Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 54


Protein arginine methyltransferase 5 (PRMT5) promotes survival of lymphoma cells via activation of WNT/β-catenin and AKT/GSK3β proliferative signaling.

Chung J, Karkhanis V, Baiocchi RA, Sif S.

J Biol Chem. 2019 May 10;294(19):7692-7710. doi: 10.1074/jbc.RA119.007640. Epub 2019 Mar 18.


Protein arginine methyltransferase 5 (PRMT5) dysregulation in cancer.

Shailesh H, Zakaria ZZ, Baiocchi R, Sif S.

Oncotarget. 2018 Nov 30;9(94):36705-36718. doi: 10.18632/oncotarget.26404. eCollection 2018 Nov 30. Review.


Recent advances in targeting protein arginine methyltransferase enzymes in cancer therapy.

Smith E, Zhou W, Shindiapina P, Sif S, Li C, Baiocchi RA.

Expert Opin Ther Targets. 2018 Jun;22(6):527-545. doi: 10.1080/14728222.2018.1474203. Epub 2018 May 21. Review.


Dietary fat/cholesterol-sensitive PKCβ-RB signaling: Potential role in NASH/HCC axis.

Huang W, Mehta D, Sif S, Kent LN, Jacob ST, Ghoshal K, Mehta KD.

Oncotarget. 2017 May 15;8(43):73757-73765. doi: 10.18632/oncotarget.17890. eCollection 2017 Sep 26.


PRMT5-PTEN molecular pathway regulates senescence and self-renewal of primary glioblastoma neurosphere cells.

Banasavadi-Siddegowda YK, Russell L, Frair E, Karkhanis VA, Relation T, Yoo JY, Zhang J, Sif S, Imitola J, Baiocchi R, Kaur B.

Oncogene. 2017 Jan 12;36(2):263-274. doi: 10.1038/onc.2016.199. Epub 2016 Jun 13.


Towards understanding the genetics of Autism.

Shailesh H, Gupta I, Sif S, Ouhtit A.

Front Biosci (Elite Ed). 2016 Jun 1;8:412-26. Review.


Promoter-enhancer looping at the PPARγ2 locus during adipogenic differentiation requires the Prmt5 methyltransferase.

LeBlanc SE, Wu Q, Lamba P, Sif S, Imbalzano AN.

Nucleic Acids Res. 2016 Jun 20;44(11):5133-47. doi: 10.1093/nar/gkw129. Epub 2016 Mar 1.


Transcriptional and post-transcriptional control of adipocyte differentiation by Jumonji domain-containing protein 6.

Hu YJ, Belaghzal H, Hsiao WY, Qi J, Bradner JE, Guertin DA, Sif S, Imbalzano AN.

Nucleic Acids Res. 2015 Sep 18;43(16):7790-804. doi: 10.1093/nar/gkv645. Epub 2015 Jun 27.


Opposing calcium-dependent signalling pathways control skeletal muscle differentiation by regulating a chromatin remodelling enzyme.

Nasipak BT, Padilla-Benavides T, Green KM, Leszyk JD, Mao W, Konda S, Sif S, Shaffer SA, Ohkawa Y, Imbalzano AN.

Nat Commun. 2015 Jun 17;6:7441. doi: 10.1038/ncomms8441.


Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation.

Alinari L, Mahasenan KV, Yan F, Karkhanis V, Chung JH, Smith EM, Quinion C, Smith PL, Kim L, Patton JT, Lapalombella R, Yu B, Wu Y, Roy S, De Leo A, Pileri S, Agostinelli C, Ayers L, Bradner JE, Chen-Kiang S, Elemento O, Motiwala T, Majumder S, Byrd JC, Jacob S, Sif S, Li C, Baiocchi RA.

Blood. 2015 Apr 16;125(16):2530-43. doi: 10.1182/blood-2014-12-619783. Epub 2015 Mar 5.


Genetic validation of the protein arginine methyltransferase PRMT5 as a candidate therapeutic target in glioblastoma.

Yan F, Alinari L, Lustberg ME, Martin LK, Cordero-Nieves HM, Banasavadi-Siddegowda Y, Virk S, Barnholtz-Sloan J, Bell EH, Wojton J, Jacob NK, Chakravarti A, Nowicki MO, Wu X, Lapalombella R, Datta J, Yu B, Gordon K, Haseley A, Patton JT, Smith PL, Ryu J, Zhang X, Mo X, Marcucci G, Nuovo G, Kwon CH, Byrd JC, Chiocca EA, Li C, Sif S, Jacob S, Lawler S, Kaur B, Baiocchi RA.

Cancer Res. 2014 Mar 15;74(6):1752-65. doi: 10.1158/0008-5472.CAN-13-0884. Epub 2014 Jan 22.


Cellular localization of protein arginine methyltransferase-5 correlates with grade of lung tumors.

Shilo K, Wu X, Sharma S, Welliver M, Duan W, Villalona-Calero M, Fukuoka J, Sif S, Baiocchi R, Hitchcock CL, Zhao W, Otterson GA.

Diagn Pathol. 2013 Dec 10;8:201. doi: 10.1186/1746-1596-8-201.


The multifunctional protein fused in sarcoma (FUS) is a coactivator of microphthalmia-associated transcription factor (MITF).

Bronisz A, Carey HA, Godlewski J, Sif S, Ostrowski MC, Sharma SM.

J Biol Chem. 2014 Jan 3;289(1):326-34. doi: 10.1074/jbc.M113.493874. Epub 2013 Nov 20.


Protein arginine methyltransferase 5 (PRMT5) inhibition induces lymphoma cell death through reactivation of the retinoblastoma tumor suppressor pathway and polycomb repressor complex 2 (PRC2) silencing.

Chung J, Karkhanis V, Tae S, Yan F, Smith P, Ayers LW, Agostinelli C, Pileri S, Denis GV, Baiocchi RA, Sif S.

J Biol Chem. 2013 Dec 6;288(49):35534-47. doi: 10.1074/jbc.M113.510669. Epub 2013 Nov 4.


PRMT5 is upregulated in malignant and metastatic melanoma and regulates expression of MITF and p27(Kip1.).

Nicholas C, Yang J, Peters SB, Bill MA, Baiocchi RA, Yan F, Sïf S, Tae S, Gaudio E, Wu X, Grever MR, Young GS, Lesinski GB.

PLoS One. 2013 Sep 30;8(9):e74710. doi: 10.1371/journal.pone.0074710. eCollection 2013.


Prmt7 is dispensable in tissue culture models for adipogenic differentiation.

Hu YJ, Sif S, Imbalzano AN.

F1000Res. 2013 Dec 18;2:279. doi: 10.12688/f1000research.2-279.v1. eCollection 2013.


Protein arginine methyltransferase 7 regulates cellular response to DNA damage by methylating promoter histones H2A and H4 of the polymerase δ catalytic subunit gene, POLD1.

Karkhanis V, Wang L, Tae S, Hu YJ, Imbalzano AN, Sif S.

J Biol Chem. 2012 Aug 24;287(35):29801-14. doi: 10.1074/jbc.M112.378281. Epub 2012 Jul 2.


Protein arginine methyltransferase 5 (Prmt5) promotes gene expression of peroxisome proliferator-activated receptor γ2 (PPARγ2) and its target genes during adipogenesis.

LeBlanc SE, Konda S, Wu Q, Hu YJ, Oslowski CM, Sif S, Imbalzano AN.

Mol Endocrinol. 2012 Apr;26(4):583-97. doi: 10.1210/me.2011-1162. Epub 2012 Feb 23.


Versatility of PRMT5-induced methylation in growth control and development.

Karkhanis V, Hu YJ, Baiocchi RA, Imbalzano AN, Sif S.

Trends Biochem Sci. 2011 Dec;36(12):633-41. doi: 10.1016/j.tibs.2011.09.001. Epub 2011 Oct 3. Review.


Bromodomain protein 7 interacts with PRMT5 and PRC2, and is involved in transcriptional repression of their target genes.

Tae S, Karkhanis V, Velasco K, Yaneva M, Erdjument-Bromage H, Tempst P, Sif S.

Nucleic Acids Res. 2011 Jul;39(13):5424-38. doi: 10.1093/nar/gkr170. Epub 2011 Mar 29.


The expression of myogenic microRNAs indirectly requires protein arginine methyltransferase (Prmt)5 but directly requires Prmt4.

Mallappa C, Hu YJ, Shamulailatpam P, Tae S, Sif S, Imbalzano AN.

Nucleic Acids Res. 2011 Mar;39(4):1243-55. doi: 10.1093/nar/gkq896. Epub 2010 Oct 14.


Methylation of histone H3 and H4 by PRMT5 regulates ribosomal RNA gene transcription.

Majumder S, Alinari L, Roy S, Miller T, Datta J, Sif S, Baiocchi R, Jacob ST.

J Cell Biochem. 2010 Feb 15;109(3):553-63. doi: 10.1002/jcb.22432.


Defective co-activator recruitment in osteoclasts from microphthalmia-oak ridge mutant mice.

Sharma SM, Sif S, Ostrowski MC, Sankar U.

J Cell Physiol. 2009 Jul;220(1):230-7. doi: 10.1002/jcp.21755.


Distinct protein arginine methyltransferases promote ATP-dependent chromatin remodeling function at different stages of skeletal muscle differentiation.

Dacwag CS, Bedford MT, Sif S, Imbalzano AN.

Mol Cell Biol. 2009 Apr;29(7):1909-21. doi: 10.1128/MCB.00742-08. Epub 2009 Feb 2. Erratum in: Mol Cell Biol. 2013 Nov;33(22):4618.


Protein arginine methyltransferase 5 suppresses the transcription of the RB family of tumor suppressors in leukemia and lymphoma cells.

Wang L, Pal S, Sif S.

Mol Cell Biol. 2008 Oct;28(20):6262-77. doi: 10.1128/MCB.00923-08. Epub 2008 Aug 11.


Interplay between chromatin remodelers and protein arginine methyltransferases.

Pal S, Sif S.

J Cell Physiol. 2007 Nov;213(2):306-15. Review.


Low levels of miR-92b/96 induce PRMT5 translation and H3R8/H4R3 methylation in mantle cell lymphoma.

Pal S, Baiocchi RA, Byrd JC, Grever MR, Jacob ST, Sif S.

EMBO J. 2007 Aug 8;26(15):3558-69. Epub 2007 Jul 12.


MITF and PU.1 recruit p38 MAPK and NFATc1 to target genes during osteoclast differentiation.

Sharma SM, Bronisz A, Hu R, Patel K, Mansky KC, Sif S, Ostrowski MC.

J Biol Chem. 2007 May 25;282(21):15921-9. Epub 2007 Apr 2.


The protein arginine methyltransferase Prmt5 is required for myogenesis because it facilitates ATP-dependent chromatin remodeling.

Dacwag CS, Ohkawa Y, Pal S, Sif S, Imbalzano AN.

Mol Cell Biol. 2007 Jan;27(1):384-94. Epub 2006 Oct 16.


The BRG1- and hBRM-associated factor BAF57 induces apoptosis by stimulating expression of the cylindromatosis tumor suppressor gene.

Wang L, Baiocchi RA, Pal S, Mosialos G, Caligiuri M, Sif S.

Mol Cell Biol. 2005 Sep;25(18):7953-65.


Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing.

Harikrishnan KN, Chow MZ, Baker EK, Pal S, Bassal S, Brasacchio D, Wang L, Craig JM, Jones PL, Sif S, El-Osta A.

Nat Genet. 2005 Mar;37(3):254-64. Epub 2005 Feb 6.


Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes.

Pal S, Vishwanath SN, Erdjument-Bromage H, Tempst P, Sif S.

Mol Cell Biol. 2004 Nov;24(21):9630-45.


ATP-dependent nucleosome remodeling complexes: enzymes tailored to deal with chromatin.

Sif S.

J Cell Biochem. 2004 Apr 15;91(6):1087-98. Review.


mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad.

Pal S, Yun R, Datta A, Lacomis L, Erdjument-Bromage H, Kumar J, Tempst P, Sif S.

Mol Cell Biol. 2003 Nov;23(21):7475-87.


Nucleosome remodeling by the human SWI/SNF complex requires transient global disruption of histone-DNA interactions.

Aoyagi S, Narlikar G, Zheng C, Sif S, Kingston RE, Hayes JJ.

Mol Cell Biol. 2002 Jun;22(11):3653-62.


The chicken RelB transcription factor has transactivation sequences and a tissue-specific expression pattern that are distinct from mammalian RelB.

Piffat KA, Hrdlicková R, Nehyba J, Ikeda T, Liss A, Huang S, Sif S, Gilmore TD, Bose HR Jr.

Mol Cell Biol Res Commun. 2001 Sep;4(5):266-75.


The p400 complex is an essential E1A transformation target.

Fuchs M, Gerber J, Drapkin R, Sif S, Ikura T, Ogryzko V, Lane WS, Nakatani Y, Livingston DM.

Cell. 2001 Aug 10;106(3):297-307.


Transcriptional activation domains of human heat shock factor 1 recruit human SWI/SNF.

Sullivan EK, Weirich CS, Guyon JR, Sif S, Kingston RE.

Mol Cell Biol. 2001 Sep;21(17):5826-37.


Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes.

Sif S, Saurin AJ, Imbalzano AN, Kingston RE.

Genes Dev. 2001 Mar 1;15(5):603-18.


BRG-1 is recruited to estrogen-responsive promoters and cooperates with factors involved in histone acetylation.

DiRenzo J, Shang Y, Phelan M, Sif S, Myers M, Kingston R, Brown M.

Mol Cell Biol. 2000 Oct;20(20):7541-9.


Mammalian SWI-SNF complexes contribute to activation of the hsp70 gene.

de La Serna IL, Carlson KA, Hill DA, Guidi CJ, Stephenson RO, Sif S, Kingston RE, Imbalzano AN.

Mol Cell Biol. 2000 Apr;20(8):2839-51.


hSWI/SNF disrupts interactions between the H2A N-terminal tail and nucleosomal DNA.

Lee KM, Sif S, Kingston RE, Hayes JJ.

Biochemistry. 1999 Jun 29;38(26):8423-9.


A model for chromatin remodeling by the SWI/SNF family.

Schnitzler GR, Sif S, Kingston RE.

Cold Spring Harb Symp Quant Biol. 1998;63:535-43. No abstract available.


Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes.

Kim J, Sif S, Jones B, Jackson A, Koipally J, Heller E, Winandy S, Viel A, Sawyer A, Ikeda T, Kingston R, Georgopoulos K.

Immunity. 1999 Mar;10(3):345-55.


Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits.

Phelan ML, Sif S, Narlikar GJ, Kingston RE.

Mol Cell. 1999 Feb;3(2):247-53.


Stable remodeling of tailless nucleosomes by the human SWI-SNF complex.

Guyon JR, Narlikar GJ, Sif S, Kingston RE.

Mol Cell Biol. 1999 Mar;19(3):2088-97.


Mitotic inactivation of a human SWI/SNF chromatin remodeling complex.

Sif S, Stukenberg PT, Kirschner MW, Kingston RE.

Genes Dev. 1998 Sep 15;12(18):2842-51.


Supplemental Content

Support Center