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Items: 21


Crystal structures of amyloidogenic segments of human transthyretin.

Saelices L, Sievers SA, Sawaya MR, Eisenberg DS.

Protein Sci. 2018 Jul;27(7):1295-1303. doi: 10.1002/pro.3420. Epub 2018 Jun 13.


Function of Novel Anti-CD19 Chimeric Antigen Receptors with Human Variable Regions Is Affected by Hinge and Transmembrane Domains.

Alabanza L, Pegues M, Geldres C, Shi V, Wiltzius JJW, Sievers SA, Yang S, Kochenderfer JN.

Mol Ther. 2017 Nov 1;25(11):2452-2465. doi: 10.1016/j.ymthe.2017.07.013. Epub 2017 Jul 27.


Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller.

Freund NT, Wang H, Scharf L, Nogueira L, Horwitz JA, Bar-On Y, Golijanin J, Sievers SA, Sok D, Cai H, Cesar Lorenzi JC, Halper-Stromberg A, Toth I, Piechocka-Trocha A, Gristick HB, van Gils MJ, Sanders RW, Wang LX, Seaman MS, Burton DR, Gazumyan A, Walker BD, West AP Jr, Bjorkman PJ, Nussenzweig MC.

Sci Transl Med. 2017 Jan 18;9(373). pii: eaal2144. doi: 10.1126/scitranslmed.aal2144.


Structural basis for germline antibody recognition of HIV-1 immunogens.

Scharf L, West AP, Sievers SA, Chen C, Jiang S, Gao H, Gray MD, McGuire AT, Scheid JF, Nussenzweig MC, Stamatatos L, Bjorkman PJ.

Elife. 2016 Mar 21;5. pii: e13783. doi: 10.7554/eLife.13783.


A New Glycan-Dependent CD4-Binding Site Neutralizing Antibody Exerts Pressure on HIV-1 In Vivo.

Freund NT, Horwitz JA, Nogueira L, Sievers SA, Scharf L, Scheid JF, Gazumyan A, Liu C, Velinzon K, Goldenthal A, Sanders RW, Moore JP, Bjorkman PJ, Seaman MS, Walker BD, Klein F, Nussenzweig MC.

PLoS Pathog. 2015 Oct 30;11(10):e1005238. doi: 10.1371/journal.ppat.1005238. eCollection 2015 Oct.


Antibody engineering for increased potency, breadth and half-life.

Sievers SA, Scharf L, West AP Jr, Bjorkman PJ.

Curr Opin HIV AIDS. 2015 May;10(3):151-9. doi: 10.1097/COH.0000000000000148. Review.


Structure-based design of functional amyloid materials.

Li D, Jones EM, Sawaya MR, Furukawa H, Luo F, Ivanova M, Sievers SA, Wang W, Yaghi OM, Liu C, Eisenberg DS.

J Am Chem Soc. 2014 Dec 31;136(52):18044-51. doi: 10.1021/ja509648u. Epub 2014 Dec 19.


Aggregation-triggering segments of SOD1 fibril formation support a common pathway for familial and sporadic ALS.

Ivanova MI, Sievers SA, Guenther EL, Johnson LM, Winkler DD, Galaleldeen A, Sawaya MR, Hart PJ, Eisenberg DS.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):197-201. doi: 10.1073/pnas.1320786110. Epub 2013 Dec 16.


Towards a pharmacophore for amyloid.

Landau M, Sawaya MR, Faull KF, Laganowsky A, Jiang L, Sievers SA, Liu J, Barrio JR, Eisenberg D.

PLoS Biol. 2011 Jun;9(6):e1001080. doi: 10.1371/journal.pbio.1001080. Epub 2011 Jun 14.


Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation.

Sievers SA, Karanicolas J, Chang HW, Zhao A, Jiang L, Zirafi O, Stevens JT, Münch J, Baker D, Eisenberg D.

Nature. 2011 Jun 15;475(7354):96-100. doi: 10.1038/nature10154.


Molecular basis for insulin fibril assembly.

Ivanova MI, Sievers SA, Sawaya MR, Wall JS, Eisenberg D.

Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):18990-5. doi: 10.1073/pnas.0910080106. Epub 2009 Oct 28.


Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process.

Wiltzius JJ, Sievers SA, Sawaya MR, Eisenberg D.

Protein Sci. 2009 Jul;18(7):1521-30. doi: 10.1002/pro.145.


Atomic structure of the cross-beta spine of islet amyloid polypeptide (amylin).

Wiltzius JJ, Sievers SA, Sawaya MR, Cascio D, Popov D, Riekel C, Eisenberg D.

Protein Sci. 2008 Sep;17(9):1467-74. doi: 10.1110/ps.036509.108. Epub 2008 Jun 12.


Draft crystal structure of the vault shell at 9-A resolution.

Anderson DH, Kickhoefer VA, Sievers SA, Rome LH, Eisenberg D.

PLoS Biol. 2007 Nov;5(11):e318.


Atomic structures of amyloid cross-beta spines reveal varied steric zippers.

Sawaya MR, Sambashivan S, Nelson R, Ivanova MI, Sievers SA, Apostol MI, Thompson MJ, Balbirnie M, Wiltzius JJ, McFarlane HT, Madsen AØ, Riekel C, Eisenberg D.

Nature. 2007 May 24;447(7143):453-7. Epub 2007 Apr 29.


Identification and biochemical characterization of serine hydroxymethyl transferase in the hydrogenosome of Trichomonas vaginalis.

Mukherjee M, Sievers SA, Brown MT, Johnson PJ.

Eukaryot Cell. 2006 Dec;5(12):2072-8. Epub 2006 Sep 15.


The TCL1 oncoprotein binds the RNase PH domains of the PNPase exoribonuclease without affecting its RNA degrading activity.

French SW, Dawson DW, Chen HW, Rainey RN, Sievers SA, Balatoni CE, Wong L, Troke JJ, Nguyen MT, Koehler CM, Teitell MA.

Cancer Lett. 2007 Apr 18;248(2):198-210. Epub 2006 Aug 28.


The 3D profile method for identifying fibril-forming segments of proteins.

Thompson MJ, Sievers SA, Karanicolas J, Ivanova MI, Baker D, Eisenberg D.

Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8. Epub 2006 Mar 7.


Editorial. An ethical responsibility.

Sievers SA.

Off Publ Dent Hyg Assoc State N Y. 1970 Fall;21(2):4. No abstract available.


Editorial. A call for unity.

Sievers SA.

Off Publ Dent Hyg Assoc State N Y. 1970 Winter;20(3):4. No abstract available.


Editorial. Prepare yourself.

Sievers SA.

Off Publ Dent Hyg Assoc State N Y. 1969 Fall;20(2):3. No abstract available.


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