbs JB, D'Alonzo JS, Sigal IS, Scolnick EM.

Nature. 1985 Feb 21-27;313(6004):700-3.

PMID:
3919305
50.

Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules.

Gibbs JB, Sigal IS, Poe M, Scolnick EM.

Proc Natl Acad Sci U S A. 1984 Sep;81(18):5704-8.

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